LOCUS       NM_032106               9385 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus roundabout guidance receptor 2 (Robo2),
            transcript variant 1, mRNA.
ACCESSION   NM_032106 XM_001064680 XM_213677
VERSION     NM_032106.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9385)
  AUTHORS   Goncalves,A.N., Correia-Pinto,J. and Nogueira-Silva,C.
  TITLE     ROBO2 signaling in lung development regulates SOX2/SOX9 balance,
            branching morphogenesis and is dysregulated in nitrofen-induced
            congenital diaphragmatic hernia
  JOURNAL   Respir Res 21 (1), 302 (2020)
   PUBMED   33208157
  REMARK    GeneRIF: ROBO2 signaling in lung development regulates SOX2/SOX9
            balance, branching morphogenesis and is dysregulated in
            nitrofen-induced congenital diaphragmatic hernia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9385)
  AUTHORS   Jin,X., Shin,Y.J., Riew,T.R., Choi,J.H. and Lee,M.Y.
  TITLE     Increased Expression of Slit2 and its Robo Receptors During
            Astroglial Scar Formation After Transient Focal Cerebral Ischemia
            in Rats
  JOURNAL   Neurochem Res 41 (12), 3373-3385 (2016)
   PUBMED   27686659
  REMARK    GeneRIF: data revealed a selective and sustained induction of Slit2
            and Robo in astrocytes localized throughout the astroglial scar
            after ischemic stroke, suggesting that Slit2/Robo signaling
            participates in glial scar formation and brain remodeling following
            ischemic injury.
REFERENCE   3  (bases 1 to 9385)
  AUTHORS   Hwang,D.Y., Kohl,S., Fan,X., Vivante,A., Chan,S., Dworschak,G.C.,
            Schulz,J., van Eerde,A.M., Hilger,A.C., Gee,H.Y., Pennimpede,T.,
            Herrmann,B.G., van de Hoek,G., Renkema,K.Y., Schell,C., Huber,T.B.,
            Reutter,H.M., Soliman,N.A., Stajic,N., Bogdanovic,R., Kehinde,E.O.,
            Lifton,R.P., Tasic,V., Lu,W. and Hildebrandt,F.
  TITLE     Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer
            risk for congenital anomalies of the kidney and urinary tract
  JOURNAL   Hum Genet 134 (8), 905-916 (2015)
   PUBMED   26026792
  REMARK    GeneRIF: Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and
            SRGAP1 confer risk for congenital anomalies of the kidney and
            urinary tract
REFERENCE   4  (bases 1 to 9385)
  AUTHORS   Mommersteeg,M.T., Yeh,M.L., Parnavelas,J.G. and Andrews,W.D.
  TITLE     Disrupted Slit-Robo signalling results in membranous ventricular
            septum defects and bicuspid aortic valves
  JOURNAL   Cardiovasc Res 106 (1), 55-66 (2015)
   PUBMED   25691540
REFERENCE   5  (bases 1 to 9385)
  AUTHORS   Zhang,H.Y., Zheng,L.F., Yi,X.N., Chen,Z.B., He,Z.P., Zhao,D.,
            Zhang,X.F. and Ma,Z.J.
  TITLE     Slit1 promotes regenerative neurite outgrowth of adult dorsal root
            ganglion neurons in vitro via binding to the Robo receptor
  JOURNAL   J Chem Neuroanat 39 (4), 256-261 (2010)
   PUBMED   20172023
  REMARK    GeneRIF: These findings indicate that Slit1/Robo2 signaling may
            have a role in regulating peripheral nerve regeneration.
REFERENCE   6  (bases 1 to 9385)
  AUTHORS   Marillat,V., Cases,O., Nguyen-Ba-Charvet,K.T., Tessier-Lavigne,M.,
            Sotelo,C. and Chedotal,A.
  TITLE     Spatiotemporal expression patterns of slit and robo genes in the
            rat brain
  JOURNAL   J Comp Neurol 442 (2), 130-155 (2002)
   PUBMED   11754167
REFERENCE   7  (bases 1 to 9385)
  AUTHORS   Patel,K., Nash,J.A., Itoh,A., Liu,Z., Sundaresan,V. and Pini,A.
