LOCUS       NM_001004075            1985 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus ring finger protein 34 (Rnf34), mRNA.
ACCESSION   NM_001004075 XM_341082
VERSION     NM_001004075.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1985)
  AUTHORS   Yamaoka,S., Oshima,Y., Horiuchi,H., Morino,T., Hino,M., Miura,H.
            and Ogata,T.
  TITLE     Altered Gene Expression of RNF34 and PACAP Possibly Involved in
            Mechanism of Exercise-Induced Analgesia for Neuropathic Pain in
            Rats
  JOURNAL   Int J Mol Sci 18 (9), 1962 (2017)
   PUBMED   28902127
  REMARK    GeneRIF: Results suggest that exercise therapy possibly involves
            pain relief in SNL rats by suppressing Rnf34 and Pacap expression
            in the spinal cord.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1985)
  AUTHORS   Jin,H., Chiou,T.T., Serwanski,D.R., Miralles,C.P., Pinal,N. and De
            Blas,A.L.
  TITLE     Ring finger protein 34 (RNF34) interacts with and promotes
            gamma-aminobutyric acid type-A receptor degradation via
            ubiquitination of the gamma2 subunit
  JOURNAL   J Biol Chem 289 (42), 29420-29436 (2014)
   PUBMED   25193658
  REMARK    GeneRIF: RNF34 regulates postsynaptic gamma2-GABAAR clustering and
            GABAergic synaptic innervation by interacting with and
            ubiquitinating the gamma2-GABAAR subunit promoting GABAAR
            degradation
REFERENCE   3  (bases 1 to 1985)
  AUTHORS   Zhang,R., Zhao,J., Song,Y., Wang,X., Wang,L., Xu,J., Song,C. and
            Liu,F.
  TITLE     The E3 ligase RNF34 is a novel negative regulator of the NOD1
            pathway
  JOURNAL   Cell Physiol Biochem 33 (6), 1954-1962 (2014)
   PUBMED   25012219
REFERENCE   4  (bases 1 to 1985)
  AUTHORS   Wei,P., Pan,D., Mao,C. and Wang,Y.X.
  TITLE     RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1alpha and
            modulates brown fat cell metabolism
  JOURNAL   Mol Cell Biol 32 (2), 266-275 (2012)
   PUBMED   22064484
REFERENCE   5  (bases 1 to 1985)
  AUTHORS   Yang,W., Dicker,D.T., Chen,J. and El-Deiry,W.S.
  TITLE     CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing
            MDM2
  JOURNAL   Cell Cycle 7 (5), 670-682 (2008)
   PUBMED   18382127
REFERENCE   6  (bases 1 to 1985)
  AUTHORS   Yang,W., Rozan,L.M., McDonald,E.R. 3rd, Navaraj,A., Liu,J.J.,
            Matthew,E.M., Wang,W., Dicker,D.T. and El-Deiry,W.S.
  TITLE     CARPs are ubiquitin ligases that promote MDM2-independent p53 and
            phospho-p53ser20 degradation
  JOURNAL   J Biol Chem 282 (5), 3273-3281 (2007)
   PUBMED   17121812
REFERENCE   7  (bases 1 to 1985)
  AUTHORS   McDonald,E.R. 3rd and El-Deiry,W.S.
  TITLE     Suppression of caspase-8- and -10-associated RING proteins results
            in sensitization to death ligands and inhibition of tumor cell
            growth
  JOURNAL   Proc Natl Acad Sci U S A 101 (16), 6170-6175 (2004)
   PUBMED   15069192
REFERENCE   8  (bases 1 to 1985)
  AUTHORS   Araki,K., Kawamura,M., Suzuki,T., Matsuda,N., Kanbe,D., Ishii,K.,
            Ichikawa,T., Kumanishi,T., Chiba,T., Tanaka,K. and Nawa,H.
  TITLE     A palmitoylated RING finger ubiquitin ligase and its homologue in
            the brain membranes
  JOURNAL   J Neurochem 86 (3), 749-762 (2003)
   PUBMED   12859687
  REMARK    GeneRIF: identified two novel Ub ligases, Momo and Sakura, carrying
            double zinc finger motif and RING finger domain; momo expression is
            enriched in the brain gray matter and testis
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079044.1.
