LOCUS       NM_022188               8237 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus roundabout guidance receptor 1 (Robo1),
            transcript variant 1, mRNA.
ACCESSION   NM_022188 XM_001066378 XM_017598060
VERSION     NM_022188.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8237)
  AUTHORS   Ying,Z., Wu,J., Jiang,W., Zhang,G., Zhu,W., Li,X., Pang,X. and
            Liu,W.
  TITLE     Expression of Slit and Robo during remodeling of corticospinal
            tract in cervical spinal cord in middle cerebral artery occlusion
            rats
  JOURNAL   Mol Biol Rep 48 (12), 7831-7839 (2021)
   PUBMED   34652618
  REMARK    GeneRIF: Expression of Slit and Robo during remodeling of
            corticospinal tract in cervical spinal cord in middle cerebral
            artery occlusion rats.
REFERENCE   2  (bases 1 to 8237)
  AUTHORS   Bianchi,G., Czarnecki,P.G., Ho,M., Roccaro,A.M., Sacco,A.,
            Kawano,Y., Gulla,A., Samur,A.A., Chen,T., Wen,K., Tai,Y.T.,
            Moscvin,M., Wu,X., Camci-Unal,G., Da Via,M.C., Bolli,N.,
            Sewastianik,T., Carrasco,R.D., Ghobrial,I.M. and Anderson,K.C.
  TITLE     ROBO1 Promotes Homing, Dissemination, and Survival of Multiple
            Myeloma within the Bone Marrow Microenvironment
  JOURNAL   Blood Cancer Discov 2 (4), 338-353 (2021)
   PUBMED   34268498
REFERENCE   3  (bases 1 to 8237)
  AUTHORS   Liu,Y., Yin,Z., Xu,X., Liu,C., Duan,X., Song,Q., Tuo,Y., Wang,C.,
            Yang,J. and Yin,S.
  TITLE     Crosstalk between the activated Slit2-Robo1 pathway and TGF-beta1
            signalling promotes cardiac fibrosis
  JOURNAL   ESC Heart Fail 8 (1), 447-460 (2021)
   PUBMED   33236535
REFERENCE   4  (bases 1 to 8237)
  AUTHORS   Chai,K.X., Chen,Y.Q., Kong,L.S., Fan,P.L., Yuan,X. and Yang,J.
  TITLE     A Study Based on the Correlation Between Slit2/Robo1 Signaling
            Pathway Proteins and Polymyositis/Dermatomyositis
  JOURNAL   Curr Mol Med 20 (9), 717-722 (2020)
   PUBMED   32213157
REFERENCE   5  (bases 1 to 8237)
  AUTHORS   Kaur,H., Xu,N., Doycheva,D.M., Malaguit,J., Tang,J. and Zhang,J.H.
  TITLE     Recombinant Slit2 attenuates neuronal apoptosis via the
            Robo1-srGAP1 pathway in a rat model of neonatal HIE
  JOURNAL   Neuropharmacology 158, 107727 (2019)
   PUBMED   31356825
REFERENCE   6  (bases 1 to 8237)
  AUTHORS   Patel,K., Nash,J.A., Itoh,A., Liu,Z., Sundaresan,V. and Pini,A.
  TITLE     Slit proteins are not dominant chemorepellents for olfactory tract
            and spinal motor axons
  JOURNAL   Development 128 (24), 5031-5037 (2001)
   PUBMED   11748139
REFERENCE   7  (bases 1 to 8237)
  AUTHORS   Wong,K., Ren,X.R., Huang,Y.Z., Xie,Y., Liu,G., Saito,H., Tang,H.,
            Wen,L., Brady-Kalnay,S.M., Mei,L., Wu,J.Y., Xiong,W.C. and Rao,Y.
  TITLE     Signal transduction in neuronal migration: roles of GTPase
            activating proteins and the small GTPase Cdc42 in the Slit-Robo
            pathway
  JOURNAL   Cell 107 (2), 209-221 (2001)
   PUBMED   11672528
REFERENCE   8  (bases 1 to 8237)
  AUTHORS   Nguyen Ba-Charvet,K.T., Brose,K., Ma,L., Wang,K.H., Marillat,V.,
            Sotelo,C., Tessier-Lavigne,M. and Chedotal,A.
