LOCUS       NM_001107339            3942 bp    mRNA    linear   ROD 04-DEC-2023
DEFINITION  Rattus norvegicus receptor tyrosine kinase-like orphan receptor 2
            (Ror2), mRNA.
ACCESSION   NM_001107339 XM_001053288 XM_225181
VERSION     NM_001107339.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3942)
  AUTHORS   Riquelme R, Li L, Gambrill A and Barria A.
  TITLE     ROR2 homodimerization is sufficient to activate a neuronal
            Wnt/calcium signaling pathway
  JOURNAL   J Biol Chem 299 (11), 105350 (2023)
   PUBMED   37832874
  REMARK    GeneRIF: ROR2 homodimerization is sufficient to activate a neuronal
            Wnt/calcium signaling pathway.
REFERENCE   2  (bases 1 to 3942)
  AUTHORS   Liu C, Shen L, Xu L, Zhu A and Huang Y.
  TITLE     Ror2 mediates chronic post-thoracotomy pain by inducing the
            transformation of A1/A2 reactive astrocytes in rats
  JOURNAL   Cell Signal 89, 110183 (2022)
   PUBMED   34728368
  REMARK    GeneRIF: Ror2 mediates chronic post-thoracotomy pain by inducing
            the transformation of A1/A2 reactive astrocytes in rats.
REFERENCE   3  (bases 1 to 3942)
  AUTHORS   Parodi J, Montecinos-Oliva C, Varas R, Alfaro IE, Serrano FG,
            Varas-Godoy M, Munoz FJ, Cerpa W, Godoy JA and Inestrosa NC.
  TITLE     Wnt5a inhibits K(+) currents in hippocampal synapses through nitric
            oxide production
  JOURNAL   Mol Cell Neurosci 68, 314-322 (2015)
   PUBMED   26311509
REFERENCE   4  (bases 1 to 3942)
  AUTHORS   Alfaro IE, Varela-Nallar L, Varas-Godoy M and Inestrosa NC.
  TITLE     The ROR2 tyrosine kinase receptor regulates dendritic spine
            morphogenesis in hippocampal neurons
  JOURNAL   Mol Cell Neurosci 67, 22-30 (2015)
   PUBMED   26003414
  REMARK    GeneRIF: ROR2 regulates dendritic spine morphogenesis through
            specific protein domains.
REFERENCE   5  (bases 1 to 3942)
  AUTHORS   Cerpa W, Latorre-Esteves E and Barria A.
  TITLE     RoR2 functions as a noncanonical Wnt receptor that regulates
            NMDAR-mediated synaptic transmission
  JOURNAL   Proc Natl Acad Sci U S A 112 (15), 4797-4802 (2015)
   PUBMED   25825749
  REMARK    GeneRIF: Data show that the receptor tyrosine kinase-like orphan
            receptor 2 (RoR2) functions as a Wnt5a receptor required to
            maintain basal NMDA receptors (NMDARs)-mediated synaptic
            transmission.
REFERENCE   6  (bases 1 to 3942)
  AUTHORS   Katoh M and Katoh M.
  TITLE     Identification and characterization of rat Ror1 and Ror2 genes in
            silico
  JOURNAL   Int J Mol Med 15 (3), 533-538 (2005)
   PUBMED   15702250
REFERENCE   7  (bases 1 to 3942)
  AUTHORS   Paganoni S, Anderson KL and Ferreira A.
  TITLE     Differential subcellular localization of Ror tyrosine kinase
            receptors in cultured astrocytes
  JOURNAL   Glia 46 (4), 456-466 (2004)
   PUBMED   15095375
REFERENCE   8  (bases 1 to 3942)
  AUTHORS   Schwabe GC, Trepczik B, Suring K, Brieske N, Tucker AS, Sharpe PT,
            Minami Y and Mundlos S.
  TITLE     Ror2 knockout mouse as a model for the developmental pathology of
            autosomal recessive Robinow syndrome
  JOURNAL   Dev Dyn 229 (2), 400-410 (2004)
   PUBMED   14745966
REFERENCE   9  (bases 1 to 3942)
  AUTHORS   Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida
            I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S
            and Minami Y.
  TITLE     The receptor tyrosine kinase Ror2 is involved in non-canonical
            Wnt5a/JNK signalling pathway
  JOURNAL   Genes Cells 8 (7), 645-654 (2003)
   PUBMED   12839624
REFERENCE   10 (bases 1 to 3942)
  AUTHORS   DeChiara TM, Kimble RB, Poueymirou WT, Rojas J, Masiakowski P,
            Valenzuela DM and Yancopoulos GD.