  TITLE     Slit proteins are not dominant chemorepellents for olfactory tract
            and spinal motor axons
  JOURNAL   Development 128 (24), 5031-5037 (2001)
   PUBMED   11748139
REFERENCE   8  (bases 1 to 9385)
  AUTHORS   Nguyen Ba-Charvet,K.T., Brose,K., Ma,L., Wang,K.H., Marillat,V.,
            Sotelo,C., Tessier-Lavigne,M. and Chedotal,A.
  TITLE     Diversity and specificity of actions of Slit2 proteolytic fragments
            in axon guidance
  JOURNAL   J Neurosci 21 (12), 4281-4289 (2001)
   PUBMED   11404413
REFERENCE   9  (bases 1 to 9385)
  AUTHORS   Brose,K., Bland,K.S., Wang,K.H., Arnott,D., Henzel,W.,
            Goodman,C.S., Tessier-Lavigne,M. and Kidd,T.
  TITLE     Slit proteins bind Robo receptors and have an evolutionarily
            conserved role in repulsive axon guidance
  JOURNAL   Cell 96 (6), 795-806 (1999)
   PUBMED   10102268
REFERENCE   10 (bases 1 to 9385)
  AUTHORS   Nguyen Ba-Charvet,K.T., Brose,K., Marillat,V., Kidd,T.,
            Goodman,C.S., Tessier-Lavigne,M., Sotelo,C. and Chedotal,A.
  TITLE     Slit2-Mediated chemorepulsion and collapse of developing forebrain
            axons
  JOURNAL   Neuron 22 (3), 463-473 (1999)
   PUBMED   10197527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Dec 20, 2022 this sequence version replaced NM_032106.3.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-931               JAXUCZ010000011.1  26525482-26526412   c
            932-1258            JAXUCZ010000011.1  26467978-26468304   c
            1259-1416           JAXUCZ010000011.1  26166227-26166384   c
            1417-1537           JAXUCZ010000011.1  26165194-26165314   c
            1538-1676           JAXUCZ010000011.1  26153698-26153836   c
            1677-1804           JAXUCZ010000011.1  26132209-26132336   c
            1805-1929           JAXUCZ010000011.1  26110299-26110423   c
            1930-2101           JAXUCZ010000011.1  26105925-26106096   c
            2102-2307           JAXUCZ010000011.1  26099764-26099969   c
            2308-2389           JAXUCZ010000011.1  26094868-26094949   c
            2390-2552           JAXUCZ010000011.1  26094318-26094480   c
            2553-2719           JAXUCZ010000011.1  26092262-26092428   c
            2720-2841           JAXUCZ010000011.1  26089300-26089421   c
            2842-3073           JAXUCZ010000011.1  26083076-26083307   c
            3074-3198           JAXUCZ010000011.1  26080171-26080295   c
            3199-3370           JAXUCZ010000011.1  26078661-26078832   c
            3371-3553           JAXUCZ010000011.1  26071336-26071518   c
            3554-3596           JAXUCZ010000011.1  26063214-26063256   c
            3597-3724           JAXUCZ010000011.1  26061659-26061786   c
            3725-4006           JAXUCZ010000011.1  26057026-26057307   c
            4007-4132           JAXUCZ010000011.1  26056492-26056617   c
            4133-4286           JAXUCZ010000011.1  26051055-26051208   c
            4287-4547           JAXUCZ010000011.1  26042623-26042883   c
            4548-4753           JAXUCZ010000011.1  26039110-26039315   c
            4754-4927           JAXUCZ010000011.1  26028892-26029065   c
            4928-5200           JAXUCZ010000011.1  26022921-26023193   c
            5201-5401           JAXUCZ010000011.1  26020845-26021045   c