  TITLE     Diversity and specificity of actions of Slit2 proteolytic fragments
            in axon guidance
  JOURNAL   J Neurosci 21 (12), 4281-4289 (2001)
   PUBMED   11404413
REFERENCE   9  (bases 1 to 8237)
  AUTHORS   Brose,K., Bland,K.S., Wang,K.H., Arnott,D., Henzel,W.,
            Goodman,C.S., Tessier-Lavigne,M. and Kidd,T.
  TITLE     Slit proteins bind Robo receptors and have an evolutionarily
            conserved role in repulsive axon guidance
  JOURNAL   Cell 96 (6), 795-806 (1999)
   PUBMED   10102268
REFERENCE   10 (bases 1 to 8237)
  AUTHORS   Kidd,T., Brose,K., Mitchell,K.J., Fetter,R.D., Tessier-Lavigne,M.,
            Goodman,C.S. and Tear,G.
  TITLE     Roundabout controls axon crossing of the CNS midline and defines a
            novel subfamily of evolutionarily conserved guidance receptors
  JOURNAL   Cell 92 (2), 205-215 (1998)
   PUBMED   9458045
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Dec 20, 2022 this sequence version replaced NM_022188.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.650181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000011.1  24067956-24068199
            245-382             JAXUCZ010000011.1  24198960-24199097
            383-466             JAXUCZ010000011.1  24625154-24625237
            467-793             JAXUCZ010000011.1  24782507-24782833
            794-951             JAXUCZ010000011.1  24955570-24955727
            952-1072            JAXUCZ010000011.1  24983511-24983631
            1073-1211           JAXUCZ010000011.1  24983954-24984092
            1212-1339           JAXUCZ010000011.1  24985697-24985824
            1340-1464           JAXUCZ010000011.1  25016894-25017018
            1465-1636           JAXUCZ010000011.1  25018983-25019154
            1637-1842           JAXUCZ010000011.1  25028279-25028484
            1843-1924           JAXUCZ010000011.1  25029954-25030035
            1925-2093           JAXUCZ010000011.1  25030181-25030349
            2094-2260           JAXUCZ010000011.1  25030461-25030627
            2261-2382           JAXUCZ010000011.1  25036004-25036125
            2383-2614           JAXUCZ010000011.1  25036897-25037128
            2615-2736           JAXUCZ010000011.1  25038209-25038330
            2737-2908           JAXUCZ010000011.1  25042150-25042321
            2909-3106           JAXUCZ010000011.1  25047965-25048162
            3107-3133           JAXUCZ010000011.1  25051945-25051971
            3134-3176           JAXUCZ010000011.1  25053379-25053421
            3177-3331           JAXUCZ010000011.1  25060815-25060969
            3332-3667           JAXUCZ010000011.1  25063296-25063631
            3668-3775           JAXUCZ010000011.1  25065678-25065785
            3776-3920           JAXUCZ010000011.1  25068818-25068962
            3921-4169           JAXUCZ010000011.1  25072498-25072746
            4170-4576           JAXUCZ010000011.1  25083571-25083977
            4577-4729           JAXUCZ010000011.1  25087053-25087205
            4730-5038           JAXUCZ010000011.1  25096794-25097102
            5039-5235           JAXUCZ010000011.1  25104171-25104367
            5236-8237           JAXUCZ010000011.1  25105693-25108694
FEATURES             Location/Qualifiers
     source          1..8237
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11p11"
     gene            1..8237
                     /gene="Robo1"
                     /note="roundabout guidance receptor 1"
                     /db_xref="GeneID:58946"
                     /db_xref="RGD:61941"
     exon            1..244
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..382
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..5250
                     /gene="Robo1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; roundabout homolog 1; roundabout, axon guidance
