LOCUS       NM_013022               7414 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus Rho-associated coiled-coil containing protein
            kinase 2 (Rock2), mRNA.
ACCESSION   NM_013022
VERSION     NM_013022.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7414)
  AUTHORS   Yang,Y.N., Luo,Y.B., Xu,G., Li,K., Ma,R.L. and Yuan,W.
  TITLE     CircHECTD1 promoted MIRI-associated inflammation via inhibiting
            miR-138-5p and upregulating ROCK2
  JOURNAL   Kaohsiung J Med Sci 39 (7), 675-687 (2023)
   PUBMED   37096660
  REMARK    GeneRIF: CircHECTD1 promoted MIRI-associated inflammation via
            inhibiting miR-138-5p and upregulating ROCK2.
REFERENCE   2  (bases 1 to 7414)
  AUTHORS   Cheng,C., Liu,X.B., Xu,D.L. and Zhang,J.
  TITLE     Increased ROCK1 not ROCK2 in circulating leukocytes in rats with
            myocardial ischemia/reperfusion
  JOURNAL   Perfusion 35 (8), 819-825 (2020)
   PUBMED   32308124
  REMARK    GeneRIF: Increased ROCK1 not ROCK2 in circulating leukocytes in
            rats with myocardial ischemia/reperfusion.
REFERENCE   3  (bases 1 to 7414)
  AUTHORS   Zhang,F., Chen,S., Wen,J.Y. and Chen,Z.W.
  TITLE     3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects
            cerebral endothelial cells against oxygen-glucose
            deprivation/reoxygenation-induced injury via mitoprotection and
            inhibition of the RhoA/ROCK pathway
  JOURNAL   Am J Physiol Cell Physiol 319 (4), C720-C733 (2020)
   PUBMED   32813542
  REMARK    GeneRIF: 3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide
            protects cerebral endothelial cells against oxygen-glucose
            deprivation/reoxygenation-induced injury via mitoprotection and
            inhibition of the RhoA/ROCK pathway.
REFERENCE   4  (bases 1 to 7414)
  AUTHORS   Fan,S., Xiong,Q., Zhang,X., Zhang,L. and Shi,Y.
  TITLE     Glucagon-like peptide 1 reverses myocardial hypertrophy through
            cAMP/PKA/RhoA/ROCK2 signaling
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 52 (6), 612-619 (2020)
   PUBMED   32386193
  REMARK    GeneRIF: Glucagon-like peptide 1 reverses myocardial hypertrophy
            through cAMP/PKA/RhoA/ROCK2 signaling.
REFERENCE   5  (bases 1 to 7414)
  AUTHORS   Chen,H., Du,J., Zhang,S., Tong,H. and Zhang,M.
  TITLE     Ghrelin suppresses migration of macrophages via inhibition of ROCK2
            under chronic intermittent hypoxia
  JOURNAL   J Int Med Res 48 (6), 300060520926065 (2020)
   PUBMED   32485129
  REMARK    GeneRIF: Ghrelin suppresses migration of macrophages via inhibition
            of ROCK2 under chronic intermittent hypoxia.
REFERENCE   6  (bases 1 to 7414)
  AUTHORS   Jeon,S., Kim,S., Park,J.B., Suh,P.G., Kim,Y.S., Bae,C.D. and
            Park,J.
  TITLE     RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558
            in hippocampal neuronal cells by glutamate
  JOURNAL   J Biol Chem 277 (19), 16576-16584 (2002)
   PUBMED   11867620
  REMARK    GeneRIF: RhoA and Rho kinase-dependent phosphorylation of moesin at
            Thr-558 in hippocampal neuronal cells by glutamate
REFERENCE   7  (bases 1 to 7414)
  AUTHORS   Begum,N., Sandu,O.A., Ito,M., Lohmann,S.M. and Smolenski,A.
