LOCUS       NM_001107929            4234 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ring finger protein 20 (Rnf20), mRNA.
ACCESSION   NM_001107929 XM_001053340 XM_001053415 XM_001053479 XM_001053543
            XM_001053616 XM_232995
VERSION     NM_001107929.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4234)
  AUTHORS   Lai,C.Y., Hsieh,M.C., Ho,Y.C., Wang,H.H., Chou,D., Wen,Y.C.,
            Yang,P.S., Cheng,J.K. and Peng,H.Y.
  TITLE     Spinal RNF20-Mediated Histone H2B Monoubiquitylation Regulates
            mGluR5 Transcription for Neuropathic Allodynia
  JOURNAL   J Neurosci 38 (43), 9160-9174 (2018)
   PUBMED   30201771
  REMARK    GeneRIF: RNF20-drive H2B monoubiquitination, which facilitates
            phosphorylated mGluR5 transcription in the dorsal horn in the
            development of neuropathic allodynia.
REFERENCE   2  (bases 1 to 4234)
  AUTHORS   Stracker,T.H., Roig,I., Knobel,P.A. and Marjanovic,M.
  TITLE     The ATM signaling network in development and disease
  JOURNAL   Front Genet 4, 37 (2013)
   PUBMED   23532176
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4234)
  AUTHORS   Wang,E., Kawaoka,S., Yu,M., Shi,J., Ni,T., Yang,W., Zhu,J.,
            Roeder,R.G. and Vakoc,C.R.
  TITLE     Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged
            leukemia
  JOURNAL   Proc Natl Acad Sci U S A 110 (10), 3901-3906 (2013)
   PUBMED   23412334
REFERENCE   4  (bases 1 to 4234)
  AUTHORS   Vethantham,V., Yang,Y., Bowman,C., Asp,P., Lee,J.H., Skalnik,D.G.
            and Dynlacht,B.D.
  TITLE     Dynamic loss of H2B ubiquitylation without corresponding changes in
            H3K4 trimethylation during myogenic differentiation
  JOURNAL   Mol Cell Biol 32 (6), 1044-1055 (2012)
   PUBMED   22252316
REFERENCE   5  (bases 1 to 4234)
  AUTHORS   Liu,Z., Oh,S.M., Okada,M., Liu,X., Cheng,D., Peng,J., Brat,D.J.,
            Sun,S.Y., Zhou,W., Gu,W. and Ye,K.
  TITLE     Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor
  JOURNAL   Mol Biol Cell 20 (3), 757-768 (2009)
   PUBMED   19037095
REFERENCE   6  (bases 1 to 4234)
  AUTHORS   Shema,E., Tirosh,I., Aylon,Y., Huang,J., Ye,C., Moskovits,N.,
            Raver-Shapira,N., Minsky,N., Pirngruber,J., Tarcic,G.,
            Hublarova,P., Moyal,L., Gana-Weisz,M., Shiloh,Y., Yarden,Y.,
            Johnsen,S.A., Vojtesek,B., Berger,S.L. and Oren,M.
  TITLE     The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a
            putative tumor suppressor through selective regulation of gene
            expression
  JOURNAL   Genes Dev 22 (19), 2664-2676 (2008)
   PUBMED   18832071
  REMARK    Erratum:[Genes Dev. 2017 Sep 15;31(18):1926. doi:
            10.1101/gad.307207.117. PMID: 29051390]
REFERENCE   7  (bases 1 to 4234)
  AUTHORS   Tan,L.B., Chen,K.T., Tyan,Y.C., Liao,P.C. and Guo,H.R.
  TITLE     Proteomic analysis for human urinary proteins associated with
            arsenic intoxication
  JOURNAL   Proteomics Clin Appl 2 (7-8), 1087-1098 (2008)
   PUBMED   21136906
REFERENCE   8  (bases 1 to 4234)
  AUTHORS   Pavri,R., Zhu,B., Li,G., Trojer,P., Mandal,S., Shilatifard,A. and
            Reinberg,D.
  TITLE     Histone H2B monoubiquitination functions cooperatively with FACT to
            regulate elongation by RNA polymerase II
  JOURNAL   Cell 125 (4), 703-717 (2006)
   PUBMED   16713563
REFERENCE   9  (bases 1 to 4234)
  AUTHORS   Kim,J., Hake,S.B. and Roeder,R.G.
