LOCUS       NM_001399688            1420 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus renalase, FAD-dependent amine oxidase (Rnls),
            transcript variant 1, mRNA.
ACCESSION   NM_001399688 XM_006231293
VERSION     NM_001399688.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Aydin,M.A., Aydogdu,N., Tastekin,E., Firat,N. and Yalcinkaya
            Yavuz,O.
  TITLE     Investigation of the Relationship of Nesfatin-1, Adropin Levels and
            Claudin-2, Renalase Immunoreactivity with Kidney Function in an
            Experimental Hypertension Model
  JOURNAL   P R Health Sci J 43 (1), 39-45 (2024)
   PUBMED   38512760
  REMARK    GeneRIF: Investigation of the Relationship of Nesfatin-1, Adropin
            Levels and Claudin-2, Renalase Immunoreactivity with Kidney
            Function in an Experimental Hypertension Model.
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Zhang,L., Zang,C.S., Chen,B., Wang,Y., Xue,S. and Wu,M.Y.
  TITLE     Renalase regulates renal tubular injury in diabetic nephropathy via
            the p38MAPK signaling pathway
  JOURNAL   FASEB J 37 (10), e23188 (2023)
   PUBMED   37732586
  REMARK    GeneRIF: Renalase regulates renal tubular injury in diabetic
            nephropathy via the p38MAPK signaling pathway.
            Erratum:[FASEB J. 2024 Jan;38(1):e23336. doi:
            10.1096/fj.202302343.. PMID: 38174882]
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Tokinoya,K., Yoshida,Y., Sugasawa,T. and Takekoshi,K.
  TITLE     Moderate-intensity exercise increases renalase levels in the blood
            and skeletal muscle of rats
  JOURNAL   FEBS Open Bio 10 (6), 1005-1012 (2020)
   PUBMED   32053739
  REMARK    GeneRIF: Moderate-intensity exercise increases renalase levels in
            the blood and skeletal muscle of rats.
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Wang,F., Zhang,G., Xing,T., Lu,Z., Li,J., Peng,C., Liu,G. and
            Wang,N.
  TITLE     Renalase contributes to the renal protection of delayed ischaemic
            preconditioning via the regulation of hypoxia-inducible
            factor-1alpha
  JOURNAL   J Cell Mol Med 19 (6), 1400-1409 (2015)
   PUBMED   25781495
  REMARK    GeneRIF: Findings suggest that hypoxia-inducible factor-1alpha
            (HIF-1alpha) up-regulated renalase directly in hypoxia.
REFERENCE   5  (bases 1 to 1420)
  AUTHORS   Beaupre,B.A., Hoag,M.R., Roman,J., Forsterling,F.H. and Moran,G.R.
  TITLE     Metabolic function for human renalase: oxidation of isomeric forms
            of beta-NAD(P)H that are inhibitory to primary metabolism
  JOURNAL   Biochemistry 54 (3), 795-806 (2015)
   PUBMED   25531177
REFERENCE   6  (bases 1 to 1420)
  AUTHORS   Wu,Y., Xu,J., Velazquez,H., Wang,P., Li,G., Liu,D.,
            Sampaio-Maia,B., Quelhas-Santos,J., Russell,K., Russell,R.,
            Flavell,R.A., Pestana,M., Giordano,F. and Desir,G.V.
  TITLE     Renalase deficiency aggravates ischemic myocardial damage
  JOURNAL   Kidney Int 79 (8), 853-860 (2011)
   PUBMED   21178975
REFERENCE   7  (bases 1 to 1420)
  AUTHORS   Li,G., Xu,J., Wang,P., Velazquez,H., Li,Y., Wu,Y. and Desir,G.V.
  TITLE     Catecholamines regulate the activity, secretion, and synthesis of
            renalase
  JOURNAL   Circulation 117 (10), 1277-1282 (2008)
   PUBMED   18299506
REFERENCE   8  (bases 1 to 1420)
  AUTHORS   Zhao,Q., Fan,Z., He,J., Chen,S., Li,H., Zhang,P., Wang,L., Hu,D.,
            Huang,J., Qiang,B. and Gu,D.
  TITLE     Renalase gene is a novel susceptibility gene for essential
            hypertension: a two-stage association study in northern Han Chinese
            population
  JOURNAL   J Mol Med (Berl) 85 (8), 877-885 (2007)
   PUBMED   17216203
REFERENCE   9  (bases 1 to 1420)
  AUTHORS   Xu,J. and Desir,G.V.
  TITLE     Renalase, a new renal hormone: its role in health and disease
  JOURNAL   Curr Opin Nephrol Hypertens 16 (4), 373-378 (2007)
   PUBMED   17565281
  REMARK    GeneRIF: Renalase deficiency occurs in salt-sensitive Dahl rats as
            they develop hypertension[review]
            Review article
REFERENCE   10 (bases 1 to 1420)
  AUTHORS   Xu,J., Li,G., Wang,P., Velazquez,H., Yao,X., Li,Y., Wu,Y.,
            Peixoto,A., Crowley,S. and Desir,G.V.