  TITLE     Active Rho kinase (ROK-alpha) associates with insulin receptor
            substrate-1 and inhibits insulin signaling in vascular smooth
            muscle cells
  JOURNAL   J Biol Chem 277 (8), 6214-6222 (2002)
   PUBMED   11739394
REFERENCE   8  (bases 1 to 7414)
  AUTHORS   Uehata,M., Ishizaki,T., Satoh,H., Ono,T., Kawahara,T.,
            Morishita,T., Tamakawa,H., Yamagami,K., Inui,J., Maekawa,M. and
            Narumiya,S.
  TITLE     Calcium sensitization of smooth muscle mediated by a Rho-associated
            protein kinase in hypertension
  JOURNAL   Nature 389 (6654), 990-994 (1997)
   PUBMED   9353125
REFERENCE   9  (bases 1 to 7414)
  AUTHORS   Leung,T., Chen,X.Q., Manser,E. and Lim,L.
  TITLE     The p160 RhoA-binding kinase ROK alpha is a member of a kinase
            family and is involved in the reorganization of the cytoskeleton
  JOURNAL   Mol Cell Biol 16 (10), 5313-5327 (1996)
   PUBMED   8816443
REFERENCE   10 (bases 1 to 7414)
  AUTHORS   Leung,T., Manser,E., Tan,L. and Lim,L.
  TITLE     A novel serine/threonine kinase binding the Ras-related RhoA GTPase
            which translocates the kinase to peripheral membranes
  JOURNAL   J Biol Chem 270 (49), 29051-29054 (1995)
   PUBMED   7493923
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1, U38481.1, CB691694.1, CK475383.1 and BF398321.1.
            
            On Jul 31, 2012 this sequence version replaced NM_013022.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U38481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMN14984024
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000006.1  45408116-45408217
            103-1095            U38481.1           101-1093
            1096-1221           CB691694.1         195-320
            1222-1674           U38481.1           1220-1672
            1675-1737           JAXUCZ010000006.1  45474784-45474846
            1738-3927           U38481.1           1736-3925
            3928-4603           CK475383.1         21-696
            4604-7297           JAXUCZ010000006.1  45499970-45502663
            7298-7414           BF398321.1         9-125               c
FEATURES             Location/Qualifiers
     source          1..7414
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..7414
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /note="Rho-associated coiled-coil containing protein
                     kinase 2"
                     /db_xref="GeneID:25537"
                     /db_xref="RGD:3590"
     exon            1..189
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..4215
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /EC_number="2.7.11.1"
                     /note="ROKalpha; p164 ROCK-2; p150 ROK-alpha; rhoA-binding
                     kinase 2; rho-associated, coiled-coil-containing protein
                     kinase 2; RhoA - binding serine/threosine kinase alpha
                     (ROK - alpha); Rho-associated coiled-coil forming kinase
                     2; rho-associated, coiled-coil-containing protein kinase
                     II"
                     /codon_start=1
                     /product="rho-associated protein kinase 2"
                     /protein_id="NP_037154.2"
                     /db_xref="GeneID:25537"
                     /db_xref="RGD:3590"
                     /translation="MSRPPPTGKMPGAPEAAPGDGAGAGRQRKLEALIRDPRSPINVE
