LOCUS       NM_001107183            3737 bp    mRNA    linear   ROD 12-JUN-2023
DEFINITION  Rattus norvegicus Ro60, Y RNA binding protein (Ro60), mRNA.
ACCESSION   NM_001107183 XM_001064741 XM_222686
VERSION     NM_001107183.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3737)
  AUTHORS   Hung T, Pratt GA, Sundararaman B, Townsend MJ, Chaivorapol C,
            Bhangale T, Graham RR, Ortmann W, Criswell LA, Yeo GW and Behrens
            TW.
  TITLE     The Ro60 autoantigen binds endogenous retroelements and regulates
            inflammatory gene expression
  JOURNAL   Science 350 (6259), 455-459 (2015)
   PUBMED   26382853
REFERENCE   2  (bases 1 to 3737)
  AUTHORS   Lai CK, Gupta N, Wen X, Rangell L, Chih B, Peterson AS, Bazan JF,
            Li L and Scales SJ.
  TITLE     Functional characterization of putative cilia genes by high-content
            analysis
  JOURNAL   Mol Biol Cell 22 (7), 1104-1119 (2011)
   PUBMED   21289087
REFERENCE   3  (bases 1 to 3737)
  AUTHORS   Jonson L, Vikesaa J, Krogh A, Nielsen LK, Hansen Tv, Borup R,
            Johnsen AH, Christiansen J and Nielsen FC.
  TITLE     Molecular composition of IMP1 ribonucleoprotein granules
  JOURNAL   Mol Cell Proteomics 6 (5), 798-811 (2007)
   PUBMED   17289661
REFERENCE   4  (bases 1 to 3737)
  AUTHORS   Chen X, Smith JD, Shi H, Yang DD, Flavell RA and Wolin SL.
  TITLE     The Ro autoantigen binds misfolded U2 small nuclear RNAs and
            assists mammalian cell survival after UV irradiation
  JOURNAL   Curr Biol 13 (24), 2206-2211 (2003)
   PUBMED   14680639
REFERENCE   5  (bases 1 to 3737)
  AUTHORS   Xue D, Shi H, Smith JD, Chen X, Noe DA, Cedervall T, Yang DD, Eynon
            E, Brash DE, Kashgarian M, Flavell RA and Wolin SL.
  TITLE     A lupus-like syndrome develops in mice lacking the Ro 60-kDa
            protein, a major lupus autoantigen
  JOURNAL   Proc Natl Acad Sci U S A 100 (13), 7503-7508 (2003)
   PUBMED   12788971
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_222686.4, XM_001064741.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3737
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..3737
                     /gene="Ro60"
                     /gene_synonym="Ssa2; Trove2"
                     /note="Ro60, Y RNA binding protein"
                     /db_xref="GeneID:304833"
                     /db_xref="RGD:1305083"
     exon            1..126
                     /gene="Ro60"
                     /gene_synonym="Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            127..727
                     /gene="Ro60"
                     /gene_synonym="Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1764
                     /gene="Ro60"
                     /gene_synonym="Ssa2; Trove2"
                     /note="Sjogren syndrome antigen A2; 60 kDa SS-A/Ro
                     ribonucleoprotein; TROVE domain family, member 2"
                     /codon_start=1
                     /product="RNA-binding protein RO60"
                     /protein_id="NP_001100653.1"
                     /db_xref="GeneID:304833"
                     /db_xref="RGD:1305083"
                     /translation="MEESANQLQPLSDNQVANSEGGYVWQVTDMNRLHRFLCFGSEGG
