LOCUS       NM_001107923            4139 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus RNA guanylyltransferase and 5'-phosphatase
            (Rngtt), mRNA.
ACCESSION   NM_001107923 XM_001057191 XM_232865
VERSION     NM_001107923.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4139)
  AUTHORS   Gonatopoulos-Pournatzis,T. and Cowling,V.H.
  TITLE     Cap-binding complex (CBC)
  JOURNAL   Biochem J 457 (2), 231-242 (2014)
   PUBMED   24354960
  REMARK    Review article
            Erratum:[Biochem J. 2014 Feb 15;458(1):185]
REFERENCE   2  (bases 1 to 4139)
  AUTHORS   Chu,C., Das,K., Tyminski,J.R., Bauman,J.D., Guan,R., Qiu,W.,
            Montelione,G.T., Arnold,E. and Shatkin,A.J.
  TITLE     Structure of the guanylyltransferase domain of human mRNA capping
            enzyme
  JOURNAL   Proc Natl Acad Sci U S A 108 (25), 10104-10108 (2011)
   PUBMED   21636784
REFERENCE   3  (bases 1 to 4139)
  AUTHORS   Tsukamoto,T., Shibagaki,Y., Murakoshi,T., Suzuki,M., Nakamura,A.,
            Gotoh,H. and Mizumoto,K.
  TITLE     Cloning and characterization of two human cDNAs encoding the mRNA
            capping enzyme
  JOURNAL   Biochem Biophys Res Commun 243 (1), 101-108 (1998)
   PUBMED   9473487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 10, 2008 this sequence version replaced NM_001107923.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.174858.1,
                                           SRR26360186.117064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000005.1  52503335-52503509
            176-285             JAXUCZ010000005.1  52515972-52516081
            286-389             JAXUCZ010000005.1  52520387-52520490
            390-478             JAXUCZ010000005.1  52520572-52520660
            479-554             JAXUCZ010000005.1  52524846-52524921
            555-795             JAXUCZ010000005.1  52525985-52526225
            796-905             JAXUCZ010000005.1  52532318-52532427
            906-1007            JAXUCZ010000005.1  52533295-52533396
            1008-1143           JAXUCZ010000005.1  52548800-52548935
            1144-1215           JAXUCZ010000005.1  52560605-52560676
            1216-1380           JAXUCZ010000005.1  52565040-52565204
            1381-1449           JAXUCZ010000005.1  52578016-52578084
            1450-1550           JAXUCZ010000005.1  52601536-52601636
            1551-1617           JAXUCZ010000005.1  52642245-52642311
            1618-1741           JAXUCZ010000005.1  52705893-52706016
            1742-4139           JAXUCZ010000005.1  52707207-52709604
FEATURES             Location/Qualifiers
     source          1..4139
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..4139
                     /gene="Rngtt"
                     /note="RNA guanylyltransferase and 5'-phosphatase"
                     /db_xref="GeneID:313131"
                     /db_xref="RGD:1311410"
     exon            1..175
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1905
                     /gene="Rngtt"
                     /EC_number="2.7.7.50"
                     /codon_start=1
                     /product="mRNA-capping enzyme"
                     /protein_id="NP_001101393.1"
                     /db_xref="GeneID:313131"
                     /db_xref="RGD:1311410"
                     /translation="MAYNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENR
                     FHPSMLSNYLKSLKVKMSLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTEN
                     TETFIRLCERFNERSPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQAR
                     PPGIYKGDYLKELFRRYGDIEEAPPPPVLPDWCFEDDDEEDEDEDGKKDSEPGSSASF
                     GKRRKERLKLGAIFLEGITVKGVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSM
                     DKQNIRLLEQKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLR
                     MHLSNTLLDGEMIIDKVNGQAVPRYLIYDIIKFNAQPVGECDFNIRLQCIEREIISPR
                     HEKMKTGLIDKTQEPFSVRPKQFFDINISRKLLEGNFAKEVSHEMDGLIFQPIGKYKP
                     GRCDDILKWKPPSLNSVDFRLKITRMGGEGLLPQNVGLLYVGGYERPFAQIKVTKELK
                     QYDNKIIECKFENNSWVFMRQRIDKSFPNAYNTAMAVCNSISNPVTKEMLFEFIDRCA
                     AAAQGQKRKYPMDPDSELMPPPPPKRLHRPT"
     exon            176..285
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            286..389
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            390..478
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            479..554
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            555..795
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            796..905
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1007
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1143
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1215
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1380
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1449
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1550
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1617
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1741
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..4139
                     /gene="Rngtt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggagtcg aacctgaatg aaagtggcgc gccgctgagg acccgggtgg agctgctgcc
       61 gttggggtct gggctggctt gctaaggagc tgtcggcgag gcggcgtaga catggcttac
      121 aacaagatcc cgcctcggtg gctgaactgt ccgaggcgcg gccagccggt ggcaggaaga
      181 ttcttacctc taaagacaat gctggggcca agatatgata gtcaagttgc tgaagaaaac
      241 cggttccatc ccagtatgct ctcaaattat ctaaagagtc tgaaggttaa aatgagcttg
      301 ttggtggatc tgacaaatac ttcaaggttc tatgacagaa atgacataga aaaagaagga
      361 atcaagtata tcaaacttca gtgtaaagga catggtgagt gccccactac tgagaacacg
      421 gaaacattca ttcgcctgtg tgagaggttt aatgaaagaa gcccacctga gcttataggt
      481 gttcactgca cccatggctt caaccgcact ggtttcctta tatgtgcctt tttggtggaa
      541 aaaatggatt ggagcattga agcagcagtt gctacttttg cccaagccag accaccagga
      601 atctataagg gtgattattt gaaggaactt tttcgtcgct atggagatat agaagaagca
      661 ccaccaccac ctgtattgcc agattggtgt tttgaagatg atgatgaaga agacgaggat
      721 gaggatggaa aaaaggactc agaaccaggg tccagtgctt cctttgggaa aaggagaaaa
      781 gagcgcttaa aactgggagc tattttcttg gaaggaataa ctgttaaagg agtaactcaa
      841 gtaacaactc aaccgaagtt aggagaggta cagcagaagt gccatcagtt ctgtggctgg
      901 gaagggtctg ggttccctgg agcacagcct gtctccatgg acaagcaaaa tattagactt
      961 ttagagcaga agccatataa agtaagctgg aaagcagacg gtactcgtta catgatgttg
     1021 attgatggca caaatgaagt ttttatgatt gacagagata attccgtttt tcatgtttca
     1081 aatctggaat ttccatttcg taaagatctc cgcatgcatt tatcaaatac tcttttggat
     1141 ggggaaatga tcatcgataa agtaaatgga caggccgttc caagatattt gatatatgac
     1201 ataattaagt tcaatgcaca accagttgga gaatgtgatt ttaatattcg tctacagtgt
     1261 attgaacgtg aaattataag tccacgacat gaaaaaatga agactgggct cattgacaaa
     1321 acacaagaac catttagtgt cagacctaaa caattttttg acatcaatat ttcaagaaag