                     SLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGA
                     FGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQ
                     DDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPD
                     NMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECD
                     WWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDTEISKHAKNLICAFLT
                     DREVRLGRNGVEEIKQHPFFKNDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKG
                     DVETFPIPKAFVGNQLPFIGFTYFRENLLLSDSPPCRENDAIQTRKSEESQEIQKKLY
                     ALEEHLSSEVQAKEELEQKCKSINTRLEKTAKELEEEITFRKNVESTLRQLEREKALL
                     QHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQSSQISTEKVNQLQKQLDE
                     ANALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQ
                     SALESERRDRTHGSEIINDLQGRISGLEEDLKTGKTLLAKVELEKRQLQEKLTDLEKE
                     KSNMEIDMTYQLKVIQQSLEQEEAEHKTTKARLADKNKIYESIEEAKSEAMKEMEKKL
                     LEERSLKQKVENLLLEAEKRCSILDCDLKQSQQKLNELLKQKDVLNEDVRNLTLKIEQ
                     ETQKRCLMQNDLKMQTQQVNTLKMSEKQIKQENNHLMEMKMNLEKQNAELRKERQDAD
                     GQMKELQDQLEAEQYFSTLYKTQVRELKEENEEKTKLCKELQQKKQDLQDERDSLAAQ
                     LEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLE
                     ETNRTLTSDVANLANEKEELNNKLKDTQEQLSKLKDEEISAAAIKAQFEKQLLTERTL
                     KTQAVNKLAEIMNRKEPVKRGSDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKEL
                     NEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGMDSSSIGSGPGDAEPDD
                     GFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDK
                     LFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEPEFPVEPVGEKSNYICHKGHE
                     FIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYD
                     ISSAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRP
                     SRQLAPNKPS"
     exon            190..271
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            272..372
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            373..510
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            511..771
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            772..916
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1055
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1147
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1307
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1368
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1380
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1460
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1509
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1645
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1737
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1984
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2091
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2251
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2412
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2597
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2667
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2771
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2958
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3052
