LOCUS       NM_001107122            4759 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ring finger protein 216 (Rnf216), mRNA.
ACCESSION   NM_001107122 XM_001064065 XM_221922
VERSION     NM_001107122.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4759)
  AUTHORS   Chen,T., Zhu,J. and Wang,Y.H.
  TITLE     RNF216 mediates neuronal injury following experimental subarachnoid
            hemorrhage through the Arc/Arg3.1-AMPAR pathway
  JOURNAL   FASEB J 34 (11), 15080-15092 (2020)
   PUBMED   32918771
  REMARK    GeneRIF: RNF216 mediates neuronal injury following experimental
            subarachnoid hemorrhage through the Arc/Arg3.1-AMPAR pathway.
            Erratum:[FASEB J. 2024 May 15;38(9):e23652. doi:
            10.1096/fj.202400924. PMID: 38708783]
REFERENCE   2  (bases 1 to 4759)
  AUTHORS   Mabb,A.M., Je,H.S., Wall,M.J., Robinson,C.G., Larsen,R.S.,
            Qiang,Y., Correa,S.A. and Ehlers,M.D.
  TITLE     Triad3A regulates synaptic strength by ubiquitination of Arc
  JOURNAL   Neuron 82 (6), 1299-1316 (2014)
   PUBMED   24945773
REFERENCE   3  (bases 1 to 4759)
  AUTHORS   Nakhaei,P., Mesplede,T., Solis,M., Sun,Q., Zhao,T., Yang,L.,
            Chuang,T.H., Ware,C.F., Lin,R. and Hiscott,J.
  TITLE     The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS
            signaling pathway by targeting TRAF3 for degradation
  JOURNAL   PLoS Pathog 5 (11), e1000650 (2009)
   PUBMED   19893624
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474012.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_221922.4, XM_001064065.1.
FEATURES             Location/Qualifiers
     source          1..4759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..4759
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /note="ring finger protein 216"
                     /db_xref="GeneID:304294"
                     /db_xref="RGD:1565135"
     exon            1..94
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            95..221
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2887
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF216"
                     /protein_id="NP_001100592.1"
                     /db_xref="GeneID:304294"
                     /db_xref="RGD:1565135"
                     /translation="MAEGNNQEEVIHLNNFHCHRGKEWMAVREGPITISDSSDEEGIP
                     MLVTPATEQQEDDLDDDVILTETHKPQTSRPNLIKPAAEWQDLNRLGEERPRKSRADF
                     EADTHSYFSFCNNSLFDSGAQDDSEDECGGFLDLKTEKKGGEAKPGPSNKQTADNTVS
                     PRLEQKVIILGENGLLFSESEPLEVQNQLSEDSETDLLSNPGEPAASVDEQLIEEEYW
                     LDHPYFQALNPQPQERTNQLVPQERHSESEMGPMFFRHDFPEPAFPRPEPQQEGIPGP
                     ASPQPAHPLGELEDQQLAIDEDPGPAYPLPGPQEANLANVWGQEAAEGDQELIPLLVK
                     ETEARFPDVANGYVEEIIHLKNYYDLNVLCNFLLENPDYPKREDRILIHPSSSLLASQ
                     DDVKLPKIDFFDYSKLTPLDQRCFIQAADLLMADFKMLSSQDIKWALHELKGHYAITR
                     KAFSDAIKKWQELSPETSGKRKKRKEMNQYSFIDFKFEQGNIKIEKRMFFLENKRRHC
                     RSYDQQALLPAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGE
                     FPFEELTQCADAHLFCKECLIRYAQEAVFGSGKSELSCMEGSCTCSFPTSELEKVLPQ
                     TILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPRCRKETCRKCQ
                     GLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRC
                     GAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEE
                     EQKRKNGENTFKRIGPPLEKPAEKVQRVEALPRPVPQNLHPQMPPYAFVHPPFPLPPV
                     RPVFNNFPINMGPVPAPYVPPLPNVRVNFDFGHVHVPLEHNLPMHFGPQPRHRF"
