LOCUS       NM_019182               1040 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ring finger protein 4 (Rnf4), mRNA.
ACCESSION   NM_019182
VERSION     NM_019182.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1040)
  AUTHORS   Branigan,E., Plechanovova,A., Jaffray,E.G., Naismith,J.H. and
            Hay,R.T.
  TITLE     Structural basis for the RING-catalyzed synthesis of K63-linked
            ubiquitin chains
  JOURNAL   Nat Struct Mol Biol 22 (8), 597-602 (2015)
   PUBMED   26148049
  REMARK    GeneRIF: Data suggest that ubiquitin-conjugating enzyme E2 variant
            2 (Ube2V2) and ring finger protein 4 (RNF4) together induce an
            active conformation of the ubiquitin-conjugating enzyme
            Ubc13-ubiquitin (Ubc13~Ub) thioester.
REFERENCE   2  (bases 1 to 1040)
  AUTHORS   Groocock,L.M., Nie,M., Prudden,J., Moiani,D., Wang,T., Cheltsov,A.,
            Rambo,R.P., Arvai,A.S., Hitomi,C., Tainer,J.A., Luger,K.,
            Perry,J.J., Lazzerini-Denchi,E. and Boddy,M.N.
  TITLE     RNF4 interacts with both SUMO and nucleosomes to promote the DNA
            damage response
  JOURNAL   EMBO Rep 15 (5), 601-608 (2014)
   PUBMED   24714598
REFERENCE   3  (bases 1 to 1040)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   4  (bases 1 to 1040)
  AUTHORS   Panier,S. and Durocher,D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   5  (bases 1 to 1040)
  AUTHORS   Plechanovova,A., Jaffray,E.G., Tatham,M.H., Naismith,J.H. and
            Hay,R.T.
  TITLE     Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for
            catalysis
  JOURNAL   Nature 489 (7414), 115-120 (2012)
   PUBMED   22842904
  REMARK    GeneRIF: crystal structure of the dimeric RING domain of rat RNF4
            in complex with E2 (UbcH5A) linked by an isopeptide bond to
            ubiquitin
REFERENCE   6  (bases 1 to 1040)
  AUTHORS   Adams,V., Lenk,K., Schubert,A., Gielen,S., Schuler,G. and
            Hambrecht,R.
  TITLE     Differentially expressed genes in L6 rat skeletal muscle myoblasts
            after incubation with inflammatory cytokines
  JOURNAL   Cytokine 13 (6), 342-348 (2001)
   PUBMED   11292317
REFERENCE   7  (bases 1 to 1040)
  AUTHORS   Lyngso,C., Bouteiller,G., Damgaard,C.K., Ryom,D., Sanchez-Munoz,S.,
            Norby,P.L., Bonven,B.J. and Jorgensen,P.
  TITLE     Interaction between the transcription factor SPBP and the positive
            cofactor RNF4. An interplay between protein binding zinc fingers
  JOURNAL   J Biol Chem 275 (34), 26144-26149 (2000)
   PUBMED   10849425
REFERENCE   8  (bases 1 to 1040)
  AUTHORS   Galili,N., Nayak,S., Epstein,J.A. and Buck,C.A.
  TITLE     Rnf4, a RING protein expressed in the developing nervous and
            reproductive systems, interacts with Gscl, a gene within the
            DiGeorge critical region
  JOURNAL   Dev Dyn 218 (1), 102-111 (2000)
   PUBMED   10822263
REFERENCE   9  (bases 1 to 1040)
  AUTHORS   Moilanen,A.M., Poukka,H., Karvonen,U., Hakli,M., Janne,O.A. and
            Palvimo,J.J.
  TITLE     Identification of a novel RING finger protein as a coregulator in
            steroid receptor-mediated gene transcription
  JOURNAL   Mol Cell Biol 18 (9), 5128-5139 (1998)
   PUBMED   9710597
REFERENCE   10 (bases 1 to 1040)
  AUTHORS   Chakraborty,C., Sharma,S., Katsumata,N., Murphy,L.J.,
            Schroedter,I.C., Robertson,M.C., Shiu,R.P. and Friesen,H.G.