  TITLE     The human homolog of yeast BRE1 functions as a transcriptional
            coactivator through direct activator interactions
  JOURNAL   Mol Cell 20 (5), 759-770 (2005)
   PUBMED   16337599
REFERENCE   10 (bases 1 to 4234)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 10, 2008 this sequence version replaced NM_001107929.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643292.21664.1, SRR26643289.15248.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               JAXUCZ010000005.1  68771615-68772008
            395-550             JAXUCZ010000005.1  68772781-68772936
            551-718             JAXUCZ010000005.1  68777806-68777973
            719-866             JAXUCZ010000005.1  68778083-68778230
            867-1049            JAXUCZ010000005.1  68778519-68778701
            1050-1168           JAXUCZ010000005.1  68781319-68781437
            1169-1315           JAXUCZ010000005.1  68783751-68783897
            1316-1393           JAXUCZ010000005.1  68784871-68784948
            1394-1513           JAXUCZ010000005.1  68785120-68785239
            1514-1693           JAXUCZ010000005.1  68788897-68789076
            1694-1829           JAXUCZ010000005.1  68790139-68790274
            1830-1951           JAXUCZ010000005.1  68790590-68790711
            1952-2316           JAXUCZ010000005.1  68790829-68791193
            2317-2434           JAXUCZ010000005.1  68792266-68792383
            2435-2584           JAXUCZ010000005.1  68793353-68793502
            2585-2797           JAXUCZ010000005.1  68793892-68794104
            2798-2923           JAXUCZ010000005.1  68794789-68794914
            2924-3064           JAXUCZ010000005.1  68795036-68795176
            3065-3166           JAXUCZ010000005.1  68795789-68795890
            3167-4234           JAXUCZ010000005.1  68796173-68797240
FEATURES             Location/Qualifiers
     source          1..4234
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4234
                     /gene="Rnf20"
                     /note="ring finger protein 20"
                     /db_xref="GeneID:313216"
                     /db_xref="RGD:1311936"
     exon            1..394
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            395..550
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..3343
                     /gene="Rnf20"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 20, E3 ubiquitin protein
                     ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase BRE1A"
                     /protein_id="NP_001101399.2"
                     /db_xref="GeneID:313216"
                     /db_xref="RGD:1311936"
                     /translation="MSGIGNKRAAGEPGTSVPPEKKTAVEDSGTTVETIKLGGVSSTE
                     ELDIRTLQSKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDE
                     NIRIILKRYDLDQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLA
                     TLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVDLLSRKLNSGDNLIMEEAV
                     QELNSFLAQENVRLQELTDLLQEKHHTMSQEFCKLQGKVETAESRVSVLESMIDDLQW
                     DIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEE
                     NKELAQNRHCELEKLRQDFEEVTTQNEKLKVELRSAVEEVVKETPEYRCMQSQFSVLY
                     NESLQLKAHLDEARTLLHGTRGTHQRQVELIERDEVSLHKKLRTEVIQLEDTLAQVRK
                     EYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDL
                     NKTRLRSGSALLQSQSSTEDAKDEPTELKQDSEDLATHSSALKASQEDEVKSKRDEEE
                     RERERREKEREREREREKEKEREREKQKLKESEKERDPVKDKDKGKHDDGRKKEAEII
                     KQLKTELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDL
                     EDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAVAKQEEEALLSEMDVTGQAFEDM
                     QEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQ
                     VVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKL
                     HDFQDEIVENSVTKEKDLFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDY
                     KARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRIYI
                     G"
     exon            551..718
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            719..866
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1049
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1168
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1315
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1393
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1513
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1693
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1829
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1951
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2316
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2434
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2584
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2797
