LOCUS       NM_001135921            3922 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ring finger protein 43 (Rnf43), mRNA.
ACCESSION   NM_001135921 XM_220829
VERSION     NM_001135921.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3922)
  AUTHORS   Wang,C., Ouyang,C., Cho,M., Ji,J., Sandhu,J., Goel,A., Kahn,M. and
            Fakih,M.
  TITLE     Wild-type APC Is Associated with Poor Survival in Metastatic
            Microsatellite Stable Colorectal Cancer
  JOURNAL   Oncologist 26 (3), 208-214 (2021)
   PUBMED   33230914
REFERENCE   2  (bases 1 to 3922)
  AUTHORS   Xu,T., Zhang,Y., Zhang,J., Qi,C., Liu,D., Wang,Z., Li,Y., Ji,C.,
            Li,J., Lin,X., Hou,T., Liu,H., Zhang,L., Han-Zhang,H., Shen,L. and
            Wang,X.
  TITLE     Germline Profiling and Molecular Characterization of Early Onset
            Metastatic Colorectal Cancer
  JOURNAL   Front Oncol 10, 568911 (2020)
   PUBMED   33194656
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3922)
  AUTHORS   Matsumoto,A., Shimada,Y., Nakano,M., Oyanagi,H., Tajima,Y.,
            Nakano,M., Kameyama,H., Hirose,Y., Ichikawa,H., Nagahashi,M.,
            Nogami,H., Maruyama,S., Takii,Y., Ling,Y., Okuda,S. and Wakai,T.
  TITLE     RNF43 mutation is associated with aggressive tumor biology along
            with BRAF V600E mutation in right-sided colorectal cancer
  JOURNAL   Oncol Rep 43 (6), 1853-1862 (2020)
   PUBMED   32236609
REFERENCE   4  (bases 1 to 3922)
  AUTHORS   Zhang,Y., Sun,L., Gao,X., Guo,A., Diao,Y. and Zhao,Y.
  TITLE     RNF43 ubiquitinates and degrades phosphorylated E-cadherin by c-Src
            to facilitate epithelial-mesenchymal transition in lung
            adenocarcinoma
  JOURNAL   BMC Cancer 19 (1), 670 (2019)
   PUBMED   31286874
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3922)
  AUTHORS   Wen,D., Wang,G., Huang,Z., Cui,X., Song,J., Zhu,Z. and Cui,L.
  TITLE     Reduced Frequency and Prognostic Significance of Ring Finger
            Protein 43 Nucleotide Polymorphisms in a Chinese Colorectal Cancer
            Cohort
  JOURNAL   DNA Cell Biol 38 (6), 541-548 (2019)
   PUBMED   31140864
REFERENCE   6  (bases 1 to 3922)
  AUTHORS   Koo,B.K., Spit,M., Jordens,I., Low,T.Y., Stange,D.E., van de
            Wetering,M., van Es,J.H., Mohammed,S., Heck,A.J., Maurice,M.M. and
            Clevers,H.
  TITLE     Tumour suppressor RNF43 is a stem-cell E3 ligase that induces
            endocytosis of Wnt receptors
  JOURNAL   Nature 488 (7413), 665-669 (2012)
   PUBMED   22895187
REFERENCE   7  (bases 1 to 3922)
  AUTHORS   Ong,C.K., Subimerb,C., Pairojkul,C., Wongkham,S., Cutcutache,I.,
            Yu,W., McPherson,J.R., Allen,G.E., Ng,C.C., Wong,B.H., Myint,S.S.,
            Rajasegaran,V., Heng,H.L., Gan,A., Zang,Z.J., Wu,Y., Wu,J.,
            Lee,M.H., Huang,D., Ong,P., Chan-on,W., Cao,Y., Qian,C.N.,
            Lim,K.H., Ooi,A., Dykema,K., Furge,K., Kukongviriyapan,V.,
            Sripa,B., Wongkham,C., Yongvanit,P., Futreal,P.A.,
            Bhudhisawasdi,V., Rozen,S., Tan,P. and Teh,B.T.
