LOCUS       NM_001108671            3533 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus receptor tyrosine kinase-like orphan receptor 1
            (Ror1), mRNA.
ACCESSION   NM_001108671 XM_001056577 XM_216445
VERSION     NM_001108671.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3533)
  AUTHORS   Heliste J, Jokilammi A, Paatero I, Chakroborty D, Stark C, Savunen
            T, Laaksonen M and Elenius K.
  TITLE     Receptor tyrosine kinase profiling of ischemic heart identifies
            ROR1 as a potential therapeutic target
  JOURNAL   BMC Cardiovasc Disord 18 (1), 196 (2018)
   PUBMED   30342492
  REMARK    GeneRIF: ROR1 was one of the most significantly regulated receptor
            tyrosine kinases in the ischemic heart and may be a potential
            target for the treatment of ischemic heart injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3533)
  AUTHORS   Diaz-Horta O, Abad C, Sennaroglu L, Foster J 2nd, DeSmidt A,
            Bademci G, Tokgoz-Yilmaz S, Duman D, Cengiz FB, Grati M, Fitoz S,
            Liu XZ, Farooq A, Imtiaz F, Currall BB, Morton CC, Nishita M,
            Minami Y, Lu Z, Walz K and Tekin M.
  TITLE     ROR1 is essential for proper innervation of auditory hair cells and
            hearing in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (21), 5993-5998 (2016)
   PUBMED   27162350
REFERENCE   3  (bases 1 to 3533)
  AUTHORS   Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li
            SS, Teasdale RD and Collins BM.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   4  (bases 1 to 3533)
  AUTHORS   Fukuda T, Chen L, Endo T, Tang L, Lu D, Castro JE, Widhopf GF 2nd,
            Rassenti LZ, Cantwell MJ, Prussak CE, Carson DA and Kipps TJ.
  TITLE     Antisera induced by infusions of autologous Ad-CD154-leukemia B
            cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a
  JOURNAL   Proc Natl Acad Sci U S A 105 (8), 3047-3052 (2008)
   PUBMED   18287027
REFERENCE   5  (bases 1 to 3533)
  AUTHORS   Katoh M and Katoh M.
  TITLE     Identification and characterization of rat Ror1 and Ror2 genes in
            silico
  JOURNAL   Int J Mol Med 15 (3), 533-538 (2005)
   PUBMED   15702250
REFERENCE   6  (bases 1 to 3533)
  AUTHORS   Paganoni S, Anderson KL and Ferreira A.
  TITLE     Differential subcellular localization of Ror tyrosine kinase
            receptors in cultured astrocytes
  JOURNAL   Glia 46 (4), 456-466 (2004)
   PUBMED   15095375
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473998.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216445.4, XM_001056577.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3533
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..3533
                     /gene="Ror1"
                     /gene_synonym="RGD1559469"
                     /note="receptor tyrosine kinase-like orphan receptor 1"
                     /db_xref="GeneID:362550"
                     /db_xref="RGD:1559469"
     exon            1..516
                     /gene="Ror1"
                     /gene_synonym="RGD1559469"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..3239
                     /gene="Ror1"
                     /gene_synonym="RGD1559469"
                     /EC_number="2.7.10.1"
                     /note="neurotrophic tyrosine kinase, receptor-related 1;
                     tyrosine-protein kinase transmembrane receptor ROR1;
                     inactive tyrosine-protein kinase transmembrane receptor
                     ROR1"
                     /codon_start=1
                     /product="inactive tyrosine-protein kinase transmembrane