            5402-9385           JAXUCZ010000011.1  26015919-26019902   c
FEATURES             Location/Qualifiers
     source          1..9385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11p11"
     gene            1..9385
                     /gene="Robo2"
                     /note="roundabout guidance receptor 2"
                     /db_xref="GeneID:84409"
                     /db_xref="RGD:620167"
     exon            1..931
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     CDS             871..5403
                     /gene="Robo2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; roundabout 2"
                     /codon_start=1
                     /product="roundabout homolog 2 isoform 1 precursor"
                     /protein_id="NP_115289.2"
                     /db_xref="GeneID:84409"
                     /db_xref="RGD:620167"
                     /translation="MTPLMFTLLLLFGFLCIRTDGSRLRQEDFPPRIVEHPSDVIVSK
                     GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSK
                     PDEGTYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGH
                     PEPTIYWKKDKVRIDEKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAE
                     LTVFERPTFLRRPINQVVLEDEPAEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDY
                     TLRIKKAISADEGTYVCIAENRVGKVEASATLTVRAPPQFVVRPRDQIVAQGRTVTFP
                     CETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQ
                     ALTVAGSILAKAQLEVTDVLTDRPPPIILQGPINQTLAVDGTALLKCKATGEPLPVIS
                     WLKEGFTFLGRDPRATIQDQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTES
                     GATISKNYDTNDLPGPPSKPQVTDVTKNSVTLSWQPGTPGVLPASAYIIEAFSQSVSN
                     SWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQG
                     VDHRQVQKELGDVTVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQAST
                     VWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTIRTTEEAPSAPP
                     QSVTVLTVGSHNSTSISVSWDPPPADHQNGIIQEYKIWCLGNETRFHINKTVDATIRS
                     VVIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGGRNEVVITENNNSITEQITDVV
                     KQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLL
                     NTGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGA
                     IYSSIDFTTKTTYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSVQQKSDL
                     MGFAYSLPDQNKGNNALLYIPDYRLAEGLSNRMPHNQSQDFSTTSSHNSSERSGSLSG
                     GKGGKKKKTKNSSKAQKNNGSTWANVPLPPPPVQPLPGTELGHYPAEQENGYDSDSWC
                     PPLPVQTYLHQGMEDELEEDEDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQP
                     MLQAHLDELTRAYQFDIAKQTWHIQSNTPPPQPPVPPLGYASGALISDLETDVPDEDA
                     DDEEEPLEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRQRPTSPFSTDSNTSAAQ
                     NQSQRPRPTKKHKGGRMDPQPVLPHRREGMPDDLPPPPDPPPGQGLRQQIGLSQHSGN
                     VESSTERKGSSLERQQAANLEDTKSSLDCPAKTTVEWQHQTQDWINSTERQEETRKAP
                     HKPGVGSEESLVPYSKPSFPSPGGHSSSGTASSKGSTGPRKAEILRGSHQRNANDLLD
                     IGYVGSNSQGQFTGEL"
     exon            932..1258
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1416
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1537
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1676
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1804