                     TCYIKEQKLGLENAEALIRLIEDGRGSEVIQEIKSFSQEGRTAKQEPLLFALAICSQC
                     ADVSTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAVADWYNEKG
                     GMAVALAVTKYKQRNGWSHKDLLRLSHLKPNSEGLAIVTKYITKGWKEVHEQYKEKPL
                     SVETDKLLKYLEAVEKVKRTKDDLEVTHLIEEHQLVREQLLTSHLKSKEVWKALLQEM
                     PLTALLRNLGKMTANSVLEPGSSEVSLVCEKLSNEKLLKKARIHPFHVLTALETYRTG
                     HGLRGKLKWIPDKEILQALDAAFYKTFKTVEPTGKRFLLAVDVSGSMDQRVLGSVLNA
                     STVAAAMCMVVTRTEKESSVVAFACDMVPFPVTTDMTLQQVLTAMNKVPAGTTDCSLP
                     MIWAQKTGTAADVFIVFTDNETFAGQVHPAIALREYRKKMAIPAKLLVCGMTSNGFTI
                     ADPDDRGMLDMCGFDTAALDVIRNFTLDVI"
     exon            728..948
                     /gene="Ro60"
                     /gene_synonym="Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1095
                     /gene="Ro60"
                     /gene_synonym="Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1233
                     /gene="Ro60"
                     /gene_synonym="Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1350
                     /gene="Ro60"
                     /gene_synonym="Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1464
                     /gene="Ro60"
                     /gene_synonym="Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1611
                     /gene="Ro60"
                     /gene_synonym="Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..3737
                     /gene="Ro60"
                     /gene_synonym="Ssa2; Trove2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggggcgg ggctcgctcc gacccgaacc tggagctgtc ctctccgttt cgggccgccg
       61 cctattcccg gtgctacgca gggtttctag gcgccgcggg tcctgagcat cgcctaccag
      121 gcacaggttc cccaagaaac aaggaacatg gaagagtctg caaaccagtt gcagcctctg
      181 agtgacaatc aggtagccaa ctccgagggc ggatatgtct ggcaggtcac cgacatgaac
      241 cggctgcacc gcttcttgtg tttcggttcc gaaggcggca cctgctatat caaagaacag
      301 aagctgggcc ttgagaatgc cgaagcctta attagactga tcgaagatgg cagaggaagc
      361 gaagtgatcc aggaaatcaa gtcctttagt caggaaggca ggactgccaa acaggagcca
      421 ttgctctttg cactggccat ctgttcccag tgtgcagacg tcagcacaaa gcaagcagca
      481 tttaaagctg tccccgaagt gtgtcgcatc ccgacccacc tcttcacttt catacagttt
      541 aagaaagacc tgaaggagag catgaagtgt ggaatgtggg gtcgcgctct ccggaaggcc
      601 gtggcagact ggtataatga aaaaggcggc atggccgtcg ccttggccgt tacaaagtat
      661 aaacagagaa atggctggtc tcacaaagat ctcctacgac tgtcccacct taaacctaac
      721 agtgaaggac ttgctattgt gaccaaatat atcacaaagg gctggaaaga agttcatgaa
      781 cagtataaag aaaaaccact ttctgtggag acggacaaac tactaaagta cctggaggct
      841 gtggagaaag tgaagcgcac aaaggacgac ctggaagtca ctcatctgat tgaagagcac
      901 cagttagtca gggagcagct gctgaccagc cacctgaagt ctaaagaggt atggaaggct
      961 ttgttacaag aaatgcccct tactgcactc ctaaggaacc tgggaaagat gactgccaat
     1021 tcagtgcttg aaccaggaag ttctgaagtt tctttagtat gtgaaaaact gagcaatgaa
     1081 aaactgctta agaaggctcg tatacatcca tttcacgttt taactgcatt agagacctac
     1141 agaacaggcc atgggctccg aggaaagttg aagtggattc cagataaaga aatcttgcaa
