LOCUS       NM_012874               7902 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus ROS proto-oncogene 1, receptor tyrosine kinase
            (Ros1), mRNA.
ACCESSION   NM_012874
VERSION     NM_012874.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7902)
  AUTHORS   Oguz,N., Kirca,M., Cetin,A. and Yesilkaya,A.
  TITLE     Effect of uric acid on inflammatory COX-2 and ROS pathways in
            vascular smooth muscle cells
  JOURNAL   J Recept Signal Transduct Res 37 (5), 500-505 (2017)
   PUBMED   28770648
  REMARK    GeneRIF: Uric acid plays an important role in CVD pathogenesis by
            inducing inflammatory COX-2 and ROS pathways. This is the first
            study demonstrating losartan's ability to reduce uric-acid-induced
            COX-2 elevation.
REFERENCE   2  (bases 1 to 7902)
  AUTHORS   Yovchev,M.I., Grozdanov,P.N., Joseph,B., Gupta,S. and Dabeva,M.D.
  TITLE     Novel hepatic progenitor cell surface markers in the adult rat
            liver
  JOURNAL   Hepatology 45 (1), 139-149 (2007)
   PUBMED   17187413
  REMARK    GeneRIF: We identified novel cell surface markers specific for
            hepatic progenitor/oval cells. Six are unique for the adult
            progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp).
REFERENCE   3  (bases 1 to 7902)
  AUTHORS   Charest,A., Wilker,E.W., McLaughlin,M.E., Lane,K., Gowda,R.,
            Coven,S., McMahon,K., Kovach,S., Feng,Y., Yaffe,M.B., Jacks,T. and
            Housman,D.
  TITLE     ROS fusion tyrosine kinase activates a SH2 domain-containing
            phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of
            rapamycin signaling axis to form glioblastoma in mice
  JOURNAL   Cancer Res 66 (15), 7473-7481 (2006)
   PUBMED   16885344
REFERENCE   4  (bases 1 to 7902)
  AUTHORS   Xu,Y., Yeung,C.H., Setiawan,I., Avram,C., Biber,J., Wagenfeld,A.,
            Lang,F. and Cooper,T.G.
  TITLE     Sodium-inorganic phosphate cotransporter NaPi-IIb in the epididymis
            and its potential role in male fertility studied in a transgenic
            mouse model
  JOURNAL   Biol Reprod 69 (4), 1135-1141 (2003)
   PUBMED   12773415
REFERENCE   5  (bases 1 to 7902)
  AUTHORS   Keilhack,H., Muller,M., Bohmer,S.A., Frank,C., Weidner,K.M.,
            Birchmeier,W., Ligensa,T., Berndt,A., Kosmehl,H., Gunther,B.,
            Muller,T., Birchmeier,C. and Bohmer,F.D.
  TITLE     Negative regulation of Ros receptor tyrosine kinase signaling. An
            epithelial function of the SH2 domain protein tyrosine phosphatase
            SHP-1
  JOURNAL   J Cell Biol 152 (2), 325-334 (2001)
   PUBMED   11266449
REFERENCE   6  (bases 1 to 7902)
  AUTHORS   Tobaben,S., Sudhof,T.C. and Stahl,B.
  TITLE     The G protein-coupled receptor CL1 interacts directly with proteins
            of the Shank family
  JOURNAL   J Biol Chem 275 (46), 36204-36210 (2000)
   PUBMED   10958799
REFERENCE   7  (bases 1 to 7902)
  AUTHORS   Sonnenberg-Riethmacher,E., Walter,B., Riethmacher,D., Godecke,S.
            and Birchmeier,C.
  TITLE     The c-ros tyrosine kinase receptor controls regionalization and
            differentiation of epithelial cells in the epididymis
  JOURNAL   Genes Dev 10 (10), 1184-1193 (1996)
   PUBMED   8675006
REFERENCE   8  (bases 1 to 7902)
  AUTHORS   Riethmacher,D., Langholz,O., Godecke,S., Sachs,M. and Birchmeier,C.