  TITLE     Plasma clearance, tissue uptake and expression of pituitary peptide
            23/pancreatitis-associated protein in the rat
  JOURNAL   J Endocrinol 145 (3), 461-469 (1995)
   PUBMED   7636430
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062024.1.
            
            On Jun 10, 2007 this sequence version replaced NM_019182.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062024.1, FN804513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1040
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1040
                     /gene="Rnf4"
                     /note="ring finger protein 4"
                     /db_xref="GeneID:29274"
                     /db_xref="RGD:3583"
     exon            1..122
                     /gene="Rnf4"
                     /inference="alignment:Splign:2.1.0"
     exon            123..280
                     /gene="Rnf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..856
                     /gene="Rnf4"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin ligase RNF4; SNURF; small nuclear ring
                     finger protein; RING-type E3 ubiquitin transferase RNF4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF4"
                     /protein_id="NP_062055.1"
                     /db_xref="GeneID:29274"
                     /db_xref="RGD:3583"
                     /translation="MSTRNPQRKRRGGAVNSRQTQKRTRETTSTPEISLEAEPIELVE
                     TVGDEIVDLTCESLEPVVVDLTHNDSVVIVEERRRPRRNGRRLRQDHADSCVVSSDDE
                     ELSKDKDVYVTTHTPRSTKDEGTTGLRPSGTVSCPICMDGYSEIVQNGRLIVSTECGH
                     VFCSQCLRDSLKNANTCPTCRKKINHKRYHPIYI"
     exon            281..407
                     /gene="Rnf4"
                     /inference="alignment:Splign:2.1.0"
     exon            408..487
                     /gene="Rnf4"
                     /inference="alignment:Splign:2.1.0"
     exon            488..497
                     /gene="Rnf4"
                     /inference="alignment:Splign:2.1.0"
     exon            498..657
                     /gene="Rnf4"
                     /inference="alignment:Splign:2.1.0"
     exon            658..706
                     /gene="Rnf4"
                     /inference="alignment:Splign:2.1.0"
     exon            707..964
                     /gene="Rnf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtgggtct tcgtgagacg gtggagtctt gcttgagcgg gtctcctcag cggctgctgg
       61 attaggtgcg tccttgctcg agcgcggtgg ccaaggcgtt tggctgataa caccaactcc
      121 aaaatttaga cattctgaac atctagttgg ctccaaattg tgaaccacag gatgagtatt
      181 cagtgggcat gagagattga gaacattcta ccacaccata aaccttggtg tagatcactt
      241 cctattctgt ggattgaagc cagagagcac aatgagtaca agaaatcctc aaagaaagcg
      301 gcgtggtgga gctgtgaatt ctagacaaac ccagaagcga actcgggaaa caacttcaac
      361 ccctgagatt tccttggaag cagaacccat agaacttgtg gaaaccgttg gagatgaaat
      421 cgtggacctc acctgtgaat ctttagagcc tgtggttgtg gacctgactc acaatgactc
      481 tgttgtgatt gttgaagaaa ggagaaggcc aaggagaaat gggaggaggt tgcgccaaga
      541 ccatgctgac agctgtgtgg tgagcagtga tgatgaagaa ctgtctaagg acaaagatgt
      601 atacgtgact acccatactc ctcgaagcac caaggatgaa ggaactactg gacttaggcc
      661 ctcgggcacc gtcagttgtc cgatctgcat ggatggatac tctgagattg tgcagaatgg
      721 gcgtctcatt gtttctacag aatgtggcca cgtcttctgt agccagtgcc tccgtgattc
      781 ccttaagaat gctaacactt gcccaacttg taggaaaaag atcaaccata aacggtacca
      841 tcccatttat atatgaaatg ttcacaactg ctcaggatag accaatggac agacaaccgg
      901 gctggctttt ctgcatggta tctgcctcca gtttcctgag ctcaaaaaga ctttcaaaaa
      961 tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1021 aaaaaaaaaa aaaaaaaaaa
//
