LOCUS       NM_001394069            2879 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus replication protein A1 (Rpa1), mRNA.
ACCESSION   NM_001394069 XM_006246673
VERSION     NM_001394069.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2879)
  AUTHORS   Bass,T.E., Luzwick,J.W., Kavanaugh,G., Carroll,C., Dungrawala,H.,
            Glick,G.G., Feldkamp,M.D., Putney,R., Chazin,W.J. and Cortez,D.
  TITLE     ETAA1 acts at stalled replication forks to maintain genome
            integrity
  JOURNAL   Nat Cell Biol 18 (11), 1185-1195 (2016)
   PUBMED   27723720
REFERENCE   2  (bases 1 to 2879)
  AUTHORS   Haahr,P., Hoffmann,S., Tollenaere,M.A., Ho,T., Toledo,L.I.,
            Mann,M., Bekker-Jensen,S., Raschle,M. and Mailand,N.
  TITLE     Activation of the ATR kinase by the RPA-binding protein ETAA1
  JOURNAL   Nat Cell Biol 18 (11), 1196-1207 (2016)
   PUBMED   27723717
REFERENCE   3  (bases 1 to 2879)
  AUTHORS   Gilmore,J.M., Sardiu,M.E., Groppe,B.D., Thornton,J.L., Liu,X.,
            Dayebgadoh,G., Banks,C.A., Slaughter,B.D., Unruh,J.R.,
            Workman,J.L., Florens,L. and Washburn,M.P.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2879)
  AUTHORS   Audry,J., Maestroni,L., Delagoutte,E., Gauthier,T., Nakamura,T.M.,
            Gachet,Y., Saintome,C., Geli,V. and Coulon,S.
  TITLE     RPA prevents G-rich structure formation at lagging-strand telomeres
            to allow maintenance of chromosome ends
  JOURNAL   EMBO J 34 (14), 1942-1958 (2015)
   PUBMED   26041456
REFERENCE   5  (bases 1 to 2879)
  AUTHORS   Safa,L., Delagoutte,E., Petruseva,I., Alberti,P., Lavrik,O.,
            Riou,J.F. and Saintome,C.
  TITLE     Binding polarity of RPA to telomeric sequences and influence of
            G-quadruplex stability
  JOURNAL   Biochimie 103, 80-88 (2014)
   PUBMED   24747047
REFERENCE   6  (bases 1 to 2879)
  AUTHORS   Lin,Y.L., Shivji,M.K., Chen,C., Kolodner,R., Wood,R.D. and Dutta,A.
  TITLE     The evolutionarily conserved zinc finger motif in the largest
            subunit of human replication protein A is required for DNA
            replication and mismatch repair but not for nucleotide excision
            repair
  JOURNAL   J Biol Chem 273 (3), 1453-1461 (1998)
   PUBMED   9430682
REFERENCE   7  (bases 1 to 2879)
  AUTHORS   Bochkarev,A., Pfuetzner,R.A., Edwards,A.M. and Frappier,L.
  TITLE     Structure of the single-stranded-DNA-binding domain of replication
            protein A bound to DNA
  JOURNAL   Nature 385 (6612), 176-181 (1997)
   PUBMED   8990123
REFERENCE   8  (bases 1 to 2879)
  AUTHORS   Lopez-Girona,A., Bachs,O. and Agell,N.
  TITLE     Calmodulin is involved in the induction of DNA polymerases alpha
            and delta activities in normal rat kidney cells activated to
            proliferate
  JOURNAL   Biochem Biophys Res Commun 217 (2), 566-574 (1995)
   PUBMED   7503737
REFERENCE   9  (bases 1 to 2879)
  AUTHORS   He,Z., Henricksen,L.A., Wold,M.S. and Ingles,C.J.
  TITLE     RPA involvement in the damage-recognition and incision steps of
            nucleotide excision repair
  JOURNAL   Nature 374 (6522), 566-569 (1995)
   PUBMED   7700386
REFERENCE   10 (bases 1 to 2879)
  AUTHORS   Seroussi,E. and Lavi,S.
