LOCUS       NM_001374059            3670 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus retinitis pigmentosa GTPase regulator (Rpgr),
            transcript variant 1, mRNA.
ACCESSION   NM_001374059 XM_003754732 XM_008773079
VERSION     NM_001374059.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3670)
  AUTHORS   Dharmat,R., Eblimit,A., Robichaux,M.A., Zhang,Z., Nguyen,T.T.,
            Jung,S.Y., He,F., Jain,A., Li,Y., Qin,J., Overbeek,P., Roepman,R.,
            Mardon,G., Wensel,T.G. and Chen,R.
  TITLE     SPATA7 maintains a novel photoreceptor-specific zone in the distal
            connecting cilium
  JOURNAL   J Cell Biol 217 (8), 2851-2865 (2018)
   PUBMED   29899041
REFERENCE   2  (bases 1 to 3670)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   3  (bases 1 to 3670)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3670)
  AUTHORS   Thompson,D.A., Khan,N.W., Othman,M.I., Chang,B., Jia,L., Grahek,G.,
            Wu,Z., Hiriyanna,S., Nellissery,J., Li,T., Khanna,H., Colosi,P.,
            Swaroop,A. and Heckenlively,J.R.
  TITLE     Rd9 is a naturally occurring mouse model of a common form of
            retinitis pigmentosa caused by mutations in RPGR-ORF15
  JOURNAL   PLoS One 7 (5), e35865 (2012)
   PUBMED   22563472
REFERENCE   5  (bases 1 to 3670)
  AUTHORS   Gakovic,M., Shu,X., Kasioulis,I., Carpanini,S., Moraga,I. and
            Wright,A.F.
  TITLE     The role of RPGR in cilia formation and actin stability
  JOURNAL   Hum Mol Genet 20 (24), 4840-4850 (2011)
   PUBMED   21933838
REFERENCE   6  (bases 1 to 3670)
  AUTHORS   Dry,K.L., Manson,F.D., Lennon,A., Bergen,A.A., Van Dorp,D.B. and
            Wright,A.F.
  TITLE     Identification of a 5' splice site mutation in the RPGR gene in a
            family with X-linked retinitis pigmentosa (RP3)
  JOURNAL   Hum Mutat 13 (2), 141-145 (1999)
   PUBMED   10094550
REFERENCE   7  (bases 1 to 3670)
  AUTHORS   Fishman,G.A., Grover,S., Jacobson,S.G., Alexander,K.R.,
            Derlacki,D.J., Wu,W., Buraczynska,M. and Swaroop,A.
  TITLE     X-linked retinitis pigmentosa in two families with a missense
            mutation in the RPGR gene and putative change of glycine to valine
            at codon 60
  JOURNAL   Ophthalmology 105 (12), 2286-2296 (1998)
   PUBMED   9855162
REFERENCE   8  (bases 1 to 3670)
  AUTHORS   Yan,D., Swain,P.K., Breuer,D., Tucker,R.M., Wu,W., Fujita,R.,
            Rehemtulla,A., Burke,D. and Swaroop,A.
  TITLE     Biochemical characterization and subcellular localization of the
            mouse retinitis pigmentosa GTPase regulator (mRpgr)
  JOURNAL   J Biol Chem 273 (31), 19656-19663 (1998)
   PUBMED   9677393
REFERENCE   9  (bases 1 to 3670)
  AUTHORS   Buraczynska,M., Wu,W., Fujita,R., Buraczynska,K., Phelps,E.,
            Andreasson,S., Bennett,J., Birch,D.G., Fishman,G.A., Hoffman,D.R.,
            Inana,G., Jacobson,S.G., Musarella,M.A., Sieving,P.A. and
            Swaroop,A.
  TITLE     Spectrum of mutations in the RPGR gene that are identified in 20%
            of families with X-linked retinitis pigmentosa
  JOURNAL   Am J Hum Genet 61 (6), 1287-1292 (1997)
   PUBMED   9399904
REFERENCE   10 (bases 1 to 3670)
  AUTHORS   Jacobson,S.G., Buraczynska,M., Milam,A.H., Chen,C., Jarvalainen,M.,
            Fujita,R., Wu,W., Huang,Y., Cideciyan,A.V. and Swaroop,A.
