LOCUS       NM_021582               1414 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus replication protein A2 (Rpa2), mRNA.
ACCESSION   NM_021582 XM_342938
VERSION     NM_021582.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1414)
  AUTHORS   Bass,T.E., Luzwick,J.W., Kavanaugh,G., Carroll,C., Dungrawala,H.,
            Glick,G.G., Feldkamp,M.D., Putney,R., Chazin,W.J. and Cortez,D.
  TITLE     ETAA1 acts at stalled replication forks to maintain genome
            integrity
  JOURNAL   Nat Cell Biol 18 (11), 1185-1195 (2016)
   PUBMED   27723720
REFERENCE   2  (bases 1 to 1414)
  AUTHORS   Haahr,P., Hoffmann,S., Tollenaere,M.A., Ho,T., Toledo,L.I.,
            Mann,M., Bekker-Jensen,S., Raschle,M. and Mailand,N.
  TITLE     Activation of the ATR kinase by the RPA-binding protein ETAA1
  JOURNAL   Nat Cell Biol 18 (11), 1196-1207 (2016)
   PUBMED   27723717
REFERENCE   3  (bases 1 to 1414)
  AUTHORS   Safa,L., Delagoutte,E., Petruseva,I., Alberti,P., Lavrik,O.,
            Riou,J.F. and Saintome,C.
  TITLE     Binding polarity of RPA to telomeric sequences and influence of
            G-quadruplex stability
  JOURNAL   Biochimie 103, 80-88 (2014)
   PUBMED   24747047
REFERENCE   4  (bases 1 to 1414)
  AUTHORS   Gong,Z. and Chen,J.
  TITLE     E3 ligase RFWD3 participates in replication checkpoint control
  JOURNAL   J Biol Chem 286 (25), 22308-22313 (2011)
   PUBMED   21504906
REFERENCE   5  (bases 1 to 1414)
  AUTHORS   Liaw,H., Lee,D. and Myung,K.
  TITLE     DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair
            and suppresses sister chromatid exchange
  JOURNAL   PLoS One 6 (6), e21424 (2011)
   PUBMED   21731742
REFERENCE   6  (bases 1 to 1414)
  AUTHORS   Lopez-Girona,A., Bachs,O. and Agell,N.
  TITLE     Calmodulin is involved in the induction of DNA polymerases alpha
            and delta activities in normal rat kidney cells activated to
            proliferate
  JOURNAL   Biochem Biophys Res Commun 217 (2), 566-574 (1995)
   PUBMED   7503737
REFERENCE   7  (bases 1 to 1414)
  AUTHORS   He,Z., Henricksen,L.A., Wold,M.S. and Ingles,C.J.
  TITLE     RPA involvement in the damage-recognition and incision steps of
            nucleotide excision repair
  JOURNAL   Nature 374 (6522), 566-569 (1995)
   PUBMED   7700386
REFERENCE   8  (bases 1 to 1414)
  AUTHORS   Seroussi,E. and Lavi,S.
  TITLE     Replication protein A is the major single-stranded DNA binding
            protein detected in mammalian cell extracts by gel retardation
            assays and UV cross-linking of long and short single-stranded DNA
            molecules
  JOURNAL   J Biol Chem 268 (10), 7147-7154 (1993)
   PUBMED   8463251
REFERENCE   9  (bases 1 to 1414)
  AUTHORS   Nakagawa,M., Tsukada,S., Soma,T., Shimizu,Y., Miyake,S.,
            Iwamatsu,A. and Sugiyama,H.
  TITLE     cDNA cloning of the murine 30-kDa protein homologous to the 32-kDa
            subunit of human replication protein A
  JOURNAL   Nucleic Acids Res 19 (15), 4292 (1991)
   PUBMED   1908076
REFERENCE   10 (bases 1 to 1414)
  AUTHORS   Erdile,L.F., Wold,M.S. and Kelly,T.J.
  TITLE     The primary structure of the 32-kDa subunit of human replication
            protein A
  JOURNAL   J Biol Chem 265 (6), 3177-3182 (1990)
   PUBMED   2406247
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 26, 2024 this sequence was replaced by
            NM_021582.3.
