LOCUS       NM_153471               3421 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus ring finger protein 40 (Rnf40), mRNA.
ACCESSION   NM_153471
VERSION     NM_153471.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3421)
  AUTHORS   Stracker,T.H., Roig,I., Knobel,P.A. and Marjanovic,M.
  TITLE     The ATM signaling network in development and disease
  JOURNAL   Front Genet 4, 37 (2013)
   PUBMED   23532176
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3421)
  AUTHORS   Lee,Y.J., Lee,J.E., Choi,H.J., Lim,J.S., Jung,H.J., Baek,M.C.,
            Frokiaer,J., Nielsen,S. and Kwon,T.H.
  TITLE     E3 ubiquitin-protein ligases in rat kidney collecting duct:
            response to vasopressin stimulation and withdrawal
  JOURNAL   Am J Physiol Renal Physiol 301 (4), F883-F896 (2011)
   PUBMED   21734099
REFERENCE   3  (bases 1 to 3421)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3421)
  AUTHORS   Pirngruber,J., Shchebet,A., Schreiber,L., Shema,E., Minsky,N.,
            Chapman,R.D., Eick,D., Aylon,Y., Oren,M. and Johnsen,S.A.
  TITLE     CDK9 directs H2B monoubiquitination and controls
            replication-dependent histone mRNA 3'-end processing
  JOURNAL   EMBO Rep 10 (8), 894-900 (2009)
   PUBMED   19575011
REFERENCE   5  (bases 1 to 3421)
  AUTHORS   Kim,J., Guermah,M., McGinty,R.K., Lee,J.S., Tang,Z., Milne,T.A.,
            Shilatifard,A., Muir,T.W. and Roeder,R.G.
  TITLE     RAD6-Mediated transcription-coupled H2B ubiquitylation directly
            stimulates H3K4 methylation in human cells
  JOURNAL   Cell 137 (3), 459-471 (2009)
   PUBMED   19410543
REFERENCE   6  (bases 1 to 3421)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
REFERENCE   7  (bases 1 to 3421)
  AUTHORS   Chin,L.S., Vavalle,J.P. and Li,L.
  TITLE     Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin
            1 for degradation
  JOURNAL   J Biol Chem 277 (38), 35071-35079 (2002)
   PUBMED   12121982
  REMARK    GeneRIF: a novel E3 ubiquitin-protein ligase that targets syntaxin
            1 for degradation
REFERENCE   8  (bases 1 to 3421)
  AUTHORS   Wen,H. and Ao,S.
  TITLE     RBP95, a novel leucine zipper protein, binds to the retinoblastoma
            protein
  JOURNAL   Biochem Biophys Res Commun 275 (1), 141-148 (2000)
   PUBMED   10944455
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF352815.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF352815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..3421
                     /gene="Rnf40"
                     /note="ring finger protein 40"
                     /db_xref="GeneID:266712"
                     /db_xref="RGD:628638"
     exon            1..20
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            21..224
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..3101
                     /gene="Rnf40"
                     /EC_number="2.3.2.27"
                     /note="BRE1-B; protein staring; syntaxin-1-interacting
                     RING finger protein; staring protein; ring finger protein
                     40, E3 ubiquitin protein ligase; RING-type E3 ubiquitin
                     transferase BRE1B"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase BRE1B"
                     /protein_id="NP_703201.1"
                     /db_xref="GeneID:266712"
                     /db_xref="RGD:628638"
                     /translation="MSGLSNKRAAGDGGSGPPEKKLNREEKTTTTLIEPIRLGGISST
                     EEMDSKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLD
                     ETVEALLQCYENQRELSSSGTEVPGCQEGLTRDVIPRTDPGTSDLREPLPMQFRAPLS
                     EPALAFVVALGASSCEEVELQLQGRMEFSKAAVSRVVEASDRLQRQVEELCQRVYSRG
                     DSEAPGEVARARTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSTETKVLEM
                     ETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSTGFQGGQITLSMQKFE
                     MLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRML
                     QAQFSLLYNESLQVKTQLDEARGLLLASKNSHLRHIEHMESDELGLQKKLRTEVIQLE
                     DTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRK
                     LREVQAEIGKLRAQASGSSHCGPNLSHPDDSGLNALAPGKEDSGPGPGGTPDSKKELA
                     LVAGATSVASSVKKEELVSSEDDAQALAPGTQGLPSRGREPEARPKRELREREGPSLG
                     PPPAASTLSRADREKAKAEEARRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPK
                     EQRDKVQLMAAERKAKAEVDELRSRIRDLEERDRRESKKIADEDALRRIRQAEEQIEH
                     LQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKAN
                     QIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQA
                     LELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDIS
                     RLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFEC
                     VRGRYEARQRKCPKCNAAFGAHDFHRVYIS"
     exon            225..392
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            393..537
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            538..744
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            745..866
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1013
