LOCUS       NM_001108868            3394 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus ring finger protein 31 (Rnf31), mRNA.
ACCESSION   NM_001108868 XM_001059460 XM_001059524 XM_344409
VERSION     NM_001108868.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3394)
  AUTHORS   Van Quickelberghe E, De Sutter D, van Loo G, Eyckerman S and
            Gevaert K.
  TITLE     A protein-protein interaction map of the TNF-induced NF-kappaB
            signal transduction pathway
  JOURNAL   Sci Data 5, 180289 (2018)
   PUBMED   30561431
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3394)
  AUTHORS   Chen S, Fragoza R, Klei L, Liu Y, Wang J, Roeder K, Devlin B and Yu
            H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   3  (bases 1 to 3394)
  AUTHORS   Damgaard RB, Walker JA, Marco-Casanova P, Morgan NV, Titheradge HL,
            Elliott PR, McHale D, Maher ER, McKenzie ANJ and Komander D.
  TITLE     The Deubiquitinase OTULIN Is an Essential Negative Regulator of
            Inflammation and Autoimmunity
  JOURNAL   Cell 166 (5), 1215-1230 (2016)
   PUBMED   27523608
REFERENCE   4  (bases 1 to 3394)
  AUTHORS   Elliott PR, Nielsen SV, Marco-Casanova P, Fiil BK, Keusekotten K,
            Mailand N, Freund SM, Gyrd-Hansen M and Komander D.
  TITLE     Molecular basis and regulation of OTULIN-LUBAC interaction
  JOURNAL   Mol Cell 54 (3), 335-348 (2014)
   PUBMED   24726323
REFERENCE   5  (bases 1 to 3394)
  AUTHORS   Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang
            C, Heman-Ackah SM, Hessa T, Guha R, Martin SE and Youle RJ.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   6  (bases 1 to 3394)
  AUTHORS   Haas TL, Emmerich CH, Gerlach B, Schmukle AC, Cordier SM, Rieser E,
            Feltham R, Vince J, Warnken U, Wenger T, Koschny R, Komander D,
            Silke J and Walczak H.
  TITLE     Recruitment of the linear ubiquitin chain assembly complex
            stabilizes the TNF-R1 signaling complex and is required for
            TNF-mediated gene induction
  JOURNAL   Mol Cell 36 (5), 831-844 (2009)
   PUBMED   20005846
REFERENCE   7  (bases 1 to 3394)
  AUTHORS   Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K,
            Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao
            T, Tanaka K and Iwai K.
  TITLE     Involvement of linear polyubiquitylation of NEMO in NF-kappaB
            activation
  JOURNAL   Nat Cell Biol 11 (2), 123-132 (2009)
   PUBMED   19136968
REFERENCE   8  (bases 1 to 3394)
  AUTHORS   Kirisako T, Kamei K, Murata S, Kato M, Fukumoto H, Kanie M, Sano S,
            Tokunaga F, Tanaka K and Iwai K.
  TITLE     A ubiquitin ligase complex assembles linear polyubiquitin chains
  JOURNAL   EMBO J 25 (20), 4877-4887 (2006)
   PUBMED   17006537
REFERENCE   9  (bases 1 to 3394)
  AUTHORS   Bromann PA, Weiner JA, Apel ED, Lewis RM and Sanes JR.
  TITLE     A putative ariadne-like E3 ubiquitin ligase (PAUL) that interacts
            with the muscle-specific kinase (MuSK)
  JOURNAL   Gene Expr Patterns 4 (1), 77-84 (2004)
   PUBMED   14678832
REFERENCE   10 (bases 1 to 3394)
  AUTHORS   Yamanaka K, Ishikawa H, Megumi Y, Tokunaga F, Kanie M, Rouault TA,
            Morishima I, Minato N, Ishimori K and Iwai K.