  TITLE     Disease expression in X-linked retinitis pigmentosa caused by a
            putative null mutation in the RPGR gene
  JOURNAL   Invest Ophthalmol Vis Sci 38 (10), 1983-1997 (1997)
   PUBMED   9331262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1 and BC162028.1.
            
            On or before Sep 10, 2019 this sequence version replaced
            XM_008773079.2, XM_003754732.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This RefSeq transcript is based on
            transcript alignments from orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1750329.1,
                                           SRR26360181.2268927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               JAXUCZ010000021.1  15239159-15239383
            226-351             JAXUCZ010000021.1  15242135-15242260
            352-444             JAXUCZ010000021.1  15242951-15243043
            445-507             JAXUCZ010000021.1  15243990-15244052
            508-666             JAXUCZ010000021.1  15244939-15245097
            667-816             JAXUCZ010000021.1  15247290-15247439
            817-975             JAXUCZ010000021.1  15250407-15250565
            976-1131            JAXUCZ010000021.1  15253226-15253381
            1132-1256           JAXUCZ010000021.1  15255763-15255887
            1257-1439           JAXUCZ010000021.1  15258594-15258776
            1440-1608           JAXUCZ010000021.1  15259830-15259998
            1609-1706           JAXUCZ010000021.1  15274534-15274631
            1707-1772           JAXUCZ010000021.1  15278906-15278971
            1773-2624           JAXUCZ010000021.1  15280280-15281131
            2625-2837           JAXUCZ010000021.1  15291106-15291318
            2838-2895           JAXUCZ010000021.1  15292652-15292709
            2896-2984           JAXUCZ010000021.1  15294852-15294940
            2985-3647           JAXUCZ010000021.1  15298341-15299003
            3648-3670           BC162028.1         2674-2696
FEATURES             Location/Qualifiers
     source          1..3670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..3670
                     /gene="Rpgr"
                     /note="retinitis pigmentosa GTPase regulator"
                     /db_xref="GeneID:367733"
                     /db_xref="RGD:1560136"
     exon            1..225
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..3191
                     /gene="Rpgr"
                     /note="isoform 1 is encoded by transcript variant 1;
                     X-linked retinitis pigmentosa GTPase regulator"
                     /codon_start=1
                     /product="X-linked retinitis pigmentosa GTPase regulator
                     isoform 1"
                     /protein_id="NP_001360988.1"
                     /db_xref="GeneID:367733"
                     /db_xref="RGD:1560136"
                     /translation="MPRGSRWGTGGLGQYLRPNRVAPAVFPKQAQIPFAAFGMAEPES
                     LVPDTGAVFTFGKTKFAENIPSKFWFKNDVPICLSCGDEHTAIVTGNNKLYMFGSNNW
                     GQLGLGSKSAISKPTCIKALKPEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLG
                     DTDDRDTFHQIGFFTPSDIIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLKNKSNV
                     CIPHEVTVGKPISWISCGYYHSAFVTTDGELYTFGEPENGKLGLPNQLLINHRSPQRV
                     LGIPDKVIQVACGGGHTVVLTEKVVYAFGLGQFGQLGLGTFLFETSEPKIIDRIKDQK
                     ISHISCGENHTALMTDIGLMYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLKFTVQLI
                     ACGGCHMLVFATPRLGTIDETEFEEVYEPYMSTGSLSINDLSPGSSLNRSLSARLRRR
                     ERERPSCSASMVGTLPPLEGTSASTSASYFSPSSIPFRLSVNNYPEKSTSDSTEPLDS
                     DYFEDKMNKETETENSSAVDLENFGETIDILNMTHMMTTSSNEKSLDFSPIQKQQNQD
                     TVEKVVESTPYTENEDSYEYEEMSKIKEGTVYKQYLAKGIFMIRAPEILGTFSDEEGG
                     NSLDQEELQAFTGVKSEQVGKERDEEIDSEKKTQAMEMADLKKVRESQENSKSDTFFD
                     DLPDKDMNSESEDNKDIAEERKSSEQNMVFDSETELVEEPDSYMECKKHSEQDSAEES
                     EQHKLVESSIEEKDDDEVETEHYLWYSRKCAEQATENELRANRFLPKYDLKHDHLSGI
                     PEEQEGAEDAEGSVVVEQEVQAQEENMELEGDREEAKAEALSDVITEKEIPQLSESVK
                     PEAEGMDEQISVPNVEDTVEEEGKKEKETVEEGSLPEDALPETEGSETVVPADEKPAE
                     MVKEENSASLLQRNLREYNENPKGHMYDRVKSSSSEILGGNEPTSKDIKKAKKISFFN
                     RMSLTGQKLMQSANDPLPEIKPIGDQIALQSDKKDANQNHMGQNLQDTATPNMEGKSK
                     SCTIL"
     exon            226..351
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            352..444
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            445..507
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            508..666
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            667..816
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            817..975
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1131
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1256
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1439
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1608
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1706
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1772
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..2624
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2837
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2895
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..2984
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3648
                     /gene="Rpgr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctttcgc cccgccccgc aaggctccgc ctccgttgcc cctagcgtct gtttgttgac
       61 ttccgggagc acagtagtgg tcgatgccaa gagggtcgcg atggggaacc ggggggctag
      121 ggcagtacct taggcccaat cgagtcgccc ctgctgtctt tccgaagcag gcacagattc
      181 cgttcgcagc cttcggcatg gcagaacctg agtcattggt gcctgatacg ggtgctgtat
      241 ttacatttgg aaaaactaaa tttgctgaaa acattcctag caaattctgg tttaaaaatg
      301 acgtacccat atgtctttca tgtggagatg aacatactgc tattgttaca ggaaataata
      361 aattgtacat gtttggcagt aacaactggg gccagttagg attaggatca aaatcagcta
      421 tcagcaagcc aacatgtatc aaagctctta agcctgaaaa ggtgaaactt gctgcgtgtg
      481 gaagaaacca taccttagtt tcaacagata ctggtggtgt atatgcagct ggtggaaata
      541 atgaaggcca attggggctt ggtgacactg atgacagaga tacctttcat caaattggct
      601 tctttacacc tagtgatatc attaaacagc tctctgctgg tgctaataca tcagctgctc
      661 taactgagga tggaaaactt tttatgtggg gagacaattc tgaagggcag atcggtttga
      721 aaaataaaag taatgtatgt atccctcacg aagtgactgt cggtaagcca atttcatgga
      781 tctcctgtgg atattaccat tcagcttttg taacaacgga tggggagctg tacacatttg
      841 gagaacctga gaatggaaag ttgggccttc ccaaccagct gctgatcaat cacagatctc
      901 cccagcgtgt gctggggatt cctgacaagg tgattcaagt agcgtgtggt ggagggcaca
      961 ctgtggttct cacagagaaa gttgtgtatg cctttgggct gggacagttt ggacaactgg