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1929
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2101
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2307
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2389
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2552
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2719
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2841
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3073
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3198
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3370
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3553
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3596
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3724
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..4006
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            4007..4132
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            4133..4286
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            4287..4547
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            4548..4753
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            4754..4927
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            4928..5200
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            5201..5401
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
     exon            5402..9385
                     /gene="Robo2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgctcctg gaggctggac cacgcactag catcctcagg gctcccaggt ccggagctcc
       61 taggtctggc ggcgctcgcc cacagcagct ggacgctaga tctctccggg gcggcccctc
      121 cggggtggcc gcggcctcgg ctcagcccct ccctcttccc ttgcttcttc tcctcgccct
      181 cctcctcgct ccctcaccac gtaggagttc ccattctcca cccaagccgt cctgcttttc
      241 ccctttcctt ccttttggaa accagagact cggaaggagg cgaccaggct gcggaggaga
      301 gggccggctc gcaaagtgct gctttgacac atccttagga tggaagttaa gtgaaaacag
      361 aacaacacaa aacaaaactc cgcgaagtgt tgcagctacg gaggagacca aggggagaga
      421 aaactcggtg ggcaggccaa tggttgctcc gcagcgcgtt ggcaagtttg tggaacactt
      481 tctaggaatt aggtcttttt ttttttgtcc cccatcatct tcttgacttc tgaagaaaga
      541 agttgggttt ggaatgcaat ggagtctaag gagacagggc tagacgcacg tgaatagtcc
      601 cgccagctgg gctgaatttg tgggaattta ggaagccagc ctgcggaagt acagcggctc
      661 tggagtcccc tgggttcatt cggatggcac ctaacgtgtc ccgcgtcaga cctcttcacc
      721 aaaagcttcc gatgttacca ttttgctctt aaatttatct ctaggaaagt ctaaacttcg
      781 gacctacctc cttttttgat acttattttt gtacttctgc tctctgggat tggtttctta
      841 aacaacctgg atcctttttc atatgtcaaa atgactcctc tgatgtttac actactattg
      901 ctctttggat ttctctgcat tcggactgac ggatctcgtc ttcgtcaaga agactttccc
      961 cccaggatcg tagaacaccc ttctgacgtc atcgtctcca agggagagcc caccactctg
     1021 aactgtaaag cagagggccg gcccactccc accattgaat ggtacaagga tggtgagcgg
     1081 gtggagacag acaaggatga tcccaggtca cacaggatgc ttctgcccag cggatcctta
     1141 ttctttttgc gaattgttca cggacgcaga agtaaaccag atgaaggaac ttacgtttgt
     1201 gttgcaagga actatcttgg tgaagcagtg agtcgcaatg catctctgga agtagcatta
     1261 ttgcgagatg acttccggca aaaccccaca gatgtggtag tcgcagcagg agagcctgca
     1321 atcttggagt gccagccacc acggggacac ccagaaccaa ccatctactg gaaaaaggac
     1381 aaagtccgaa ttgatgagaa ggaagagaga ataagtatcc gtggtgggaa gctgatgatc
