LOCUS       NM_001394075            4594 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus roundabout guidance receptor 3 (Robo3), mRNA.
ACCESSION   NM_001394075
VERSION     NM_001394075.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4594)
  AUTHORS   Zhuang,M., Li,X., Zhu,J., Zhang,J., Niu,F., Liang,F., Chen,M.,
            Li,D., Han,P. and Ji,S.J.
  TITLE     The m6A reader YTHDF1 regulates axon guidance through translational
            control of Robo3.1 expression
  JOURNAL   Nucleic Acids Res 47 (9), 4765-4777 (2019)
   PUBMED   30843071
REFERENCE   2  (bases 1 to 4594)
  AUTHORS   Li,L., Liu,S., Lei,Y., Cheng,Y., Yao,C. and Zhen,X.
  TITLE     Robo3.1A suppresses slit-mediated repulsion by triggering
            degradation of Robo2
  JOURNAL   J Neurosci Res 92 (7), 835-846 (2014)
   PUBMED   24936616
REFERENCE   3  (bases 1 to 4594)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   4  (bases 1 to 4594)
  AUTHORS   Garcia,M., Dogusan,Z., Moore,F., Sato,S., Hartmann,G., Eizirik,D.L.
            and Rasschaert,J.
  TITLE     Regulation and function of the cytosolic viral RNA sensor RIG-I in
            pancreatic beta cells
  JOURNAL   Biochim Biophys Acta 1793 (11), 1768-1775 (2009)
   PUBMED   19747951
  REMARK    GeneRIF: Visfatin through STAT3 activation enhances IL-6 expression
            that promotes endothelial angiogenesis.
REFERENCE   5  (bases 1 to 4594)
  AUTHORS   Tamada,A., Kumada,T., Zhu,Y., Matsumoto,T., Hatanaka,Y.,
            Muguruma,K., Chen,Z., Tanabe,Y., Torigoe,M., Yamauchi,K., Oyama,H.,
            Nishida,K. and Murakami,F.
  TITLE     Crucial roles of Robo proteins in midline crossing of
            cerebellofugal axons and lack of their up-regulation after midline
            crossing
  JOURNAL   Neural Dev 3, 29 (2008)
   PUBMED   18986510
  REMARK    GeneRIF: Data show that cerebellofugal axons express Rig-1 (Robo3)
            before they reach the midline but not after the longitudinal turn.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4594)
  AUTHORS   Chen,Z., Gore,B.B., Long,H., Ma,L. and Tessier-Lavigne,M.
  TITLE     Alternative splicing of the Robo3 axon guidance receptor governs
            the midline switch from attraction to repulsion
  JOURNAL   Neuron 58 (3), 325-332 (2008)
   PUBMED   18466743
REFERENCE   7  (bases 1 to 4594)
  AUTHORS   Wehrle,R., Camand,E., Chedotal,A., Sotelo,C. and Dusart,I.
  TITLE     Expression of netrin-1, slit-1 and slit-3 but not of slit-2 after
            cerebellar and spinal cord lesions
  JOURNAL   Eur J Neurosci 22 (9), 2134-2144 (2005)
   PUBMED   16262652
REFERENCE   8  (bases 1 to 4594)
  AUTHORS   Marillat,V., Sabatier,C., Failli,V., Matsunaga,E., Sotelo,C.,
            Tessier-Lavigne,M. and Chedotal,A.
  TITLE     The slit receptor Rig-1/Robo3 controls midline crossing by
            hindbrain precerebellar neurons and axons
  JOURNAL   Neuron 43 (1), 69-79 (2004)
   PUBMED   15233918
REFERENCE   9  (bases 1 to 4594)
  AUTHORS   Sabatier,C., Plump,A.S., Le,Ma., Brose,K., Tamada,A., Murakami,F.,
            Lee,E.Y. and Tessier-Lavigne,M.