     exon            222..352
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            353..1162
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1239
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1342
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1507
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1622
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1762
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1813
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1951
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2100
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2179
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2277
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2500
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2570
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..4759
                     /gene="Rnf216"
                     /gene_synonym="RGD1565135"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagtagcg gcctcggcgg cagcggcggc ggcgacgaca gcattggcag tggcggctgt
       61 agcagcgggg aagcttttcg agcggatgct tcagaacaga tgatcaccat gtctgggttc
      121 tagcaatcac atacgtttat atctgaattt gaaaatggca gagggaaaca accaagagga
      181 ggtcattcac ttgaacaact ttcactgcca ccgggggaag gagtggatgg ctgtcagaga
      241 ggggcccatc accatatctg actcctctga tgaggaaggg attccaatgc tggttacccc
      301 ggctactgag caacaggaag acgacctgga tgatgatgtc atcctgacag aaacacataa
      361 acctcagaca tcccggccca atctcatcaa accagctgcc gagtggcaag atctgaacag
      421 attgggagaa gaaaggccta gaaaatctag agcagacttt gaagcagata cccacagcta
      481 tttttccttt tgtaacaact cattgtttga ttctggggca caggatgatt ctgaggatga
      541 atgtggtgga tttctggatc ttaagactga gaaaaaagga ggagaagcca aacctggacc
      601 aagcaataag cagacagcag acaatactgt cagccccagg ctggagcaga aagtcattat
      661 tttgggagaa aatggtcttc ttttttcaga aagtgagcct ctggaagttc agaaccaatt
      721 atctgaagac tcagagacag atcttttatc aaatcctggt gagccagctg cctcagtaga
      781 tgagcagcta attgaagaag agtactggct tgaccatccc tacttccagg ctctgaatcc
      841 acagcctcag gagagaacaa accagcttgt gccccaagag cgacattctg aatcagaaat
      901 gggcccaatg tttttccgcc atgatttccc ggagccagct tttccaaggc cagaacccca
      961 gcaggagggg attccaggac ccgcttctcc acaaccagcc catcctctag gagagcttga
     1021 agaccagcaa ttagcaattg atgaagaccc tgggcctgcc taccccctgc caggacccca
     1081 ggaggccaat ttggcaaatg tgtggggaca agaagctgct gaaggggatc aagagctcat
     1141 tccactgtta gtgaaagaaa cggaagcaag atttccagac gtagcaaatg gatatgttga
     1201 agagataatt catttgaaaa attactatga tttgaatgta ctttgtaatt ttctcctgga
     1261 aaatccagat tatccaaaga gagaagaccg aatccttatc caccccagca gtagcctgct
     1321 tgccagccag gatgatgtga agttgcctaa gatagacttt tttgactatt ccaaattgac
     1381 tccacttgac cagcgctgct tcatccaagc tgctgacctc ttgatggctg atttcaagat
     1441 gctcagcagc caggacatca agtgggccct gcacgagctc aaagggcatt acgcaatcac
     1501 ccgaaaggcc ttttctgatg ccattaaaaa atggcaggag ctatcacctg aaaccagtgg
     1561 aaagcggaaa aagaggaaag aaatgaatca gtattctttc atagacttca aatttgaaca
     1621 aggtaacata aaaatagaaa agaggatgtt ctttctggaa aacaagcgtc gacactgtag
     1681 gtcctatgac cagcaggccc tccttccagc tgtgcagcaa gagcaggagt tctatgagca
     1741 gaaaattaaa gagatggcag agcacgaaga ttttttgctt gccctgcaga tgaatgaaga
     1801 gcagtatcaa aaggatggcc agctgattga atgccgctgc tgctatgggg agtttccatt
     1861 tgaggagctg acacaatgcg ctgatgctca cttgttctgc aaagaatgtc tcatcagata
     1921 tgcccaagag gccgtgtttg gatctggaaa gtcagagctc agctgcatgg aaggcagctg
