LOCUS       NM_001399122            2273 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ribulose-5-phosphate-3-epimerase (Rpe),
            transcript variant 1, mRNA.
ACCESSION   NM_001399122 XM_006245104
VERSION     NM_001399122.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2273)
  AUTHORS   Liang,W., Ouyang,S., Shaw,N., Joachimiak,A., Zhang,R. and Liu,Z.J.
  TITLE     Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new
            insights from structural and biochemical studies on human RPE
  JOURNAL   FASEB J 25 (2), 497-504 (2011)
   PUBMED   20923965
REFERENCE   2  (bases 1 to 2273)
  AUTHORS   Veech,R.L.
  TITLE     A humble hexose monophosphate pathway metabolite regulates short-
            and long-term control of lipogenesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 5578-5580 (2003)
   PUBMED   12721358
  REMARK    Review article
REFERENCE   3  (bases 1 to 2273)
  AUTHORS   Bublitz,C. and Steavenson,S.
  TITLE     The pentose phosphate pathway in the endoplasmic reticulum
  JOURNAL   J Biol Chem 263 (26), 12849-12853 (1988)
   PUBMED   2843500
REFERENCE   4  (bases 1 to 2273)
  AUTHORS   Casazza,J.P. and Veech,R.L.
  TITLE     The interdependence of glycolytic and pentose cycle intermediates
            in ad libitum fed rats
  JOURNAL   J Biol Chem 261 (2), 690-698 (1986)
   PUBMED   3079759
REFERENCE   5  (bases 1 to 2273)
  AUTHORS   Spencer,N. and Hopkinson,D.A.
  TITLE     Biochemical genetics of the pentose phosphate cycle: human ribose
            5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase
            (RPE)
  JOURNAL   Ann Hum Genet 43 (4), 335-342 (1980)
   PUBMED   7396409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006245104.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.24370.1,
                                           SRR26643295.35571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000009.1  75641041-75641185
            146-225             JAXUCZ010000009.1  75647027-75647106
            226-318             JAXUCZ010000009.1  75651469-75651561
            319-458             JAXUCZ010000009.1  75656762-75656901
            459-593             JAXUCZ010000009.1  75657281-75657415
            594-680             JAXUCZ010000009.1  75657858-75657944
            681-2273            JAXUCZ010000009.1  75659417-75661009
FEATURES             Location/Qualifiers
     source          1..2273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..2273
                     /gene="Rpe"
                     /note="ribulose-5-phosphate-3-epimerase"
                     /db_xref="GeneID:501157"
                     /db_xref="RGD:1564890"
     exon            1..145
                     /gene="Rpe"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..803
                     /gene="Rpe"
                     /EC_number="5.1.3.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ribulose-phosphate 3-epimerase"
                     /codon_start=1
                     /product="ribulose-phosphate 3-epimerase isoform 1"
                     /protein_id="NP_001386051.1"
                     /db_xref="GeneID:501157"
                     /db_xref="RGD:1564890"
                     /translation="MASGCKIGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFV
                     PNITFGHPVVESLRKQLGQDPFFGSLLSTFYLLSSVCPDAMPPSYPTHFFFLDLDMHM
                     MVSRPEQWVKPMAVAGANQYTFHLEATENPGALIKDIRENGMKVGLAIKPGTTVEYLA
                     PWANQIDMALVMTVEPGFGGQKFMEDMMPKVHWLRTQFPTLDIEVDGGVGPDTVQKCA
                     EAGANMIVSGSAIMRSDDPRAVINLLRNVCSEAAQKRSLDR"