  TITLE     Biochemical and functional characterization of the murine ros
            protooncogene
  JOURNAL   Oncogene 9 (12), 3617-3626 (1994)
   PUBMED   7970722
REFERENCE   9  (bases 1 to 7902)
  AUTHORS   Chen,F., Cooney,A.J., Wang,Y., Law,S.W. and O'Malley,B.W.
  TITLE     Cloning of a novel orphan receptor (GCNF) expressed during germ
            cell development
  JOURNAL   Mol Endocrinol 8 (10), 1434-1444 (1994)
   PUBMED   7854358
REFERENCE   10 (bases 1 to 7902)
  AUTHORS   Matsushime,H. and Shibuya,M.
  TITLE     Tissue-specific expression of rat c-ros-1 gene and partial
            structural similarity of its predicted products with sev protein of
            Drosophila melanogaster
  JOURNAL   J Virol 64 (5), 2117-2125 (1990)
   PUBMED   2139140
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M35106.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M35106.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132281,
                                           SAMD00132297 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..7902
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..7902
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /note="ROS proto-oncogene 1, receptor tyrosine kinase"
                     /db_xref="GeneID:25346"
                     /db_xref="RGD:3591"
     exon            1..524
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..7418
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /EC_number="2.7.10.1"
                     /note="proto-oncogene tyrosine-protein kinase ROS;
                     proto-oncogene tyrosine-protein kinase ROS-like; c-ros-1;
                     proto-oncogene c-Ros-1; v-ros UR2 sarcoma virus oncogene
                     homolog 1; heart - derived c - ros - 1 proto - oncogene;
                     Ros1 proto-oncogene; c-Ros receptor tyrosine kinase;
                     receptor tyrosine kinase c-ros oncogene 1; c-ros oncogene
                     1, receptor tyrosine kinase"
                     /codon_start=1
                     /product="proto-oncogene tyrosine-protein kinase ROS
                     precursor"
                     /protein_id="NP_037006.1"
                     /db_xref="GeneID:25346"
                     /db_xref="RGD:3591"
                     /translation="MKRIRWLTPKPATFVVLGCVWISVAQGTILSSCLTSCVTNLGRQ
                     LDSGTRYNLSEACIQGCQFWNSIDQEKCALKCNDTYVTICERESCEVGCSNAEGSYEE
                     EVLDNTELPTAPFASSIGSNGVTLRWNPANISGVKYIIQWKYAQLPGSWAYTETVSKL
                     SYMVEPLHPFTEYIFRVVWIFTAQLHLYSPPSPSYRTHPYGVPETAPFITNIESSSPD
                     TVEVSWAPPYFPGGPILGYNLRLISKTQKLDSGTQRTSFQFYSTLPNTTYRFSIAAVN
                     EVGEGPEAESMITTPSPAVQEEEQWLFLSRKTSLRKRSLKYLVDEAHCLWSDAIRHNI
                     TGISVNTQQEVVYFSEGTIIWMKGAANMSDVSDLRIFYRGSALVSSISVDWLYQRMYF
                     IMDNRVHVCDLKHCSNLEEITPFSIVAPQKVVVDSYNGYVFYLLRDGIYRVHLPLPSV
                     RDTKAVRIVESGTLKDFAVKPQSKRIIYFNGTMQVFMSTFLDGSAFHRVLPWVPLADV
                     KSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHIEEFGFGNLVIFGSSVQSYPL