     1441 tccaatacta ggaaaagcga tgctggcatg tatacctgtg tgggaaccaa catggtggga
     1501 gaaagggaca gcgaccctgc agagctcact gtctttgaac gacccacgtt tctcaggagg
     1561 ccaatcaacc aggtggtgct ggaggacgag cctgcagaat tccgctgtca ggtccaagga
     1621 gatccccagc caacggtgag gtggaaaaag gatgacgcag acttaccaag aggaaggtat
     1681 gatatcaagg acgactacac cctgagaatc aaaaaggcca taagtgcaga tgaaggcacc
     1741 tatgtgtgca ttgctgagaa ccgggtggga aaagtggaag cttctgccac cctcactgtc
     1801 cgagctcctc cacagtttgt ggttaggcca agagatcaga tcgttgctca gggccggaca
     1861 gtgacattcc cctgtgaaac taaaggaaac ccacagccag ctgtcttctg gcagaaagaa
     1921 ggcagccaga acctactttt cccgaatcaa cctcagcagc ccaatagccg ctgttcagtg
     1981 tcgcccacgg gggacctcac catcaccaac attcagcgtt cagatgcggg ttactacatc
     2041 tgccaggccc taactgtggc aggaagcatt ttagctaaag cacagctgga agttactgac
     2101 gttttgacag atagacctcc acccataatc ttgcaaggac caataaacca aacacttgcg
     2161 gtagatggca cagcattact gaaatgtaaa gccactggcg aacctcttcc tgtaattagc
     2221 tggctaaagg agggctttac ttttctgggt agagatccaa gagctacgat ccaagaccaa
     2281 ggaacactgc agattaagaa tttacggatt tctgatactg gcacttatac atgtgtggct
     2341 acaagttcga gtggggagac ttcctggagt gcagtgctgg atgtaacaga atctggagca
     2401 acaatcagta aaaattatga tacaaatgac ctcccggggc caccatccaa acctcaggtc
     2461 actgatgtta cgaagaacag tgtcacccta tcctggcaac caggtacccc tggcgttctt
     2521 ccagcaagcg catatatcat tgaggctttc agccaatcgg tgagcaacag ctggcagaca
     2581 gtggcaaacc atgttaagac gactctctat acagtcagag gactaaggcc caacacaatc
     2641 tatctgttca tggtcagagc gatcaacccc caaggtctca gtgatccaag ccccatgtcg
     2701 gatcctgtac gcacacaaga tatcagtccc ccagcacaag gcgtggacca cagacaagtg
     2761 cagaaggagt taggagatgt cactgttcgt ctccacaatc cagttgtcct gacacctaca
     2821 actgttcaag tcacatggac ggtggaccga caaccccagt ttattcaggg ctacagagtg
     2881 atgtaccgac agacttctgg tctacaagct tcaactgtgt ggcagaatct agatgccaaa
     2941 gtcccgactg agaggagtgc tgtccttgtg aatctgaaaa agggggtgac ttatgaaatt
     3001 aaagtcaggc catatttcaa tgagttccaa ggaatggaca gtgaatcaaa aacaatccgt
     3061 actactgagg aagctccaag tgcgcctccc cagtctgtca cggtgctgac cgttggaagc
     3121 cataacagca caagcattag tgtttcctgg gatcctccac cagccgacca ccagaatgga
     3181 atcatacagg aatacaagat ctggtgtctg ggaaatgaaa cgcgattcca tatcaataaa
     3241 actgtggatg caaccattcg ctctgtagta ataggtggct tgttccctgg aattcagtac
     3301 cgggtggaag tggcagctag tacaagtgca ggggttggag taaaaagtga accacagcca
     3361 ataatcattg ggggacgtaa cgaagttgtc attactgaaa acaataacag cataactgag
     3421 caaatcactg atgtcgtgaa gcaaccagca tttatagctg gcatcggtgg tgcctgctgg
     3481 gtaattttga tgggttttag catctggtta tactggagaa gaaagaagag aaagggactt
     3541 agcaattatg ctgtaacatt tcaaagagga gatggaggac taatgagcaa tgggagccgt
     3601 ccaggtcttc taaatactgg cgaccccagt tatccatggc ttgctgactc atggccagcc
     3661 acgagtttgc cagtcaacaa cagcaatagt ggcccaaatg aaatcggaaa ttttgggcgt
     3721 ggagatgtgc tgcctccagt cccaggccaa ggggataaaa cagcaacaat gctctcagat
     3781 ggagctattt atagtagcat tgacttcact accaagacca cttacaacag ttccagccaa
     3841 ataacgcagg ccaccccata tgccactacc cagatcctgc attccaacag catccatgaa
     3901 ctggcagttg atcttcctga tccacagtgg aaaagctcag ttcaacagaa atcagacctc
     3961 atgggatttg cttactcact acctgatcag aacaagggga acaatgcctt actttacatc
     4021 cctgactacc gattggctga gggattgtct aatagaatgc cacacaacca gtcacaggat
