LOCUS       NM_133518               2657 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus rabphilin 3A (Rph3a), mRNA.
ACCESSION   NM_133518
VERSION     NM_133518.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   Li,T., Cheng,Q., Wang,S. and Ma,C.
  TITLE     Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE
            complex assembly in exocytosis
  JOURNAL   Elife 11, e79926 (2022)
   PUBMED   36173100
  REMARK    GeneRIF: Rabphilin 3A binds the N-peptide of SNAP-25 to promote
            SNARE complex assembly in exocytosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2657)
  AUTHORS   Franchini,L., Stanic,J., Barzasi,M., Zianni,E., Mauceri,D.,
            Diluca,M. and Gardoni,F.
  TITLE     Rabphilin-3A Drives Structural Modifications of Dendritic Spines
            Induced by Long-Term Potentiation
  JOURNAL   Cells 11 (10), 1616 (2022)
   PUBMED   35626653
  REMARK    GeneRIF: Rabphilin-3A Drives Structural Modifications of Dendritic
            Spines Induced by Long-Term Potentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2657)
  AUTHORS   Stanic,J., Mellone,M., Napolitano,F., Racca,C., Zianni,E.,
            Minocci,D., Ghiglieri,V., Thiolat,M.L., Li,Q., Longhi,A., De
            Rosa,A., Picconi,B., Bezard,E., Calabresi,P., Di Luca,M.,
            Usiello,A. and Gardoni,F.
  TITLE     Rabphilin 3A: A novel target for the treatment of levodopa-induced
            dyskinesias
  JOURNAL   Neurobiol Dis 108, 54-64 (2017)
   PUBMED   28823933
  REMARK    GeneRIF: Findings indicate that Rph3A activity is linked to the
            aberrant synaptic localization of GluN2A-expressing NMDARs
            characterizing levodopa-induced dyskinesias; suggest that
            Rph3A/GluN2A complex could represent an innovative therapeutic
            target for those pathological conditions where NMDAR composition is
            significantly altered.
REFERENCE   4  (bases 1 to 2657)
  AUTHORS   Stanic,J., Carta,M., Eberini,I., Pelucchi,S., Marcello,E.,
            Genazzani,A.A., Racca,C., Mulle,C., Di Luca,M. and Gardoni,F.
  TITLE     Rabphilin 3A retains NMDA receptors at synaptic sites through
            interaction with GluN2A/PSD-95 complex
  JOURNAL   Nat Commun 6, 10181 (2015)
   PUBMED   26679993
  REMARK    GeneRIF: Rph3A interacts with GluN2A and PSD-95 forming a complex
            that regulates NMDARs stabilization at postsynaptic membranes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2657)
  AUTHORS   Pang,Z.P., Bacaj,T., Yang,X., Zhou,P., Xu,W. and Sudhof,T.C.
  TITLE     Doc2 supports spontaneous synaptic transmission by a
            Ca(2+)-independent mechanism
  JOURNAL   Neuron 70 (2), 244-251 (2011)
   PUBMED   21521611
REFERENCE   6  (bases 1 to 2657)
  AUTHORS   Kato,M., Sasaki,T., Ohya,T., Nakanishi,H., Nishioka,H., Imamura,M.
            and Takai,Y.
  TITLE     Physical and functional interaction of rabphilin-3A with
            alpha-actinin
  JOURNAL   J Biol Chem 271 (50), 31775-31778 (1996)
   PUBMED   8943213
REFERENCE   7  (bases 1 to 2657)
  AUTHORS   Stahl,B., Chou,J.H., Li,C., Sudhof,T.C. and Jahn,R.
  TITLE     Rab3 reversibly recruits rabphilin to synaptic vesicles by a
            mechanism analogous to raf recruitment by ras
  JOURNAL   EMBO J 15 (8), 1799-1809 (1996)
   PUBMED   8617225
REFERENCE   8  (bases 1 to 2657)
  AUTHORS   Imazumi,K., Sasaki,T., Takahashi,K. and Takai,Y.
  TITLE     Identification of a rabphilin-3A-interacting protein as GTP
            cyclohydrolase I in PC12 cells
  JOURNAL   Biochem Biophys Res Commun 205 (2), 1409-1416 (1994)
   PUBMED   7802677
REFERENCE   9  (bases 1 to 2657)
  AUTHORS   Li,C., Takei,K., Geppert,M., Daniell,L., Stenius,K., Chapman,E.R.,
            Jahn,R., De Camilli,P. and Sudhof,T.C.