                     PGHPQEVSVLFGSREALIQWKPPILAIGASPSAWQNWTYEVKVSSQDILETTQVFLNI
                     SRTVLNVPKLQSSTKYMVSVRASSPKGPGPWSEPSVGTTLVPATEPPFIMAVKEDGLW
                     SKPLSSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNVYVRPLNGMDISENYHISSI
                     AGACALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDPVGGYLYW
                     TTLYSVESTRLNGESSLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQCIHLYTAV
                     LRGWSGADATITEFAAWSTSEISQNALMYYSGRLFWINGFRIITAQEIGQRTSVSVSE
                     PGKFNQFTIIQTSLKPLPGNFSSTPTVIPDSVQESSFRIEGHTSSFRILWNEPPAVDW
                     GIVFYSVEFSAHSKFLAIEQQSLPVFTVEGLEPYALFNLSVTPYTYWGKGQKTSLSFR
                     APESVPSAPENPRIFILSLGRYTRKNEVVVEFRWNKPKHENGVLTKSEIFYHISKQSG
                     TNKSTEDWVSVSVTPPVMSFQLEAMSPGYIVSFQVRVFTSKGPGPFSDIVMSKTSEIK
                     PCPYLISLLGNKIEFLDMDQNQVVWTFSLEGAVSTVGYTADDEMGYFAQGDALFLLNL
                     HNHSSSKLFQDVLASDIAVIAVDWIARHLYFALKASQDGTQIFDVDLEHKVKSPREVK
                     ICKSHTAIISFSMYPLLSRLYWTEVSDLGYQMFYCNISSHTLHHVLQPKASNQHGRRQ
                     CSCNVTESELSGAMTVDTSDPDRPWIYFTKQQEIWAMDLEGCQCWKVIMVPATPGKRI
                     ISLTVDGEFIYWITTMKDDTEIYQAKKGSGAILSQVKAPRSKHILAYSSALQPFPDKA
                     YLSVASNMVEASILNATNTSLILKLPPVKTNLTWHGITTPTSTYLVYYMEANRANSSD
                     RKHNMLESQENVARIEGLQPFSTYVIQIAVKNYYSDPLEHLSLGKEIQGKTKSGVPGA
                     VCHINATVLSDTSLLVFWTESHKPNGPKELVRYQLVMSYLAPIPETPLRQDEFPSARL
                     SLLVTKLSGGQQYVLKILACHSEEMWCTESHPVSVNMFDTPEKPSALVPENTSLLLDW
                     KAPSNANLTRFWFELQKWKYSEFYHVKASCSQGPVYVCNIANLQPYTPYNIRVVVVYT
                     TGENSSSIPESFKTKAGVPSKPGIPKLLEGSKNSIQWEKAEDNGNRLMYYTLEVRKSI
                     SNDSRDQSLRWTAVFNGSCSSICTWRSKNLKGTFQFRAVASNAIGFGEYSEISEDITL
                     VEDGFWITETSFILTIIVGIFLVATVPLTFVWHRSLKNHKATKEGLSVLNDNDQELAE
                     LRGLAAGVGLANACYAVHTLPTQEEIESLPAFPREKLSLRLLLGSGAFGEVYEGTAVD
                     ILGRGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLSEPQYI
                     ILELMEGGDLLSYLRKARGTTLSGPLLTLADLVELCVDISKGCVYLEQMHFIHRDLAA
                     RNCLVSVKDYTSPRVVKIGDFGLAREIYKHDYYRKRGEGLLPVRWMAPENLMDGIFTS
                     QSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMFRCW
                     AQEPDQRPTFYNIQDQLQLFRNVSLNNVSHCGQAAPAGGVINKGFEGEDNEMATLNSD
                     DTMPVALMETRNQEGLNYMVLATKCSQSEDRYEGPLGSKESGLHDLKKDERQPADKDF
                     CQQPQVAYGSPGHSEGLNYACLAHSGHGDVSE"
     exon            525..569
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            570..629
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            630..656
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            657..717
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            718..866
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1005
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1207
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1284
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1407
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1592