                     receptor, homolog 1"
                     /codon_start=1
                     /product="roundabout homolog 1 isoform 1 precursor"
                     /protein_id="NP_071524.2"
                     /db_xref="GeneID:58946"
                     /db_xref="RGD:61941"
                     /translation="MKWKHLPLLVMISLLTLSKKHLLLAQLIPDPEDLERGNDNGTPA
                     PTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWY
                     KGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYICVARNYLGEAVSHN
                     ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERI
                     TIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD
                     DSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN
                     MVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL
                     LFSYQPPQSSSRFSVSQTGDLTVTNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA
                     DRPPPVIRQGPVNQTVAVDGTLTLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLESG
                     VLQIRYAKLGDTGRYTCTASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSK
                     PEVTDVSKNTVTLLWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETFAIKGL
                     KPNAIYLFLVRAANAYGISDPSQISDPVKTQDVPPTTQGVDHKQVQRELGNVVLHLHN
                     PTILSSSSVEVHWTVDQQSQYIQGYKILYRPSGASHGESEWLVFEVRTPTKNSVVIPD
                     LRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPRSVTVSKNDGNGTAILVTW
                     QPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPSLVPGIRYSVEVAAST
                     GAGPGVKSEPQFIQLDSHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVF
                     SIWLYRHRKKRNGLSSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAT
                     QPWLADTWPNTGNSHNDCSINCCTASNGNSDSNLTTYSRPADCIANYNNQLDNKQTNL
                     MLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQANLSNNMN
                     NGGGDSSEKHWKPPGQQKQEVAPIQYNIMEQNKLNKDYRANDTIPPTIPYNQSYDQNT
                     GGSYNSSDRGSSTSGSQGHKKGARTPKAPKQGGMNWADLLPPPPAHPPPHSNSEEYSM
                     SVDESYDQEMPCPVPPARMYLQQDELEEEEAERGPTPPVRGAASSPAAVSYSHQSTAT
                     LTPSPQEELQPMLQDCPEDLGHMPHPPDRRRQPVSPPPPPRPISPPHTYGYISGPLVS
                     DMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSAS
                     EEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQ
                     CPRPTSPVSTDSNMSAAVIQKARPTKKQKHQPGHLRREAYTDDLPPPPVPPPAIKSPS
                     VQSKAQLEARPIMGPKLASIEARADRSSDRKGGSYKGREALDGRQVTDLRTSPGDPRE
                     AQEQPNEGKARGTKTAKRDLPPAKTHLIPEDILPYCRPTFPTSNNPRDPSSSSSMSSR
                     GSGSRQREQANVGRRNMAEMQVLGGFERGDENNEELEETES"
     exon            383..466
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..793
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..951
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1072
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1211
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1339
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1464
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1636
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1842
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1924
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2093
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2260
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2382
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2614
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2736
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2908
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3106