  TITLE     Replication protein A is the major single-stranded DNA binding
            protein detected in mammalian cell extracts by gel retardation
            assays and UV cross-linking of long and short single-stranded DNA
            molecules
  JOURNAL   J Biol Chem 268 (10), 7147-7154 (1993)
   PUBMED   8463251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 30, 2021 this sequence version replaced XM_006246673.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1533930.1,
                                           SRR26360172.1501623.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000010.1  60698154-60698279   c
            127-177             JAXUCZ010000010.1  60691584-60691634   c
            178-256             JAXUCZ010000010.1  60690477-60690555   c
            257-365             JAXUCZ010000010.1  60689743-60689851   c
            366-454             JAXUCZ010000010.1  60676059-60676147   c
            455-547             JAXUCZ010000010.1  60665805-60665897   c
            548-680             JAXUCZ010000010.1  60663352-60663484   c
            681-783             JAXUCZ010000010.1  60662097-60662199   c
            784-852             JAXUCZ010000010.1  60660299-60660367   c
            853-1045            JAXUCZ010000010.1  60659982-60660174   c
            1046-1185           JAXUCZ010000010.1  60659698-60659837   c
            1186-1334           JAXUCZ010000010.1  60659235-60659383   c
            1335-1467           JAXUCZ010000010.1  60657116-60657248   c
            1468-1644           JAXUCZ010000010.1  60654330-60654506   c
            1645-1752           JAXUCZ010000010.1  60653468-60653575   c
            1753-1839           JAXUCZ010000010.1  60649445-60649531   c
            1840-2879           JAXUCZ010000010.1  60647185-60648224   c
FEATURES             Location/Qualifiers
     source          1..2879
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2879
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /note="replication protein A1"
                     /db_xref="GeneID:287524"
                     /db_xref="RGD:1307376"
     exon            1..126
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1938
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /codon_start=1
                     /product="replication protein A 70 kDa DNA-binding
                     subunit"
                     /protein_id="NP_001380998.1"
                     /db_xref="GeneID:287524"
                     /db_xref="RGD:1307376"
                     /translation="MVGHLSEGAIAAIMQQGDTSIKPVLQVINIRPITTGNSPPRYRL
                     LMSDGLNTLSSFMLATQLNALVEGGQLASNCVCQVHRFIVNTLKDGRRVVILMDLEVV
                     KSAGEVGVKIGNPVPYNEGHAQQQAVSAPASAATPPASKPQPQNGSLGVGSTVAKAYG
                     ASKPFGKPAGTGLLQPTSGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGE
                     GKLFSIELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFSAVKNDY
                     EMTFNNETSVLPCEDGHHLPTVQFDFTGIGDLESKSKDSLVDIIGICKSYEDATKITV
                     KSNNREVAKRNICLMDMSGKVVTATLWGEDADKFDGSRQPVMAIKGARVSDFGGRSLS
                     VLSSSTVLVNPDIPEAYKLRGWFDSEGQALDGVSISDLRSGGTGGSNTNWKTLYEAKS
                     ENLGQGDKADYFSTVATVVFLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDREFP
                     NFKYRMILSVNIADFQENQWVTCFQESAEAILGQNTVYLGELKEKNEQAFEEVFQNAN
                     FRSFTFRIRVKLETYNDESRIKATVIDVKPVDYRDYSKRLIMNIRKNI"
     exon            127..177
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            178..256
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            257..365
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            366..454
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            455..547
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            548..680
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            681..783
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            784..852
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1045
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1185