  TITLE     The divergent Robo family protein rig-1/Robo3 is a negative
            regulator of slit responsiveness required for midline crossing by
            commissural axons
  JOURNAL   Cell 117 (2), 157-169 (2004)
   PUBMED   15084255
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. The exon-intron structure is
            inferred based on available transcript data and further supported
            by similar exon-intron structure of the orthologous human gene,
            GeneID 64221, and mouse GeneID 19649.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               JAXUCZ010000008.1  45339930-45340222   c
            294-620             JAXUCZ010000008.1  45336571-45336897   c
            621-778             JAXUCZ010000008.1  45336112-45336269   c
            779-899             JAXUCZ010000008.1  45335172-45335292   c
            900-1038            JAXUCZ010000008.1  45334932-45335070   c
            1039-1166           JAXUCZ010000008.1  45334555-45334682   c
            1167-1291           JAXUCZ010000008.1  45334198-45334322   c
            1292-1463           JAXUCZ010000008.1  45332328-45332499   c
            1464-1669           JAXUCZ010000008.1  45331849-45332054   c
            1670-1751           JAXUCZ010000008.1  45331543-45331624   c
            1752-1917           JAXUCZ010000008.1  45331092-45331257   c
            1918-2084           JAXUCZ010000008.1  45330397-45330563   c
            2085-2206           JAXUCZ010000008.1  45329729-45329850   c
            2207-2432           JAXUCZ010000008.1  45329312-45329537   c
            2433-2554           JAXUCZ010000008.1  45329038-45329159   c
            2555-2726           JAXUCZ010000008.1  45328637-45328808   c
            2727-2912           JAXUCZ010000008.1  45328113-45328298   c
            2913-2936           JAXUCZ010000008.1  45327287-45327310   c
            2937-2979           JAXUCZ010000008.1  45327166-45327208   c
            2980-3119           JAXUCZ010000008.1  45326818-45326957   c
            3120-3314           JAXUCZ010000008.1  45326284-45326478   c
            3315-3453           JAXUCZ010000008.1  45325994-45326132   c
            3454-3666           JAXUCZ010000008.1  45325648-45325860   c
            3667-3818           JAXUCZ010000008.1  45325119-45325270   c
            3819-3929           JAXUCZ010000008.1  45324880-45324990   c
            3930-4106           JAXUCZ010000008.1  45324536-45324712   c
            4107-4324           JAXUCZ010000008.1  45323909-45324126   c
            4325-4594           JAXUCZ010000008.1  45323344-45323613   c
FEATURES             Location/Qualifiers
     source          1..4594
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..4594
                     /gene="Robo3"
                     /note="roundabout guidance receptor 3"
                     /db_xref="GeneID:315564"
                     /db_xref="RGD:1311018"
     exon            1..293
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..4336
                     /gene="Robo3"
                     /note="roundabout, axon guidance receptor, homolog 3"
                     /codon_start=1
                     /product="roundabout homolog 3"