  TITLE     Synaptic targeting of rabphilin-3A, a synaptic vesicle
            Ca2+/phospholipid-binding protein, depends on rab3A/3C
  JOURNAL   Neuron 13 (4), 885-898 (1994)
   PUBMED   7946335
  REMARK    Erratum:[Neuron 1995 Jul;15(1):following 239]
REFERENCE   10 (bases 1 to 2657)
  AUTHORS   Mizoguchi,A., Yano,Y., Hamaguchi,H., Yanagida,H., Ide,C.,
            Zahraoui,A., Shirataki,H., Sasaki,T. and Takai,Y.
  TITLE     Localization of Rabphilin-3A on the synaptic vesicle
  JOURNAL   Biochem Biophys Res Commun 202 (3), 1235-1243 (1994)
   PUBMED   8060298
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133518.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U12571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000012.1  41203562-41203713
            153-262             JAXUCZ010000012.1  41203824-41203933
            263-339             JAXUCZ010000012.1  41230483-41230559
            340-351             JAXUCZ010000012.1  41237021-41237032
            352-498             JAXUCZ010000012.1  41244784-41244930
            499-628             JAXUCZ010000012.1  41254850-41254979
            629-715             JAXUCZ010000012.1  41256473-41256559
            716-881             JAXUCZ010000012.1  41258685-41258850
            882-920             JAXUCZ010000012.1  41260492-41260530
            921-1082            JAXUCZ010000012.1  41260614-41260775
            1083-1169           JAXUCZ010000012.1  41264358-41264444
            1170-1229           JAXUCZ010000012.1  41264888-41264947
            1230-1421           JAXUCZ010000012.1  41265770-41265961
            1422-1501           JAXUCZ010000012.1  41268098-41268177
            1502-1576           JAXUCZ010000012.1  41269725-41269799
            1577-1686           JAXUCZ010000012.1  41271186-41271295
            1687-1813           JAXUCZ010000012.1  41272031-41272157
            1814-1870           JAXUCZ010000012.1  41273102-41273158
            1871-2025           JAXUCZ010000012.1  41273665-41273819
            2026-2107           JAXUCZ010000012.1  41274659-41274740
            2108-2204           JAXUCZ010000012.1  41277203-41277299
            2205-2657           JAXUCZ010000012.1  41277775-41278227
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2657
                     /gene="Rph3a"
                     /note="rabphilin 3A"
                     /db_xref="GeneID:171039"
                     /db_xref="RGD:620073"
     exon            1..152
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            153..262
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            263..339
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..2335
                     /gene="Rph3a"
                     /note="exophilin-1; rabphilin 3A homolog"
                     /codon_start=1
                     /product="rabphilin-3A"
                     /protein_id="NP_598202.2"
                     /db_xref="GeneID:171039"
                     /db_xref="RGD:620073"
                     /translation="MTDTVVNRWMYPGDGPLQSNDKEQLQAGWSVHPGAQTDRQRKQE
                     ELTDEEKEIINRVIARAEKMEAMEQERIGRLVDRLETMRKNVAGDGVNRCILCGEQLG
                     MLGSACVVCEDCKKNVCTKCGVETSNNRPHPVWLCKICLEQREVWKRSGAWFFKGFPK
                     QVLPQPMPIKKTKPQQPAGEPATQEQPTPESRHPARAPARGDMEDRRAPGQKPGPDLT
                     SAPGRGSHGPPTRRASEARMSTTTRDSEGWDHGHGGGAGDTSRSPGGEQGLRRANSVQ
                     ASRPAPASMPSPAPPQPVQPGPPGGSRAAPGPGRFPEQSTEAPPSDPGYPGAVAPARE
                     ERTGPTGGFQAAPHTAGPYSQAAPARQPPPAEEEEEEANSYDSDEATTLGALEFSLLY
                     DQDNSNLQCTIIRAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPVWN
                     ETLQYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKANQRKNFNICLER
                     VIPMKRAGTTGSARGMALYEEEQVERIGDIEERGKILVSLMYSTQQGGLIVGIIRCVH
                     LAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKS
                     LDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVS
                     SD"
     exon            340..351
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            352..498
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            499..628
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            629..715
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            716..881