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1690
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..2187
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2400
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2511
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2690
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2882
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2983
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3198
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3359
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3504
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3767
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            3768..3831
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..4034
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            4035..4240
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            4241..4524
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4701
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            4702..4901
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            4902..5046
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            5047..5279
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            5280..5456
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            5457..5625
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            5626..5743
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            5744..5934
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            5935..6018
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            6019..6154
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            6155..6317
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            6318..6382
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            6383..6512
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            6513..6610
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            6611..6811
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            6812..6946
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            6947..7110
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
     exon            7111..7902
                     /gene="Ros1"
                     /gene_synonym="ROS1C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catagctcag ccaacctcaa agaagtgcgg tggctggccg acctgagtgt tctgcgtcag
       61 gactgtgtgg actggctcgc tggaaagcaa tctaagttcc tactgcttat tttgcatgtg
      121 gagagctctt ccacgatcta gcctttagcc agggaacgtc tttcattatg ggagtaaaag
      181 gaagctaaac tataaaatag tcttgctgcg atgttctggg ctatctgaga tccaaaggtc
      241 taaaccggtt tcaataagag agtacgatat tctaacatcg caaaagaaaa cagataaccc
      301 accaagctca cttgcaaccg aagtatgaag cctaaagaat tgttaaagca acatggagac
      361 atgaggacgc cagccgtgta ggaagctggc cttcctgagg gatgaagagg atccgctggc
      421 tcaccccaaa acctgcgacc tttgtggtcc ttgggtgcgt atggatttcc gtggcgcagg
      481 gtaccattct gagcagctgc ctaacgtcct gtgtaactaa cttgggcagg cagcttgaca
