LOCUS       NM_001401068            2389 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ring finger protein 41 (Rnf41), transcript
            variant 2, mRNA.
ACCESSION   NM_001401068 XM_006240772
VERSION     NM_001401068.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2389)
  AUTHORS   Zhu,J., Zhu,Z., Ren,Y., Dong,Y., Li,Y. and Yang,X.
  TITLE     Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent
            Hypoxia in Rats via Regulating the Protein Levels of ErbB3
  JOURNAL   Neurotox Res 38 (1), 124-132 (2020)
   PUBMED   32200526
  REMARK    GeneRIF: Role of the Nrdp1 in Brain Injury Induced by Chronic
            Intermittent Hypoxia in Rats via Regulating the Protein Levels of
            ErbB3.
REFERENCE   2  (bases 1 to 2389)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2389)
  AUTHORS   Zheng,J., Min,S., Hu,B., Liu,Q. and Wan,Y.
  TITLE     Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary
            bypass-induced cognitive dysfunction via the regulation of ErbB3
            protein levels
  JOURNAL   Int J Mol Med 43 (4), 1747-1757 (2019)
   PUBMED   30720051
  REMARK    GeneRIF: Nrdp1 serves an important role in regulating the apoptosis
            induced by cardiopulmonary bypass in vivo and in vitro through
            regulating ErbB3 and phosphoAKT protein levels.
REFERENCE   4  (bases 1 to 2389)
  AUTHORS   Hatakeyama,J., Wald,J.H., Rafidi,H., Cuevas,A., Sweeney,C. and
            Carraway,K.L. 3rd.
  TITLE     The ER structural protein Rtn4A stabilizes and enhances signaling
            through the receptor tyrosine kinase ErbB3
  JOURNAL   Sci Signal 9 (434), ra65 (2016)
   PUBMED   27353365
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2389)
  AUTHORS   Zhang,Y., Su,L. and Zhang,K.
  TITLE     Transcriptional Effects of E3 Ligase Nrdp1 on Hypertrophy in
            Neonatal Rat Cardiomyocytes by Microarray and Integrated Gene
            Network Analysis
  JOURNAL   Cardiology 135 (4), 203-215 (2016)
   PUBMED   27428330
  REMARK    GeneRIF: Pathway network analysis identified myocardial metabolism,
            DNA replication, and the cell cycle as the most important pathways
            targeted by Nrdp1.
REFERENCE   6  (bases 1 to 2389)
  AUTHORS   Zhang,Y., Zeng,Y., Wang,M., Tian,C., Ma,X., Chen,H., Fang,Q.,
            Jia,L., Du,J. and Li,H.
  TITLE     Cardiac-specific overexpression of E3 ligase Nrdp1 increases
            ischemia and reperfusion-induced cardiac injury
  JOURNAL   Basic Res Cardiol 106 (3), 371-383 (2011)
   PUBMED   21312039
REFERENCE   7  (bases 1 to 2389)
  AUTHORS   Jing,X., Infante,J., Nachtman,R.G. and Jurecic,R.
  TITLE     E3 ligase FLRF (Rnf41) regulates differentiation of hematopoietic
            progenitors by governing steady-state levels of cytokine and
            retinoic acid receptors
  JOURNAL   Exp Hematol 36 (9), 1110-1120 (2008)
   PUBMED   18495327
REFERENCE   8  (bases 1 to 2389)
  AUTHORS   Yu,F. and Zhou,J.
  TITLE     Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced
            oxidative stress
  JOURNAL   Neurosci Lett 440 (1), 4-8 (2008)
   PUBMED   18541373
REFERENCE   9  (bases 1 to 2389)
  AUTHORS   Yen,L., Cao,Z., Wu,X., Ingalla,E.R., Baron,C., Young,L.J.,
            Gregg,J.P., Cardiff,R.D., Borowsky,A.D., Sweeney,C. and
            Carraway,K.L. 3rd.
  TITLE     Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell
            growth
  JOURNAL   Cancer Res 66 (23), 11279-11286 (2006)
   PUBMED   17145873
REFERENCE   10 (bases 1 to 2389)
  AUTHORS   Qiu,X.B., Markant,S.L., Yuan,J. and Goldberg,A.L.