     1381 cttctggaag gaaattttgc caaagaagtc agccatgaaa tggatggact tatttttcag
     1441 ccgattggaa aatacaaacc tggtcgatgt gatgacattt tgaaatggaa acctcccagc
     1501 ctaaattctg tggactttcg acttaagata acaagaatgg gaggagaagg gttgctgcca
     1561 cagaatgttg gccttctcta tgttggaggt tatgaaagac cctttgcaca aatcaaggtg
     1621 acaaaagaac taaaacagta cgacaacaaa attatagaat gcaaatttga gaacaacagc
     1681 tgggtcttca tgagacagag aatagacaaa agtttcccaa atgcctacaa cacagccatg
     1741 gccgtgtgca atagtatctc aaaccctgtc accaaggaga tgctgttcga gttcattgac
     1801 agatgtgcag cggctgctca gggacagaag cgaaagtatc ccatggaccc tgactcagag
     1861 ctcatgccac ccccaccgcc caaacgactg caccggccaa cctagtccct gcctctgacc
     1921 tctcgctcaa gatgagagaa gaggaggaag aatgctgttg tctctttttc tcaaccagag
     1981 aaactgaaga gacagtgtgg cttggtactg gtacacgtgt tttaagggaa gacatcagtc
     2041 agcctgtata tatttagtac acttgttttc tcggaactac agtacatcat ggacctaaat
     2101 attttattta tacctgataa attcagcctt accctgtgga gtctacagat tgaaatatcc
     2161 aaaggtttaa tcagattgaa gttaatgaaa tagaggcctt gtttatatgt gaatagacac
     2221 ctttacattt gattcataac tagcaatctg aagctgtaag cacattgagt tttttaaagt
     2281 tggtttttaa gttttcctct ttaaaatgtg ggcagtggca ttagaaattc tcactaactt
     2341 atcatggatt tcttatattt ttgaattttt tatattctga gcaatgacaa ggtcaagtat
     2401 tatgtacatt aaacagtttg gtctggcata ccattttaag aagtttttgt ttttgttgtc
     2461 tgtgagggtg gtatgtaaac attagcatag ctccatttgc ttgtgagttg aatccttcct
     2521 ttaggaacca ttttgagcat cttactgttt ctcttgtttg aaccatggtg tcagatgtct
     2581 ggtgttccca tcctggcact ggttttgagt tcctttgtgg cacttgggtt cagagccgca
     2641 ggtccctcat gtgctgctgc tgctctggga tcattgctcc cttcagacag cagggctcct
     2701 cctgctttac ctcctcactg tgatctgagc agcatcagac acaaccgctg ttgtgttatg
     2761 tcctgcaaca atgcgtcaga agcagtggca gctttgccta gaaggtaatg tcagttgaac
     2821 aaagtgttgt ctctaggaaa tgctggcctc ccactggaca gatacagagg cattgcagag
     2881 atgggtcacg gaggacagga agatgttgct cccattgcta cagcttgggc gtggtgtttc
     2941 actaccgagg ccgcatttcc atgtttactc tccacaggag gtttaaaagg cagctagcgg
     3001 tccctgccat tgtgaaaatt gttctgattg gctcgtgagg gaattcagaa gtggctacta
     3061 acaagcagct tacttaatgt atttattttt agagacaggg gttttaagga aacgtattta
     3121 aaacagatgt ccgtgatctg tatttatatg tataagcgta tctggaggca tatgcagcag
     3181 tgtccattct tgcactgatg cagccagaaa tggacacctg agtgcggcac ctgaggctga
     3241 ggagctgggg gggttatttg gcatagcaca gattaagcaa aactgtattt ctatgaacct
     3301 gagttttaat gtttttaaac aaactttact tctgcagtgc ttttttgtgt ggaatacgaa
     3361 gactgtgctt gggcttatgc ctctgttgtt cccaagttat ataatgtgtt agcaaattta
     3421 tttaaaatgc catattaact ttttcctaga ttgcttttgt acatttgggc actgaaggga
     3481 tttaagcacc tgactgggat ggttgagggg aaaatgtcaa ggttccttct gtcttttaca
     3541 tggtagatcc aaaactgcct gtggactcca ggcaatgtag tgcctgctcc ccagggtcac
     3601 ggagtggtcc gctcccaagc cggtgcaaga gcagcgccct tgtgaagatc gtgtcatgct
     3661 ttgccagtga tctgtgatag aactggaacg ttggtaaccg tgaccttcag atgaattgtg
     3721 gaaagagcat gatacaggac ttggtttcca gctcaccctt cccttccact tgtggtgaca
     3781 gagtcactgc cttaaaagca gatgccatgg agccccaaca caccgcctcc tgaggtgtcc
     3841 tgacagtcat ttagtctctc ggatgaaagg taggatttgg acatcttgaa ggaaaacttc
     3901 ccttctcggc tcatgttaca ccagctgttt tctctagctg atattttcta gacaagaata
     3961 agactgtttc cctgagttat cgcatgtaaa ggcttgcttt ttgtttagaa aaaaaaaaaa
     4021 tatggatgac tactgcctag atggttactt tgctttccat gaaatgctca gaaatgccag
     4081 aacattcctt ctctaattgt gtcagtgtgt attgtaataa aactactggt gtaaaataa
//