  TITLE     Ror2, encoding a receptor-like tyrosine kinase, is required for
            cartilage and growth plate development
  JOURNAL   Nat Genet 24 (3), 271-274 (2000)
   PUBMED   10700181
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473977.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_225181.4, XM_001053288.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3942
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..3942
                     /gene="Ror2"
                     /note="receptor tyrosine kinase-like orphan receptor 2"
                     /db_xref="GeneID:306782"
                     /db_xref="RGD:1305275"
     exon            1..298
                     /gene="Ror2"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..3033
                     /gene="Ror2"
                     /EC_number="2.7.10.1"
                     /note="tyrosine-protein kinase transmembrane receptor
                     ROR2"
                     /codon_start=1
                     /product="tyrosine-protein kinase transmembrane receptor
                     ROR2 precursor"
                     /protein_id="NP_001100809.1"
                     /db_xref="GeneID:306782"
                     /db_xref="RGD:1305275"
                     /translation="MARGWVRPSRVPLCVRAVWTAAALLLWTPWTAGEVEDSEAIDTL
                     GQLDGPDSPLPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPV
                     VQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPTHSP
                     NHNFQDDDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTH
                     LSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLENDLCRQEYTIARSNPL
                     ILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGTDYRGMASTTKSG
                     HQCQPWALQHPHSHRLSSTEFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRVELCDVP
                     PCSPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQ
                     DMEMPLISQHKQAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEPTQVVAIKT
                     LKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMVFSYCCHGDLHEFLV
                     MRSPHSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVY
                     DKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSDIWSYGVVL
                     WEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSGRPRFK
                     DIHGRLRSWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYMAPKQKAQPFPQ
                     PQFIPMKGQIRPLVPPAQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMV
                     PKPSSHHSGSGSTSTGYVTTAPSNTSVADRAALLSEGTEDVQNMPEDVAQSPVQEAEE
                     EEEGSVPETELLGDSDTLQVNEAHVHLEA"
     exon            299..376
                     /gene="Ror2"
                     /inference="alignment:Splign:2.1.0"
     exon            377..664
                     /gene="Ror2"
                     /inference="alignment:Splign:2.1.0"
     exon            665..695
                     /gene="Ror2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..823
                     /gene="Ror2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1138
                     /gene="Ror2"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1384
                     /gene="Ror2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1587
                     /gene="Ror2"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..3942
                     /gene="Ror2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgccggagc cccggagcct ctgcagccga tctgtgcatc ggggcaggga gagagggacg
       61 tcagagtggc cctcgaaggg aaccagcttg cgaagcgcgg ggaaggaaag cgcggacgcg
      121 tggcggggag gggttaaggc gccccggccc gaagcccgaa ggccgagcgc ggcaggcgac
      181 ccggcaccca cggcccgcag catggctcgg ggctgggtgc ggccgagccg agtgcctctg
      241 tgcgtccggg ctgtctggac ggctgctgcg ctcctgctct ggacaccctg gacggcaggt
      301 gaagtggagg actcagaggc cattgacacc ttgggacaac ttgatggccc ggacagccca
      361 cttcccactc tgaaaggcta ctttctgaat tttctggagc ccgtcaacaa tatcaccatc
      421 gtccagggcc agacggcaat tctgcactgc aaggtggcgg gaaacccacc tcccaacgtg
      481 cggtggctga agaatgatgc ccctgtcgta caggagccac ggagggtcat catccggaag
      541 acagaatatg gctcccggct gcggatccag gatctggaca cgacagacac gggctactac