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3133
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3176
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3331
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3332..3667
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3775
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3776..3920
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3921..4169
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            4170..4576
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            4577..4729
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            4730..5038
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            5039..5235
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
     exon            5236..8237
                     /gene="Robo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattaatag taatacagat aacgggtgtg aaagaattct ctactgaaga agggttgaat
       61 atgtttccag gctgctgaga ctgagaagaa atctgactct actctcccgg ttcctcattc
      121 acggaaaagt ctcagccggc ttttgctggg tttaaactcg gaggctgttc tctgcatagc
      181 aaagttggag ggctgcgcct gcctcgggga gctgctggat ttctgaaaag aatcttatgg
      241 aaggataaca tacgtctgta tcgctgactg gtgtaatgta agggaggggt aaagatgaaa
      301 tggaaacatc ttcctcttct ggtcatgata tctctcctca ctctatcaaa aaagcatctt
      361 cttctggccc agcttattcc agaccctgag gacctagaga gggggaacga caacgggacg
      421 ccagccccca cctctgataa tgatgacaat tcgctgggct acacaggctc ccgtctccgt
      481 caggaagatt tcccaccgcg cattgttgag cacccttcag acctgatcgt ctctaaaggg
      541 gaacccgcca ccctcaactg taaagctgaa ggccgcccta ccccgactat agaatggtac
      601 aagggcggcg aaagagtgga aacggacaaa gacgaccctc gctcacaccg aatgctgctg
      661 ccaagtggat ctttattttt cttacgcata gtgcatggac ggaagagtag gcctgacgaa
      721 ggggtctaca tctgtgtagc aaggaattac ctcggagagg ctgtgagcca caatgcatcg
      781 ctggaggtag ctatactacg ggatgacttc agacaaaacc cttcagatgt tatggtggcg
      841 gtgggcgagc ctgcagtaat ggaatgccag cctcctcggg gccacccaga gcccaccatc
      901 tcctggaaaa aggatggctc acccctggat gataaagacg agcgaatcac tatccgaggc
      961 gggaagctca tgatcacgta cacccgtaaa agcgatgctg gcaagtatgt ttgtgttggt
     1021 accaacatgg taggggagcg ggagagcgaa gtcgcggagc tgactgtctt agagagaccg
     1081 tcctttgtaa agagacccag taatttggca gtgactgtgg atgacagtgc tgagtttaag
     1141 tgtgaggccc gaggagaccc cgtgcctacg gttcggtgga ggaaagatga cggagagctg
     1201 cccaaatcca gatatgagat ccgagatgat catactttga aaattcggaa ggtgacagct
     1261 ggcgacatgg gatcatacac ttgtgttgca gaaaatatgg ttgggaaagc cgaagcatca
     1321 gccactttga cagttcaaga gccaccacat tttgtcgtga agcctcgaga ccaggtggtt
     1381 gccttggggc gaactgtgac ttttcagtgt gaagcaactg gaaatcctca accagctatc
     1441 ttttggcgga gagaggggag tcagaatctg cttttctcat accagcctcc acagtcctct
     1501 agccggtttt cagtttccca gacgggggac ctcactgtta cgaacgtcca gaggtctgat
     1561 gtcggttact atatctgtca gactttgaac gtggctggaa gcatcatcac aaaggcatat
     1621 ttggaagtta ctgatgtgat tgcggaccgg cctcccccag tcatccgaca aggtcctgtg
     1681 aatcagactg tagcagtgga tggtacttta actctcagct gtgtggccac aggcagtccc
     1741 gtgcccacaa ttctgtggag gaaggatgga gtccttgttt caacccaaga ttctcggatc
     1801 aaacagctgg agagcggggt cctgcagatc cgctacgcta agctgggtga caccggtcgg
     1861 tacacctgca ctgcttcgac ccccagtggt gaggccacgt ggagcgctta catcgaagtc
     1921 caggaatttg gagttccagt tcaacctcca agacccaccg accccaattt aatccccagt
     1981 gcgccttcaa agcctgaagt cacagatgtg agcaaaaaca cagtcacttt attgtggcag
     2041 cctaacctga actcaggagc aaccccaacg tcttatatta tagaagcctt cagccatgca
     2101 tctggtagca gctggcagac cgtggcagaa aatgtgaaaa cagaaacatt cgccatcaaa
     2161 gggctcaaac ctaatgcgat ctaccttttc ctggtgaggg cagcaaatgc ctatgggatt
     2221 agcgatccaa gccaaatatc cgatccagtg aaaacacaag atgtcccacc aaccacccaa