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            882..920
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1082
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1169
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1229
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1421
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1501
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1576
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1686
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1813
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1870
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2025
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2107
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2204
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2657
                     /gene="Rph3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgcctacg ctgcccagag agggagagag gaaagagaag aggggagaga aagagagact
       61 tacaaaacct tccttccatg tggagtagtc tgagtgaatc actgcccacc gttgtagact
      121 ccaactgtac ttagttttct cctttgacgg gggcatatct gctggtcttt caagccaagt
      181 cgctggcact taacatctcc ccccggcagg gagttggcaa gaatttggct cacgccttct
      241 gctgcaatcc tccgttgtct tggtgtgcca gccttccacc atgactgaca ctgtggtgaa
      301 ccgttggatg taccctggtg atggcccact gcagtcaaat gacaaggaac agctgcaggc
      361 aggatggtcc gtccatcctg gagcacagac ggacaggcag aggaagcagg aagaactgac
      421 agacgaggag aaggagataa tcaaccgggt gatagctcgg gcagagaaga tggaagccat
      481 ggagcaggag cgcatcgggc gcctggtgga ccgtctggag accatgagga agaatgtagc
      541 tggagatggt gtgaaccgtt gcatcctgtg cggggaacag ctgggcatgc tgggctctgc
      601 gtgtgtcgtg tgtgaagact gtaagaagaa tgtctgcacc aagtgtgggg tggagacctc
      661 caacaaccgt ccgcatccag tatggctctg taagatctgc cttgagcaga gagaggtctg
      721 gaagcgctcg ggagcatggt tcttcaaggg tttcccaaaa caggtccttc cacagcccat
      781 gcctataaag aagaccaagc cccagcagcc tgctggtgag ccggccaccc aggagcagcc
      841 tacacccgag tccaggcatc cagccagagc tccagctcga ggtgacatgg aggacaggag
      901 ggccccagga cagaagccag gccctgacct cacctctgct cctggacgag gaagccatgg
      961 gcctcccaca cgcagggcct ctgaggcccg gatgagtaca accacccgtg attctgaggg
     1021 ctgggaccat ggtcatggtg ggggtgctgg agacaccagc cggagcccag gaggtgagca
     1081 aggtttgagg cgagctaact cagtccaggc ctcccgccca gctccagcct ccatgccaag
     1141 cccggcacct cctcagcccg tgcagccagg gccccctggg ggcagcaggg ccgctcctgg
     1201 gccgggacgc tttccagagc agagcacaga ggctcctcca agtgaccctg gctatccagg
     1261 ggctgttgcc ccagcccggg aggagaggac aggacccaca gggggcttcc aggcagcgcc
     1321 ccacactgcg ggtccctatt cccaggcggc ccctgcccgc cagccaccgc ctgctgagga
     1381 agaggaggaa gaagccaaca gctatgactc agatgaagca accacactgg gtgccctgga
     1441 attcagcctt ctctatgacc aagacaacag caacctgcag tgcaccatca tcagggcgaa
     1501 gggactgaag cccatggact ccaacggctt agcggatccc tatgtgaagc tgcatctgct
     1561 gcctggagcc agcaagtcca acaagcttcg tacaaagacc ctgcgcaaca cccggaaccc
     1621 tgtgtggaac gagacgctgc agtatcatgg cattactgag gaggacatgc agaggaagac
     1681 actcaggatc tccgtatgtg acgaggacaa gtttggccac aatgagttca ttggtgagac
     1741 caggttctcg ctcaagaaac tgaaggcgaa ccagaggaaa aacttcaaca tctgcctgga
     1801 gcgggtgatc ccgatgaagc gcgcaggaac cactgggtca gcacgtggca tggctctcta
     1861 tgaggaggag caggtggagc ggatcggaga catagaggaa cggggcaaga tcctggtgtc
     1921 cctcatgtac agcacgcagc agggcggcct catcgtggga attatccgct gtgtgcacct
     1981 ggctgccatg gacgccaacg gctactcaga ccccttcgtc aagctctggc tgaaaccgga
     2041 catggggaag aaagccaagc acaagactca gattaaaaag aagaccctga atcccgagtt
     2101 taatgaggag ttcttttatg atatcaaaca cagcgacctg gccaaaaagt ccctggatat
     2161 ctcagtgtgg gactacgaca ttggcaaatc gaatgattac atcggaggct gccagctggg
     2221 gatctcggcc aagggcgagc gcttgaaaca ttggtatgag tgtctgaaga acaaagacaa
     2281 gaagattgaa cgttggcacc aactgcagaa cgagaaccac gtgtcgagcg actaggacct
     2341 ggcgccctgc tgtcatcgtc tctgccccag ctgctctccc ctctaaagtc tcccttgcca
     2401 accacgaacc ttcgatgtcc cccccacttc aggttctgca acaaacgaac tctatgagct
     2461 tcagggtcca gatgagagcc ctttctggtc ctcagagatt gggtggtggg tgtggggaga
     2521 catttacgaa gatttactct gaccttaaac atatttgtgt ctccttgggc attggtggac
     2581 cctcaggctg tgaggaccag cagggggcag aagttatata ttgaggctgc ctctgtccct
     2641 ccaaatcact cgagaaa
//