  TITLE     Identification of the ubiquitin-protein ligase that recognizes
            oxidized IRP2
  JOURNAL   Nat Cell Biol 5 (4), 336-340 (2003)
   PUBMED   12629548
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474049.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344409.3, XM_001059460.1, XM_001059524.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3394
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..3394
                     /gene="Rnf31"
                     /note="ring finger protein 31"
                     /db_xref="GeneID:364386"
                     /db_xref="RGD:1305513"
     exon            1..307
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..3307
                     /gene="Rnf31"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF31"
                     /protein_id="NP_001102338.2"
                     /db_xref="GeneID:364386"
                     /db_xref="RGD:1305513"
                     /translation="MPGDEERAFLAAREELASALRWDSAQVFPLEQLTPLLATSLPLS
                     SRYRQLDAGRLVRCNAHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRSVKFNNP
                     VFRSTVDAVQGGRDVLRLYGYTEERPDGLSFPGGQEEPDEYQVAIVTLEVLLLRTELN
                     LLLQNTHPRQNALDQLLRDSVEDDMLQLSEFHPLLREIVPGPLPSAPGHTPGPCFLCG
                     SAPGTLHCPACNQASCPACDLLFHGHPSRAHHLRHTLPGAHQTTNLSSSLPASSQPRP
                     HSSSLAMGDSSLSSPDPANACLPWHCPTCATLNEPWAVFCAACSQPKGCKVRGRESSQ
                     GTGVLEPEPARDQWACQSCTFENEAAAVLCAICERPRLAQPPSLVVDSHDAGVYQQPL
                     KQEDTLLSAAQSQVWHCDHCTFCNSGPVWVCAMCNRTRSPIPAQPYPSSLEKGLSQPG
                     SSQHLSSSLPASCGDPEKQRQDKMRKESLQLVNMIQEGEAAGASPEEIFSALQYSGTE
                     VPLQWLRSELSYVLEMVAELAGQRDPELGAFSCQEARKAWLDRHGNLDEAVEECVRAR
                     RRKVQELQSLGFEPKEGSLQALFQHGGDVARALTELQRQRLEPFHQRLWGRDPEPTPC
                     WDGLDRQSLVRRLLAVYTLPSWGRAELALALLQETPRNYELLDVVEAVRHSQDRAFLR
                     RLLAQECAVCGWALPRNRMQALISCECTICPECFRQHFTIALKEKHITDMVCPACGRP
                     DLTDDAQLLSYFSTLDIQLRESLEPDAYALFHKKLTEAVLMRDPKFLWCAQCSFGFIY
                     EREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRTNDPEYQAQGLAMYLQE
                     NGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPDPNCKVKKSLHG
                     HHPRDCLFYLRDWPAARLQKLLQDNNVMFNTEPPAGTRAVPGGGCRVMEQKEVPSGFR
                     DEACGKETPPGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATARYLHLTPQP
                     MDGEDLPAYQARLLQKLREEVPLGQSIARRRK"
     exon            308..454
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            455..610
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            611..670
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            671..740
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            741..918
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1297
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1576
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1825
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..2011
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2218
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2392
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2491
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2581
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2696
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2815
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2929
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..2987
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3084
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3253
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3394
                     /gene="Rnf31"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgtggctg ggtttgtagc ggggcggtgg cttgagtgac cccgggctgt tgtggcgctg
       61 cgcgcacctg cgcccgcccc ttgaggacag cgaagctgag cctgtctccg gtctcaggat
      121 gccaggagac gaggagcgag ccttcctagc ggcccgcgag gagctggcga gcgccctgag
      181 gtgggattct gcgcaggtat ttcccctgga gcagctcacg ccgcttctgg ccacctctct