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1088
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1208
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1388
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1524
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1646
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..2074
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2192
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2342
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2555
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2681
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2822
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2924
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3421
                     /gene="Rnf40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcttggc tgaccctacc gtgacggaag tgccgcctcc gcccgcctga cagccccgga
       61 gagctctgag ctgtccctcc gccaccgccg ctatgtctgg cctcagcaac aagcgcgccg
      121 ccggcgacgg gggctcagga cccccagaga agaagctgaa ccgcgaggag aagactacga
      181 ccactctaat cgagcccatt cgtctcgggg gcatttcttc cacggaggag atggattcca
      241 aggtgctgca gtttaagaat aagaagctgg cggagcggct ggagcagcgg caagcctgtg
      301 aggacgagct ccgggagaga attgagaaat tggagaagag gcaggccacg gacgatgcca
      361 cactcctcat cgtcaaccgc tactgggccc agctggatga aactgtagaa gcccttctcc
      421 agtgctacga gaaccagagg gagctgtctt catcagggac agaggtgcct gggtgccaag
      481 agggcctaac ccgtgatgtg atccctcgaa cagatccagg gacatcagat ctgagggaac
      541 cactgccgat gcagttccga gcccctctca gtgagccagc cttggctttt gtggtggcac
      601 tgggcgccag cagctgtgag gaagtagagc tgcagctgca gggtcgcatg gaattctcca
      661 aggctgctgt gtctcgggtg gtagaggcct cggaccgcct acagcgtcag gtggaagaac
      721 tctgtcagcg agtatacagc cggggggaca gtgaggcgcc cggggaggtg gcacgggcac
      781 gcacccggga actaggcaga gagaaccgta ggctacagga cttggccact cagctgcagg
      841 agaagcacca ccgcatctcg ttggagtact ctgagctcca agacaaagtg acatcgacgg
      901 agaccaaggt cctagagatg gagacaacag tggaggactt acagtgggac atcgagaagc
      961 tgcgcaagcg agaacagaag ctcaataagc acttggcaga ggccttggag cagctcaact
     1021 ctggctacta tgtgtctggg agctccacgg gctttcaggg aggccagatt acacttagca
     1081 tgcagaagtt tgagatgttg aatgcagagc tggaagaaaa tcaggaattg gccaatagcc
     1141 gaatggcaga gctcgagaag ttacaggctg agcttcaggg ggctgttcgg accaatgaac
     1201 gtctcaaggt ggccctgcga agccttcctg aggaggtcgt tcgtgagacg ggggagtacc
     1261 gcatgctgca ggcccagttc tcactgctct acaatgagtc tttgcaagtg aagacccagc
     1321 tagatgaggc ccggggactg ctgctggcct ccaagaactc ccacttgaga cacatcgaac
     1381 atatggagag cgatgagttg gggctgcaga agaagctgcg cacagaagtt atccagctgg
     1441 aagacaccct ggcccaggta cgcaaggagt acgagatgct gcgcattgag tttgagcaga
     1501 accttgcggc caacgagcag gctgggccta tcaaccgtga aatgcgccac ctgattagca
     1561 gcctccagaa ccacaatcac cagctaaaag gagatgccca gcgatataag cggaaacttc
     1621 gagaagtaca ggctgagatt ggtaaactcc gggcacaggc cagcggctct tcccactgcg
     1681 gccccaactt gagccaccct gatgactctg gcctcaatgc ccttgcccca gggaaagaag
     1741 atagtgggcc tggccctgga ggcacccctg acagcaagaa ggagttggct ttagtggcgg
     1801 gagctacgtc tgttgcttct tccgtaaaga aagaggagct ggtctcctcc gaagatgatg
     1861 cccaggccct agcccctgga acccagggct tgccctcccg gggccgagaa cctgaggcca
     1921 gacccaagcg agaacttcgg gaacgggaag ggcctagcct gggaccccca cctgcagcct
     1981 ccactctgtc cagggctgat cgagaaaagg ccaaggcaga ggaagccagg aggaaggaat
     2041 cagaactgct caaaggtctc cgagcagagc tcaagaaggc ccaggaaagc cagaaggaga
     2101 tgaagctgct gctggacatg tacaagtccg cacccaagga gcagcgggat aaggtgcaac
     2161 tcatggcagc tgaacggaag gccaaggccg aggtggatga gcttcggagc cgcatccgag
     2221 acctggaaga gagagaccga agagaaagca agaagattgc cgatgaggat gccctgcggc
     2281 ggatccggca ggcagaagag cagattgaac acttgcaacg caaattgggt gcgaccaagc
     2341 aggaggaaga ggcactgctg tcggagatgg atgtgacagg tcaagccttt gaagacatgc
     2401 aggagcaaaa cgggcggctg ctccagcagt tacgggaaaa ggatgacgcc aactttaagc
     2461 tcatgtcaga gaggatcaag gccaaccaga ttcacaagct gctccgagaa gagaaggacg
     2521 agttgggcga gcaggttctt ggccttaagt cccaggtgga tgcccagctg ttgacagtcc
     2581 agaagcttga ggaaaaggag cgggctctgc agggcagcct tgggggtgtc gagaaggagt
     2641 tgacattgcg cagccaggcc ctggagctta ataagagaaa ggctgtagaa gcagcccagt
     2701 tggctgagga cctgaaggtg cagttggagc acgtgcagac tcggcttcga gagatccagc
     2761 cctgcctggc agagagccgg gctgcccggg agaaagagag cttcaacctc aagagagctc
     2821 aggaggacat ttcccggctg cggcgcaaac tagagaaaca gcggaaagta gaagtttatg
     2881 cagatgcgga tgagatcctg caggaagaga tcaaggagta caaggcccgg ctgacctgcc
     2941 cctgctgtaa cacccgcaag aaggacgctg tgcttaccaa gtgcttccac gtcttctgct
     3001 ttgaatgcgt gcggggccgc tatgaggccc gccagaggaa gtgtcccaag tgcaacgctg
     3061 cctttggtgc ccacgacttc caccgtgtgt acatcagctg aacctgaaac tcaggggact
     3121 ttgaaacatc catataccct aggggctgtg cccccagctc cccactcccc cgggggcaat
     3181 ggccccaacc tcccttccag actccatgag cccagcccct ctatgccgag atggtttggg
     3241 gccactggtg catgcaggag aggtgggact aaccgagctg agtgccatct cctgaatgtc
     3301 acatctgcag cctctgggac tcccgggttc acaacatccc actgtaacct cgggagctgg
     3361 ccagacctgt ttctactgag aaggcagata catccttgcc cctaaagggg atccctccac
     3421 c
//