                     receptor ROR1 precursor"
                     /protein_id="NP_001102141.1"
                     /db_xref="GeneID:362550"
                     /db_xref="RGD:1559469"
                     /translation="MHRPRRRGTRPPPLALLAALLLAARGAAAQETELSVSAELVPTS
                     SWNTSSEIDKDSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPNIRWFKNDAPVVQEP
                     RRISFRATNYGSRLRIRNLDTTDTGYFQCVATSGKKVVSTTGVLFVKFGPPPTASPGS
                     SDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDK
                     CSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEVLENVLCHTEYIFARSNPMILMR
                     LKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQC
                     QPWNSQYPHTHSFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACD
                     SKDSKEKNKMEILYILVPSVAIPLAIAFLFFFICVCRNNQKSPSPPVQRQPKPVRGQN
                     VEMSMLNAYKPKSKAKELPLSAVRFMEELGECTFGKIYKGHLYLPGMDHAQLVAIKTL
                     KDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEFLIM
                     RSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIG
                     EQLHVKISDLGLSREIYSADYYRVQSKSSLPIRWMPPEAIMYGKFSSDSDIWSFGVVL
                     WEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFK
                     DIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRFPNYMFPSQGIPP
                     QGQIAGFIGPAIPQNQRFIPINGYPIPPGYAAFPAAHYQPAGPPRVIQHCPPPKSRSP
                     SSASGSTSTGHVASLPSSGSNQEANVPLLPHMSIPNHPGGMGITVFGNKSQKPYKIDS
                     KQPSLLGDSNIHGHTESMISAEV"
     exon            517..588
                     /gene="Ror1"
                     /gene_synonym="RGD1559469"
                     /inference="alignment:Splign:2.1.0"
     exon            589..876
                     /gene="Ror1"
                     /gene_synonym="RGD1559469"
                     /inference="alignment:Splign:2.1.0"
     exon            877..907
                     /gene="Ror1"
                     /gene_synonym="RGD1559469"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1035
                     /gene="Ror1"
                     /gene_synonym="RGD1559469"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1353
                     /gene="Ror1"
                     /gene_synonym="RGD1559469"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1599
                     /gene="Ror1"
                     /gene_synonym="RGD1559469"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1811
                     /gene="Ror1"
                     /gene_synonym="RGD1559469"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..3533
                     /gene="Ror1"
                     /gene_synonym="RGD1559469"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtccgggc tggggcgctg agttgtggag ttggtggaaa gtgacaagtt gggcgagaag
       61 agagatcgcg gagagctgga ggagccgcgg ccgagtgagc ccagagacct ccgccccagg
      121 cactgggcac gctcttctgg agtcggagcc ggagacacac agtgtgctgg agcgacacgg
      181 agagcctgga actgaaccgc tggcggaggc acggctgcta cggagtaccg ggaggagccg
      241 cgctcccagg tccggggcgg ccgagcggag gcgagggagc aggtcagagg gacaaagagt
      301 tttgcaaagg ccccccggtg tcctgcgagt gcctgcggca ggacgaagtg gccgggagca
      361 ctgggagaac ccgtggatgt tctgcgcgcc gccagggagc cgccagcacc gccacgagag
      421 gaggaatgca ccggccgcgc cgccgcggga cgcgcccgcc accgctggcg ctgctggccg
      481 cgctgctgct ggccgcacgc ggggctgctg cccaagaaac agagttgtca gtcagtgctg
      541 agctggtgcc tacctcatcc tggaacactt caagtgaaat tgacaaagat tcttacttaa
      601 cccttgatga acctatgaat aacatcacaa catccctggg ccagactgca gaactgcact