      241 gccactctcc tcccgctacc ggcagctgga tgccggacgc ctggtccgct gcaacgctca
      301 tggggagcct cgaaactacc tcaacactct atccacggcc ctgaacatcc tggaaaagta
      361 tggtcgaaac ctcctcagcc cacagcggcc ccggtattgg cgctcagtga agtttaataa
      421 ccctgtcttt cgcagcacgg tggatgctgt gcagggtggc cgggatgtgc tacggttgta
      481 tggctatacc gaggagcgcc cagatggatt gagtttcccc ggagggcagg aggaaccaga
      541 tgaataccag gttgccatag tcacactaga agtactactg cttcgcacgg agctcaattt
      601 gctgttgcag aatactcatc caagacagaa cgcactggac cagctactaa gagacagcgt
      661 tgaagatgac atgctgcagc tttcagagtt tcaccccctt ttgagagaga ttgttcctgg
      721 ccccctcccc tctgccccag gccatactcc tggtccctgc tttctctgtg gttctgcccc
      781 aggcacactg cactgtccag cctgtaacca agcttcatgc ccagcttgtg accttttgtt
      841 ccatgggcat ccgtcccgtg cgcatcacct tcgccacacc ctacccgggg cccaccagac
      901 caccaaccta agctctagtt tacctgcctc gtcccaacca cggccccact cctcctccct
      961 ggccatggga gatagctctc tctcttcccc tgaccctgca aatgcttgtc tgccctggca
     1021 ctgtcctacc tgtgccacat taaacgagcc ttgggcagtg ttctgtgcag cctgtagtca
     1081 gcccaaaggc tgtaaggtgc ggggaagaga gagttcccaa ggaactgggg tcctagagcc
     1141 cgagcctgca cgggatcagt gggcctgcca gagctgtacc tttgagaatg aggcagcagc
     1201 cgtgctctgt gccatctgtg agcgacctcg gctggcccag cctcccagct tggtggtgga
     1261 ttcccatgac gctggtgttt accaacagcc ccttaagcag gaggatactt tgctctccgc
     1321 tgcccagtct caggtgtggc actgtgacca ttgtaccttc tgcaattcag gccctgtctg
     1381 ggtgtgtgcc atgtgtaacc ggactcgcag ccccatccct gcacagccct atcccagctc
     1441 cttggagaag ggactctcac agccagggtc ctcacaacac ctcagctcct ccctgcctgc
     1501 ttcctgtgga gatccagaga aacagcgcca agataagatg cggaaggaaa gtctccagct
     1561 agtgaacatg atccaggaag gggaagctgc aggtgccagt ccagaagaga tcttctcggc
     1621 tctacaatac tcgggcactg aggtgcccct gcagtggttg cgttcagagc tgtcctacgt
     1681 cttggagatg gtggctgagc tagctggaca acgggatcca gagctcggtg ccttttcctg
     1741 tcaggaagcc cggaaagcct ggcttgatcg tcatggcaac cttgatgaag ctgtagagga
     1801 gtgtgtgagg gccaggagga ggaaggtgca ggagctccag tccctgggct ttgagcctaa
     1861 agaagggtcg ctgcaggcat tgttccagca tgggggtgat gtggcccggg ccctaactga
     1921 gttacagcga cagcgcctgg agcctttcca ccagcgcctc tggggcagag accccgaacc
     1981 cactccctgc tgggatggcc tggatagaca gagcctggtc agacgccttc tggcggtata
     2041 cacactcccc agctggggtc gagcagagtt ggcgttagcg ctgctgcagg agacacccag
     2101 gaactatgag ttgttggacg tggtggaggc cgtgaggcac agtcaggacc gggcctttct
     2161 gcgccgactg cttgcccagg aatgtgctgt gtgcgggtgg gcccttcccc gaaaccggat
     2221 gcaggccctg atctcctgcg agtgcaccat atgccctgag tgtttccgcc agcatttcac
     2281 cattgccctg aaggagaagc acatcacaga catggtgtgc cctgcctgtg gccgccctga
     2341 cctcaccgat gatgcgcagt tactcagtta cttctccacc cttgacatcc agctcagaga
     2401 gagcctagag ccggatgcat atgctctgtt tcataagaag ctaaccgagg ctgtgctcat
     2461 gcgagacccc aagttcttgt ggtgtgccca gtgttccttc ggcttcatat atgaacgaga
     2521 acagctggag gcgacatgtc cccagtgtca ccagaccttc tgtgtgcgct gcaagcgcca
     2581 gtgggaggag cagcacagag ggcggagctg tgaggatttc cagaactgga aacgcaccaa
     2641 tgacccagag taccaggctc aaggcctggc catgtacctt caggaaaacg gcatagactg
     2701 ccccaaatgc aagttctcat acgcactggc ccgaggaggc tgcatgcact tccactgcac
     2761 acagtgtcgc caccagttct gcagcggctg ctacaatgcc ttttacgcca agaataaatg
     2821 tccagaccct aactgcaagg tgaaaaagtc cctgcatggt caccaccctc gagattgcct
     2881 cttctaccta cgggattggc ctgctgcccg gctccagaaa cttttgcagg acaataatgt
     2941 catgtttaac acagagcctc ctgccggcac acgggcagtc cctggaggtg gctgccgagt
     3001 gatggaacag aaggaggttc ccagtgggtt cagggatgaa gcttgtggca aggaaactcc
     3061 gcctggctat gccggcctgt gtcaggcaca ctacaaagag tatcttgtga gcctcatcaa
     3121 tgcccactcg ctggacccag cgaccctgta tgaagtggag gaactggaga cagccactgc
     3181 acgctaccta catttaacgc cccaacccat ggatggagag gatcttcctg cttaccaggc
     3241 ccggttgtta cagaagctga gagaagaggt gcccttggga cagagtattg ctcgcagaag
     3301 aaagtagctg agagccgggt cctaatggac cttcctgaac ccagccttca gcagcagttc
     3361 cagcaccaat aaagaggcat cttatggcct aggc
//