  TITLE     Exome sequencing of liver fluke-associated cholangiocarcinoma
  JOURNAL   Nat Genet 44 (6), 690-693 (2012)
   PUBMED   22561520
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3922)
  AUTHORS   Hao,H.X., Xie,Y., Zhang,Y., Charlat,O., Oster,E., Avello,M.,
            Lei,H., Mickanin,C., Liu,D., Ruffner,H., Mao,X., Ma,Q., Zamponi,R.,
            Bouwmeester,T., Finan,P.M., Kirschner,M.W., Porter,J.A.,
            Serluca,F.C. and Cong,F.
  TITLE     ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive
            manner
  JOURNAL   Nature 485 (7397), 195-200 (2012)
   PUBMED   22575959
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3922)
  AUTHORS   Okuno,K., Sugiura,F., Hida,J., Tokoro,T., Ishimaru,E. and Ueda,K.
  TITLE     [Preliminary study of Peptide vaccine with UFT/LV as adjuvant
            setting for stage III colorectal cancer]
  JOURNAL   Gan To Kagaku Ryoho 38 (12), 1906-1908 (2011)
   PUBMED   22202234
REFERENCE   10 (bases 1 to 3922)
  AUTHORS   Okuno,K., Sugiura,F., Hida,J.I., Tokoro,T., Ishimaru,E.,
            Sukegawa,Y. and Ueda,K.
  TITLE     Phase I clinical trial of a novel peptide vaccine in combination
            with UFT/LV for metastatic colorectal cancer
  JOURNAL   Exp Ther Med 2 (1), 73-79 (2011)
   PUBMED   22977472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 27, 2022 this sequence version replaced NM_001135921.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.206279.1,
                                           SRR26643297.35409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-501               JAXUCZ010000010.1  72963366-72963866
            502-624             JAXUCZ010000010.1  73017809-73017931
            625-699             JAXUCZ010000010.1  73026148-73026222
            700-831             JAXUCZ010000010.1  73026320-73026451
            832-936             JAXUCZ010000010.1  73026986-73027090
            937-1098            JAXUCZ010000010.1  73028402-73028563
            1099-1201           JAXUCZ010000010.1  73029231-73029333
            1202-2554           JAXUCZ010000010.1  73029948-73031300
            2555-3922           JAXUCZ010000010.1  73033173-73034540
FEATURES             Location/Qualifiers
     source          1..3922
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..3922
                     /gene="Rnf43"
                     /gene_synonym="RGD1305204"
                     /note="ring finger protein 43"
                     /db_xref="GeneID:303412"
                     /db_xref="RGD:1305204"
     exon            1..501
                     /gene="Rnf43"
                     /gene_synonym="RGD1305204"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..2598
                     /gene="Rnf43"
                     /gene_synonym="RGD1305204"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase RNF43"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF43 precursor"
                     /protein_id="NP_001129393.1"
                     /db_xref="GeneID:303412"
                     /db_xref="RGD:1305204"
                     /translation="MSGGHQLQLAVLWPWLLMATLHAGFGHTGLVLAAAVESERSAEQ
                     KAIIRVIPLKMDPTGKLNLTLEGVFAGVAEVSPAEGKLMQSHPLYLCNASDDDNLEPG
                     FISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRSAAEQLQQPLGLTKP
                     VVLIWGSDAEKLMEFVYKNRKAYVWIELKEPPAWANYDVWILLTVVGTVFVIILASVL
                     RIRCRPHPSRPDPLQQRTARAISQLATRRYQASCRRARAEWPDSGSSSSSAPVCAICL
