LOCUS       NM_001195490             404 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus reactive oxygen species modulator 1 (Romo1),
            mRNA.
ACCESSION   NM_001195490 XM_001053409 XM_002726261
VERSION     NM_001195490.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 404)
  AUTHORS   Liu,D., Liu,Y., Xia,Z., Dong,H. and Yi,Z.
  TITLE     Reactive oxygen species modulator 1 regulates oxidative stress and
            induces renal and pulmonary fibrosis in a unilateral ureteral
            obstruction rat model and in HK-2 cells
  JOURNAL   Mol Med Rep 16 (4), 4855-4862 (2017)
   PUBMED   28791399
  REMARK    GeneRIF: the expression of ROMO1 induces ROS production and
            activates the TGFbeta signaling pathway. It may be concluded that
            ROMO1 helps to provide a molecular basis for improved clinical
            intervention and prognosis of patients.
REFERENCE   2  (bases 1 to 404)
  AUTHORS   Wenz,L.S., Opalinski,L., Wiedemann,N. and Becker,T.
  TITLE     Cooperation of protein machineries in mitochondrial protein sorting
  JOURNAL   Biochim Biophys Acta 1853 (5), 1119-1129 (2015)
   PUBMED   25633533
  REMARK    Review article
REFERENCE   3  (bases 1 to 404)
  AUTHORS   Schulz,C., Schendzielorz,A. and Rehling,P.
  TITLE     Unlocking the presequence import pathway
  JOURNAL   Trends Cell Biol 25 (5), 265-275 (2015)
   PUBMED   25542066
  REMARK    Review article
REFERENCE   4  (bases 1 to 404)
  AUTHORS   Sha,J., Zhao,G., Chen,X., Guan,W., He,Y. and Wang,Z.
  TITLE     Antibacterial potential of hGlyrichin encoded by a human gene
  JOURNAL   J Pept Sci 18 (2), 97-104 (2012)
   PUBMED   22083756
REFERENCE   5  (bases 1 to 404)
  AUTHORS   Chung,Y.M., Lee,S.B., Kim,H.J., Park,S.H., Kim,J.J., Chung,J.S. and
            Yoo,Y.D.
  TITLE     Replicative senescence induced by Romo1-derived reactive oxygen
            species
  JOURNAL   J Biol Chem 283 (48), 33763-33771 (2008)
   PUBMED   18836179
REFERENCE   6  (bases 1 to 404)
  AUTHORS   Na,A.R., Chung,Y.M., Lee,S.B., Park,S.H., Lee,M.S. and Yoo,Y.D.
  TITLE     A critical role for Romo1-derived ROS in cell proliferation
  JOURNAL   Biochem Biophys Res Commun 369 (2), 672-678 (2008)
   PUBMED   18313394
REFERENCE   7  (bases 1 to 404)
  AUTHORS   Chung,Y.M., Kim,J.S. and Yoo,Y.D.
  TITLE     A novel protein, Romo1, induces ROS production in the mitochondria
  JOURNAL   Biochem Biophys Res Commun 347 (3), 649-655 (2006)
   PUBMED   16842742
REFERENCE   8  (bases 1 to 404)
  AUTHORS   Shultz,M.A., Zhang,L., Gu,Y.Z., Baker,G.L., Fannuchi,M.V.,
            Padua,A.M., Gurske,W.A., Morin,D., Penn,S.G., Jovanovich,S.B.,
            Plopper,C.G. and Buckpitt,A.R.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
REFERENCE   9  (bases 1 to 404)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Sep 18, 2010 this sequence version replaced
            XM_001053409.2, XM_002726261.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF108387.1, AI029733.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                JAXUCZ010000003.1  165119794-165119855
            63-193              JAXUCZ010000003.1  165120035-165120165
            194-404             JAXUCZ010000003.1  165121184-165121394
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..404
                     /gene="Romo1"
                     /note="reactive oxygen species modulator 1"
                     /db_xref="GeneID:679572"
                     /db_xref="RGD:1587111"
     exon            1..62
                     /gene="Romo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..302
                     /gene="Romo1"
                     /codon_start=1
                     /product="reactive oxygen species modulator 1"
                     /protein_id="NP_001182419.1"
                     /db_xref="GeneID:679572"
                     /db_xref="RGD:1587111"
                     /translation="MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLR
                     IGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC"
     exon            63..193
                     /gene="Romo1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..404
                     /gene="Romo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgccctcc gcctagcttt cggtgtgaga cgtcgagctg agcgaccgcg gcagagaacg
       61 agatgccggt ggctgtgggt ccctacgggc agtcccagcc cagctgcttc gaccgcgtga
      121 agatgggctt tgtcatgggt tgcgccgtgg gtatggcggc cggggccctg ttcggcacct
      181 tctcctgtct caggatcgga atgcggggtc gggagctgat gggcggcatt gggaaaacca
      241 tgatgcagag tggcggtacc tttggcactt tcatggccat cggaatgggc atacgatgct
      301 aattagggca cggatgccct gctacaccca aacttcctca tccatttcga accttgtaca
      361 ataaagtttt tttcttcttg ttatcagtct aatttgactt caaa
//