     1201 gcattggatg ctgcttttta taaaacattt aagacagttg agccaactgg gaagcgcttc
     1261 ttgctggctg ttgatgtcag tggttctatg gaccagagag tcttgggtag tgtactcaat
     1321 gctagtactg ttgccgcggc aatgtgcatg gtggttacac ggacagagaa agagtcttca
     1381 gtagttgctt ttgcgtgtga tatggtacca tttccagtga cgacagacat gacattacag
     1441 caggttttaa cggctatgaa caaagttcca gcaggcacca cggattgctc tcttccaatg
     1501 atctgggccc agaaaacagg cacagctgca gacgtcttca tcgtgttcac tgataatgag
     1561 acctttgctg ggcaggtgca cccggctatt gccctgcggg agtaccgaaa gaaaatggct
     1621 attcctgcta aattgcttgt ttgtgggatg acatcaaacg gctttacgat cgcagaccca
     1681 gacgatagag gcatgttgga tatgtgcggc tttgatactg cagctctgga tgtaattcgg
     1741 aatttcacgt tggatgtcat ttaaccctaa gtacctgaat gatctgagag gtgcactgct
     1801 tcccagctag atgcagttgt gagaaatgtc atcagtatgt gcatgttaga aatgtacatt
     1861 ggcaggaaca ggaagagaga aggaaggaaa cacgttgagc ctaacggtgc gtgtactcag
     1921 ctagctcttg cgaagtcttc aggatactgt agctttctct atagagaact tctttttaat
     1981 agacactata aaatagtcgt gttttacgtc actgaatcac acctttgtac tgaaagtgag
     2041 atacaaagtc taagtagcct cacatcatgt cacttgtttg agaaatgctt gttttcttaa
     2101 atgtcttcat tggaaaagga cagttttgat aatgtccaaa aactctgagg tgcactagac
     2161 catgtgactg tgatggaaaa tttttatacc aaggagttta aaaaaaaaag acatttggtt
     2221 aaactaaatt atgaatgaat tttacaaatt cagagctttc taagatcata tgaacaacag
     2281 ctttcttatt caatgcaaaa gatgttttct ttcaggtgtt taatttgtac ttgttaggat
     2341 ttgataccat ttggccaaaa catggtggaa atgttgaatt ataagggact tgttgaatgg
     2401 atatagcctg agggattcgc tttgtagcct tgtgttagat gagcaacaac ggtgtcttac
     2461 acactcacgc attcctagtg tttcgtcccc catctgtaat cctgacagta taataactaa
     2521 aactctactg taaagacata gctttctgta cccctaaata tctttagttc attttcatat
     2581 ttttctaata ttaagtttgt ctgaagtctt ttatattttt gcccactatt catcttgtgt
     2641 ctaatttcct ttttatagag tatagaaata ataacaagct agatccttcc agttcaaaca
     2701 attttagagt agccatatca accaatcagt ttatgtagga aatttaaaaa cttactttgt
     2761 ataaattaaa cgtctttttc acatactaaa atacattctt ttcttgagca agtatatgtt
     2821 ttcaccaggg aagcttagcc tattgagcac cagtagttct tctcttgatt cagtaatggt
     2881 atctacagta gtttatacta aaactctaat ttttatgtat tactctttaa atattaaaga
     2941 tttactgtgg gtttataaag cccttccaaa gctagtatgt gtaggttaca taaccttaca
     3001 agtgtttaag ggtgaagttc ttttatttgg gaaagaaagt gctagtgtaa ggatttgtgt
     3061 acatattttc tttttttttc ctaagaaatt tagtctcaga gaataagaaa atattccctt
     3121 cagatgactt gacattaatt aagtttcata tgtagccatt cctccaagac agtaacaaat
     3181 tttcaatatt attagcaaag atagtatcat ctgcagttct aaacaccatt gcttctaatg
     3241 ctgttttggc ttgaccactg tcacatggga aatttcacat tttaactaat tatgatatac
     3301 taaagtctca tattcaaact gaatttaagg ttaaaaacac tagtaattac atgagagcta
     3361 ttgaattcct tagacccagg atctaagttt taacttatta tgaaatttac atggaatatt
     3421 atataaaagc ttatttcttt tttttttatg ctacttagat tgtgctttta ggcaagcata
     3481 gtatatctag gagctaccca tcagggaaat aagggtctac ctaaataccg tagaaaggta
     3541 cagtatttag gtagacctaa ctaaatagat taagattgaa gacagaggcc gaatgtgatg
     3601 atgcatgcct ttactcctgg ggaaacagag gcaggtagat ttcttaagtt agaagccagc
     3661 ctgctctaca tagtatattt cagaccaatc aggcctacgt agtgagactc tgtctccaaa
     3721 aaggaaaaag gtttaag
//