      661 gcaaagtgtc tgggaatcca cctcccaata tccgctggtt caagaatgac gcacctgtgg
      721 ttcaagaacc gcgtagaatc tccttccggg ccaccaacta tggctctcgg ctgcggatca
      781 gaaacctcga caccacagac actggttact tccagtgtgt ggcaacaagt ggcaagaaag
      841 tggtttctac cactggagtc ctgtttgtca agtttggacc tcctccaact gcaagcccag
      901 gatcctcaga cgagtatgaa gaagatggat tctgtcagcc ataccgaggc attgcatgtg
      961 cacgatttat tggcaaccgc actgtgtata tggagtcttt gcatatgcag ggggaaatag
     1021 aaaatcagat cacagctgcc ttcaccatga ttggcacctc cagccattta tctgataagt
     1081 gctctcagtt cgccatccct tccctgtgcc actacgcctt cccatactgt gacgaaacct
     1141 catctgtccc aaagccccga gacctgtgtc gggatgaatg tgaagtgcta gaaaatgtcc
     1201 tgtgtcacac agagtacatt tttgccagat cgaatcccat gattctgatg aggctgaagt
     1261 tgccaaactg tgaggatctc cctcagccgg agagcccaga agctgcaaac tgcattcgga
     1321 ttggcatccc catggcggat cctataaaca aaaatcacaa atgctacaac agcacaggtg
     1381 tagactaccg gggaactgtc agtgtgacca agtcaggacg ccagtgccaa ccttggaatt
     1441 ctcagtaccc acacacacac agcttcactg ccctgcgctt tccggagctc aacggaggcc
     1501 actcctactg ccgcaaccct ggcaaccaga aggaagctcc ctggtgcttt accttggatg
     1561 aaaactttaa gtctgacctg tgcgacatcc cggcatgtga ttccaaagat tccaaagaga
     1621 agaataaaat ggaaatcctg tatattctgg tgccaagtgt ggccattccc ctggctattg
     1681 ccttcctctt cttcttcatc tgtgtgtgcc gaaataacca gaagtccccg tcaccacccg
     1741 tccagaggca gccaaaacct gtcagaggac agaacgtaga gatgtccatg ctgaatgcat
     1801 acaagcccaa gagcaaagct aaggagctgc ctctttctgc tgtgcgtttc atggaagaat
     1861 tgggtgaatg tacctttgga aaaatctata agggccatct ctacctccca ggcatggacc
     1921 atgcacagct ggtggctatc aaaaccttga aagactataa caacccccag cagtggacag
     1981 aatttcaaca ggaagcctct ctcatggccg aactacacca ccctaatatt gtatgtctcc
     2041 ttggtgccgt cacccaggaa caacctgtgt gtatgctctt tgagtatatg aaccagggag
     2101 atctccatga gttcctcatc atgcgatccc cacattccga tgttggctgc agcagtgatg
     2161 aggacggaac ggtcaaatcc agcctggacc acggagattt cttacacatc gcaattcaga
     2221 tcgcggctgg catggagtac ctctctagtc acttcttcgt gcacaaggac cttgcagctc
     2281 gcaacatttt aattggagaa caactgcatg tgaagatttc agaccttggg ctttccagag
     2341 aaatttactc tgccgattac tatagggtgc agagtaagtc ttcactgccc atccgctgga
     2401 tgccccctga ggcgatcatg tacggcaaat tctcctcaga ttctgatatc tggtcttttg
     2461 gggttgtgtt gtgggagatt ttcagctttg gactccagcc atattatggg tttagtaatc
     2521 aggaagtgat tgaaatggtg cggaagcgac agctcttacc gtgttctgaa gactgcccgc
     2581 cgcgaatgta cagcctcatg accgagtgct ggaatgagat tccttccagg agaccacgct
     2641 ttaaggacat ccacgtccgg cttcgatcct gggagggcct ctcaagtcac accagctcaa
     2701 ccactccctc gggtggaaat gctaccacgc agaccacctc cctcagcgcc agccctgtga
     2761 gtaacctcag caacccccga tttcccaatt acatgttccc gagccagggg atcccaccac
     2821 agggtcaaat cgctggtttc attggcccag cgataccgca gaaccagcgc ttcatcccca
     2881 ttaacggata tccaatacct cccggatacg cagcctttcc tgctgcccac taccagcctg
     2941 cgggacctcc cagggtgatt cagcactgcc cgcctccaaa gagccggtcc ccaagcagcg
     3001 ccagtggatc gaccagcact ggccatgtgg ccagcttgcc ctcatcagga tccaatcagg
     3061 aagcaaacgt tcctttgcta ccccacatgt caatcccaaa tcaccccggt ggaatgggga
     3121 tcactgtttt cggcaacaaa tctcaaaaac cctacaaaat agactcaaaa caaccatctt
     3181 tgcttgggga ctccaatatc catgggcaca ccgagtctat gatttctgcg gaagtgtaaa
     3241 atgtgggact tttgtaaata cgctatccag gaaaaactag aaggtggcag aaaagattta
     3301 tattcaaatg tttttattga cggttctcat ttagcagaca ttgcaaccag tatcttctgt
     3361 gaagtttaac tgtgtcttac cggaaagaca ccaaccagga aaaataatgc attgtgggat
     3421 ttacactcca tcagggtgta tgatatgttg ttgggaacag accttttatt tcaaggactg
     3481 aaaactgcaa aaccaatgaa gatgaacaga acatagtaat taaatagcaa acc
//
