LOCUS       NM_001109025            1142 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus ring finger protein 5 (Rnf5), mRNA.
ACCESSION   NM_001109025
VERSION     NM_001109025.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1142)
  AUTHORS   El Khouri,E., Le Pavec,G., Toledano,M.B. and Delaunay-Moisan,A.
  TITLE     RNF185 is a novel E3 ligase of endoplasmic reticulum-associated
            degradation (ERAD) that targets cystic fibrosis transmembrane
            conductance regulator (CFTR)
  JOURNAL   J Biol Chem 288 (43), 31177-31191 (2013)
   PUBMED   24019521
REFERENCE   2  (bases 1 to 1142)
  AUTHORS   Kuang,E., Okumura,C.Y., Sheffy-Levin,S., Varsano,T., Shu,V.C.,
            Qi,J., Niesman,I.R., Yang,H.J., Lopez-Otin,C., Yang,W.Y.,
            Reed,J.C., Broday,L., Nizet,V. and Ronai,Z.A.
  TITLE     Regulation of ATG4B stability by RNF5 limits basal levels of
            autophagy and influences susceptibility to bacterial infection
  JOURNAL   PLoS Genet 8 (10), e1003007 (2012)
   PUBMED   23093945
  REMARK    Erratum:[PLoS Genet. 2020 May 11;16(5):e1008795. doi:
            10.1371/journal.pgen.1008795.. PMID: 32392217]
REFERENCE   3  (bases 1 to 1142)
  AUTHORS   Tcherpakov,M., Delaunay,A., Toth,J., Kadoya,T., Petroski,M.D. and
            Ronai,Z.A.
  TITLE     Regulation of endoplasmic reticulum-associated degradation by
            RNF5-dependent ubiquitination of JNK-associated membrane protein
            (JAMP)
  JOURNAL   J Biol Chem 284 (18), 12099-12109 (2009)
   PUBMED   19269966
REFERENCE   4  (bases 1 to 1142)
  AUTHORS   Zhong,B., Zhang,L., Lei,C., Li,Y., Mao,A.P., Yang,Y., Wang,Y.Y.,
            Zhang,X.L. and Shu,H.B.
  TITLE     The ubiquitin ligase RNF5 regulates antiviral responses by
            mediating degradation of the adaptor protein MITA
  JOURNAL   Immunity 30 (3), 397-407 (2009)
   PUBMED   19285439
REFERENCE   5  (bases 1 to 1142)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY573537.1 and BC088341.1.
            
            On Dec 27, 2007 this sequence version replaced NM_001109025.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088341.1, DV721801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DY573537.1         1-24
            25-1142             BC088341.1         1-1118
FEATURES             Location/Qualifiers
     source          1..1142
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1142
                     /gene="Rnf5"
                     /note="ring finger protein 5"
                     /db_xref="GeneID:407784"
                     /db_xref="RGD:1588458"
     exon            1..238
                     /gene="Rnf5"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..641
                     /gene="Rnf5"
                     /EC_number="2.3.2.27"
                     /note="ing finger protein 5 pseudogene; ring finger
                     protein 5, E3 ubiquitin protein ligase; RING-type E3
                     ubiquitin transferase RNF5"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF5"
                     /protein_id="NP_001102495.1"
                     /db_xref="GeneID:407784"
                     /db_xref="RGD:1588458"
                     /translation="MAAAEEEDGGPEGPNRERGGASATFECNICLETAREAVVSVCGH
                     LYCWPCLHQWLETRPDRQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQR
                     PAPESRGGFQPFGDAGGFHFSFGVGAFPFGFFTTVFNAHEPFRRGAGVDLGQGHPASS
                     WQDSLFLFLAIFFFFWLLSI"
     exon            239..257
                     /gene="Rnf5"
                     /inference="alignment:Splign:2.1.0"
     exon            258..370
                     /gene="Rnf5"
                     /inference="alignment:Splign:2.1.0"
     exon            371..425
                     /gene="Rnf5"
                     /inference="alignment:Splign:2.1.0"
     exon            426..543
                     /gene="Rnf5"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1118
                     /gene="Rnf5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgtgtgt gtgtgcccgt gtgtgtgccg tgtgtgagtg tatatgtgtg tgtgcctggg
       61 ggtactgagg gctacgtggg ggcgaagcag aacttgccat ggcagcagca gaggaagagg
      121 acgggggccc cgaagggcca aatcgcgagc ggggcggggc gagcgcgacc ttcgaatgta
      181 atatatgttt ggagacagct cgcgaagctg tggtcagcgt gtgtggccac ctctattgtt
      241 ggccctgtct ccatcagtgg ctggagacac ggccagaccg gcaagaatgc ccggtgtgta
      301 aagccggaat aagcagggag aaggtcgtcc ctctttatgg tcgagggagc cagaagccac
      361 aggatcccag attgaaaacc ccaccccgcc ctcagggcca gcggccagct ccggagagca
      421 gaggggggtt ccagccattc ggtgatgcag ggggatttca cttctccttt ggtgttggcg
      481 ccttcccctt tggcttcttt accaccgtgt tcaatgccca cgagcctttc cgaaggggtg
      541 caggtgtgga tctggggcag ggtcacccag cctccagctg gcaagattcc ttgttcctgt
      601 tcctcgccat ctttttcttt ttctggctgc tcagtatttg agccgcatct cctccctgcc
      661 cacctccagc tagaggagaa tcagtattgg gagtcccttg ctggcccttc cttgcttccg
      721 gaccaccctc ttacttccat gacccatctc tttgccgagg cctctttcgg gaggacgtgg
      781 ggaggagtga gcagtatgct taccatggga gtgcctgctg ctgtgtactg ctggcccagt
      841 agcacagaca cgcccagcct ggaggactag acaggtgtct ggttctcccc tctcccaagc
      901 ctttgctttc cccaagattt cttgatttgg tgtttaaagg tgggctctcc ccaactcctc
      961 cactcgactt aatttaattt ttctctccac actgtctaat atgaattttg actcttttaa
     1021 gtgtctcttt ccacccctca ctacctcctt tattacaaat tcaaataata ataataataa
     1081 taatgataat aataataaat gaaatgcatt gctgggaaaa aaaaaaaaaa aaaaaaaaaa
     1141 aa
//