            
            On Nov 27, 2020 this sequence version replaced NM_021582.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079180.1, SRR22582424.2083530.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000005.1  150260772-150260866
            96-202              JAXUCZ010000005.1  150261064-150261170
            203-304             JAXUCZ010000005.1  150262786-150262887
            305-418             JAXUCZ010000005.1  150263857-150263970
            419-493             JAXUCZ010000005.1  150266152-150266226
            494-610             JAXUCZ010000005.1  150267835-150267951
            611-718             JAXUCZ010000005.1  150269050-150269157
            719-813             JAXUCZ010000005.1  150269481-150269575
            814-1414            JAXUCZ010000005.1  150270729-150271329
FEATURES             Location/Qualifiers
     source          1..1414
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1414
                     /gene="Rpa2"
                     /note="replication protein A2"
                     /db_xref="GeneID:59102"
                     /db_xref="RGD:619714"
     exon            1..95
                     /gene="Rpa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..898
                     /gene="Rpa2"
                     /note="RP-A p32; RF-A protein 2; replication factor A
                     protein 2; p32-subunit of replication protein A"
                     /codon_start=1
                     /product="replication protein A 32 kDa subunit"
                     /protein_id="NP_067593.1"
                     /db_xref="GeneID:59102"
                     /db_xref="RGD:619714"
                     /translation="MWNSGFESFSSSSYGAAGGYTQSPGGFGSPTPSQAEKKSRARAQ
                     HIVPCTISQLLSATLTDEVFKIGDVEISQVTIVGIIRHAEKAPTNIVYKIDDMTAAPM
                     DVRQWVDTDDTSGENTVVPPETYVKVAGHLRSFQNKKSLVAFKIIPLEDMNEFTAHIL
                     EVVNSHLMLSKANSQASVGRPSMSNPGMGEPGNFSGNNFMPANGLTVVQNQVLNLIKA
                     CPRPEGLNFQDLRSQLQHMPVASIKQAVDFLCNEGHIYSTVDDDHFKSTDAE"
     exon            96..202
                     /gene="Rpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            203..304
                     /gene="Rpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..418
                     /gene="Rpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..493
                     /gene="Rpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..610
                     /gene="Rpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            611..718
                     /gene="Rpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..813
                     /gene="Rpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1414
                     /gene="Rpa2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccggagcg gcaaacactt cttaagtctt cttattttcc gagtccaaac ttcttggcct
       61 ctttctcagg aaaactgcga ccaggatgtg gaatagcgga ttcgaaagct tcagcagctc
      121 ctcctatggc gcagcgggcg gctacacgca gtcccccggt ggcttcgggt cacccacacc
      181 gtcgcaggca gagaagaaat caagagcccg agcccagcac attgtgccct gtaccatatc
      241 tcagctgctc tctgctactc tgactgatga ggtgttcaaa attggggatg tcgagatttc
      301 acaggtcact attgtgggaa taatcagaca tgcagagaaa gcgccaacca acattgtcta
      361 caaaatagac gacatgaccg cagcgcccat ggacgttcgc cagtgggttg acacagatga
      421 taccagtggc gagaacactg tggttcctcc agaaacatac gtgaaagttg ctggccacct
      481 caggtctttt cagaacaaaa agagcctggt ggcctttaag atcattcctc tggaggatat
      541 gaatgagttc acggcgcaca ttctggaagt ggtcaattca cacttgatgc tcagcaaagc
      601 caacagccag gcctctgtag ggagaccatc tatgagcaac ccaggaatgg gtgagccagg
      661 aaacttcagt gggaataact tcatgccagc aaatggcctc accgtggtcc aaaaccaggt
      721 gctgaatttg attaaggctt gcccaagacc tgaaggattg aacttccagg atctcaggag
      781 ccagctccag cacatgcctg tagcctcaat caaacaagca gtggattttc tatgcaacga
      841 gggccacatt tactctacag tggatgatga tcactttaaa tccacggacg cagagtaacg
      901 agctctggga actggcatcc cagcgggcct gtcatcatct atctgttctt cccagctctg
      961 caggttttgg acagaagttc cctgtagaag gtctcagctg aagtcctttt ggaacgcatt
     1021 gctctttgtt ttgtcactta ttgtttagag gttcaaaagg agataggcag ttgagaaaga
     1081 agtaaactga gcaggatttc ttaagagaaa ttccgataag ctagtcagga ctccagatgg
     1141 atggtgggaa tggaaggagg accagcagag cagagcagaa ccacgtcatg cttgggagcc
     1201 tctgttcttg aaaggcttcc gtcgagaacg aaccatacta gggccaaggg cccaagaaga
     1261 acctaccttc cttccccttg tcctgcctgc agttgaaaga aggtttaaat gagcctgagg
     1321 ttctgtgcaa aggcctcatg gggcagacag gaagaaatgt tactgtgttt gtaatataaa
     1381 tgttcatatg tttgataaaa cagttcactt gtaa
//
