LOCUS       NM_031097               2199 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Rattus norvegicus arginyl aminopeptidase (Rnpep), transcript
            variant 1, mRNA.
ACCESSION   NM_031097
VERSION     NM_031097.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2199)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   2  (bases 1 to 2199)
  AUTHORS   Flister,M.J., Hoffman,M.J., Reddy,P., Jacob,H.J. and Moreno,C.
  TITLE     Congenic mapping and sequence analysis of the Renin locus
  JOURNAL   Hypertension 61 (4), 850-856 (2013)
   PUBMED   23460292
REFERENCE   3  (bases 1 to 2199)
  AUTHORS   Pham,V.L., Gouzy-Darmon,C., Pernier,J., Hanquez,C., Hook,V.,
            Beinfeld,M.C., Nicolas,P., Etchebest,C., Foulon,T. and Cadel,S.
  TITLE     Mutation in the substrate-binding site of aminopeptidase B confers
            new enzymatic properties
  JOURNAL   Biochimie 93 (4), 730-741 (2011)
   PUBMED   21237246
  REMARK    GeneRIF: A structural analysis using circular dichroism,
            fluorescence spectroscopy, molecular modelling and dynamics was
            performed to investigate the role that residue G(298) plays in the
            catalytic mechanism of Ap-B
REFERENCE   4  (bases 1 to 2199)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 2199)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2199)
  AUTHORS   Cadel,S., Foulon,T., Viron,A., Balogh,A., Midol-Monnet,S., Noel,N.
            and Cohen,P.
  TITLE     Aminopeptidase B from the rat testis is a bifunctional enzyme
            structurally related to leukotriene-A4 hydrolase
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2963-2968 (1997)
   PUBMED   9096329
REFERENCE   7  (bases 1 to 2199)
  AUTHORS   Fukasawa,K.M., Fukasawa,K., Kanai,M., Fujii,S. and Harada,M.
  TITLE     Molecular cloning and expression of rat liver aminopeptidase B
  JOURNAL   J Biol Chem 271 (48), 30731-30735 (1996)
   PUBMED   8940051
REFERENCE   8  (bases 1 to 2199)
  AUTHORS   Ramirez,M., Arechaga,G., Sanchez,B., Ozaita,A. and Lardelli,P.
  TITLE     Developmental and ageing changes in aminopeptidase activities in
            selected tissues of the rat
  JOURNAL   Experientia 49 (4), 300-303 (1993)
   PUBMED   8477833
REFERENCE   9  (bases 1 to 2199)
  AUTHORS   Ramirez,M., Arechaga,G., Garcia,S., Sanchez,B., Lardelli,P. and
            Gandarias,J.M.
  TITLE     Soluble and membrane-bound leucyl- and arginyl-aminopeptidase
            activities in subcellular fractions of young and adult rat brains
  JOURNAL   Rev Esp Fisiol 46 (4), 393-397 (1990)
   PUBMED   2099537
REFERENCE   10 (bases 1 to 2199)
  AUTHORS   Wright,J.W., Sullivan,M.J. and Harding,J.W.
  TITLE     Dysfunction of central angiotensinergic aminopeptidase activity in
            spontaneously hypertensive rats
  JOURNAL   Neurosci Lett 61 (3), 351-356 (1985)
   PUBMED   3001599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Dec 7, 2020 this sequence version replaced NM_031097.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U61696.1, AY724503.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-458               JAXUCZ010000013.1  49269173-49269630   c
            459-599             JAXUCZ010000013.1  49265231-49265371   c
            600-748             JAXUCZ010000013.1  49264158-49264306   c
            749-865             JAXUCZ010000013.1  49260864-49260980   c
            866-1101            JAXUCZ010000013.1  49260015-49260250   c
            1102-1215           JAXUCZ010000013.1  49256936-49257049   c
            1216-1328           JAXUCZ010000013.1  49256033-49256145   c
            1329-1437           JAXUCZ010000013.1  49255750-49255858   c
            1438-1662           JAXUCZ010000013.1  49254036-49254260   c
            1663-1805           JAXUCZ010000013.1  49252569-49252711   c
            1806-2199           JAXUCZ010000013.1  49251259-49251652   c
FEATURES             Location/Qualifiers
     source          1..2199
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2199
                     /gene="Rnpep"
                     /note="arginyl aminopeptidase"
                     /db_xref="GeneID:81761"
                     /db_xref="RGD:621137"
     exon            1..458
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1964
                     /gene="Rnpep"
                     /EC_number="3.4.11.6"
                     /note="isoform 1 is encoded by transcript variant 1; AP-B;
                     arginine aminopeptidase; cytosol aminopeptidase IV;
                     aminopeptidase B"
                     /codon_start=1
