LOCUS       NP_001381004            1400 aa            linear   ROD 31-MAR-2024
DEFINITION  roundabout homolog 3 [Rattus norvegicus].
ACCESSION   NP_001381004
VERSION     NP_001381004.1
DBSOURCE    REFSEQ: accession NM_001394075.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1400)
  AUTHORS   Zhuang,M., Li,X., Zhu,J., Zhang,J., Niu,F., Liang,F., Chen,M.,
            Li,D., Han,P. and Ji,S.J.
  TITLE     The m6A reader YTHDF1 regulates axon guidance through translational
            control of Robo3.1 expression
  JOURNAL   Nucleic Acids Res 47 (9), 4765-4777 (2019)
   PUBMED   30843071
REFERENCE   2  (residues 1 to 1400)
  AUTHORS   Li,L., Liu,S., Lei,Y., Cheng,Y., Yao,C. and Zhen,X.
  TITLE     Robo3.1A suppresses slit-mediated repulsion by triggering
            degradation of Robo2
  JOURNAL   J Neurosci Res 92 (7), 835-846 (2014)
   PUBMED   24936616
REFERENCE   3  (residues 1 to 1400)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   4  (residues 1 to 1400)
  AUTHORS   Garcia,M., Dogusan,Z., Moore,F., Sato,S., Hartmann,G., Eizirik,D.L.
            and Rasschaert,J.
  TITLE     Regulation and function of the cytosolic viral RNA sensor RIG-I in
            pancreatic beta cells
  JOURNAL   Biochim Biophys Acta 1793 (11), 1768-1775 (2009)
   PUBMED   19747951
  REMARK    GeneRIF: Visfatin through STAT3 activation enhances IL-6 expression
            that promotes endothelial angiogenesis.
REFERENCE   5  (residues 1 to 1400)
  AUTHORS   Tamada,A., Kumada,T., Zhu,Y., Matsumoto,T., Hatanaka,Y.,
            Muguruma,K., Chen,Z., Tanabe,Y., Torigoe,M., Yamauchi,K., Oyama,H.,
            Nishida,K. and Murakami,F.
  TITLE     Crucial roles of Robo proteins in midline crossing of
            cerebellofugal axons and lack of their up-regulation after midline
            crossing
  JOURNAL   Neural Dev 3, 29 (2008)
   PUBMED   18986510
  REMARK    GeneRIF: Data show that cerebellofugal axons express Rig-1 (Robo3)
            before they reach the midline but not after the longitudinal turn.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1400)
  AUTHORS   Chen,Z., Gore,B.B., Long,H., Ma,L. and Tessier-Lavigne,M.
  TITLE     Alternative splicing of the Robo3 axon guidance receptor governs
            the midline switch from attraction to repulsion
  JOURNAL   Neuron 58 (3), 325-332 (2008)
   PUBMED   18466743
REFERENCE   7  (residues 1 to 1400)
  AUTHORS   Wehrle,R., Camand,E., Chedotal,A., Sotelo,C. and Dusart,I.
  TITLE     Expression of netrin-1, slit-1 and slit-3 but not of slit-2 after
            cerebellar and spinal cord lesions
  JOURNAL   Eur J Neurosci 22 (9), 2134-2144 (2005)
   PUBMED   16262652
REFERENCE   8  (residues 1 to 1400)
  AUTHORS   Marillat,V., Sabatier,C., Failli,V., Matsunaga,E., Sotelo,C.,
            Tessier-Lavigne,M. and Chedotal,A.
  TITLE     The slit receptor Rig-1/Robo3 controls midline crossing by
            hindbrain precerebellar neurons and axons
  JOURNAL   Neuron 43 (1), 69-79 (2004)
   PUBMED   15233918
REFERENCE   9  (residues 1 to 1400)
  AUTHORS   Sabatier,C., Plump,A.S., Le,Ma., Brose,K., Tamada,A., Murakami,F.,
            Lee,E.Y. and Tessier-Lavigne,M.