  TITLE     Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel
            pathway for triggering apoptosis
  JOURNAL   EMBO J 23 (4), 800-810 (2004)
   PUBMED   14765125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 1, 2022 this sequence version replaced XM_006240772.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.19614.1,
                                           SRR26643296.18813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000007.1  1422754-1422925
            173-264             JAXUCZ010000007.1  1424896-1424987
            265-447             JAXUCZ010000007.1  1426408-1426590
            448-560             JAXUCZ010000007.1  1438095-1438207
            561-832             JAXUCZ010000007.1  1444473-1444744
            833-968             JAXUCZ010000007.1  1445614-1445749
            969-1072            JAXUCZ010000007.1  1446095-1446198
            1073-2389           JAXUCZ010000007.1  1446848-1448164
FEATURES             Location/Qualifiers
     source          1..2389
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2389
                     /gene="Rnf41"
                     /note="ring finger protein 41"
                     /db_xref="GeneID:362814"
                     /db_xref="RGD:1309557"
     exon            1..172
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            173..264
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            265..447
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            448..560
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     CDS             471..1424
                     /gene="Rnf41"
                     /EC_number="6.3.2.38"
                     /note="isoform 1 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase NRDP1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NRDP1 isoform 1"
                     /protein_id="NP_001387997.1"
                     /db_xref="GeneID:362814"
                     /db_xref="RGD:1309557"
                     /translation="MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACIT
                     QWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDSLMSH
                     LSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHK
                     HQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMI
                     STPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYV
                     AKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI"
     exon            561..832
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            833..968
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1072
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..2389
                     /gene="Rnf41"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagggctag ctcgagaagg cgaggagtgg tcggaacctt cttctccatc cttctcttcc
       61 ccttccccta cggggaaagg ttgagacccg gtacgcaggc tgcgccgcgg cccccgtggc
      121 ctcagctaca gccaggtccc gcgtccggag aagccaggcc gcgtcccgtg cgttgtctga
      181 gaagggctcc tgcctcgtag cctctgctga ccttgagttc acagtgacct tcccaactca
      241 gcctcccagg tgttgggatt gcagagcgct cctgattgtg acatcacacc cacccctggg
      301 ccatgaaact tgtctctagg aagaaagact cagttggaga atagccaaca agatgggata
      361 cttggagtgt ctcctgagtg gcaccaagca gaggcatcag gggcttggaa ccttgtgaac
      421 agggaacctg cccccaccac ttagaaggac ctgggtttca gtgatgagac atggggtatg
      481 atgtaacccg gttccagggg gacgttgacg aggacctcat ctgccctatt tgcagtggag
      541 tcttggagga gccagtacag gcgcctcatt gtgagcatgc cttctgcaac gcctgcatca
      601 cccaatggtt ctctcagcag cagacgtgtc cggtagaccg tagcgttgtc acggttgccc
      661 acctgcgccc agtgcctcgg atcatgcgga acatgttgtc aaagctgcag attgcctgtg
      721 acaacgctgt gtttggctgc agtgctgttg tcaggcttga cagcctcatg tcccacctca
      781 gtgactgtga gcacaacccg aagcggcctg tgacctgcga gcagggctgc ggcctggaga
      841 tgcccaaaga tgagctgcca aaccacaatt gcattaagca cctgcgctcc gtggtccagc
      901 agcagcagac gcgcatcgca gagctggaga agacatctgc tgaacacaag caccagctgg
      961 cagaacagaa gcgagacatt cagttgctga aggcgtatat gcgagccatc cgcagtgtca
     1021 accccaacct tcagaacctg gaggagacaa tcgagtacaa cgagatcctt gagtgggtga
     1081 actccctaca gccggcaaga gtgacgcgct ggggggggat gatctccact cctgacgctg
     1141 tgctgcaggc tgtaatcaag cgctccctcg tggaaagtgg ctgcccagct tctatcgtca
     1201 acgagctgat cgaaaatgcc catgaacgca gctggcccca gggtctggcc acactagaga
     1261 caagacagat gaaccggcgc tactatgaga actacgtggc caagcgcatc cctggcaagc
     1321 aggctgtggt ggtgatggcc tgcgagaacc agcacatggg tgacgacatg gtgcaggagc
     1381 cggggctggt catgatcttt gcacatggtg tggaggagat ttaagagcgt gactgactat
     1441 gaggaagagg tagagtggga acctatggcc gctccagcag ctgagccctg acctccccac
     1501 acacaaccct gtgccacggc ttgtactgga gcctcgcact ccctgcttct ggcatgaagg
     1561 accttgggcc acttagctca gcctttcagc ggggaaccca agttcctgcc ttttgctata
     1621 ttcctccccc cacaatgtct gtaaattttc agtcagggtg gagaaatccc cacttctgta
     1681 tttgctgact aagatccctg gttcccaaat attttcagaa agcacaaaga cacttgtttt
     1741 ccctagaggg tcagggtgga gtgaggcatt tctacacttg atcttagcca aaaggccgag
     1801 aagcgatgag tgaggcattt ctaattgtcc ctctcttcca aaaccagggg atccaagcag
     1861 gcaggcttgc tggctccatg cagcattgag agagcagctc tgacatccag cagaagggct
     1921 aacagtgtga ccaaagcccc tctaactagt gaggccagga cttggtcctc actaacagcc
     1981 cttggggaag acctttgtgc tgagcacatc cctgtccagg cccctgtgac tgtgcaggcc
     2041 ttgctgggtg tgcagggaag gaagagggta ggcattggtg ttcacgcact cagcaggaaa
     2101 gctgtctggc tctgctgaag gaggatacca ctgccccttg aggcacgtct atgttgcctc
     2161 gtaggcccct cttcagtcct gtgattgtag ttggctggat ttcctttggt gtttgtttat
     2221 attccccaag tctcaaacct catctgttac ccagtcttgt tttcatagaa tggactggct
     2281 gtgtctgtcc tccgatccag cccagccaca ttgttggcaa tttaatttat ttactttttt
     2341 ttttttaaga aaggagaaaa gaaaaaaaaa tgaagaaaac ttaaaacct
//
