LOCUS       NM_001109012            4254 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus RP2 activator of ARL3 GTPase (Rp2), mRNA.
ACCESSION   NM_001109012 XM_001056880 XM_039099931 XM_346266
VERSION     NM_001109012.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4254)
  AUTHORS   Lokaj,M., Kosling,S.K., Koerner,C., Lange,S.M., van Beersum,S.E.,
            van Reeuwijk,J., Roepman,R., Horn,N., Ueffing,M., Boldt,K. and
            Wittinghofer,A.
  TITLE     The Interaction of CCDC104/BARTL1 with Arl3 and Implications for
            Ciliary Function
  JOURNAL   Structure 23 (11), 2122-2132 (2015)
   PUBMED   26455799
REFERENCE   2  (bases 1 to 4254)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 4254)
  AUTHORS   Evans,R.J., Schwarz,N., Nagel-Wolfrum,K., Wolfrum,U.,
            Hardcastle,A.J. and Cheetham,M.E.
  TITLE     The retinitis pigmentosa protein RP2 links pericentriolar vesicle
            transport between the Golgi and the primary cilium
  JOURNAL   Hum Mol Genet 19 (7), 1358-1367 (2010)
   PUBMED   20106869
REFERENCE   4  (bases 1 to 4254)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 4254)
  AUTHORS   Veltel,S., Gasper,R., Eisenacher,E. and Wittinghofer,A.
  TITLE     The retinitis pigmentosa 2 gene product is a GTPase-activating
            protein for Arf-like 3
  JOURNAL   Nat Struct Mol Biol 15 (4), 373-380 (2008)
   PUBMED   18376416
REFERENCE   6  (bases 1 to 4254)
  AUTHORS   Grayson,C., Bartolini,F., Chapple,J.P., Willison,K.R.,
            Bhamidipati,A., Lewis,S.A., Luthert,P.J., Hardcastle,A.J.,
            Cowan,N.J. and Cheetham,M.E.
  TITLE     Localization in the human retina of the X-linked retinitis
            pigmentosa protein RP2, its homologue cofactor C and the RP2
            interacting protein Arl3
  JOURNAL   Hum Mol Genet 11 (24), 3065-3074 (2002)
   PUBMED   12417528
REFERENCE   7  (bases 1 to 4254)
  AUTHORS   Bartolini,F., Bhamidipati,A., Thomas,S., Schwahn,U., Lewis,S.A. and
            Cowan,N.J.
  TITLE     Functional overlap between retinitis pigmentosa 2 protein and the
            tubulin-specific chaperone cofactor C
  JOURNAL   J Biol Chem 277 (17), 14629-14634 (2002)
   PUBMED   11847227
REFERENCE   8  (bases 1 to 4254)
  AUTHORS   Sharon,D., Bruns,G.A., McGee,T.L., Sandberg,M.A., Berson,E.L. and
            Dryja,T.P.
  TITLE     X-linked retinitis pigmentosa: mutation spectrum of the RPGR and
            RP2 genes and correlation with visual function
  JOURNAL   Invest Ophthalmol Vis Sci 41 (9), 2712-2721 (2000)
   PUBMED   10937588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Apr 10, 2021 this sequence version replaced
            XM_039099931.1, NM_001109012.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.21181.1,
                                           SRR26643429.58411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               JAXUCZ010000021.1  4469911-4470189     c
            280-945             JAXUCZ010000021.1  4458239-4458904     c
            946-1060            JAXUCZ010000021.1  4445006-4445120     c
            1061-1146           JAXUCZ010000021.1  4429525-4429610     c
            1147-4254           JAXUCZ010000021.1  4426073-4429180     c
FEATURES             Location/Qualifiers
     source          1..4254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq11"
     gene            1..4254
                     /gene="Rp2"
                     /gene_synonym="RGD1565124; Rp2h"
                     /note="RP2 activator of ARL3 GTPase"
                     /db_xref="GeneID:367714"
                     /db_xref="RGD:1565124"