  TITLE     Renalase is a novel, soluble monoamine oxidase that regulates
            cardiac function and blood pressure
  JOURNAL   J Clin Invest 115 (5), 1275-1280 (2005)
   PUBMED   15841207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 12, 2022 this sequence version replaced XM_006231293.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.4656.1,
                                           SRR26643290.5851.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               JAXUCZ010000001.1  240722706-240723043 c
            339-444             JAXUCZ010000001.1  240721907-240722012 c
            445-587             JAXUCZ010000001.1  240721282-240721424 c
            588-746             JAXUCZ010000001.1  240709168-240709326 c
            747-920             JAXUCZ010000001.1  240524397-240524570 c
            921-1096            JAXUCZ010000001.1  240486768-240486943 c
            1097-1420           JAXUCZ010000001.1  240454579-240454902 c
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..1420
                     /gene="Rnls"
                     /gene_synonym="RGD1309804"
                     /note="renalase, FAD-dependent amine oxidase"
                     /db_xref="GeneID:361751"
                     /db_xref="RGD:1309804"
     exon            1..338
                     /gene="Rnls"
                     /gene_synonym="RGD1309804"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1249
                     /gene="Rnls"
                     /gene_synonym="RGD1309804"
                     /EC_number="1.6.3.5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; MAO-C; monoamine oxidase-C; alpha-NAD(P)H
                     oxidase/anomerase"
                     /codon_start=1
                     /product="renalase isoform 1 precursor"
                     /protein_id="NP_001386617.1"
                     /db_xref="GeneID:361751"
                     /db_xref="RGD:1309804"
                     /translation="MFRVLVVGAGLTGSLCAALLRKEITAPLYLALWDKAGDIGGRMT
                     TANSPHNPRCTADLGAQYITCTPHYAKKHQNFYEELLAHGILEPLTSPIKGMEVKEGE
                     SNFVAPHGVSSIIKYYLKESGAEVFLRQCVTQINLRDNKWEVSEDTGSTQQFDLVILT
                     MPAPQILGLQGDIVNLISERQRQQLASVSYSSRYALGLFYEAGMKIDVPWAGQYITSN
                     PCIRFISIDSKKRNTESSECGPLLVVHTTVPFGVTHLEHSEEDVQELITQQLETILPG
                     LPPPVATKCWKWRYSQVTNSAANSPGQMTLHLNPFLVCGGDGFTHSNFDGCVASALSV
                     VEALKSYI"
     exon            339..444
                     /gene="Rnls"
                     /gene_synonym="RGD1309804"
                     /inference="alignment:Splign:2.1.0"
     exon            445..587
                     /gene="Rnls"
                     /gene_synonym="RGD1309804"
                     /inference="alignment:Splign:2.1.0"
     exon            588..746
                     /gene="Rnls"
                     /gene_synonym="RGD1309804"
                     /inference="alignment:Splign:2.1.0"
     exon            747..920
                     /gene="Rnls"
                     /gene_synonym="RGD1309804"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1096
                     /gene="Rnls"
                     /gene_synonym="RGD1309804"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1420
                     /gene="Rnls"
                     /gene_synonym="RGD1309804"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggctgat gggattgggg ctcaccctgt aggcaagctg ctctgtggag gctggggcag
       61 gcccttctct gggtttgagt caccactgca gggttccccg ccctctcagg agcagatgtc
      121 ccgcccaggg cacggccctg accctcgcgg ggacacggtg gctgagtagg ctagcgcctc
      181 tctgagcctc tgccagcggc ctagctgaag gcccgccgcc atgttccggg tactggtggt
      241 gggcgccggg ctaaccggaa gtttgtgtgc cgcgctgctg aggaaggaga taaccgctcc
      301 cctgtacctc gccctgtggg acaaggctgg ggacataggg ggaagaatga ctactgccaa
      361 cagtcctcat aatccccgat gcacggctga cttgggagct cagtacatca cctgtactcc
      421 tcattatgcc aaaaagcacc aaaattttta tgaggagctt ttagctcatg ggattttgga
      481 gcctctgacg tctcccatta aaggaatgga agtgaaggaa ggagaaagca actttgtggc
      541 acctcacggc gtttcttcca ttatcaagta ctacttgaaa gaatcaggtg ctgaagtctt
      601 cctcaggcag tgtgtgactc agatcaatct aagagataac aagtgggaag tctctgagga
      661 caccggctcc acccagcagt ttgaccttgt catccttacc atgccagctc ctcagattct
      721 gggtcttcaa ggtgacattg tgaacttaat tagtgaacgc cagaggcagc aactggcatc
      781 tgtgagctac tcctctcgct atgctctggg cctcttttat gaagcaggca tgaagattga
      841 tgtcccttgg gctggccagt acatcaccag taatccctgc atacgcttca tctccattga
      901 cagtaagaag cgcaacacag agtcatcaga atgtggccca ttgctggtgg tccataccac
      961 cgtcccattt ggagtcacac acttggagca cagtgaggag gatgtgcagg agttaatcac
     1021 ccagcaactg gaaaccattc tgccgggctt gccgccgcca gttgctacca aatgctggaa
     1081 gtggagatat tcacaggtta caaactcagc tgccaacagt cccggccaga tgactcttca
     1141 tctcaaccct ttcctggtgt gtggagggga tggattcact cactccaact tcgatggctg
     1201 cgttgcctct gccctgagtg tcgtggaagc tttaaagagt tatatttagt gtctgtgttt
     1261 ttgttttcta cagttacttt gcgatttttg ttttcacaat catattatta attgttctat
     1321 tttcctttct atggagagaa attgtttggg aaaatgtctt catgttctgt catttttaat
     1381 atgaaatata aaaactatta taattgatag ctaccaccca
//