                     /protein_id="NP_001381004.1"
                     /db_xref="GeneID:315564"
                     /db_xref="RGD:1311018"
                     /translation="MLRYLLKTLLQMNLFADSLAGDITNSSELLFGFNSSLAALNPSL
                     LPPGDPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGA
                     RVATAREDPRAHRLLLPSGALFFPRIVHGRRSRPDEGVYTCVARNYLGAAASRNASLE
                     VAVLRDDFRQSPGNVVVAVGEPAVMECVPPKGHPEPLVTWKKGNTKLKEEEGRITIRG
                     GKLMMSHTFKSDAGMYMCVASNMAGERESGAAELVVLERPSFLRRPINQVVLADAPVN
                     FLCEVQGDPQPNLRWRKDDGELPTGRYEIRSDHSLWIEQVSAEDEGTYTCVAENSVGR
                     AEASGSLSVHVPPQFVTKPQNQTAAPGENVSFQCETKGNPPPAIFWQKEGSQVLLFPS
                     QSLQPMGRLLVSPRGQLNITEVKIGDGGYYVCQAVSVAGSILAKALLEIKGASIDGLP
                     PIILQGPANQTLVLGSSVWLPCRVIGNPQPNVQWKKDETWLQGDNSQFNLMDNGTLYI
                     ASVQEMDMGFYSCVAKSSIGEATWNSWLRKREHWGASPGPATEPGNPPGPPSQPIVTE
                     VTTNSITLTWKPNPQSGARATSYVIEAFSQAAGNTWRTVADGVQLETHTVSGLQPNTI
                     YLFLVRAVGAWGLSEPSPVSEPVQTQDSSLSRPVEDPWKGQQGLAEVAVRMQEPIVLG
                     PRTLQVSWTVEGPGQLVQGFRVSWRIAGLDQGSWTALDVQSPHKQSTVLRGLPPGSQI
                     QIKVQVQGQEGLGAESPSVTRSIPEEAPSGPPQGVAVALGGDRNSSITVSWEPPLPSQ
                     QNGVITEYQIWCLGNESRFHLNRSAAGWARSVMFRGLLPGLLYRAIVAAATSAGVGVA
                     SAPVLVQLPFPPVAEPGPEVSEGLAERLSRVLRKPAFLAGSSAACGALLLGLCAALYR
                     RQKQRKELSHYTASFAYTPAVSFPHSEGLSGSSSRPPMGLGPAAYPWLADSWPHPSRS
                     PSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGANAPGEGPVYSTIDPVGEELQ
                     TFHGGFPQHSSGDPSTWSQYAPPEWSEGDSGARGGKGKLLGKPVQMPSLSWPEALPPP
                     PPSCELSCPEGPEEELKGSSDLEEWCPPMPEKKHLIDSRSSGACMVAPARGETPSPTS
                     SYGQQSTATLTPSPPDPPQPPSDIPHLHQMPRRVPLGPSSPLSVSQPALSSHDGRPVG
                     LGAGPIVSYHPSPSPVPSTASSAPGRTRQVTGEMTPPLHGHRARIRKKTKALPHRREH
                     SPGDLPPPPLPPPEEETSWPLGLRAAGSMSSLEREHSGERRVAQAVPLGAQPPGAQRG
                     PHPDAALLGCAAEEAWLPYGRPSFLSHGQGTSTCSTAGSNSSRGSNSSRGSRGSRGPG
                     RSRSRSQSQSQRPGRNRRQEPR"
     exon            294..620
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            621..778
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            779..899
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1038
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1166
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1291
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1463
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1669
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1751
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1917
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2084
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2206
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2432
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2554
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2726
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2912
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..2936
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..2979
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3119