     4081 ttcagcacca ccagctctca caacagctca gaaaggagtg gcagtctctc aggtgggaaa
     4141 ggtggaaaaa agaagaaaac taaaaattct tcaaaggcgc aaaaaaacaa cggatccact
     4201 tgggctaatg tccctctacc tcctcctcct gtccagcccc ttccgggtac agagctcgga
     4261 cactatcctg cggaacagga aaatggctat gacagtgata gctggtgccc accattacca
     4321 gtgcaaacct atttgcatca gggaatggaa gacgagttgg aagaggatga agatcgcgtc
     4381 ccaacacctc ctgttcgcgg tgtggcctct tcacccgcta tctcctttgg gcagcagtcc
     4441 actgccactc ttacaccatc cccacgggag gagatgcaac ccatgctgca agctcacttg
     4501 gatgagttaa ccagggccta tcagtttgat atagcaaaac aaacatggca cattcaaagc
     4561 aatactccac ctccacaacc cccagttcca ccattaggtt acgcgtccgg agccttgatt
     4621 tctgacttgg agacagatgt tccagatgag gatgctgatg atgaagagga accattagaa
     4681 attcccaggc ccctcagagc actagaccag actcctggtt ccagtatgga caatctagac
     4741 agctctgtaa caggaaaagc ctttacttcc tctcaaaggc agcggcccac cagcccattt
     4801 tctacagaca gtaacaccag tgctgcccag aatcaaagcc agaggcctcg gcccaccaaa
     4861 aaacacaagg gagggcggat ggacccacag ccagtgttac ctcatcggag ggaagggatg
     4921 ccagatgatc ttcccccacc accagatccc ccaccaggtc agggtttaag gcagcagata
     4981 ggcctgagcc aacactctgg taacgtggaa agctcaacag agaggaaagg aagctctcta
     5041 gagagacaac aagcagccaa cttagaagac acaaagagct cattggattg tccggctaaa
     5101 actactgtag agtggcagca tcaaacccag gactggataa actctacaga gcgccaagaa
     5161 gaaacacgga aagccccaca caaaccaggg gttggatcag aggagtccct ggtgccctac
     5221 agcaagccca gcttcccatc tccaggcggg cacagctcat ccggaacagc ctcctctaaa
     5281 gggtccactg gtcctcggaa ggctgagatt ctgaggggca gccaccagcg gaatgccaat
     5341 gaccttctcg acattggata tgtgggctca aatagtcaag ggcagtttac aggtgaattg
     5401 tagtaactga gaggagacat acaaagacgc tctgaggacc atcaggtcca aactcatgga
     5461 agtgatgaca tttaacagtg caatgaacaa tttctttatt tatgtactat taaaaaatac
     5521 tgtaaatgca atgtaaagac acagccacac atatcccaca gttcttttct tgtgtccttc
     5581 tcttacttac accacccacc ttaactcttt cttgtcagga gtatataaga aaaagaaaga
     5641 aagcaaaact cgccctccag gaagaaaagg attttcctct gtacataatt tctttggtgc
     5701 attgctatgc aagctcactc tttttaactc tgttcgtatt attgtctgtt cttattggtc
     5761 tgttgtacta tatgtgaatt aatgggctgt ggtaccatat attaactttt aattgtgtaa
     5821 ctttttatgt ttaaattttg cactgcaatt ttatttggtg ataagcacaa atctctcctc
     5881 ctcataacat gaagaaaaga ttgaatgtga agggagtgtt ctgtactgta agctaggtgg
     5941 acaatgctgg tgtgaccaat cctgttagac ggttttcagt tgggggtgta gaaataggaa
     6001 gatgcgaagg aatgatgggt gttggcaaag tcttcttgaa ccatcagata ctgagtcaat
     6061 tttaagaagc agaaagatgg atgctattga ctatagcagg ggtcaaaaga aggggctttg
     6121 agtctagaca gaatatgtaa gaaagtatgg cggtggcaaa gatgtactaa cttgctttaa
     6181 aaatcttatt aaagttttat ttagaatgaa cttcactggc cattgtaatt aacccatctt
     6241 agaattacaa tgagcaaaat aaaatcaagg tggttcaaga gatctgtatt tatatattcc
     6301 agctttaaaa aaaaacagca gttttgaatt accataatta atctctccaa ctcattaagt
     6361 cagactataa catagagttc cccaaggaaa caaagaaaat gaactccaga gattccagca
     6421 aatagttaaa ggagccactt attgtcaggg cacactcggc tgctctggac tataagctca
     6481 gttgtagtat tgtgttcgtc tttctaatac acatacagta cataatagag gatgtagtca
     6541 catcacttcg gttcatttct ttgctttttt taaaagcaaa ccaatgcatt ctacatacaa
     6601 ttttgtgttt cttctgatga aaacgtgaaa ccaatgctac cacatgtata gctgagttat
     6661 cagtgcctaa gggcagtgct cgcagtgtgt tcagtttctg gttagttgat ttactgggct