            
            On Sep 3, 2004 this sequence version replaced XM_341082.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079044.1, SRR8487231.120655.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1985
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1985
                     /gene="Rnf34"
                     /gene_synonym="Momo"
                     /note="ring finger protein 34"
                     /db_xref="GeneID:282845"
                     /db_xref="RGD:628636"
     exon            1..101
                     /gene="Rnf34"
                     /gene_synonym="Momo"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1241
                     /gene="Rnf34"
                     /gene_synonym="Momo"
                     /EC_number="2.3.2.27"
                     /note="RING finger protein MOMO; ring finger protein 34,
                     E3 ubiquitin protein ligase; RING-type E3 ubiquitin
                     transferase RNF34"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF34"
                     /protein_id="NP_001004075.1"
                     /db_xref="GeneID:282845"
                     /db_xref="RGD:628636"
                     /translation="MKAGATSMWASCCGLLNEVMGTGAVRGQQAGFPGSTGPFRFTPS
                     SDFPTYPPAATEGPNIVCKACGLSFSVFRKKHVCCDCKKDFCSLCSVSQENLRRCSTC
                     HLLQETAFQRPQLMRLKVKDLRQYLLLRNVPTDTCREKEDLVDLVLCHRGLGSGDGLD
                     SRSLSSSRSQTSSFFTQSYFSNYTPPSATVSSFQGELMDREGTFRSEVLTQVQSELAS
                     ANTDDEDGEEDDDDDDDDDDEDDDEQEENLEEQNPGLSKKKARASLSDLSSLEEVEGM
                     SVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYGERMQLQDEEDDSLC
                     RICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS"
     exon            102..320
                     /gene="Rnf34"
                     /gene_synonym="Momo"
                     /inference="alignment:Splign:2.1.0"
     exon            321..728
                     /gene="Rnf34"
                     /gene_synonym="Momo"
                     /inference="alignment:Splign:2.1.0"
     exon            729..848
                     /gene="Rnf34"
                     /gene_synonym="Momo"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1050
                     /gene="Rnf34"
                     /gene_synonym="Momo"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1960
                     /gene="Rnf34"
                     /gene_synonym="Momo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgccgcctt agaaggaagg aggtccgttg tgtgagcagt ctgctatggt gctgagttcc
       61 cgggtagagc cgaccgagcc gaggcggtcg cggccatgaa ggcgggtgct acctctatgt
      121 gggcttcatg ctgtggactg ctgaatgaag tcatgggaac tggagctgtc agaggccagc
      181 aggcaggatt cccaggaagc actggtccat tcaggtttac accgagttct gactttccta
      241 cctacccacc agcagctaca gaaggaccca atatagtttg caaagcctgt ggactttcat
      301 tttcagtctt tagaaagaag cacgtctgct gtgactgcaa gaaggacttt tgctcccttt
      361 gttcggtctc acaagaaaac ctccgcagat gctctacatg tcacctactc caagagacag
      421 ccttccagcg ccctcagttg atgagactaa aagtgaagga cctgcggcag tatctgctcc
      481 tcagaaacgt accgaccgac acttgtcgcg agaaggagga cttagtggat ctagtgctgt
      541 gccatcgtgg actgggctcg ggggatggcc tggactcaag gagtctcagt tcctcaagat
      601 cccagacttc tagttttttt acacaatcct atttttcaaa ttatacaccc ccctctgcta
      661 ctgtgtcctc cttccaggga gagctgatgg acagagaggg caccttcagg tcagaagttc
      721 tcacacaggt acaaagtgaa ttagcttcag caaacacgga tgatgaggat ggggaggaag
      781 atgacgacga tgatgacgat gacgacgacg aggatgacga tgaacaagaa gaaaacttag
      841 aggaacagaa cccggggctc tctaagaaga aggcgagagc ttccctgtcc gacctgtcaa
      901 gccttgaaga ggtggaaggg atgagcgtgc gccagctgaa ggaaatcctg gctcggaatt
      961 ttgtcaacta ttctggctgc tgtgaaaagt gggagctggt ggagaaagtc aaccggctgt
     1021 acaaggagaa tgaggaaaac caaaagtcat atggtgagcg gatgcaactt caggatgagg
     1081 aagacgacag cctgtgccga atctgcatgg atgcggtcat tgactgtgtc ctgctggagt
     1141 gtgggcacat ggtcacctgc accaagtgcg gcaagcgcat gagtgagtgt cccatctgca
     1201 ggcagtatgt ggttcgagct gtgcatgttt tcaagtcctg aaattgaggc ccctacagtg
     1261 ggacactcac atgaccccaa acatttcagt gcactaaagg gactggaaac ttactgttct
     1321 aaggcagaag ctatttttta aaattatttt catgaccaac tggggacaga aagttcatcc
     1381 taagtcttag aaacctgggc tgtgccatag gcccgtcaac cgtggacaca tggcttccca
     1441 ggttctgctg agttctgtca cttgtctccc ctgagcacta ggtgaagcca gactgttcag
     1501 tgtgggtgtg gaggccactc gcctgtctct tactttacct ttatcctgtg tttgacactt
     1561 ttgttctctg aactgagctc actgttcgtg actgggctag tgtgggctct cctgagccgt
     1621 agctgctcgg aatgttcacc taattagcca tgtatattct aaatgctaat acttaatgaa
     1681 tgtacgtttc aacattattg ctatttctgc atttaaacat aattgggaga caactgacat
     1741 tctatagtcc actgcccggg ccttagacta aacgtccatt tttgtttggg tacagctttt
     1801 aatagcaagg gctgcatcta gcttcttatc ttagaagtgt atgtgtgcta aattctttat
     1861 taatatgtaa tcaatttaca atgttttgta tagtgaaggt gtatttttag tgctacctgc
     1921 tagtaatttc aactttagga ataaaattaa attaaaaggc aaaaaaaaaa aaaaaaaaaa
     1981 aaaaa
//