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3147
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3327
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3496
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3567
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..3656
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..3735
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..3997
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            3998..4211
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
     exon            4212..7407
                     /gene="Rock2"
                     /gene_synonym="ROCK-II; ROK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccggggc ggaggttccg cgggcggcgc taggccgggc gaagcggcat gagccggccc
       61 ccgccgacgg ggaaaatgcc cggcgccccc gaggccgcgc cgggggacgg ggcgggcgcg
      121 ggtcgtcaga ggaagctgga ggcgctcatc cgagaccctc gctcgcccat caacgtggaa
      181 agcctgctgg atggcttaaa ttccttggtc cttgatttgg attttcctgc tttgaggaaa
      241 aataaaaata tagataattt cctaaataga tatgagaaaa ttgtgaaaaa aatcagaggt
      301 ttacagatga aagcagaaga ctatgatgtt gtaaaagtta ttggaagagg tgcttttggt
      361 gaagttcagt tggttcgtca taaggcatca cagaaggttt atgcaatgaa gcttcttagt
      421 aaatttgaaa tgataaaaag atcagattct gcttttttct gggaagaaag agatattatg
      481 gcttttgcta acagtccgtg ggtggttcag ctcttttgtg cctttcaaga tgacaggtat
      541 ctgtacatgg tgatggagta catgccaggt ggagaccttg ttaacctgat gagcaattat
      601 gatgtgcctg agaagtgggc caagttttat actgctgaag tcgtgcttgc actggatgca
      661 atacactcca tgggcttaat acacagagat gtgaagcccg ataacatgct attggataaa
      721 cacggacatc taaaattagc agattttggc acatgtatga aaatggatga aacaggcatg
      781 gtgcattgtg atacagcagt tggaactcca gactacatat cacctgaggt tctgaaatca
      841 caaggaggtg atggttacta tggacgagaa tgtgattggt ggtctgtagg tgttttcctt
      901 tttgagatgt tagtagggga cactccattt tatgcagatt cacttgtagg aacctacagc
      961 aaaattatgg atcataaaaa ttcactgtgt tttcctgaag atacagaaat ttctaaacat
     1021 gcgaagaatc tcatatgtgc cttcttaaca gacagggagg tacgacttgg aagaaatggg
     1081 gtagaagaaa tcaaacagca tcctttcttt aagaatgatc agtggaattg ggataacata
     1141 agagagacgg cagctccagt ggtgcctgag ctcagcagtg acatagacag cagcaacttt
     1201 gatgacattg aggatgacaa aggcgatgta gagaccttcc cgattcctaa agcttttgtg
     1261 ggaaatcagc tgccttttat aggatttacc tactttagag aaaatttgtt actaagtgat
     1321 tctccacctt gtagagaaaa tgatgcaata caaacaagga aaagtgaaga aagtcaggag
     1381 attcagaaaa aattatatgc actagaagaa caccttagca gtgaggtaca agccaaggag
     1441 gaactggaac agaagtgcaa gtctattaat actcgtctag agaaaacagc aaaggaacta
     1501 gaagaagaga ttacctttag gaaaaatgtg gaatcaacat taagacagct agaaagagaa
     1561 aaggcccttc ttcagcacaa aaatgcagaa tatcaacgga aagctgatca tgaagctgac
     1621 aagaaacgga atttggaaaa tgatgttaac agcttaaaag atcaacttga agatctgaag
     1681 aaaagaaacc agagctctca gatatccact gagaaggtca atcagctcca gaaacaactg
     1741 gatgaagcta atgctttgct aagaacagag tctgatactg cagcacggtt aagaaaaacc
     1801 caggcagaaa gttccaaaca gattcagcag ctggaatcta acaatagaga tctacaagat
     1861 aaaaactgcc tgcttgaaac tgccaagtta aaacttgaga aggaatttat caatcttcag
     1921 tcagctctag aatctgaaag aagggaccgg acccatggat cagagataat taatgattta
     1981 caaggtagaa tatctgggtt ggaagaagat ttgaagactg gcaaaacctt actagcaaaa
     2041 gtagagctgg agaagagaca gctgcaggag aagctcactg acttagagaa ggaaaagagc