     2281 ggggtggacc acaagcaggt ccagagagaa ctgggcaatg ttgtcttgca tctccacaac
     2341 cctaccatcc tttcttcctc ttctgtcgaa gtgcactgga cggtggacca acaatctcaa
     2401 tatattcaag gttataaaat tctctaccga ccatctggag ccagccatgg cgaatcggag
     2461 tggttagttt ttgaagtgag gaccccaacc aaaaatagtg tggtgatccc cgatctgaga
     2521 aaaggcgtca actacgagat taaggcccgc ccatttttta atgagttcca aggagcagat
     2581 agtgaaatca aatttgccaa aaccttagaa gaagcaccaa gtgcccctcc ccgaagtgtc
     2641 actgtatcca agaatgatgg aaatgggaca gcaattctgg tcacttggca accgcctcct
     2701 gaagacacac agaatggaat ggtccaagaa tataaggttt ggtgtctcgg gaatgagact
     2761 aggtatcaca taaacaagac agtagatggc tctacctttt cggtggtcat cccctctctg
     2821 gttcctggga tccgctacag tgtagaagtg gctgcaagca ctggggctgg ccctggggtg
     2881 aagagtgaac cccagttcat ccagttagat tcccatggaa accccgtgtc tcccgaggac
     2941 caagtgagcc tggctcagca gatctccgac gtggtgaagc agccagcctt cattgcgggc
     3001 atcggggccg cctgttggat cattctcatg gtcttcagta tctggcttta ccgacaccgc
     3061 aagaagagaa acgggctcag cagcacgtac gcggggatcc ggaaagtccc gtcctttacc
     3121 ttcacaccaa cagtaactta tcaaagagga ggcgaagccg tcagcagtgg agggaggccg
     3181 ggactcctca acatcagtga acctgccaca cagccatggc tggcggacac gtggcccaac
     3241 acaggcaaca gtcacaatga ctgctccatc aactgctgca cagccagcaa cggcaacagc
     3301 gacagcaacc tgaccaccta cagtcgccca gctgattgta tagcaaatta taacaaccaa
     3361 ctggataaca aacaaacaaa tctgatgctc cctgagtcaa ctgtttatgg tgatgtggac
     3421 cttagtaaca aaatcaatga gatgaaaacc ttcaatagcc caaatctgaa ggacgggcgt
     3481 tttgtcaatc catcagggca gcccactccc tacgccacca cgcagctcat ccaggcaaat
     3541 ctcagcaaca atatgaataa cggcggcggg gactccagcg agaaacactg gaagcctccg
     3601 gggcagcaga aacaggaagt ggcaccaatt cagtataaca tcatggagca aaacaagctg
     3661 aacaaagatt atcgggcaaa tgacacaatc cctccaacca tcccgtacaa ccaatcctat
     3721 gaccagaata caggaggatc ttacaacagc tcagatcggg gcagtagtac atctgggagt
     3781 caaggccaca agaaaggggc acggacacca aaggcaccca agcagggtgg catgaactgg
     3841 gcagacttgc tgccccctcc cccagcgcat cctcccccac acagcaacag cgaggaatac
     3901 agcatgtctg tagatgaaag ctatgatcaa gaaatgccgt gccctgttcc gcctgcacgg
     3961 atgtatttgc aacaggatga attagaagaa gaggaagctg aaagaggccc cacgccccct
     4021 gtccgggggg cagcttcgtc cccagctgct gtgtcctaca gccatcagtc cacggccact
     4081 ctcaccccgt ctccccagga agagctccag cctatgttac aggattgtcc ggaggacctc
     4141 ggccacatgc cccacccacc agacaggagg cggcagccgg tgagtcctcc tccaccacca
     4201 cggccaattt ccccaccaca tacttacggc tacatttcag gacccctggt ctcagacatg
     4261 gatacggatg ccccagaaga ggaggaagac gaagctgaca tggaagttgc taagatgcag
     4321 acccgaaggc tgttgttacg tgggcttgaa cagaccccag catctagtgt tggggacctc
     4381 gagagctcgg tcactggctc catgatcaat ggctggggct cagcctcaga agaggacaac
     4441 atttccagtg ggcgctccag tgtcagttca tcggatggtt cctttttcac tgacgctgat
     4501 tttgcccagg cagttgccgc agccgccgag tatgcgggcc tgaaggtggc tcgccgccag
     4561 atgcaggatg ctgctggccg ccgacacttc catgcctccc agtgccctag gcccacgagt
     4621 cctgtgtcta cagacagcaa catgagtgct gctgtaatcc agaaagccag acccaccaag
     4681 aaacagaagc accagccagg acatctgcgc agagaggcct acacagatga tcttccaccc
     4741 cctccagtgc caccacctgc tataaaatcg cccagtgtcc agtccaaggc acagctggag
     4801 gcacggccta taatggggcc aaagctcgct tctatagaag cgagagcaga cagatcatca
     4861 gacagaaaag gcggcagtta caaggggaga gaagctctgg acggaagaca agtcactgac
     4921 ctgcgaacaa gcccaggtga ccccagagaa gcacaggagc agccaaacga agggaaagca
     4981 cgagggacga agacagcaaa gcgagacctt ccaccagcga agacacacct catcccagag
     5041 gatatccttc cgtactgtag gcctactttc ccaacgtcaa acaaccctag ggatcccagt
     5101 tcttcaagct caatgtcatc aagaggctca ggaagccgac agagagagca agcaaatgtg
     5161 ggccgaagaa atatggcaga aatgcaagta cttgggggat ttgaaagagg agatgagaat
     5221 aatgaagaat tagaggaaac tgaaagctga agaccaccag agaggcttat gatgcccatg