     1981 cacatgttcc ttcccaacca gtgaactgga gaaagtgctc ccccagacca ttctgtacaa
     2041 atactatgaa cggaaagctg aagaggaagt cgcagcagcc tatgctgacg agcttgtccg
     2101 gtgcccctct tgcagcttcc ctgctctgtt ggacagcgat gtgaagaggt tcagctgccc
     2161 taaccctcgc tgccgaaagg agacctgtag gaagtgtcag ggactctgga aagaacacaa
     2221 tggcctcacc tgtgaagagc tggcagaaaa ggatgacatc aagtaccgga catctattga
     2281 agaaaaaatg actgctgctc gaattagaaa atgccacaag tgtgggactg gcctcatcaa
     2341 atctgaaggc tgcaaccgca tgtcttgccg ctgtggtgcc cagatgtgct acctctgtcg
     2401 agtttctatc aatggctatg accacttctg ccagcatcct cgctctccag gagccccttg
     2461 ccaggaatgt tccaggtgct ccctctggac cgaccccact gaagatgatg agaagctgat
     2521 tgaggagatc caaaaggagg ctgaggagga gcagaaaaga aagaatggag agaacacttt
     2581 caaacgcatc gggcccccac tggagaagcc ggctgagaaa gtgcagcgtg tggaagccct
     2641 gccacggcct gtcccacaga acctgcaccc tcagatgcca ccctatgcct ttgtccaccc
     2701 acccttcccc ctgccacctg tgcggcccgt gttcaacaac ttccccatca acatgggtcc
     2761 tgtgcccgca ccctatgtac cccctctgcc caacgtgcgt gtcaacttcg actttggcca
     2821 cgtgcatgtg cccctggagc acaacctgcc catgcacttt ggcccccaac cacggcatcg
     2881 cttctgacac ccaaagccct gtccagctgt gctgagtctg caggaggacc cagtctcatc
     2941 ctctgagtag ggatgaagtc ctcgactccc tatggggtgt gggctcgtgt cctcctgctc
     3001 ttcccgttgc gaggtccact gctccttcgg gtctgatgcg ccttgggtgc tgactgtcgc
     3061 tgcaccagta atagggcagc tccccgggtc tgccatctat cttagcagcc agtccagggg
     3121 ccttggccga gaagcaggcc ctttaagcat ttgccatact tcctccccag cagaccactg
     3181 aaagcccaag ggaaaatggc ctaccctccc caggccaggg ctctctcctt gttgcccaag
     3241 gcccactcag gtccaagggc cgccaagaat cttctgtggc gcaagttttg ttctgttgtt
     3301 acctagaggt tgctcctatt cacatagttt gagctgaagt tttttgtgtg tccccatccg
     3361 tggaaagtca ggttgaaggt atttccccag ggctggcaac tgctgagaac cagtagtcct
     3421 gacacttgac atcaaacaga aggacccttt tagggccctt tattcctggg ctgccccttt
     3481 tctgggagag acctcacttg tcaccaacct gggatgagca gcatctctcc taaggttttt
     3541 aggggcttcc ctagcagtgc agatgacctc atggagctgc tgcagctatc acagcaaccc
     3601 tcctgcccgc tcagctgtcc ctcactagtt agcagtggat gcagacagga gaggtctagc
     3661 tccaagatga ggacagctgg cttccctaga gtcagatgaa aatcggcctg cacagtcttt
     3721 gccatgttcc cactacctgt gtcccctcct gtccagacca gatctttata ctctcctcca
     3781 gtgtgtgttg accagggctg atagcaagtg tctcactcag ttgtactggc tgtccttgtc
     3841 gtggagtgtc ccatgttcag agtgtacaga cttagaagag agaagatgtc cctgggaaaa
     3901 ggaaagactc cctgaggtgc ccactgtcac tggagtgtgg gtagggcaca cagggcaact
     3961 caggagccct gccatgggtc acctgaactg tgatgctagt ctgaatgaca gtgccttgga
     4021 aagatgggcc acatgctgca tgacaggatc ctccaagtac cttaacaatt agtgtactcg
     4081 tgttctctgc acttctccag aagccctgca gggggcggta ctccgagcac tgcccctcca
     4141 aggcctcatg agccgctgga ctgggcaccc agttctgggc gcctcagtac cctatcacat
     4201 tgttccacca agaggccaga tggaaaaact ggcagtttct ggggtagctg gaagagcagg
     4261 ccaggcaggt gccatccaga ccctggcact ccatttggag aggtgaggcc agagacgtat
     4321 ccttcaaaat attgtcagtc tgtgacaggg agactgctac tgcctgtctc catcaaggag
     4381 tgaccctccc atgttgccag cagggctagg gagtgagggg tgggccagca aggatcccca
     4441 aggcagctgc caccttaacc cctaggaccc agactgcttc ctggtttaag aaactgccta
     4501 gccactccca gtgtatttgc cttaaaactg gagagaatct agtatttgca cttagcaaaa
     4561 gatttcaaag ttaagagaaa agtgcatgat ctcactttgt acaaaagaaa aaaaggaaaa
     4621 aaaatgaagt agatggttaa acgtttttct ttaccttttg gtagtaaaaa tagagaaaac
     4681 aagtctgttt aaactactgt gtaaaaagac tgtatcatat gtaacttgaa ttttgtgtaa
     4741 ataaatgttt gtgaacgct
//