      541 gcggcacccg gtacaatctg agtgaggcat gcatccaagg atgtcagttt tggaactcta
      601 tagatcagga gaagtgtgct ttgaagtgta atgatacata tgtcaccatt tgtgagaggg
      661 agtcctgtga ggtcggctgc agcaacgcgg agggtagcta cgaagaggaa gtgctggaca
      721 acacagagct tcctacagca cccttcgcat cttccattgg aagtaacggg gtgacattac
      781 gatggaaccc tgccaacatc tctggagtaa aatacatcat tcagtggaaa tatgcccaac
      841 ttccgggaag ctgggcttac acagaaactg tgtctaagct ctcatacatg gtggaacccc
      901 tgcatccatt tactgaatat atttttcgag tggtttggat tttcacagcc cagctgcacc
      961 tttattcccc gccaagtccc agttacagga ctcatcctta tggagttcca gaaactgcgc
     1021 ctttcatcac gaacatcgaa agctcgagcc ctgacactgt ggaggtcagc tgggctccac
     1081 cctatttccc aggtggacct attttgggtt ataatttaag gctgatcagt aaaactcaaa
     1141 aattagattc agggacacag agaaccagtt tccagtttta ttctactctt ccaaacacca
     1201 cttacaggtt ttctatcgca gcagtcaatg aagtcggtga ggggccagaa gcagaatcta
     1261 tgattaccac tccatcccca gcagttcaag aagaagaaca atggctcttt ttatccagaa
     1321 aaacttctct aagaaagagg tctttgaagt acttagtaga cgaagcacat tgcctttggt
     1381 cagatgctat acgtcataat attacaggaa tatcagtcaa cactcagcag gaagtggttt
     1441 atttctcaga aggaaccatc atatggatga agggggctgc taacatgtct gatgtgtctg
     1501 acctgaggat cttttatcga ggctcagctc tagtctcttc tatctctgta gactggcttt
     1561 accaaaggat gtatttcatc atggataatc gggtgcatgt ctgtgactta aagcattgct
     1621 caaatcttga ggaaatcact ccattctcta ttgttgcacc tcaaaaagtt gtggttgatt
     1681 cctacaatgg gtatgtcttt tatctcctaa gagacggcat ttatagagtc catcttcctt
     1741 tgccgtctgt cagggacacc aaagctgtgc gtattgtgga gagtggcaca ttaaaggact
     1801 tcgcagtaaa gccgcagtcc aagcgaatca tttacttcaa tggcaccatg caagtcttca
     1861 tgtcgacatt tctggatggc tcggcattcc acagggttct gccgtgggtc ccccttgcgg
     1921 atgtgaagag ctttgcttgt gaaaacaatg acttcctcat cacagatggc aaggccattt
     1981 tccaacagga ctctctgtct ttcaatgagt tcatcgtggg atgtgacctg agtcacatag
     2041 aagaatttgg gtttggtaac ttggtcatct ttggctcctc cgtccagtcg taccctctgc
     2101 caggccatcc acaggaggtc tcggtgctgt ttggttctcg agaggccctt attcagtgga
     2161 agcctccgat tctcgccata ggagccagtc cttccgcctg gcagaactgg acttatgagg
     2221 tcaaagtttc ctcccaggac attctggaaa ccactcaagt tttcttgaac ataagcagga
     2281 ctgtgctgaa tgtacccaag ctgcaaagtt ctacaaagta catggtgtct gtgcgagcaa
     2341 gttctcctaa aggcccaggc ccatggtcag aaccctcagt gggtactacc ttggtaccag
     2401 ccactgagcc accgttcatc atggctgtga aagaagatgg gctttggagc aaaccactca
     2461 gtagttttgg cccaggagag ttcctatcct ctgacgtagg aaacgtgtca gatatggatt
     2521 ggtataacaa cagcctctac tacagtgaca caaaaggcaa tgtgtatgtg cggcctctga
     2581 atgggatgga tatctcggag aattaccaca tatccagcat tgcaggagct tgtgccttgg
     2641 cctttgaatg gctgggtcac tttctctact gggctgggaa gacatatgtg attcaaaggc
     2701 agtctgtgtt aacgggacac acagacattg tgactcacgt gaagctgttg gtgaatgaca
     2761 tggccgtgga tccagttggt ggctatctgt actggacgac gctctactcg gttgaaagca
     2821 ccagactcaa tggagaaagt tctcttgtac tacaggctca gccctggctc tctggaaaaa
     2881 aggttattgc tctaacatta gacctcagcg atgggctcct gtactggctg gtgcaggaca
     2941 atcagtgtat tcacctgtac acggctgttc tccggggatg gagtggtgcg gatgctacca