     5281 tgaaaagccg tcactcaaga ggcctcacgt cagatgacac accgtaccag atgaaacgtt
     5341 cagtgcgatc ggagtggaca aatcgtcgtt tttattcctc ctgttgggat aacattttta
     5401 aaaagtttct tgggttttta gtgttgctga ttgattgcct aacccttaat gaatctcccc
     5461 ctgccgagat gctgttgcag ccgttatact tgacttccgg tattggaagt gtcttgaatg
     5521 cttgcttcag ccagcagcca gcgagaaaga acagatcagt tctttttgca atttgcccct
     5581 gagatatggc attgcactgc ttatctatcc agctaattga tagcaaaata ttgatcaaag
     5641 atacaaaggg gatcactcaa cctcatgcca agggctctca aagtataacc gttccatgac
     5701 caactgctaa tgccagttaa agcgtacttc attttatgtg agttttagaa tcagtctttc
     5761 atgccaccct ttgctgggat aaactaaaaa tctatcacac gcagaattac agttcatttg
     5821 aatgggatag aagcattgta aatatatact ctttgcaact cctggtggta ctttattttg
     5881 tctttatttc aatcattgaa atatattctt ggaaatgtac ttttggataa gtaaggctaa
     5941 gccagttgga cctctggttg tctagtcatt gtgagaagta aacctagcaa aaatcttgtt
     6001 ctatttttca atcaaaaagc aactacgaat gcatattaca agcaaatgga tgtttttaat
     6061 gaccaattgg gtaaggacat ccctatctta actggcctga atttcttctg gtagtgtcaa
     6121 ttcaactttc agaagtgcca cttaaggagg tttgtttgat ttattttgtt tgtttttgta
     6181 atgcactgtt tttaatcttt tttttttttt ttggttttaa aagcacaatc actaaacttt
     6241 atttgtaaac cattgtaact attaaccttt tttgtcttat tgaggaagct gttgagaagt
     6301 gtttttagcc tgttttgtta atgctctgtg tttctatttg caatatttga atggtgacag
     6361 ctagcaaggt caggtacctt atcgtgggct gtgaaccaag tggttccaat tttttgtgga
     6421 cttaaagaga aaaaaaaaaa aaagagttgt tttaagtttg ttgtggccaa tgttgaatct
     6481 tataagattt ccttagacac tcatgagagg cattccgact tggaactgag aagtgatgct
     6541 ccgtgactgt agatttctat gggttttctt ttttcttttt tttttttttg tttgtttttt
     6601 ggtgttttta cattttacaa atttcattga ctttataatt ggtgctattt gaagaaaaca
     6661 aaatgaacct ttagtcatac ataggtatca ggcttgaccc cacaaaacca aacaaaattg
     6721 acccacaaaa tagataaata aataaaatca aaaggctggt attcaccaga aactaagtgt
     6781 attcatttag ataatttgaa aaggccccat gtcccataga aaggatgtgc agttctaagg
     6841 gaacaaccca cgtgattaat gttttcatta tgttcatgta agaaacctct tatttttagc
     6901 catacttttg catactgaaa attcaataat caaaaaagta attttgtcat attatttatt
     6961 aaaaatgttc tcaaatacat catccttcct tgtgttgatt tctttttcat tatatgatta
     7021 tcagatttat tccatgagat cacaaagtcg ttttgtctta acatttcacc actacgttat
     7081 gaaaaaagaa ggagttctca gttttcttaa cgagaatcca gcttctactg ctaagcaaaa
     7141 gttctcgctt cagttggggg gagtaagtgg gagatgattc tgaagttgaa gttagctgtg
     7201 tgatcagaga tgaactctga aaagtgtgct gtgcttgttt ccgtgtgtgt atctgaattt
     7261 cagttagcct atttctaaaa taatcaggat gcaactctgt acagtaaacc tcttttgtca
     7321 agtttaaggc acctatgctc tgtcgggaac aaagtttata aatcccattg gttgtcagaa
     7381 aatttggact agcacttata gaccaggttg cacattatga tcaattaaat caccctattg
     7441 cagaatttca cttgggtgga tgagatgggt accatgtcgt ggaaatgtca agatcaacag
     7501 aatatactgg agtttagacc ccgcccccga cacccaccct gtggtatata tatttttcct
     7561 ttaacctaat ttttgtgttt accagaattt gaaaagctga agaacagaca tggaacaacg
     7621 aagggcttaa tttggaattt aattttataa aagggatgta attatcaact ccatttaata
     7681 cctctacaga cccagtagtc aaggagttag tttctaagct attttttaaa gaaacaaatc
     7741 actggggggg tggggacata tgtaatggac tggtttttct ttttctaggt gggtaagcta
     7801 ctaagccact gcctctcttt ttctattaca tgctgcaatt cacacacaaa atctgcacgt
     7861 cagagggccg ggacaacact gggttctagt tttgtcatgg ctgtgtttcc ttggacatgt
     7921 tacttaacct ctaagtctca ggtacttcac ctgtaaagtc aataagacct acctcatgga
     7981 gctgttgtca tgattcagtg agttgatgta tctacataga ctctgtaaac ttcacaatgg
     8041 tataagatat tgtttattta tggactgaaa ttcgctacac atgcaatctc cacttttcga
     8101 atctgatttg ttcctaaaat tttgcatgaa agtaaaagca ttaagtgtgg tataaggaca
     8161 agggtcctcc cacctctggt aagtaaaact cactgtgaaa tacccccatc gtgaaataaa
     8221 tgcttcgtgt tcttgtt
//