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3314
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3453
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..3666
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..3818
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            3819..3929
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            3930..4106
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            4107..4324
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
     exon            4325..4594
                     /gene="Robo3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgcaggac agcggcatcg tggctgcggc agcgcgcaaa ggctgtggag gggcttacgg
       61 ctcccggccc acgggttcca gacccagggg ctgggctccg aggcccccac ccaagaccca
      121 ggcaggccgc attatgctgc gctacctgct taaaacacta ctacagatga acttgttcgc
      181 ggactccctg gcgggagaca tcaccaactc cagcgagcta ctcttcggtt tcaactcctc
      241 gctggcagcg ctcaacccta gcctgcttcc tcctggagac ccctctctca atgggtcaag
      301 agttggaccc gaggatgcca tgccacgcat cgtggagcag ccgccagatc tgctcgtttc
      361 caggggcgag ccggccactc tgccctgccg tgctgaaggc cggcctcgac ccaacatcga
      421 gtggtacaag aatggggcgc gcgtggccac tgcacgcgag gatccgcggg ctcaccgcct
      481 gctgctgccc agcggcgccc tcttctttcc ccgcatcgtg cacgggcgtc gctctcggcc
      541 tgacgagggt gtctacacct gtgtggctcg caactacctg ggagcagcgg ctagcagaaa
      601 cgcctctctg gaagtagctg tcctccgaga cgatttccgg caatctcctg ggaacgtggt
      661 ggtagcagtg ggggagccag cagtaatgga atgcgtgccc cctaagggtc acccagagcc
      721 tttggtgacc tggaagaagg gcaatacaaa gcttaaggaa gaggagggaa ggatcaccat
      781 acgtggagga aagctgatga tgtcacatac attcaagagt gatgctggca tgtacatgtg
      841 tgtagcctcc aacatggctg gagaacgaga gagtggggca gctgaacttg tggtactgga
      901 gcgtccctca tttctgcgta gaccaataaa ccaggttgtc ctggctgatg cccctgtgaa
      961 tttcctgtgt gaggtgcagg gagatcccca gcccaatcta cgctggcgca aggatgatgg
     1021 ggagctgccc actggcaggt atgagattcg gagtgaccac agcctttgga tcgagcaagt
     1081 gagtgctgaa gacgagggga cttacacctg tgtggcagaa aacagtgtgg gccgagcaga
     1141 ggcatctggc tccctcagtg ttcacgtccc accacagttt gtgactaagc cccagaacca
     1201 gacagcagct cctggagaaa acgtgtcttt ccaatgtgag accaaaggaa acccaccacc
     1261 tgccatcttc tggcagaagg aagggagtca agtcttgctt ttccctagtc agtcactcca
     1321 gcccatggga cgcctcttag tctctccaag aggccagctc aacatcactg aagtaaagat
     1381 cggggatggt ggctactatg tgtgccaggc tgtcagtgtg gctggtagca tcctggctaa
     1441 ggccctgtta gagataaaag gagcctccat agatggacta cctcccatca ttctccaggg
     1501 accagccaat cagacattgg tacttggctc ttctgtgtgg ctgccatgca gagtgattgg
     1561 aaaccctcag cccaatgtcc aatggaagaa ggatgagacg tggctgcagg gggataactc
     1621 acagttcaac ttaatggaca acggcacact atacattgcc agtgtacagg agatggacat
     1681 gggtttctac agctgtgtgg ccaagagttc cataggggag gccacatgga atagctggct
     1741 taggaagcga gaacattggg gagcatcacc aggtccagca acagaacccg gtaatcctcc
     1801 aggccctccc tctcagccaa tagtcacaga ggtaaccaca aacagcatta ccttgacctg
     1861 gaagcccaat ccacagtctg gggccagagc tacctcctat gtgatagagg ccttcagcca
     1921 agcagctggc aacacgtggc ggacggtggc agatggggta cagctggaaa cgcacaccgt
     1981 cagcggcctg cagcccaata ccatctacct attcctcgtg agagctgttg gagcctgggg
