LOCUS       NM_001107118            3319 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ring finger protein 6 (Rnf6), mRNA.
ACCESSION   NM_001107118 XM_001070453 XM_039089337 XM_221888
VERSION     NM_001107118.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3319)
  AUTHORS   Liu B, Zhang G, Cui S and Du G.
  TITLE     Inhibition of RNF6 alleviates traumatic brain injury by suppressing
            STAT3 signaling in rats
  JOURNAL   Brain Behav 10 (12), e01847 (2020)
   PUBMED   32955171
  REMARK    GeneRIF: Inhibition of RNF6 alleviates traumatic brain injury by
            suppressing STAT3 signaling in rats.
REFERENCE   2  (bases 1 to 3319)
  AUTHORS   Cai J, Xiong Q, Jiang X, Zhou S and Liu T.
  TITLE     RNF6 facilitates metastasis and radioresistance in hepatocellular
            carcinoma through ubiquitination of FoxA1
  JOURNAL   Exp Cell Res 374 (1), 152-161 (2019)
   PUBMED   30496760
REFERENCE   3  (bases 1 to 3319)
  AUTHORS   Xu K, Shimelis H, Linn DE, Jiang R, Yang X, Sun F, Guo Z, Chen H,
            Li W, Chen H, Kong X, Melamed J, Fang S, Xiao Z, Veenstra TD and
            Qiu Y.
  TITLE     Regulation of androgen receptor transcriptional activity and
            specificity by RNF6-induced ubiquitination
  JOURNAL   Cancer Cell 15 (4), 270-282 (2009)
   PUBMED   19345326
REFERENCE   4  (bases 1 to 3319)
  AUTHORS   Tursun B, Schluter A, Peters MA, Viehweger B, Ostendorff HP,
            Soosairajah J, Drung A, Bossenz M, Johnsen SA, Schweizer M, Bernard
            O and Bach I.
  TITLE     The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in
            axonal growth cones
  JOURNAL   Genes Dev 19 (19), 2307-2319 (2005)
   PUBMED   16204183
  REMARK    Erratum:[Genes Dev. 2005 Nov 1;19(21):2643]
REFERENCE   5  (bases 1 to 3319)
  AUTHORS   Lo HS, Hu N, Gere S, Lu N, Su H, Goldstein AM, Taylor PR and Lee
            MP.
  TITLE     Identification of somatic mutations of the RNF6 gene in human
            esophageal squamous cell carcinoma
  JOURNAL   Cancer Res 62 (15), 4191-4193 (2002)
   PUBMED   12154016
REFERENCE   6  (bases 1 to 3319)
  AUTHORS   Lopez P, Vidal F, Martin L, Lopez-Fernandez LA, Rual JF, Rosen BS,
            Cuzin F and Rassoulzadegan M.
  TITLE     Gene control in germinal differentiation: RNF6, a transcription
            regulatory protein in the mouse sertoli cell
  JOURNAL   Mol Cell Biol 22 (10), 3488-3496 (2002)
   PUBMED   11971979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000224.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001107118.3.