     2101 aacatggaaa tagatatgac atatcaactg aaagttatac agcagagttt agaacaagaa
     2161 gaagctgaac acaagaccac aaaagcacga ctagcggata aaaataagat ctatgaatcc
     2221 attgaagaag ctaaatcaga agccatgaaa gaaatggaga agaagctgtt ggaagagagg
     2281 tctttaaagc agaaagtgga gaacctactc ctggaagccg agaagagatg ttctatattg
     2341 gattgtgacc tcaaacagtc tcagcagaaa ctgaatgagc tgctgaagca gaaagatgtg
     2401 ctgaatgagg atgttagaaa tttgacatta aaaatagagc aggaaactca gaagcgttgt
     2461 cttatgcaaa atgacctgaa gatgcagacc cagcaagtta acaccctaaa aatgtcagaa
     2521 aagcaaataa aacaagaaaa taatcatctt atggaaatga aaatgaactt ggaaaagcaa
     2581 aatgctgaac ttcgaaaaga gcggcaggat gcagatgggc agatgaagga actgcaagac
     2641 caacttgaag cagagcagta tttctcaacc ctctataaaa cacaagttag agaacttaaa
     2701 gaagaaaatg aagagaaaac taaactttgt aaagagttgc agcagaaaaa gcaggattta
     2761 caggatgaaa gagactcctt ggctgcccag ctggagatca ccctcaccaa agcagactct
     2821 gagcagctgg ctcgctccat tgctgaggag caatactctg acttggaaaa agagaagatc
     2881 atgaaagagc tggaaatcaa agagatgatg gctagacaca aacaagagct tactgaaaag
     2941 gacgctacaa ttgcatccct tgaagaaaca aatagaacac taactagtga tgttgcaaat
     3001 cttgcaaacg agaaagaaga actaaacaac aagttgaaag atacccaaga acaactgtca
     3061 aagttgaaag atgaagagat cagtgcagcg gctattaaag cacagtttga gaagcagctg
     3121 ctgactgagc gaacactcaa gactcaagct gtgaataagt tggcagagat catgaatcga
     3181 aaagaacctg tcaagcgtgg tagtgacaca gatgtgcgaa gaaaagaaaa ggaaaacaga
     3241 aaattacata tggagcttaa gtctgaacgt gaaaaattga cacaacagat gatcaaatat
     3301 cagaaagaac tgaatgaaat gcaggctcaa atagctgaag agagccaaat tcgaatagaa
     3361 ctgcagatga ccctggacag taaagacagt gacattgaac agcttcggtc gcagctccag
     3421 gccttgcata ttggtatgga cagttccagt ataggcagtg gaccagggga tgctgagcct
     3481 gatgacggat ttccagaatc acgattagaa ggatggctgt cgttgcctgt gcggaacaac
     3541 actaaaaagt ttggatgggt taagaagtat gtgattgtaa gcagcaagaa gattcttttc
     3601 tatgatagtg aacaagataa agagcagtct aacccttaca tggtgttaga catagacaag
     3661 ctatttcatg tccgacctgt tactcagaca gatgtataca gagcagatgc taaagaaatt
     3721 ccaaggatat ttcagatcct gtatgccaat gaaggagaaa gtaaaaagga accagaattt
     3781 ccagtggaac cagtgggaga aaaatctaat tatatttgcc acaaaggaca tgagtttatt
     3841 cctactcttt atcacttccc aaccaactgt gaggcctgta tgaagccact gtggcacatg
     3901 tttaaacctc ctcctgctct agagtgccgt agatgccaca ttaaatgtca taaagatcac
     3961 atggacaaaa aggaagagat catagccccc tgcaaagttt attatgatat atcatcggca
     4021 aagaatctgt tgttattagc aaattcaacg gaagaacagc agaaatgggt tagtcggttg
     4081 gtgaaaaaga tacctaaaaa gcctccagct ccagaccctt ttgcccgatc atcccctaga
     4141 acctcaatga aaatacaaca aaaccagtcc attcggcggc ccagtcgaca gcttgctcca
     4201 aacaaaccaa gctaactgcc ttctatgaaa gcagttattg aaggtgatca tattcttcca
     4261 gccacaagac tgaaatatgg tttctcaaaa cttaactaaa aagctatatt ttactgagac
     4321 acatacatac accacatgcg cgtgcgtgca tgcttgcact cccttccccc ctgaaataat
     4381 tacaaatcat ggagaggttt gtctgggcta ctttgaaaca agttgaacaa acaatggttg
     4441 gtgagtaaaa aaagtgtcct acaattctcc cagacttgct tcataaagct cttggcagtc
     4501 acactacatt gcacaggatt gagaagagtt taaagaaatc acatttcagc ttcaacagag
     4561 ggtttcacca gcatattagt cagaagaatt tgggagtgaa tcccactaca gtgatgctga
     4621 ctgcatcttt aagaagtgac catgatgttg tgttcatgta tggtatgtat atacatatga
     4681 gttgagcctc atatatatat acacatacac acatacacat aaacacattg tactgtaata