     6721 caatattttc tggtacagtc tcagaaattg gccaccaact aaaacctgtt tgacccattt
     6781 tgaatgagta aatcggaaag aacagtcaaa agggagaaaa aaaatgcatg tttatacact
     6841 ttttaaataa aaccaaatct tgtacgtgga cattaatgac agtgtcctgc ctcatttgtt
     6901 ttcacgactt tgagaacaag gagttcctga acatcaatta tgtatgctca agataaatgt
     6961 gactttgaaa tgtatgttag ctactgtaca tgtatgtaag tcaagtagat gatagccttc
     7021 ctaaaattac cacttatgat attttcccat gtgctcctta cagagcttaa gttctacttc
     7081 agccggtaat ttttattatt tctcttatga tatattcaat agatggtacc ttaaaaaatt
     7141 ctcagtgtga tgggcaatat attgagtttt caagtagggg atatttatgt tgacagtaca
     7201 tgccttgcat cattggctca gatgccaatt catgggacat tattgtaggg aatggataat
     7261 gtaagtacac ggtcctaagg gtccttctcc acgggcaagc atagaatttg aggttcttca
     7321 tgggttccaa cattttctta gtgctctatc cttaacttca ctgaagtaac aaaaaattct
     7381 gacacaccct ttaacaactt tctaccatca gtgcctgaat tttattgaag tttcgtatct
     7441 ctggtacaaa gaaataggaa aaactgaaca gtttctgtgg ggaaaaaaga tttatgtaat
     7501 tattgtcaat tctaagttgt gatgaattta acttttcgtt tatacagttc ctgatatcct
     7561 gacctctatt taaaagcatg ggatctttta aaatacatat tttacttgtg ttttcactgt
     7621 atgttcacga ataatataat ttagtggaaa acttcagtat atcacatgta tggcaactga
     7681 catttgcaga ttattatcaa accaaatcat atgaattgat atctgtagat cacttgatga
     7741 cttacagaac aatttcaggt tttagcacca tgtcattctg attgttctca gtatatgatc
     7801 ataattatat tgtgtttata cagattgcag actgtgatta gtgcaaaatc ttgtatctga
     7861 tatctactgt aaaggtgaac taacatgctc tggtgatttg aattcaggca taagcaagct
     7921 aacagcaata caaaactttc ctcatctagg tattggacaa atccattcat catcaaccat
     7981 cagatggtta actgagaaac atatacctct ccccccatga aaaccccatc tcttttcatc
     8041 ttgtcgttga ttgaatgtga tagaaaatct actgagttta ctcttctgtg ggcctgagca
     8101 gaaacatgca taagccatca agaaggaagt ctgggtggga atgaaccctc atcttttact
     8161 cataggcaat actgctgtgc tgtcatggca gacccaagca cagcttcttt cagaacaggc
     8221 aacatctcct tagggaatgt atatatcagt gctcaaactc aggtatgcca gtataaacag
     8281 taaggctccc ttaccccccc ttttcatgcc ctttgacata aagtaggtta gaagactata
     8341 aagctatgaa aaccctcgat tccttcacag gatttggagc aagtttatgg aagtatatgg
     8401 gacagtcaag accaatgtaa atacaaccga agtaaagaaa agccttgcag aaacgcacac
     8461 ttccactagc aaaacagatt taccatgttc tatgtggtag tttaacgctc tccatgttta
     8521 aatcccatcg tcaatgggat ttaagttgta agtttatatg tggtttcaca tccaagttct
     8581 aacttaataa atttatgcaa tttgtttcat tgatgaaaac acaatattca catcagtgag
     8641 ctcccaactg aggatcgctt ttccgaaaaa agcaatcctg tcagtattaa agatatgcag
     8701 aaccataaca ttcactacta atgttatttt gttcaactac ttctgtatag tgtgaaaagg
     8761 gggtaggggc acaaccgttt ccacattatc tgagaggtaa aactattttt gcgttgcttg
     8821 gtcctaatgg atacttcaaa tgaaacacca tacaatttta aatgacatgc aatttatgaa
     8881 tattttttac tcttataatt ttaaaaccat ttgttgtgat tttaaagtgt tacaagatag
     8941 gagattttgt ggttgtgggt agacttttta tactttgttt tatagctgaa tttttttcac
     9001 tgtagtttat ttgagtgaac aaacactatt ccaaatctcg atgtgtttca tttgatattg
     9061 ttagatgagc aaagaaattg gcataaaatt gattcatagt attgtcaatg aattgtgtat
     9121 tgtgtattca ctgggaaaaa taaaaatata ttcacatttc aattttgtaa aaaaaaaagc
     9181 catttatgta aaaccaattt gtctgtagac aaaccaaaaa tagatcctgt gtcactttca
     9241 gaattctgtg actattttgt ggcccaatat tcctatttct tttttctatt caaatatgga
     9301 tcagaagtgc taagtaggaa ataatgttga ctagttagtc atgattaaaa gacagcaata
     9361 aagactgcaa gtatttgaaa ttata
//