            
            On or before Mar 9, 2021 this sequence version replaced
            XM_039089337.1, NM_001107118.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487227.70506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               JACYVU010000224.1  4783368-4783587
            221-303             JACYVU010000224.1  4784332-4784414
            304-499             JACYVU010000224.1  4786251-4786446
            500-595             JACYVU010000224.1  4787982-4788077
            596-3319            JACYVU010000224.1  4790696-4793419
FEATURES             Location/Qualifiers
     source          1..3319
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..3319
                     /gene="Rnf6"
                     /note="ring finger protein 6"
                     /db_xref="GeneID:304271"
                     /db_xref="RGD:1306092"
     exon            1..220
                     /gene="Rnf6"
                     /inference="alignment:Splign:2.1.0"
     exon            221..303
                     /gene="Rnf6"
                     /inference="alignment:Splign:2.1.0"
     exon            304..499
                     /gene="Rnf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..2328
                     /gene="Rnf6"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein (C3H2C3 type) 6"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF6"
                     /protein_id="NP_001100588.1"
                     /db_xref="GeneID:304271"
                     /db_xref="RGD:1306092"
                     /translation="MNPSRSRSGGSGEEISFQENERRWQQERLHREEAYYQFINALND
                     EDYRLMRDHNLLGTPGDITSEELQQRLDRAKEQLVSQPGSGSGTSDGDSENLRENSDE
                     GSLLRWLSTFRRTGNVTRSGQNGSQSWRAVSRTNPNSGEFGFSLEIHINPDSRGSGVR
                     GAEPVDIPLSGVSREHGQQRPSSPVARRTRSQTSVSSSAGLSSAPGGRRSRRQGSVQG
                     SFSALGRLRNGIGAALGVSRVSAPRTHVINTHTNQSDGSAPRQSGRQRFGAAHIWENG
                     ARSNVTVRNTNQRLEPIRLRPALSSRSRSPIQRQNGTGHNSQRQGRPLQQTGRNRSVR
                     QRGGTRVFLEQGRERRGTDYTPLSNSRLVSRITVEEGESSRSSAATQRHPAITLDLQV
                     RRIRPGETRDRDSIANRTRSRAGLAESTVESNSGGFHRTISQLERSGVRTYVSTITVP
                     LRRISENEVVEPSSVALRSILRQIMTGFGELSSLMEVEPASENQSNDQHLPEVYLELS
                     NGGAADDSGQHGGGSSQAPQAQDDSAEMPDVSEPAPPQARTRSRRQLRRADNVVEAGT
                     LPILRLAHFFLLNEGDDDPIRGLTKEQIDNLSTRSYEQSAVDSELGKVCSVCISDYVA
                     GNKLRQLPCLHEFHIHCIDRWLSENCTCPVCRRPVLELGATDSG"
     exon            500..595
                     /gene="Rnf6"
                     /inference="alignment:Splign:2.1.0"
     exon            596..3319
                     /gene="Rnf6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagacgcacc gacagggtcg gcgcagacag tggcgtgcct tagttcttct agatggtgaa
       61 agaaggcctg agaccggacg gtcttctctc agctttctct ctgctcggtc gactccgagc
      121 agcagcagag actctaagct tcgcgcctca gtggaagatt agagggcgta gaggccttcg
      181 aaggctcggc cagtgaatct tccgccccct cactgcctcg atgagcagct ctcaaaaaag
      241 acagaaatat cagaagcatg gatacagtct tatctgttag aagaatgctc aaaggaaaat
      301 aaggaaacta gaagtctcag gatgaatcca tctagatcta gatcaggtgg tagtggagaa
      361 gaaatctcat ttcaagaaaa tgagagaaga tggcaacaag agcgtctcca cagagaagaa
      421 gcctattacc agtttattaa tgcgctcaat gatgaagatt atcggttaat gagagatcat
      481 aatcttttag gcacccctgg agacataaca tccgaggagc tacagcagcg cctggataga
      541 gcgaaggagc agctggtgtc tcagcctggc tcggggagtg ggacaagtga cggagactca