     exon            1..279
                     /gene="Rp2"
                     /gene_synonym="RGD1565124; Rp2h"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1230
                     /gene="Rp2"
                     /gene_synonym="RGD1565124; Rp2h"
                     /note="retinitis pigmentosa 2 homolog; retinitis
                     pigmentosa 2 (X-linked recessive); RP2, ARL3 GTPase
                     activating protein"
                     /codon_start=1
                     /product="protein XRP2"
                     /protein_id="NP_001102482.1"
                     /db_xref="GeneID:367714"
                     /db_xref="RGD:1565124"
                     /translation="MGCCFSKRRKSGKESRTEGEEEQPKLYSWDQREKVDPKDYTFSG
                     LKDETVGRLPGKVAGQQFVIQDCENCNIYIFDHSATITIDDCTNCVIFLGPVKGSVFF
                     RNCRDCKCTLACQQFRVRDCRKLEVFLCCATQPIIESSTNIKFGCFQWYYPELAAQFK
                     DAGLSIFNNIWSHVHDFTPVSGELNWSLLPENAVVQDYVPLPTTEEFKAVRISTDPNR
                     SIVPVSRGQRQKYSDESCLVVLFADDYTTANARKLIDEMVGKGFSLVQTKEMSMKTED
                     AQRVFREKASDFLLLLNKGPVIALEFNGDDAVQECHLIVNGLFNGTKMFVSEKKETAS
                     GDVDSFYNFAEIQMGI"
     exon            280..945
                     /gene="Rp2"
                     /gene_synonym="RGD1565124; Rp2h"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1060
                     /gene="Rp2"
                     /gene_synonym="RGD1565124; Rp2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1146
                     /gene="Rp2"
                     /gene_synonym="RGD1565124; Rp2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..4254
                     /gene="Rp2"
                     /gene_synonym="RGD1565124; Rp2h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagggggg ggtgaagggt gttgggcctg gcgggagtgc tgagggttgc aggcggctgg
       61 gttgctctcc tgggcggtgt ccggggagct gttggccaac tcaccctggg ttcccaccac
      121 cctccgagag gtgtctgagc gagtggggtc cactagcaag acccttaagc cggcaccatg
      181 ggctgctgct tctctaagag gcggaagagt ggaaaggagt cgcggactga gggagaggag
      241 gagcagccca agctgtacag ctgggaccaa cgggagaagg ttgatccaaa agattacacg
      301 tttagtggac taaaggacga aacagtaggt cgcttacctg gaaaagtggc aggacaacag
      361 tttgtcattc aagactgtga gaactgtaac atctatattt ttgaccactc agctactatt
      421 actattgatg actgtactaa ctgtgtaatt tttttgggac cagtgaaagg cagtgtgttt
      481 ttccgaaatt gtagagattg caagtgcaca ttggcttgcc aacaatttcg tgtaagggac
      541 tgtagaaagt tggaagtctt tttgtgctgt gccactcaac ccattattga atcttctaca
      601 aacatcaagt ttggctgttt tcaatggtac taccctgaat tggcagccca attcaaagat
      661 gcaggcctca gtatcttcaa taacatatgg agtcatgttc atgattttac acctgtgtcc
      721 ggagagctca actggagcct tctgccagaa aatgctgtgg ttcaagacta tgttcctctc
      781 ccaacgactg aagagttcaa agctgtgcga atttccacag atcccaatag aagcattgtt
      841 cctgtatccc ggggtcagag acagaagtac agtgatgaat catgtctcgt ggtgttattt
      901 gccgatgatt atacaacagc aaatgccagg aaactaattg atgagatggt tggcaaaggc
      961 ttttccctag tgcagacaaa ggaaatgtca atgaaaactg aagatgctca gagggttttc
     1021 cgggaaaagg catcagactt tttacttctt ctaaacaaag gtcctgtgat tgccctggaa
     1081 tttaatggag atgatgctgt acaagaatgt caccttattg taaatgggct attcaacggg
     1141 acaaagatgt ttgtatcaga aaaaaaggag accgcatctg gagatgttga cagcttctat
     1201 aactttgctg agatccagat ggggatatga agcggattgt ggtattagcc tcttccaacc
     1261 tttatataga cagtttgata atatacttat gtatgttagt catttagcaa ttagtatttt
     1321 tttttctttt tctgtttttc ggagctgggg accgaaccca gggccttgcg ctttctaggc
     1381 aagcgctcta ccactgagct aaatccgcaa ccccagcaat tagtaatttt tactaatgct