     exon            146..225
                     /gene="Rpe"
                     /inference="alignment:Splign:2.1.0"
     exon            226..318
                     /gene="Rpe"
                     /inference="alignment:Splign:2.1.0"
     exon            319..458
                     /gene="Rpe"
                     /inference="alignment:Splign:2.1.0"
     exon            459..593
                     /gene="Rpe"
                     /inference="alignment:Splign:2.1.0"
     exon            594..680
                     /gene="Rpe"
                     /inference="alignment:Splign:2.1.0"
     exon            681..2273
                     /gene="Rpe"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgctcta gggaaccggc accatggcgt cgggctgcaa gatcggcccg tccatcctca
       61 acagcgacct ggccaacctg ggggccgagt gcctgcgcat gctggactcg ggggccgact
      121 acctgcacct ggatgtaatg gacggacatt ttgttcccaa catcactttt ggtcaccctg
      181 tggttgaaag cctccgaaag cagctgggcc aggacccttt ctttggctca cttctcagta
      241 ctttttatct tttatcatca gtctgtcctg atgcaatgcc accctcatat ccaacccact
      301 ttttcttcct ggatttagat atgcacatga tggtttctag gccagaacag tgggtaaaac
      361 caatggctgt ggcaggtgcc aatcaataca cctttcatct tgaggcaact gagaacccag
      421 gggctttgat taaagacatc cgggagaatg ggatgaaggt tggccttgcc atcaaaccag
      481 gaactacagt cgaatatttg gccccatggg ctaatcaaat agatatggcc ttggtaatga
      541 ccgtagaacc tgggtttgga gggcagaaat tcatggaaga tatgatgccc aaggttcact
      601 ggttgaggac ccagttccca actttggata tagaggtcga tggtggagta ggtcctgaca
      661 ctgttcagaa gtgtgcggag gcaggagcta acatgattgt gtctggcagt gccattatga
      721 gaagtgatga ccccagagct gttatcaact tactaagaaa cgtttgctca gaagcggctc
      781 agaaacgttc ccttgaccga tgaagccaca aggaacccag tttctgccca tgaaccctgt
      841 tttttactgg aaacgaggaa tattgactac caatcacatt gcaattgaag caatgctgca
      901 ttccagggat tcaagtcaat tgtgcaggat ggtcaagagg ttagaaataa ctaccttttt
      961 agagatgcca tttagaaatt aacgtggtga aaagtattca catttatact gggagaatga
     1021 tttttgtaaa gagtgaaaat ttgatttgtt aagattacag atagaaatgt gtcttaatgc
     1081 ctaaagagga aaattagcta ctatgaaaaa catttttctg tatttttaca aagaatgttc
     1141 tgttgattcc ctggtttatc cctaaagcaa atgacatcca tattttctct agttcatgtc
     1201 atttgtgatt tgtttatatg cctgagaata tgaatggaat gagatgaaaa ttagaaggtt
     1261 tggtggggta gcatgtcatg gtctggtatt tgaattattt tttcttttta tcttatactt
     1321 ggtttattaa aaactataaa aataatgtat gaagcctagg gtttctgaaa tgcaagcgca
     1381 gacttatcaa ggtgtcacct ttgtcacagc aggctactct gtaattcctt cctgctgcct
     1441 cactcatcca ccattcctag gggtatgaaa tagaaccata cagtttctct tggaagtgcc
     1501 actgggttga ataccaatag aacagaatat cctattctag ctctttaatg aaatcaccca
     1561 tcttgttttc actataaact cttatatata ttgaatggaa tcataactat tgtgcatttg
     1621 agaattaaaa gggtaacatg gttttggaag gcctatacct agactataga ggatgctcaa
     1681 cataaaatgg caagcatcat gtctgttttg agtgattaag cacttttgta taatcaaatt
     1741 aactgctaaa ttgtcctata attgttggaa caggtattct tttcctatta gaaaagtaag
     1801 gctccacagt agcctgatac atagaaaacc tggtatagca gaagcagttt ctggtgggca
     1861 ctgctgctct gactacaaac agagctcctg agatgttaga gaaaaggaag tttacttttc
     1921 ttattttcag tgtaactgta tcctctagca gaatcagagt aagtcaagaa tacttgggaa
     1981 gtacagattt tgaccccaag gatggatgga tatataaaac atttctaaca aagaagaagg
     2041 gagctaagag atgacagata ttaatacttg tttctatttt agcttaccaa aggtttgttc
     2101 atttaatcaa atcacacaat acaaggcata tagaaataac tttaattaaa aaaactatgt
     2161 agaaggttat aatatcagtc atgacaaaga tttgaattta tttgctggga caacttgtat
     2221 ttttctggct tttgttcttt ttctttaaaa ataaatgtac agtaaaacta taa
//