     4741 ctgcaagatt tttttaactt accgttttat ttttttatac acgttaatca gatatcatta
     4801 tttcagttgc aactatgcac ttgtataaag ccatgatgtt ggagtttata tccttcactc
     4861 atgtacctga taaggagctg catgtttgtg taaacaataa ctgtaacaag aaatttgaag
     4921 ttaattattc cagttttcta atgcttaaga taggcaactt tacccatttt gaatgcctta
     4981 atttaatttt ttctccctcc aaatctcagc ccttttctat atttaactaa agaaagaaca
     5041 gtgtttacca gctcatagga tgcagcttgc tttatgggga aagaagtgca ctattttacg
     5101 tgtaatactt atgtcagtgt cagactattt gatgtatgac ggtttttaat gtacttgctc
     5161 atagaaacaa taatggatca tattgaaact aatgtgtgtg atgtacatct gttatttttt
     5221 aatccctttt ttcgcagact tcagctagtc tgtgactatg gaatatttcc tgtgctttga
     5281 acttgctggt taccctagat gtgtttttat ttatgataaa gacaattttt ttcacatttt
     5341 cattcaagat tcaaaaattg tctcaaatat aaagaaaact aacatgttct gtgtagatat
     5401 attttaaata tttaaatgtg attttaaagc aaacacctgt gtatagcagt atttcagctt
     5461 tgatatctgg aaagaagcag cctcagaagt acttaatttg attttcactg ttaaatgctg
     5521 ctgaggctag agaacaggtg gaacctaccc tgccatgctg ctggcccagg taagtgtgct
     5581 tgactccaca gcagagtgca gcagtgggca gcatcaggct ctgtacatac gcagtgttca
     5641 atgtgatatt gacatgtttg cctgatatta gtgaagccag tagacatttt tgattgtttt
     5701 cttctggggt cactgtagag atgctgtaaa aagttcgatc ctccttatag atgctattgt
     5761 agacatagtg gctgttgccc actgatatac taaatccaat tctgtgatct tcagatggca
     5821 cagtttgcat ctctcatgct gtctgattac atgtgcatgc catttccctg gaggcagctg
     5881 aactctggtt tggaacacaa cttgcttcct cccttcccct ccctccttcc ttccttcagg
     5941 tttaaaaatg aaaatatata aaatttatat agaagaacta tttccattca ttagagttgt
     6001 ttaaaaggag actgaattaa tattttatat aaagattttg ttactatggg aggttctatc
     6061 ctattctgag ttggagagta tatatatata tttttaataa actttattaa ggtgacataa
     6121 tgtcaagttt acacatgaat aattgaagta tttgagtaaa aaaggcaaaa gttttaattt
     6181 tggatgctgt tcgtgtatat atgtataaga gtttggagaa tcatggtgtg atacgactgt
     6241 acaaggcaat taatgtgaag gattcagggg aataaaacat tctgaggggt gaaaaaaatc
     6301 tctccatgga gcgtcttcat atatggttta atagggattt ataaggtcat ttgtccagct
     6361 gtcagaattc caagtaaaaa ccacatgacc atagagaagc atttgctttc ctgctctcat
     6421 ttgcatgcac gtcggtgcat gtacctgcca ttttttcccc aacccaacaa tcattacaag
     6481 agcaacctaa ttttgccagt tccatttttc ttgaggcctc caatccttca agataaatgc
     6541 gtaccagcac aaatactgct tcctttgttt agtcccccag agctgtaaat acttgcactt
     6601 gggacctaaa agacagggga tgctgggttt ccttggttgg atgctattct tttgctttgt
     6661 gaaataaaaa agacagaagg aaaagaaact taagtaccag tattactgtt gaaaattaat
     6721 ggaaaataaa ttttaagcat taattttcaa taacatctaa aagcaagatt taaaaaaaaa
     6781 aatctgtgat cccaagggaa ggctgctctt tgtggccagc ctttgagagg ccatggccct
     6841 agaggggctt cccttagttc atgtgtagat cctagtaaga catgctcgag gctgccaaac
     6901 caactgaaaa ggtcatactg ctgctatcag gctggtggat tgcagggtga agtaagagac
     6961 tcagactcta gttaaccttg tagagatgct ttaagcagca tgttgacccc agggaaagca
     7021 agtagcttcc gagcttctca ggcccttgac tgctactgat tctctttttc tgtctgaaga
     7081 tgacttcagc tcccctggct cgtggaggtg ccacagccaa tattaaagca ctttgacaag
     7141 cactgtgtga cagtgctgag tgttgttccc cgggacctcg ccttgttccc ttccctgtgg
     7201 tgacttttgt ttgaaactgt aataagttat aaactgcatg atttagagag tcatcttgaa
     7261 ccagctcctt tccccaacac aaaaatcatc ccctcttatt ttttattttg ttgcatcttt
     7321 gtagtaatgt aattgtattt ttatgcctgc tttttgttta aaaaataaat aaaagaaact
     7381 aagatgtaag caatcttttc ctgtgaaaaa aaaa
//