                     /product="aminopeptidase B isoform 1"
                     /protein_id="NP_112359.2"
                     /db_xref="GeneID:81761"
                     /db_xref="RGD:621137"
                     /translation="MESSGPSSCHSAARRPLHSAQAVDVASASSFRAFEILHLHLDLR
                     AEFGPPGPGPGSRGLNGKATLELRCLLPEGASELRLDSHSCLEVMAATLLRGQPGDQQ
                     QLTEPVPFHTQPFSHYGQALCVVFPKPCCAAERFRLELTYRVGEGPGVCWLAPEQTAG
                     KKKPFVYTQGQAVLNRAFFPCFDTPAVKCTYSALVEVPDGFTAVMSASTWERRGPNKF
                     FFQMNQPIPSYLIALAIGDLASAEVGPRSRVWAEPCLIEAAKEEYNGVIEEFLATGEK
                     LFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGN
                     LVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDVSGEENPL
                     NKLRVKIEPGVDPDDTYNETPYEKGYCFVSYLAHLVGDQEQFDKFLKAYVDEFKFQSI
                     LAEDFLEFYLEYFPELKKKGVDSIPGFEFNRWLNTPGWPPYLPDLSPGDSLMKPAEEL
                     AELWAASEPDMQAIEAVAISTWKTYQLVYFLDKILQKSPLPPGNVKKLGETYPKISNA
                     QNAELRLRWGQIILKNDHQEEFWKVKDFLQSQGKQKYTLPLYHAMMGGSEMARTLAKE
                     TFAATASQLHSNVVNYVQQILEPKGS"
     exon            459..599
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            600..748
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            749..865
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1101
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1215
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1328
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1437
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1662
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1805
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..2199
                     /gene="Rnpep"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctaagagc catggagagc agcggaccca gcagctgcca cagcgcggcc cggcggccac
       61 ttcactcggc acaagccgtg gacgtggcct cggcctccag tttccgcgcc ttcgagatcc
      121 tgcacctgca cctggacctg cgggccgagt tcgggcctcc gggcccgggt ccggggagcc
      181 gcggactgaa cggcaaggcg acgctggaac tgcgctgctt gctgccggag ggcgcctcgg
      241 agctgcggct cgattcgcac agttgcctgg aggtgatggc ggcgaccctg ctgcgggggc
      301 agcccggaga ccagcagcag ctcacggagc ccgtgccttt ccacacacag cccttctcgc
      361 actatggcca ggccctgtgc gtggtctttc cgaagccctg ctgtgccgcc gagcgcttcc
      421 ggctggagct cacctaccgc gtcggagagg gaccaggggt ttgctggtta gctcctgagc
      481 agacagcagg aaagaagaaa ccctttgtgt atacccaggg tcaggcagtc ttaaaccgag
      541 cctttttccc ttgcttcgac accccagccg tgaaatgcac gtattcggct cttgttgagg
      601 ttccagatgg cttcacagct gtgatgagtg caagcacatg ggagaggaga ggaccaaata
      661 agttcttctt ccagatgaac cagcccatcc cctcctatct gatagctttg gccattggag
      721 atctggcttc agctgaggtt ggacccagga gccgggtgtg ggcagagccc tgcctgattg
      781 aagccgccaa ggaggaatac aatggggtca tagaagaatt tctggcaaca ggagagaagc
      841 ttttcggacc ctatgtttgg ggaagatatg atttactctt tatgccacca tctttcccgt
      901 ttggaggaat ggagaatccc tgcctgacct ttgtcacccc gtgcctgcta gcaggggacc
      961 gctccttagc cgacgtcatc atccacgaga tctcccacag ttggtttggg aacctggtca
     1021 ccaatgccaa ctggggggaa ttctggctca atgaaggctt caccatgtat gcccagagga
     1081 ggatctccac catcctgttc ggagctgctt acacttgctt ggaggccgca acggggaggg
     1141 ctctgctacg gcagcacatg gatgtgtctg gagaggaaaa cccactcaac aagcttcggg
     1201 tgaagattga accaggtgtt gacccagatg acacctacaa tgaaaccccc tacgagaaag
     1261 gttactgctt tgtctcatac ctggcccatc tggtgggtga tcaggaacag tttgacaagt
     1321 ttctcaaggc ctatgtagat gagtttaagt tccaaagtat cttggctgaa gactttctgg
     1381 aattctacct ggagtatttc cctgagctga agaagaaggg agtggattcc atcccaggtt
     1441 ttgagttcaa ccgatggctg aacacccctg gctggccccc ctacctcccc gacctctccc
     1501 ctggggactc actcatgaag ccagctgaag agctggcgga gctgtgggcg gcctcagagc
     1561 cagacatgca agccatcgag gctgtggcca tctctacctg gaagacctac cagcttgtct
     1621 acttcctaga taagatcctg cagaagtctc ctctccctcc tgggaacgtg aaaaaacttg
     1681 gggagacata cccaaagatt tccaatgctc agaatgctga gttacggcta agatggggcc
     1741 aaatcatcct taagaatgac caccaagaag agttctggaa agtgaaggac ttcctgcaga
     1801 gtcagggaaa gcagaagtac actctgccac tgtaccatgc catgatgggt ggcagcgaga
     1861 tggcccggac cctcgccaag gagacctttg cagccaccgc ttcccagctc cacagtaacg
     1921 tggtcaacta tgtccagcag atcctggagc ccaagggcag ttagaggctc acctgggtgg
     1981 tccctgcctt tctgaagaat tgttccttcc caaattcatg ttctcaagtc agcgtcccgg
     2041 agtttctgtt ctctgggttt gggtctctgc cgtggtggca gcttctggtc tagagagtcc
     2101 tgagagtcct aaaagggcct cccatgctcc ccttagacca ggctgcagag cataaaatgt
     2161 cattcttttt ctcttcgaat aaatgttttt aagcaagaa
//