                     EEFTEGQELRVISCLHEFHRTCVDPWLHQHRTCPLCMFNIVEGDSFSQALGASPSYQE
                     PGRRLHLIRQHPGHAHYHLPSAYLLGPSRNSVAQTPRPRPFLPSQEPSMGSRHQRLPR
                     ASHLRAPEEQQHLAVSPGHPYAQGWGPNRLRCTSQHPNACPVALRRARPHESSGSGES
                     YCTERSGYLADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFRSSLSSDFDP
                     LVYCSPEGALQGKEVQPSMTSRPRSLDSVVPTGETQVSSHIHYHRHRHHHYKKQFQWH
                     SRKPGLETGVPQSRPAASHTQLEPSLPDQQLTTPNPAVSSMLPNPQRPRALTEPAPGL
                     AEAVSPSPSPNPSLLNLQKSNLPVRYPQRKRRGGPSEALPTSQPQDLTVHTACPVPPH
                     YSPSLAYPWPPEVHPLIFRPPGLDRRLLHDVPGPCYSSSQPVWLYLNPRQPLGPCLPG
                     EGHSKWSFDTPEDRRCPYSHCQVLPAQPGSEEELEELCEQAV"
     exon            502..624
                     /gene="Rnf43"
                     /gene_synonym="RGD1305204"
                     /inference="alignment:Splign:2.1.0"
     exon            625..699
                     /gene="Rnf43"
                     /gene_synonym="RGD1305204"
                     /inference="alignment:Splign:2.1.0"
     exon            700..831
                     /gene="Rnf43"
                     /gene_synonym="RGD1305204"
                     /inference="alignment:Splign:2.1.0"
     exon            832..936
                     /gene="Rnf43"
                     /gene_synonym="RGD1305204"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1098
                     /gene="Rnf43"
                     /gene_synonym="RGD1305204"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1201
                     /gene="Rnf43"
                     /gene_synonym="RGD1305204"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..2554
                     /gene="Rnf43"
                     /gene_synonym="RGD1305204"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..3922
                     /gene="Rnf43"
                     /gene_synonym="RGD1305204"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgacaatggg agaaaatgac atacctgccc cagaggtggg ctgaaaagac catctcctcc
       61 tcccagccag gaatgccacc tgtacttggg aatctatttt agaaaaagga aggacatagg
      121 atctgactgg gctctctgaa acggaggaat agcatctctc cccttcattt tctgcaccga
      181 ggacctgcct tcgggatgag ctagtggaag cagtatgcat ggccggagaa cgttgatgca
      241 gctggtagca tgagtggtgg ccaccagctg cagctggctg tcctctggcc ctggctgctg
      301 atggcgacgc tgcatgcagg ctttggacac acaggactgg tgctggcagc agcggtggag
      361 tcggaaagat cagcagaaca gaaagctatc atcagagtga tccccctgaa aatggacccc
      421 acaggaaaac tgaacctcac cttggaaggt gtgtttgctg gtgttgcaga agtgagtcca
      481 gcagaaggga agctaatgca gtcccacccc ttgtacctgt gcaacgccag tgatgacgac
      541 aacctagagc ctggcttcat cagcatcgtc aagctggaga gtcctcggcg ggctcctcgc
      601 ccctgcctgt cactggccag taaggcgcga atggctggcg agcgaggagc cagcgctgtg
      661 ctctttgaca tcacagaaga ccgatcagct gctgagcagc tgcagcagcc cctggggctg
      721 actaagccgg tggtgctgat ctggggtagt gatgcggaga agctgatgga gtttgtgtac
      781 aagaatcgga aggcctatgt gtggattgag ctgaaggagc ccccggcttg ggcaaattac
      841 gatgtgtgga tcctcctgac tgtggtgggc acggtctttg tgatcatcct ggcttcggtg
      901 ctacgcatca ggtgtcgccc ccaccctagc agaccggacc ctcttcagca gcggacagcc
      961 cgggccatca gccagctggc caccaggagg taccaagcca gctgtagacg ggctcgagct
     1021 gagtggccag actcagggag cagcagcagc tcggcccctg tgtgtgctat ctgtctggaa
     1081 gagttcacag aggggcagga gctccgggtc atttcctgcc tccacgagtt tcatcgaacc
     1141 tgtgtggacc cctggctaca ccagcatcgg acttgccctc tctgcatgtt caacatcgta