     3001 tcaccgagtt tgcagcctgg agtacttctg aaatttccca gaatgcactg atgtactaca
     3061 gcggtagact cttctggatc aatggcttta ggatcatcac agcacaggaa ataggtcaga
     3121 gaaccagcgt gtctgtttct gagccaggga aattcaatca gtttacgatc atacagacat
     3181 ccctcaagcc tctgccaggg aacttttcct ctactcccac ggttatccca gattctgttc
     3241 aggagtcctc atttcgaatt gaaggacaca cttcaagttt ccgaatcctg tggaatgagc
     3301 cccctgcggt ggactggggc atagttttct acagtgtgga atttagtgct cattctaagt
     3361 tcctggctat tgaacaacag tctttacctg tttttactgt ggaaggactg gagccctatg
     3421 ccttatttaa tctttctgtc actccttata cctattgggg aaaaggtcaa aaaacatctc
     3481 tatcatttcg agcgcctgaa tcagttccgt cagcaccaga gaaccccaga atatttatat
     3541 tgtcacttgg aagatacacc aggaagaatg aagtcgtggt agagtttagg tggaataaac
     3601 ctaagcatga aaatggagtg ctaaccaaat ctgaaatctt ctaccacata tctaaacaaa
     3661 gtggcacaaa taaatcaacg gaagactggg tatctgtcag cgttacaccg ccggtgatgt
     3721 cttttcaact tgaagccatg agtcctgggt atattgtttc cttccaggtt cgagtcttca
     3781 cctccaaagg gccaggacca ttttctgata tagtgatgtc taaaacatca gaaatcaagc
     3841 catgtccata tctcatatct cttcttggca ataagattga gttcttagac atggaccaaa
     3901 atcaagttgt gtggacattt tccctggagg gagccgtcag cacagtgggg tacacagcgg
     3961 atgatgaaat ggggtatttc gctcaaggag atgcactctt ccttctgaat ttgcacaatc
     4021 attccagctc caagcttttc caggacgtgc tggcttctga cattgcggtt attgctgttg
     4081 actggatcgc aaggcacctc tactttgctc tgaaagcatc gcaagatgga acacagatat
     4141 tcgatgttga ccttgaacac aaggtgaaat cccccaggga ggtgaagatt tgcaaaagcc
     4201 atacagcaat aatttctttc tctatgtatc ccctcttaag tcgcctgtat tggacagaag
     4261 tttcagatct gggctaccag atgttctact gcaatattag cagtcacacc ttgcatcacg
     4321 ttctacaacc caaggcctca aaccagcatg gaaggagaca gtgttcttgt aatgtgacag
     4381 aatccgagtt aagtggggca atgactgtgg acacgtctga tccagacaga ccttggatat
     4441 actttaccaa acagcaagag atctgggcca tggatctgga aggatgtcag tgttggaaag
     4501 tcatcatggt acctgctacc cctggaaaaa gaatcattag tttaacagtg gatggggagt
     4561 ttatatattg gatcacaaca atgaaggacg acacagaaat ttatcaagca aagaagggaa
     4621 gtggggccat cctctcccag gtgaaggccc ccaggagtaa gcatatcttg gcttacagtt
     4681 cagctctgca accttttcca gataaagcat atctgtctgt agcttccaat atggtagaag
     4741 caagtatatt gaatgccacc aacaccagcc tcattctcaa gttacctcca gtcaagacaa
     4801 acctcacgtg gcatggaatt accactccca cgtcaacata cctggtttac tatatggagg
     4861 ctaatagggc aaacagctct gacaggaaac acaacatgtt ggaatcacag gagaatgtag
     4921 cccggattga aggtctgcag ccattttcaa catacgtgat tcagatagct gtgaagaact
     4981 attattctga tcctttagaa catctctctc tgggaaaaga gattcaagga aaaactaaaa
     5041 gtggagtgcc cggggcagtt tgtcatatca atgcaactgt gctgtcggac accagtcttc
     5101 ttgtattctg gacagaatcg cataaaccaa acggacccaa agagttagtc cgctatcagt
     5161 tggttatgtc atacctggct ccgattcctg agactcctct aagacaggac gaatttccaa
     5221 gcgccaggct ttctctactt gtcactaaac tctctggtgg acaacaatat gtgctgaaga
     5281 tccttgcctg ccactcagag gaaatgtggt gtactgagag tcatcctgtc agtgtcaaca
     5341 tgtttgacac accggagaaa ccttctgcct tggttccaga gaacactagt ctgctgttgg
     5401 attggaaggc tccgtctaac gctaacctca ccagattttg gtttgaactc cagaagtgga