     1021 gccttggcac ttttcttttt gaaacttcag aacccaaaat cattgatcgt attaaggatc
     1081 agaaaataag tcatatttcc tgtggagaaa accatacagc tttgatgaca gatataggcc
     1141 ttatgtatac ttttggagac ggacggcatg gaaaattagg gcttggaatg gagaatttta
     1201 ccaatcagtt cttccctact ttgtgctcta attttttgaa atttacagtt caattgattg
     1261 cctgtggtgg atgtcacatg ctagtttttg ccactccacg acttggtaca atagacgaaa
     1321 ctgaatttga agaagtatat gagccttata tgagtacagg ttctttgtcc atcaatgatc
     1381 tctccccagg aagttctctg aatagatctt tatcagcgcg tctgagacga agagagcggg
     1441 agagaccctc atgctctgct tcaatggtgg gaacactgcc tccattagag gggacttctg
     1501 cctccacttc agcttcttat ttttccccca gttcaatccc cttccgtttg tctgtgaata
     1561 actacccaga gaaaagcacc tctgactcca cggagccgct ggactcagat tattttgaag
     1621 ataaaatgaa caaagagaca gagacagaaa attcttcagc agtggattta gaaaactttg
     1681 gtgaaaccat tgatatctta aatatgacac atatgatgac cacgagttcc aatgagaagt
     1741 cattagattt ttcaccaatt caaaaacagc agaatcaaga cacggttgag aaagtggtgg
     1801 aaagtacacc gtacactgaa aatgaggata gttatgaata tgaagagatg tcaaaaataa
     1861 aagaagggac agtgtacaaa caatatttag caaaagggat cttcatgata cgagcacctg
     1921 agattctggg aacattttca gatgaggaag ggggtaatag cctagaccag gaggagctgc
     1981 aggccttcac cggtgtaaaa agtgagcaag tgggaaagga acgtgatgaa gaaatagact
     2041 ctgagaagaa aactcaggcg atggaaatgg cagatttgaa aaaggttaga gaaagtcaag
     2101 agaactcaaa atcagatacg ttttttgatg acttaccaga taaagacatg aattctgaga
     2161 gtgaagacaa taaagatatt gctgaggaaa ggaaaagcag tgaacagaat atggtctttg
     2221 acagtgaaac agagttggtg gaagagccag acagttacat ggagtgcaaa aagcacagcg
     2281 agcaggacag tgctgaggag tcggagcagc acaagctggt agaatctagt atcgaagaga
     2341 aagatgacga cgaagtggag actgagcact acttatggta cagcaggaag tgtgctgagc
     2401 aggcaaccga gaatgaactc agagcaaaca gatttctccc aaagtacgat cttaagcatg
     2461 accacttgtc agggataccc gaggagcagg agggagcaga ggatgcggaa ggaagcgtag
     2521 tagtggagca agaggtacag gcacaagagg aaaatatgga actggaagga gacagagagg
     2581 aagcaaaggc agaagccctg tcagatgtca ttacagaaaa agagattcct caactttcag
     2641 aaagtgtgaa accagaagca gaaggcatgg atgagcaaat tagtgtccca aatgtagaag
     2701 acactgtaga agaagaaggg aagaaagaaa aggagactgt agaagaagga agtctacctg
     2761 aggatgccct tcctgaaaca gaaggctccg aaactgtcgt tcctgctgat gagaagccag
     2821 ctgagatggt taaagaggaa aacagtgcca gccttctgca acggaacctt cgtgagtaca
     2881 atgaaaatcc aaaaggacac atgtatgacc gagtaaagag cagctcttca gaaattctgg
     2941 gaggtaatga accaacaagt aaagacataa aaaaggctaa aaaaatttcc ttctttaatc
     3001 ggatgtcatt gacaggtcag aaactgatgc agagtgctaa tgatccactc ccagagataa
     3061 agccaatagg agaccaaata gccttacaaa gtgataagaa agatgccaac cagaaccaca
     3121 tgggtcagaa tcttcaggat actgcaacac caaatatgga gggaaagtcc aaatcctgta
     3181 caattctata aatgtatgtt tatgtttcca tggtcaccga gcacatttat tcttcatact
     3241 tgaaaaatgt tgtgacttct gaaggaaatt cccccataac actgtttaaa aagatattaa
     3301 ttagtaagtt tggcttggtt tggacaatat gaacagattt aatatttatt tatgttaata
     3361 ttcttatcaa gcagtttcca aagtacatgt acctccaact ctccttgaag tgttctggcc
     3421 ttaactgctc agtgttgcat aaagcaatat atttttatat ttggaaacca aatgaagcta
     3481 tttcatagtt ttgccaacat agttattgta ctttgtaatt tcctaagaca atgttcatac
     3541 tattacaaca ctggaacagt tttggataaa tttacaacat tttaaaacag gcaacattgt
     3601 aatgaactta ttttaataaa ttatatctgg ttggttctgc tgtaaaaaaa aaaaaaaaaa
     3661 aaaaaaaaaa
//