     1201 gagggagatt cattttccca agccctggga gcttctccat cctaccagga accaggcaga
     1261 aggctccacc tcattcgcca acatcctggc cacgcccact atcatctccc ttctgcctac
     1321 ctgctgggcc cttccaggaa ttcagtagcc cagaccccaa gacctagacc cttcctgccc
     1381 tcccaggagc caagtatggg ctctcggcat cagcgccttc ccagggcttc ccatctccgg
     1441 gcaccagaag agcagcaaca cttggcagta tcccctgggc acccctacgc ccagggctgg
     1501 gggccaaatc gcctccgatg tacctctcag catcccaacg cttgcccagt ggccctacgg
     1561 cgggcccggc ctcatgagag cagtgggtct ggagaaagct actgtacgga acgcagtggt
     1621 tacttggctg atgggccagc cagcgactcc agctcagggc cctgtcatgg ctcttctagt
     1681 gactcagtgg tcaactgcac ggacatcagc ctgcagggcg tccatggcag cagttctacc
     1741 ttccggagct ccctgagcag tgactttgac cccttggtat actgtagccc tgaaggggct
     1801 ctccagggga aagaggtgca acctagcatg acctctcgac cccgctcgtt ggactcagtg
     1861 gtacccacgg gggagaccca ggtttccagc cacatacact atcaccggca ccgccaccac
     1921 cactacaaaa agcagttcca gtggcatagc aggaagcctg gcctagaaac tggggttcca
     1981 cagtccaggc ctgctgcttc tcacactcag ctggagccat ctctccctga ccagcagctc
     2041 accacaccca acccagcagt ttcctcaatg ctccccaacc cacaacggcc cagggccctt
     2101 acggagccag cccctggcct agcagaagct gtcagcccta gccccagtcc caaccccagt
     2161 cttttgaatt tgcagaaatc caacctcccc gtcagatacc cacagagaaa acggcggggt
     2221 ggcccctcag aagccctgcc aacctctcag ccccaggact tgactgtgca cacagcttgc
     2281 cccgttcccc cccactacag ccccagtcta gcataccctt ggcccccaga ggttcatcca
     2341 ttgatattca gacctccagg cctggatagg aggctgctac atgatgtacc aggcccctgt
     2401 tactcaagtt cacagccagt gtggttgtat ctgaatcccc gccagcctct gggaccatgc
     2461 ttacctggag agggacattc caagtggagt tttgacaccc cagaggacag gagatgtcct
     2521 tactcacact gccaggtgct gccagcccag cctggctcgg aagaggagct tgaagagctg
     2581 tgtgaacagg ctgtgtgaca ggagttggtc agatgaagct ctaacctcga gtgtgctcca
     2641 gatgactcag ggttctacct gggacagggt cctgctcatg ggaggagcaa ggaccttagc
     2701 aagcatctcc ttttgccata cttctgtgac cgatagaagt gtgctgatgg tgggtcgtgg
     2761 gaggtgctgt tcccagaccc cagtcatctt gtctgcacaa cacacaccta cagtgcagaa
     2821 agtcttgtgt ccaaccagac aaccagtcag tatacatttg tgggggagac tcttaaaggc
     2881 tgagtttttg acaggaagct atgactgaat agctagctgt cctaaaggtg ctgctccttc
     2941 ctcaagccct gctgggttcc cctgctgggt ctcctttgcc ccaggcctca agctcacaca
     3001 agccagtggg ttcaactgaa tgcacgacca cgtctcacct cctttcaagg cctcactggg
     3061 gcaacttcag ctttatcact tcctgtcttc acaaatgaac agtttaggtg agccccactc
     3121 ccaagagagg tctctgtacc ttctccagcc ggcacctgcc tgcttggtgc tcagggagga
     3181 gtgcttcttc ctttttgttc ttaaactaat cttaccccgc aggcttgggg gagccaagga
     3241 atagagttct gtcccagagg tgggtagtgt gacagacctg ggatgaatct tttgcttatc
     3301 aaacttcttg tcactccagc aaacccagtt cctctgaggt agagaacagg aatggaagga
     3361 attaatgctc cttgaagctt tcctatctct aagtccaagg caggcagaaa ggaatgtcta
     3421 ctaaacttca tttgggaaga gggggatgaa aggaaggcag agagagcaca gctacagccc
     3481 agaaaggacg ggattcttct ctgagagatt cttggagcag agatggagaa agataacatt
     3541 cgacctcctg ggtcaccttc ccagtataag ccatacaaac cagcaaccca cctgaaggtg
     3601 tgcaagtgga attggggtaa agagttggcc tgggcagctt gtgccaagtg ggcaagggct
     3661 gacgagcctc ctgtggctct tcaccccagg gcatcctgac catgtcagcc cctcaggcag
     3721 catccttgcc tgaaatgtga atgtgggggc aaagtgggca gaggatccta ctggggaacc
     3781 ttgtctcctc agagtcaatg gggagacaag catccaggca cccacatggg tatttatatc
     3841 tgaaccagac agaaagacgc ttgaatcagg cactatgttg agaaatgtat ttatttgcta
     3901 atatatttat ccataaatat ga
//
