LOCUS       NM_001270763            1679 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ribonuclease/angiogenin inhibitor 1 (Rnh1),
            transcript variant 3, mRNA.
ACCESSION   NM_001270763
VERSION     NM_001270763.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1679)
  AUTHORS   Zhao,C., Ni,Y., Liu,Y., Liu,T., Yang,S., Liu,Z. and Liu,S.
  TITLE     Identification and distribution of rRNH1, a gene upregulated after
            spinal cord primary neuron injury
  JOURNAL   In Vitro Cell Dev Biol Anim 50 (3), 183-187 (2014)
   PUBMED   24288130
  REMARK    GeneRIF: RNH1 protein is upregulated after spinal cord injury.
REFERENCE   2  (bases 1 to 1679)
  AUTHORS   Zhao,C.F., Liu,Y., Que,H.P., Yang,S.G., Liu,T., Liu,Z.Q., Hui,H.D.
            and Liu,S.
  TITLE     Rnh1 promotes differentiation and myelination via RhoA in
            oligodendrocytes
  JOURNAL   Cell Tissue Res 353 (3), 381-389 (2013)
   PUBMED   23624614
  REMARK    GeneRIF: Rnh1-mediated RhoA inactivation enhances the
            differentiation and myelination in oligodendrocytes.
REFERENCE   3  (bases 1 to 1679)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1679)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1679)
  AUTHORS   Kawanomoto,M., Motojima,K., Sasaki,M., Hattori,H. and Goto,S.
  TITLE     cDNA cloning and sequence of rat ribonuclease inhibitor, and tissue
            distribution of the mRNA
  JOURNAL   Biochim Biophys Acta 1129 (3), 335-338 (1992)
   PUBMED   1536887
REFERENCE   6  (bases 1 to 1679)
  AUTHORS   Shapiro,R. and Vallee,B.L.
  TITLE     Human placental ribonuclease inhibitor abolishes both angiogenic
            and ribonucleolytic activities of angiogenin
  JOURNAL   Proc Natl Acad Sci U S A 84 (8), 2238-2241 (1987)
   PUBMED   3470787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and BC070501.1.
            
            Transcript Variant: This variant (3) has an alternate exon in place
            of the first exon compared to variant 1. The resulting isoform (b)
            is shorter at the N-terminus compared to isoform a. Variants 2 and
            3 both encode the same isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ233708.1, FQ218714.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000001.1  205706706-205706810 c
            106-1679            BC070501.1         22-1595
FEATURES             Location/Qualifiers
     source          1..1679
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1679
                     /gene="Rnh1"
                     /gene_synonym="Rnh"
                     /note="ribonuclease/angiogenin inhibitor 1"
                     /db_xref="GeneID:100360501"
                     /db_xref="RGD:621398"
     exon            1..105
                     /gene="Rnh1"
                     /gene_synonym="Rnh"
                     /inference="alignment:Splign:2.1.0"
     exon            106..210
                     /gene="Rnh1"
                     /gene_synonym="Rnh"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1495
                     /gene="Rnh1"
                     /gene_synonym="Rnh"
                     /note="isoform b is encoded by transcript variant 3;
                     ribonuclease inhibitor"
                     /codon_start=1
                     /product="ribonuclease inhibitor isoform b"
                     /protein_id="NP_001257692.1"
                     /db_xref="GeneID:100360501"
                     /db_xref="RGD:621398"
                     /translation="MSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIR
                     SAIQANPALTELSLRTNELGDAGVGLVLQGLQNPTCKIQKLSLQNCSLTEAGCGVLPD
                     VLRSLSTLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLASV
                     LRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSACQLESLKLENCGITSANCKDLCDVV
                     ASKASLQELDLGSNKLGNTGIAALCSGLLLPSCRLRTLWLWDCDVTAEGCKDLCRVLR
                     AKQSLKELSLAGNELKDEGAQLLCESLLEPGCQLESLWVKTCSLTAASCPHFCSVLTK
                     NRSLFELQMSSNPLGDSGVVELCKALGYPDTVLRVLWLGDCDVTDSGCSSLATVLLAN
                     RSLRELDLSNNCMGDTGVLQLLESLKQPSCALQQLVLYDIYWTDEVEDQLRALEEERP
                     SLRIIS"
     exon            211..381
                     /gene="Rnh1"
                     /gene_synonym="Rnh"
                     /inference="alignment:Splign:2.1.0"
     exon            382..552
                     /gene="Rnh1"
                     /gene_synonym="Rnh"
                     /inference="alignment:Splign:2.1.0"
     exon            553..723
                     /gene="Rnh1"
                     /gene_synonym="Rnh"
                     /inference="alignment:Splign:2.1.0"
     exon            724..894
                     /gene="Rnh1"
                     /gene_synonym="Rnh"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1065
                     /gene="Rnh1"
                     /gene_synonym="Rnh"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1236
                     /gene="Rnh1"
                     /gene_synonym="Rnh"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1407
                     /gene="Rnh1"
                     /gene_synonym="Rnh"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1656
                     /gene="Rnh1"
                     /gene_synonym="Rnh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaaaggct agttggggcc agagaatggg aaccagccaa agtctctagg ccccgccctg
       61 ggcggaagaa accggagcga ctgggacctt tagcagcggc accagactac actgtgcacc
      121 caccatgagt cttgacatcc agtgtgagca gctgagtgat gcccggtgga cagagctcct
      181 tcccctgatc caacaatacc aagtggtcag gctggatgac tgtggcctca ctgaagtgcg
      241 gtgcaaagac atcaggtcag cgatccaggc caaccctgcc ctgacagagc tcagcctacg
      301 caccaatgaa ctgggtgatg ctggtgtggg tctggtgctc cagggcctgc agaatcccac
      361 ttgtaagatc cagaagctga gccttcagaa ctgcagcttg acggaagctg gctgtggggt
      421 cctgcctgat gtgctgcgct ctttgtctac cctgcgtgaa ctacatctca atgacaaccc
      481 tctgggggat gaaggcctga agctgctctg tgaaggactc cgggaccccc agtgccgtct
      541 tgagaagctt cagttggaat actgtaacct cacagctacc agctgcgagc ccctggcctc
      601 agtgctcagg gtgaaacctg actttaaaga gctagtattg agcaacaatg acttccatga
      661 ggctggtatc cacactctgt gccagggcct gaaggattct gcctgtcaac tggagtcact
      721 caaactggag aactgtggta tcacatcagc caactgcaag gatctgtgtg atgttgtggc
      781 ctccaaagcc tcactgcaag aactggactt gggcagcaac aagctgggca acacaggcat
      841 tgcagcactg tgctcaggac tgctgcttcc cagctgcagg ctgaggactc tgtggctctg
      901 ggactgtgat gtcactgcag aaggctgcaa ggacctgtgc cgtgtcctca gagccaagca
      961 gagcctgaag gaactcagcc tagctggcaa tgagctgaag gatgagggtg cccaactgct
     1021 gtgtgagagc ctgttagagc ctggctgtca gctggagtca ctgtgggtaa agacctgtag
     1081 cctcacagct gcctcttgtc cccacttctg ctcggtgttg accaaaaatc gttctctgtt
     1141 tgagctgcaa atgagcagca acccgctggg agactcggga gtcgtggagc tttgcaaggc
     1201 cctgggctat ccggacacag tgctgcgtgt gctttggctg ggagactgtg atgtgacaga
     1261 cagtggctgc agcagccttg ccactgtcct gctggccaac cgcagcttga gggaactgga
     1321 cctcagtaac aactgcatgg gggacaccgg tgtcctacaa ctgctggaga gcctcaaaca
     1381 gcccagctgc gcccttcagc agcttgtcct gtatgacatt tactggacgg atgaggtgga
     1441 agaccagctt cgggccctgg aggaggaaag gccatccctg aggatcattt cctgagatgt
     1501 acacctctgg acacaagata ttaatccagc cccagaggca gcccaccaga tctctggctt
     1561 tgggtgtcct agggttgact ggcgataagc attgggatct tacttcagta gaaaacttta
     1621 agacacttta taactattaa aatactttgt tggcaaaaaa aaaaaaaaaa aaaaaaaaa
//