      601 cagtgcgtgg ctaccaacgg gctgaagacc attaccgcca ctggtgttct gtatgtgcgg
      661 ctcggtccaa cgcacagccc gaaccacaat tttcaggatg acgaccagga agatggcttc
      721 tgccaacctt accgagggat cgcctgtgca cgcttcattg ggaaccgaac tatttatgtg
      781 gactccctcc agatgcaggg ggagattgaa aaccgaatca cagctgcctt caccatgatt
      841 ggcacctcca cgcacctgtc agaccagtgc tcgcagtttg ccatcccatc cttctgccac
      901 ttcgtctttc ctctatgcga cgcgcgctcc cgggcgccca agccgcggga gctgtgccgg
      961 gatgaatgtg aggtgttgga gaatgacctg tgccgccagg agtacaccat cgcccgctcc
     1021 aaccctctca tcctcatgcg gctccagctg cccaagtgcg aagcgctgcc catgcccgag
     1081 agccctgatg ctgcgaactg catgcgcatc gggatccccg ccgagaggct gggtcgctat
     1141 caccagtgtt acaacggctc aggcactgat tacaggggca tggccagcac caccaagtca
     1201 ggccaccaat gtcagccttg ggctctgcaa catccccaca gccatcgcct gtccagcaca
     1261 gaatttccag agctgggagg aggccacgcc tactgccgga acccgggagg ccagatggaa
     1321 ggcccgtggt gctttacgca gaataaaaac gtacgagtgg aactgtgtga cgtaccccca
     1381 tgtagtcccc gagacggcag caagatgggg atcctgtaca tcctggtccc cagcattgcc
     1441 atccccctgg tcatcgcctg ccttttcttc cttgtctgca tgtgccggaa caagcagaag
     1501 gcctcagcct ccaccccgca gcgccggcag ctgatggcct cgcccagcca ggatatggag
     1561 atgccactca tcagccagca caaacaggcc aaacttaaag agatcagctt gtccacggtg
     1621 aggttcatgg aggagcttgg ggaggaccgg tttggcaagg tctacaaagg ccacctgttc
     1681 gggcccgccc caggagaacc aacccaggtg gtggccatca agacgttgaa agacaaggct
     1741 gaggggcccc tgcgggagga gttccggcaa gaggccatgc tccgggcacg gctacagcac
     1801 cccaacatcg tctgtctact aggtgtggtg accaaagacc aacccctgag catggtcttc
     1861 agttactgct gccacggcga cctccacgag ttcctggtca tgcgctcacc gcactcggac
     1921 gtgggcagca ctgacgatga ccgcacggtg aagtcagccc tggagccccc ggacttcgtt
     1981 cacgtggtgg cgcagatcgc cgcggggatg gagttcctgt ccagccacca cgtggtccat
     2041 aaggacctgg ccacccgtaa tgtgctggtg tatgacaagc tgaacgtgag gatctcagac
     2101 ttgggcctct tccgagaggt gtactccgcc gattactaca aactcatggg caactcgctg
     2161 cttcccatcc gctggatgtc ccccgaggcc gtcatgtacg gaaagttctc cattgactcc
     2221 gacatctggt cctatggtgt ggtcctctgg gaggtcttca gctacggcct gcagccctac
     2281 tgtggctact ccaaccagga cgtggtggag atgatccgta gccggcaggt actgccctgc
     2341 ccggatgact gccccgcctg ggtctacgcc ctcatgatcg aatgctggaa cgagtttcct
     2401 agcgggaggc cccgctttaa ggacatccac ggccggctcc gatcctgggg caacctgtcc
     2461 aactacaata gctcggccca gacctcagga gccagcaaca ccacacagac cagctccctg
     2521 agcaccagcc ctgttagcaa tgtgagcaat gcccgctata tggcacctaa gcagaaggcc
     2581 cagcccttcc cacagcctca gttcatcccc atgaagggtc agatcagacc cttggtgccc
     2641 ccggcacagc tctacatccc agttaatggc taccagccag taccggcata tggggcctac
     2701 ctgcccaact tctacccggt ccaaatcccc atgcagatgg ccccacagca ggtgccccct
     2761 cagatggtcc ccaagcccag ctcacaccac agtggcagcg gctccaccag cactggctat
     2821 gtcaccacgg caccctctaa cacatctgtg gcggacaggg cagccctcct ctcggagggc
     2881 actgaggatg tacaaaacat gccagaagac gtggcccaga gccctgtgca ggaagcggag
     2941 gaggaggagg aaggttctgt cccagagact gagctcctgg gagacagtga cacgctccag
     3001 gtgaacgagg cccatgtcca ccttgaagcc tgagcagtat tcggggcctg gagcactggg
     3061 gcggaaagtt cctgatgtgg ccagtgggga cctcaaaatg gctctgagaa atccccaaga
     3121 ggggtccatc accagagccc agggactggc aggctggttt gagcctaccc acttgagact
     3181 gtgagagatc ttacactatc tcctgcaccc tgtgcccata gagctgtctc tgcagccccg
     3241 gttcggctgg aggccatctc agctagggac cccgggcagg gtccctgcag catgaccacc
     3301 tcagaaacgg gacggggaga cccccacctc tgtctgcttc atcctcatgg tagatgggta
     3361 gtgagctaaa gatgctgtgc aaagagacag gctacatctt cgctccctgt tttctgggcg
     3421 gaagattcag aaactggggt agaaacaggg ctgtgaaggg tagcagagag gcgccttggg
     3481 gtgtagatgc tgagcgagcc tcctgctggc tgaggacgga gagagagctg ttctctctgt
     3541 ggccggctgc agaacttgtt cgtttgaaca gccaaaggcc agcagaagca ggatgctgcc
     3601 acctgctggg gtccgaagga caggggagct tctgaacagt tgggagtgcc ttgtattaaa
     3661 gggggggaaa gtgcctttac gaaaaccagc acgaccttgt attttgtgaa gggttttaat
     3721 gattactgcg tatgtaattc aagggtgggg ggggaatgtt tcctgggttt agaatgtcca
     3781 aaaggaagca acgttgtaca aaaaaaaaaa aaaatcagtg ttgttaattt ttttttttta
     3841 agaatcctgt gcagacctta aatgtaattt atatggtttt ctgtgtgcca ttttcgtgga
     3901 agtattttga tcctaaataa tgagttagta atttaatcat gt
//