     5461 agtatagtga gttttaccat gtcaaggctt catgcagcca aggtccagtt tatgtctgta
     5521 acatcgcaaa tctgcagcct tacactcctt ataacatccg agtggtggtg gtctatacga
     5581 caggagaaaa tagctcctcg attcccgaga gcttcaagac aaaagctgga gtcccaagca
     5641 aaccagggat tcctaagtta ctagaaggga gtaaaaattc aatccagtgg gaaaaagccg
     5701 aagataacgg gaacagattg atgtactaca ccctggaggt cagaaaaagc atttcaaatg
     5761 actcacggga ccagagttta aggtggacgg cggtgtttaa tgggtcctgc agtagcattt
     5821 gcacatggag gtcaaaaaac ctaaaaggaa ctttccagtt cagagcagta gcgtcaaatg
     5881 ctattggatt tggagaatac agtgaaatca gtgaagatat tacattagtg gaagatggtt
     5941 tttggataac agaaacaagt tttatactta ctatcatagt tgggatattt ctggttgcca
     6001 cagtcccact gacctttgtc tggcatagaa gcttgaaaaa ccacaaagct accaaggaag
     6061 gcctctcagt tctcaacgac aatgaccaag agttggctga gcttcgagga ctggcggctg
     6121 gagtgggcct ggccaatgcc tgctatgcag tacatactct tccaacccaa gaggagattg
     6181 aaagtcttcc cgccttccct cgggagaagc tgagcctgcg ccttctgttg ggaagtggag
     6241 cttttggaga agtgtacgag ggcacagctg tagacatcct aggacgggga agtggagaaa
     6301 tcaaggtggc cgtgaagacc ctgaagaaag gttcgacaga ccaggagaag atcgagttcc
     6361 tgaaggaggc acacctgatg agcaagttta atcaccccaa cattctgaag cagctgggag
     6421 tctgtctgct gagtgaaccc cagtacatta tcctggaact gatggaaggg ggagaccttc
     6481 taagctatct gcgcaaagcc cgagggacaa cgttgtctgg ccctttactc acattggctg
     6541 acctggtaga gctgtgtgta gatatttcaa aaggctgcgt ctacttggag cagatgcact
     6601 tcattcacag ggatctggca gctcggaatt gccttgtgtc tgtgaaagac tataccagtc
     6661 ctcgggtagt caagatcggt gactttggtt tggcaaggga aatctataag catgattatt
     6721 atagaaagag aggggaaggc ctgcttcctg tccggtggat ggctcctgaa aacttgatgg
     6781 atggaatctt cacttcccag tctgatgtat ggtcttttgg aattttggtt tgggagattt
     6841 taactcttgg tcatcaacct tatccagcgc attccaacct tgatgtttta aactatgtgc
     6901 aagcaggagg gagactggag ccaccgagaa actgtcctga tgatctgtgg aatttaatgt
     6961 tccgatgttg ggcccaagaa cctgaccaaa gacccacttt ctataacatt caagaccagc
     7021 ttcagttatt cagaaatgtt tccttaaaca atgtttctca ctgtggacaa gcagctcctg
     7081 ctggtggagt catcaacaaa ggctttgaag gtgaagacaa tgaaatggcc actttgaatt
     7141 cagatgacac gatgccagtt gccttgatgg aaaccaggaa ccaagaagga ttaaattata
     7201 tggtacttgc cacaaagtgt agccaaagtg aggatcgtta tgagggtcct ctaggctcta
     7261 aggaatctgg gttgcatgat ctgaagaaag acgagaggca accagcagac aaagatttct
     7321 gccagcaacc acaggtggct tatggctctc ctggccactc tgaaggcctg aactatgcct
     7381 gtcttgctca cagtggacat ggagatgtgt ctgaataata gtatctcata ggaaacatag
     7441 cactgagatg aacactgtat taagttaaaa agaagaaagg tggggtggca gtctagactc
     7501 tgaactgaca cagccaagtt ccaaagttct gatcttggtt ccaagagcca ttatgtttca
     7561 ttcagcattc tctttaccag tgacgtaacc ttcagtggat tatcagagga acctgtgtgt
     7621 gtgcggaaat cccaggacaa atcctaagtc tgggaagaaa acatcactgt ctctctcctc
     7681 tgaagccctt tacttcagag cattgcctgc cctggcaatc ttactaggtt catgcaagga
     7741 tgtgagtggg ggaggggccg gagtctgctg aggaccacct gaactacaga ttaccttaag
     7801 aggatgcagg aaacaattac tcacacagga ggaagcagcc tgtggaccat gaggaatcat
     7861 ctggcacgct attattccaa taaaatattc cctttaatca tc
//