      601 gaaaacctta gagaaaattc agatgagggt tctctgctgc gatggctgag cactttccgg
      661 cgtactggga acgtgacgcg gagtgggcag aatgggagcc agagctggag ggctgtgagt
      721 cggacaaacc cgaacagtgg ggagttcggg ttcagcctgg agatccacat caaccctgac
      781 agcagaggct ccggagtgcg tggagcggag cctgtggaca ttcctctgtc aggtgtcagc
      841 agagagcatg ggcagcagag accctccagt cctgtggcta ggcgaacccg aagccagacc
      901 tccgtgagct ccagtgctgg tctctccagt gctcctgggg gcaggcgctc gaggaggcag
      961 ggctctgtgc aaggatcttt ctcagcactg gggaggttaa ggaatggcat tggagcagcg
     1021 cttggcgttt ccagagttag tgcccctcgc actcacgtta ttaacaccca cacgaaccag
     1081 tccgatggta gtgctcccag gcaaagtgga cggcagcggt ttggagcagc acatatttgg
     1141 gaaaatgggg ctagaagtaa tgttacagta aggaacacaa accaaagatt agagccaata
     1201 agattacgtc ctgctctcag tagtcgaagc cggtccccta ttcagagaca gaatggtact
     1261 ggtcataatt cccaaagaca gggtagaccg ctacagcaaa cgggtagaaa caggtctgtg
     1321 aggcagagag gtggaacaag ggtgttttta gaacaaggca gagaacgcag aggcaccgat
     1381 tataccccac tgtccaactc aagactcgtg tcaaggataa cagtagaaga aggagaatcc
     1441 agcaggtcct cagctgccac ccagcgccac ccagcaatca cactagacct gcaagtcagg
     1501 aggattcgtc ctggagaaac tagagatcgg gatagcattg caaatagaac ccggtctagg
     1561 gcagggctgg ccgaaagtac agttgagagc aacagtgggg gcttccacag aactatttct
     1621 cagttagaac ggtcgggtgt ccggacctat gtgagcacca ttacagttcc tcttcggagg
     1681 atttccgaga atgaggtggt tgagccatcc tctgtggctc ttcggtcaat tctaaggcag
     1741 atcatgactg ggtttggaga gctgagttct ctaatggagg tggagcctgc atcagagaat
     1801 caaagcaatg atcagcattt accagaggtg tacctagaac tgagtaatgg aggtgcagct
     1861 gatgacagcg gtcagcatgg aggaggctcc tcacaggccc ctcaggccca agacgacagt
     1921 gctgaaatgc cagatgtgag tgagcccgcc ccaccacagg ctcgcaccag aagtagaagg
     1981 cagttacgca gggcagacaa tgtcgttgag gctgggacat tgcccattct gcgccttgct
     2041 catttcttcc tactgaatga aggcgatgat gacccaattc gtggtctaac caaggagcag
     2101 attgacaatc tttctaccag gagttatgag caaagcgcag ttgacagtga gttaggtaaa
     2161 gtgtgcagtg tgtgcatcag tgactatgtg gccgggaaca agctccggca gctgccgtgc
     2221 ctgcacgagt tccacattca ctgtatcgat cgctggctgt cagagaactg cacctgcccc
     2281 gtctgtcggc gacctgtttt agaattgggg gccacagaca gcgggtgagc gatggggtct
     2341 gctcagtgct gtgtgttcct ggagtcatgg tcgaacactt ttcttgagtt acttgtgatg
     2401 gtgtaaccaa gacaaaaaaa cctatcagat tatagtttgc actatttttt gtgtgctttt
     2461 tttttaaaac ttgttacaga gagtttgttt atataaaaat ttaaaatgca gatgttaaat
     2521 tatccaaaag taaagaatag ttaatattgc tagaaccaaa taacctttaa aatgttttta
     2581 ttttggtaat tttgtcatgc taagcacttt tgtatctgca caactcagta tgttagggat
     2641 cttgattctt tctcaactct gcagtaggtt ttgctggggt ttcccagttc gagctcagtg
     2701 cttcctttgg acactactgt ctgagtcttc gtagcctgtt aggctgaatg tctgctagat
     2761 atacttaagt tacttgaatt ggtaatttag cacgtggcac acggcgcgtg tgtctgcagg
     2821 tatgtactgt gggaacatat ccaggctgac aactgcaggc tggagactga ggctgtgggg
     2881 cttagactgc acttggcaca gtgatcatct ctaagaggga gtgaattagt cgagatggag
     2941 attgtttact gaagcgtgtc tgacaatctg acctactaag agcgagcgat gtataataat
     3001 gaacctagta tttctttatt catggaatgt ggaaatttta tcacaaatat ttttagtttt
     3061 tcttttttgt gttttttttt tttttttttt tttttttttt tagaagtaca aacacttctg
     3121 gggttaggta gggtttacag catgcttgat ttctcaaatt tagttttaaa atctaaaata
     3181 ctttaaagtc tatgaagtag tgaaatgcat agaaaatatg taaatttgga tgccaaaaag
     3241 ctccaaatta aagcctttaa aagaacatag agtttatata aacacaaagt atgcattaaa
     3301 gtctatttct accagtaaa
//