  TITLE     The divergent Robo family protein rig-1/Robo3 is a negative
            regulator of slit responsiveness required for midline crossing by
            commissural axons
  JOURNAL   Cell 117 (2), 157-169 (2004)
   PUBMED   15084255
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. The exon-intron structure is
            inferred based on available transcript data and further supported
            by similar exon-intron structure of the orthologous human gene,
            GeneID 64221, and mouse GeneID 19649.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     Protein         1..1400
                     /product="roundabout homolog 3"
                     /note="roundabout, axon guidance receptor, homolog 3"
                     /calculated_mol_wt=149672
     Region          64..162
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          81..85
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409490"
     Region          94..98
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409490"
     Region          121..125
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409490"
     Region          140..145
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409490"
     Region          154..157
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409490"
     Region          169..254
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          183..187
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409389"
     Region          197..201
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409389"
     Region          219..223
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409389"
     Region          233..238
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409389"
     Region          247..250
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409389"
     Region          261..343
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          275..279
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409390"
     Region          288..292
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409390"
     Region          309..313
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409390"
     Region          323..328
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409390"
     Region          336..339
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409390"
     Region          348..445
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          364..368
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409391"
     Region          377..381
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409391"
     Region          407..411
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409391"
     Region          421..426
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409391"
     Region          434..437
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409391"
     Region          452..536
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          468..472
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409544"
     Region          481..485
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409544"
     Region          504..508
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409544"
     Region          518..523
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409544"
     Region          531..534
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409544"
     Region          <549..>809
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          556..649
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(556,621,636)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(637..638,640..641)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          770..863
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(853..854,856..857)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..1400
                     /gene="Robo3"
                     /coded_by="NM_001394075.1:134..4336"
                     /db_xref="GeneID:315564"
                     /db_xref="RGD:1311018"
ORIGIN      
        1 mlryllktll qmnlfadsla gditnssell fgfnsslaal npsllppgdp slngsrvgpe
       61 dampriveqp pdllvsrgep atlpcraegr prpniewykn garvatared prahrlllps
      121 galffprivh grrsrpdegv ytcvarnylg aaasrnasle vavlrddfrq spgnvvvavg
      181 epavmecvpp kghpeplvtw kkgntklkee egritirggk lmmshtfksd agmymcvasn
      241 mageresgaa elvvlerpsf lrrpinqvvl adapvnflce vqgdpqpnlr wrkddgelpt
      301 gryeirsdhs lwieqvsaed egtytcvaen svgraeasgs lsvhvppqfv tkpqnqtaap
      361 genvsfqcet kgnpppaifw qkegsqvllf psqslqpmgr llvsprgqln itevkigdgg
      421 yyvcqavsva gsilakalle ikgasidglp piilqgpanq tlvlgssvwl pcrvignpqp
      481 nvqwkkdetw lqgdnsqfnl mdngtlyias vqemdmgfys cvakssigea twnswlrkre
      541 hwgaspgpat epgnppgpps qpivtevttn sitltwkpnp qsgaratsyv ieafsqaagn
      601 twrtvadgvq lethtvsglq pntiylflvr avgawglsep spvsepvqtq dsslsrpved
      661 pwkgqqglae vavrmqepiv lgprtlqvsw tvegpgqlvq gfrvswriag ldqgswtald
      721 vqsphkqstv lrglppgsqi qikvqvqgqe glgaespsvt rsipeeapsg ppqgvavalg
      781 gdrnssitvs wepplpsqqn gviteyqiwc lgnesrfhln rsaagwarsv mfrgllpgll
      841 yraivaaats agvgvasapv lvqlpfppva epgpevsegl aerlsrvlrk paflagssaa
      901 cgalllglca alyrrqkqrk elshytasfa ytpavsfphs eglsgsssrp pmglgpaayp
      961 wladswphps rspsaqeprg sccpsnpdpd dryyneagis lylaqtarga napgegpvys
     1021 tidpvgeelq tfhggfpqhs sgdpstwsqy appewsegds garggkgkll gkpvqmpsls
     1081 wpealppppp scelscpegp eeelkgssdl eewcppmpek khlidsrssg acmvaparge
     1141 tpsptssygq qstatltpsp pdppqppsdi phlhqmprrv plgpssplsv sqpalsshdg
     1201 rpvglgagpi vsyhpspspv pstassapgr trqvtgemtp plhghrarir kktkalphrr
     1261 ehspgdlppp plpppeeets wplglraags msslerehsg errvaqavpl gaqppgaqrg
     1321 phpdaallgc aaeeawlpyg rpsflshgqg tstcstagsn ssrgsnssrg srgsrgpgrs
     1381 rsrsqsqsqr pgrnrrqepr
//