     1441 aaagttgtta aggctctttt aaataactct ttgaatacca tatcatttat ttgaggatct
     1501 aaaacagttc atttaaattg agtagtttta atcaccttat aaactaacct gcttcaataa
     1561 gcttgaagtt ttatttcttt ttatacaata gtcttattag gaaatattca agattttact
     1621 cctaattaaa agttctttca tatctctggt aatttaaact ttccaacttt ccttagtgtt
     1681 ctatggtact tcatttaata tatattttgt ttcttatttt ctcttttaat ttagagaaat
     1741 ttgttactag gtgaaattaa ataaacctat gcactttttt ttaaaaaaac acatacccag
     1801 ttaaataatc atgtccttct tgcattatat aactaatgag attagttggc atactatttt
     1861 ataaatttgg aagttttttt ttttttaaat atgggtattt gaaagctgac tatagtcatg
     1921 gcatctgtag ttccagacta cttgggatgc tgaagtggaa gaatcacttc agctcaagag
     1981 ttcaagacca gccctggcaa gtaagatgct attttagcag aaagaaaaac ctaggataat
     2041 cagctttgct aaacttctaa ctgatcctgg cattgctgtt ttaaggacta cttctaaaat
     2101 agtatggctg ccagatgatt cttctgtttt ctaataagaa aaagtataca caacataaaa
     2161 ctatagaaca ccaatcacca gcggatttga cagaggatca ctgtctgata gctgttgtga
     2221 ctagcaagaa acctagagca aaacttagga cttttaagta agggacactt aggtatgatg
     2281 ataatctaga caggttatta acaatctcca ttttttactc tagtcaacta atattaaaat
     2341 atgataaagt ttgggttact tgaaatcatt atttctcaaa tgcatctgat aatagtaatt
     2401 tcccaggagg aggcatggga attgttcaga aacacatatt gatggatcca gtctacaggc
     2461 gcacagattt ggttctcaag ggaaaccgaa tgagggtgtg ttatcatcta aactaatcaa
     2521 ttctgaagat gttggttcat cgattttatc acatttgtca gggaacagca atagctttca
     2581 taggctcatt taaaggaatc tgagtgaagc tctattttta taaaactgag attgagtatg
     2641 gccacttgta aaattccttt catggttgtt attaaaagtg tattttcatg tttaaagtgg
     2701 ttttggatac tttcaggcca gcttataact accatgttaa attgtgaatg tgtagaagta
     2761 atgctttttt attttgaatt aataatattg agtacctaca ctgtgcctag ccttgtgctg
     2821 accatcaaca tttcaacatt tcttttgtta taagagcatc atgttataca aagtcaatat
     2881 aatctcataa ggtgcaaata aaaactgctg gcaggtataa caatttctat cataatttac
     2941 aaatggtctt tgcaaataat ggtcagagcc attaatgttt cccttagcta agctaactta
     3001 aatgcattct tttctgcctt gattatatca ctaattgtct ttatccacat ttgaaataat
     3061 ctcagtacgt gttttttcag aactaaaatg caatgtcaca caaaatgtca cacattgagt
     3121 ttttatcata tcagtaacgg tctacaaata ctcaggaata ttatgtaaag gagacattaa
     3181 tttaagattt tcccaccaaa tttagtatgt taaccaaagc ctgaaacttt atatccattt
     3241 aggtaagaac tttttacaag tacttcatgt tgtttctgca agtgtaactt tgatagtaat
     3301 catgatatat taactacatt tggtttctga ataactttaa actcatgaaa aattaatagc
     3361 catgaaaagt gatttttatt gtcatatttg tttaaacatc ttatcagttt acttctcttg
     3421 cattagtagt actgctatat tttgggtctg tatgtttatg tgtagctttt atatgtaaat
     3481 ttatctagta tttataaaat gtgctttgaa ataaatgtta aaatggttta atgctaattt
     3541 tttgaagagt actctatatt tactcataca tgtaccaaaa tttgataaaa tttttatttt
     3601 attttgggtg ttttgttata caatttttaa ttttaaaaca aaataaatgt ctaatctctg
     3661 tctcatacta atgagaaatg aactgtacac tgagtgtgta tttgatgtaa tacgtgcata
     3721 tgtgtataca tgtgtatata tacaaggtac tcaaaagaaa tgaaaaggaa gaaacatatt
     3781 ttgatataag gaatttctat catgttttct ttttttaaat aagtcacatt ttgttatgac
     3841 tgaatatttg ctaagattag gcatctttcc ttccatattt taaaaatgct gggtgtagca
     3901 tataccattg taattccagt actcaggaat tcaaggccag cctaggttat atattgaatt
     3961 ccaggccagt ctgggctata tagcaagagc ctgtctcaaa aaataaagaa gtatgataaa
     4021 ttttcattca agtttataag agtagatggt atttttattg tcaaatttac tagtctttgt
     4081 cttcctttcc tagctcataa aacaaatact aaaagtccaa attggttagt ttgtaaaaat
     4141 ataacattgt gtttatttct acttataaag gttcaacaag cacattaaga tcacttggag
     4201 cattgagaac aagcagaaat gataacacaa taataaaatt acttcctgtt ggat
//