     2041 cctcagtgaa cccagtcctg tctctgagcc tgttcaaacc caggacagca gcctatctag
     2101 gccagtggag gacccgtgga aaggccagca aggactggct gaagtggccg tgcgaatgca
     2161 ggagcccata gtccttggac ccagaactct gcaggtgtcc tggactgtag agggccctgg
     2221 ccagctggtt cagggattcc gtgtgtcttg gaggattgca ggccttgacc agggaagctg
     2281 gacagcgcta gacgtacaga gtccacacaa gcaaagtact gtgctaagag gcctcccccc
     2341 agggtcccaa atacagatca aggtgcaagt ccaaggccag gaggggctgg gggctgaaag
     2401 cccctctgtg acccggagca ttcctgaaga ggcccccagt ggcccccctc agggagtggc
     2461 tgtggccttg gggggtgatc gcaacagcag tatcactgta tcctgggagc ctccacttcc
     2521 ctcccagcaa aatggggtta tcactgaata ccagatctgg tgcctgggta atgaaagccg
     2581 attccacctc aatcgatctg cagcaggctg ggcacgctct gtgatgttcc ggggactgct
     2641 accgggcctg ctctatagag ccatagtggc agcagctacc agcgctggcg tgggcgtggc
     2701 cagtgcccca gtgctagtgc agctgccatt ccctccggtt gcggagcccg ggcctgaggt
     2761 cagcgagggg ctggcggaac ggttgtctag ggtgctgcgg aagcctgctt tcctggctgg
     2821 cagcagcgcg gcctgtgggg cgctgcttct cgggctctgc gccgccctct atcggcgcca
     2881 gaagcaacgc aaagagctca gtcattatac cgcctccttt gcctacacac ctgcagtgtc
     2941 ctttccacac tcagagggcc tttctggatc cagttccagg ccacccatgg gccttggccc
     3001 tgctgcctac ccatggctgg cagactcctg gccccaccca tctcgaagtc cctcagctca
     3061 ggaaccccgg gggagctgct gccccagcaa tcctgatcca gatgatagat actacaatga
     3121 ggcaggaatc tccctgtact tggctcagac tgcacggggt gctaatgccc ctggcgaggg
     3181 tcctgtctac agcaccattg acccagtagg ggaagagcta cagaccttcc acggagggtt
     3241 ccctcaacat tcttctgggg acccaagcac ctggagccag tatgctcccc ccgaatggag
     3301 cgagggggac agtggagcca ggggaggcaa agggaagctt ctaggcaaac ctgtgcagat
     3361 gccctctttg agctggccag aagccctgcc gccacctccc ccttcctgtg aattgagctg
     3421 cccagagggg cctgaggagg agctgaaggg cagttcagat ctggaagagt ggtgcccacc
     3481 aatgcctgag aaaaaacact tgattgactc acgttccagt ggtgcgtgca tggtggctcc
     3541 agcccgaggg gaaactccct cccctacctc ttcttacgga cagcagtcca cagccactct
     3601 taccccctca cctcctgacc ctccccagcc ccctagcgac atcccacatc tccatcagat
     3661 gcccaggagg gtgccccttg gaccaagttc tcctctcagc gtatcccagc ctgctctgag
     3721 tagccatgat ggaaggcctg ttggcctggg tgctggccct atagtctctt atcaccctag
     3781 ccccagtcct gtccctagta cagccagcag tgcaccaggg agaactcgcc aggtaactgg
     3841 agagatgact cccccactcc atggacaccg tgcccgaatc cggaagaaaa ccaaggctct
     3901 tccacataga agggaacaca gtcctgggga cttgccccca ccacccttgc caccaccaga
     3961 ggaagagacg agctggccct tgggtctgag agcagcaggc agcatgtctt ccctagagcg
     4021 agagcacagt ggggagagga gagtggccca ggcagtgcct ctaggggccc aacctccagg
     4081 ggcccaacgt ggcccccacc ctgatgctgc acttctgggt tgtgctgcag aagaggcctg
     4141 gcttccatac ggcagaccaa gcttcctgag ccatggccag ggcaccagca cctgctctac
     4201 cgctggtagc aattcttcta ggggttccaa cagctctcga ggttctcggg gctctcgggg
     4261 ccctggacgc agccgaagcc ggagccagag tcagagccag aggccgggac ggaatcgccg
     4321 acaggaacca agatgaccct tcctgaagca acgagcatat tgaaagtgcc acagggcaag
     4381 aatggggacc ccttccctgg tcagcataca tgagtcacga ggagcaagga tggaccacct
     4441 ttcctcccgg cagtgatgct cgtgactcac tgaagcacaa ggtctcaaca gttctagttg
     4501 ctatgggaac cggaggagca gctcttccct ttccatccct ttatgactga gacatgtctg
     4561 tacaaaagga gaaaagaaaa agcctctgct ctga
//