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1334
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1467
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1644
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1752
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1839
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2879
                     /gene="Rpa1"
                     /gene_synonym="Cb1-727"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcctttag ccaatcgttg agcagcccgc gggaccccgg caaagaagct ggggcggtgc
       61 aggagcgcga gcgcgggagt tagcggtgca gccatggtgg gacacctgag cgagggggcc
      121 attgcggcca taatgcagca gggagataca tccataaaac ccgttcttca agtcattaac
      181 atccgtccca ttactacagg gaatagtcca ccgcggtatc gactgcttat gagtgatggg
      241 ttgaacacgc tttcctcctt catgctggcc acgcagctga acgccctggt cgaggggggc
      301 cagctggcca gcaactgtgt ctgccaggtc caccgcttca tcgtcaacac cctgaaggac
      361 ggaaggagag tagttatttt gatggacttg gaagttgtga aatctgctgg cgaagttgga
      421 gtaaagattg ggaatccagt gccctataat gaaggacatg cgcagcagca agcagtctct
      481 gccccagcct ctgcagcgac accaccagcc agcaagcccc aaccgcagaa tgggagcttg
      541 ggagtgggtt ccactgtagc taaggcatac ggggcctcaa agccgtttgg aaagcctgct
      601 ggaactggcc tgctgcagcc tacaagtggg acacagtcca aagtggtacc catcgccagc
      661 ctcacccctt accaatccaa gtggacgatt tgtgcccgtg tcaccaacaa aagtcagatc
      721 cgtacctgga gcaattcccg tggggaagga aagctcttct ctatagaact tgtggatgaa
      781 agtggtgaaa tcagagctac ggctttcaat gagcaggtgg acaagttctt tccccttatt
      841 gaagtgaaca aggtgtatta cttctccaag ggcactctga aaatcgctaa caaacagttc
      901 tcagctgtta aaaatgacta tgagatgacc ttcaataatg agacgtctgt ccttccctgc
      961 gaagatggcc atcacttacc cacagttcag tttgacttca cagggatcgg tgacctagag
     1021 agcaagtcta aagactcact tgtagacata attggaatct gcaagagcta tgaagatgcg
     1081 actaaaatca cagtgaagtc taacaacaga gaagttgcta agagaaatat ctgtttgatg
     1141 gacatgtcag ggaaagtggt gactgcgacg ctgtggggag aagacgctga caagtttgac
     1201 ggttctaggc agcctgtgat ggccatcaaa ggagcccgag tgtccgactt tggtgggcgg
     1261 agcctctctg tcctatcatc tagcactgtc cttgtgaatc ctgacatccc agaggcctat
     1321 aagctccgtg gatggtttga ctcagaagga caagccttag atggagtttc catctctgat
     1381 ctcaggagtg gagggaccgg agggagcaac accaactgga aaactttgta tgaagctaaa
     1441 tccgagaacc tgggccaggg cgacaaggcg gactatttca gcactgtggc aacagtggtg
     1501 tttcttcgca aagagaactg tatgtaccag gcctgcccga cccaggactg caataagaaa
     1561 gtgattgacc agcagaatgg gttgtaccgc tgtgagaagt gcgaccggga atttcccaat
     1621 ttcaaatacc gcatgatctt atcggtaaat attgcagatt ttcaggagaa tcagtgggtg
     1681 acgtgtttcc aggagtccgc ggaggccatt cttggacaga acactgtgta ccttggggaa
     1741 ctcaaagaga agaacgagca ggcgtttgaa gaggttttcc agaatgccaa cttccgatca
     1801 tttacattca gaatcagagt caagctggag acctacaatg atgaatctcg aattaaggcc
     1861 actgtgatag acgtgaagcc cgtggactac agagactata gcaaaaggct gatcatgaac
     1921 atcaggaaga acatttgatg tgagcaagta ctgctggtgg atggagagga aagaacggaa
     1981 atagaatggc ttccttccca cccccaccct atatgacagc cccacaatga caatgaagat
     2041 cctcaggaga gactggcaac ctgtctgcac cccttttggg actccttgat aggcaaaagg
     2101 cagcgagctt agagggctgt gtctagacct tcatgaagtg ccagctctcg gctggcaggt
     2161 agcgtagcag cagtccctcc tgtctctagc tttgtcggtc acgcaggaat tatgtcacag
     2221 gtcactgacc ccactctgga taatgaggtg aattatatga cctgaagttt gcttttccag
     2281 tggtggcacc tttttgtctt gggttcctcc tggaggcagt aagagcgggg aagaacccag
     2341 gtgtttagag ggtgtgtctg cctagaatca aaggctccat tttgcagagg taccacatgc
     2401 ttgttaatgc ttggaatggc agaagggtgg aattattaat caaaggccta tcattaatat
     2461 ctgaatatcc ttcagggtct aatgggttta atagactgag tcagatgcat ctgatattaa
     2521 tcaaaattgt ctcttctgag gatggctgat aagcattgac ttgctgtccc cttggggaaa
     2581 agcaaacccc aaattgcata atttacctca ttatccacag ggtggggtcg gttactggta
     2641 atatagttcc tgtgtgaaga taacaggatc ttggtaaatc cggcaaagcc agagacagag
     2701 gagggactgg gacatccagg ccacggcaga gcactgctgc ggtttcctca gttaatgttc
     2761 ggtttggtta ccagatggcc ctggaccttt attagagctc tgttaaatag agagagttta
     2821 agaaagacgc cctttgtttc ccttgcttta tttgaataaa cagtgtatct gtgatccta
//