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2923
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3064
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3166
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..4234
                     /gene="Rnf20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatccctctt ggagcaggtc cgaaatgagg gattgaatcc cgcaccgccc ttcgtaaata
       61 acccctggaa gctgcgcgcc cgcggcggga gttgctagag cccaggtttg ctctgttgtc
      121 cggtgctcct gggccctgag tggcgaggtc ccatcttccc ggcctgtggc ttgccacgcc
      181 ggaggttgcg gccagcgctt tccattcaag ttgcgctccc tcctcatctc ttgtttcctc
      241 tctttccagg cgagatccaa ctcagattgc tgcttgccat aggttccttg tcctggagtt
      301 tgaattggaa gccggcgggg tgtagactcg tgatggtcgc gtttctcgcg atctagcatc
      361 cattcctcct cctttaagca tcggaaccag tcagaaaaaa tagctgtcat cttataccaa
      421 gatgtcaggg attggaaata aaagagcggc tggagagcca ggcacatctg tgcccccaga
      481 gaagaagaca gctgtcgaag attcagggac cacagtggaa acaattaaac taggaggtgt
      541 ctcttcaacg gaggaattag acattcgaac actgcaatcg aaaaatcgta agctagcaga
      601 aatgctagat cagcggcagg ccattgaaga tgagcttcgg gagcacattg agaagctgga
      661 gcgacgccag gccaccgacg atgcctcact gttgatcgtg aaccggtact ggagccagtt
      721 tgatgaaaac atccgcatca tccttaaacg ttatgatctg gaccagggtt tgggagacct
      781 actcacagaa aggaaagcct tggttgtgcc agagcctgag cccgactctg acagtaatca
      841 ggagcgcaaa gatgaccgtg agagagggga agggcaagag ccagctttct ctttccttgc
      901 tactttggct agcagttcca gtgaggagat ggagtcccag cttcaggagc gcgtggagtc
      961 ctcccgccgt gctgtgtctc agattgtgac cgtctatgat aaattgcaag aaaaagtgga
     1021 tctcttgtcc cggaaactga acagtggaga taacctgata atggaggaag cagtacagga
     1081 gctgaactcc ttccttgcgc aagagaatgt gaggctccag gaactgacag atctccttca
     1141 ggagaagcat cacaccatgt ctcaggagtt ctgtaagctg cagggtaaag tagagacagc
     1201 agagtcacga gtgtccgtct tggagtccat gattgatgac ctgcagtggg atattgacaa
     1261 aattcgaaaa agagaacagc ggctcaaccg gcatttggct gaagtcctag agcgggtgaa
     1321 ctcaaaaggc tataaagtgt acggagcagg gagcagtctc tatggaggca caatcaccat
     1381 caatgcccgg aagtttgagg aaatgaatgc tgagcttgag gagaacaaag agttggctca
     1441 gaaccgacat tgtgagctag agaaacttcg tcaagacttt gaagaggtca ctacacagaa
     1501 tgaaaagttg aaggtggagt tgcggagcgc agtggaggaa gtggttaagg aaaccccaga
     1561 atatcgctgc atgcagtcac agttctctgt cctgtacaat gagagtctac agttgaaagc
     1621 tcacttggat gaagctcgga ccctgcttca tggcacccgg ggaactcacc agcgccaggt
     1681 tgaactcatt gagcgagatg aggttagtct gcataagaag ctgagaactg aagtgattca
     1741 gctggaggat accttggccc aggtccgcaa ggagtatgag atgttgagga tagagtttga
     1801 gcagaccctt gcggccaatg aacaagcagg ccccataaac cgggagatgc ggcacctcat
     1861 tagcagtctc cagaaccata accaccagct gaagggggag gtcctgaggt ataagcggaa
     1921 actcagagag gcacagtctg acctgaacaa gacgcgtctg cgcagtggca gtgccctcct
     1981 gcagtcgcag tctagtactg aggacgccaa ggatgaaccc acagagctga agcaagactc
     2041 tgaggacctc gccactcatt cctcagcatt gaaggcctct caggaggatg aagtgaagtc
     2101 taagcgggat gaggaagaga gagaacgaga aaggagggag aaagaaagag agagagaacg
     2161 agaacgggaa aaggaaaagg agagagaacg agagaaacag aaactgaaag agtcggaaaa
     2221 agagagagat cctgttaagg ataaggacaa agggaagcac gatgacggga ggaagaagga
     2281 ggcagagatc atcaagcagc tgaagactga gctcaagaaa gcacaagaga gccagaagga
     2341 gatgaagctg ctcctggaca tgtaccgctc tgcccccaag gagcagagag acaaagtgca
     2401 gctaatggcg gccgagaaga agtcaaaggc agagttggag gatctcaggc aaagactcaa
     2461 ggatctggaa gataaggaga agaaggagaa taagaaaatg gctgatgagg acgccttgag
     2521 gaagatccgg gcagtggaag agcagatcga atacctgcag aagaagctgg ctgtggccaa
     2581 gcaggaggaa gaagctctcc tgtctgagat ggatgtcaca ggacaggcct ttgaggacat
     2641 gcaggagcag aacatccgtt tgatgcagca gttgcgggag aaggatgatg caaacttcaa
     2701 gctcatgtca gagcggatca agtctaatca gatccataag ttgcttaaag aggaaaagga
     2761 agagttagct gaccaggttt tgacactgaa gactcaggta gatgcccagt tacaggtagt
     2821 aagaaagctg gaagagaagg agcacctgct tcagagtaac attggcacag gggagaagga
     2881 gctgggtctt aggactcaag ccttagagat gaataaacgc aaggccatgg aggcggccca
     2941 gcttgcagat gacctcaaag cacagctgga actggctcag aagaagctcc atgattttca
     3001 ggatgaaatt gtggagaaca gtgtcaccaa ggaaaaggac ttgttcaatt tcaaacgcgc
     3061 acaggaagac atctctaggc tccgaagaaa gctggagaca accaagaagc cagacaacgt
     3121 gcccaaatgt gacgagattc tgatggagga gataaaggac tacaaggcgc ggctgacctg
     3181 cccttgctgt aacatgcgta aaaaggatgc agtacttacc aagtgttttc acgttttctg
     3241 ctttgagtgt gtgaagacgc gctatgacac tcgccagcgc aagtgtccca agtgtaacgc
     3301 tgctttcggt gccaatgatt tccatcgcat ctacattggc tgagtgcagt caagagagag
     3361 aactggctag gcaagcactt actcatcagt caccaggcct ctacctctcc ctctgtgaca
     3421 gctggccggc tccctgctcc ccggactgtc caggttctct tcgccagtag ccagagaaca
     3481 ttcgtgaaaa agactgcaag tcttggggtt tagaatgaac tagaagctac tagtgtttgt
     3541 cttcctatca gctttcttta tgtcctttca gagttttcag cattttcttc ttgggcaaag
     3601 cctgtaaact tggatttacc catcctcctg aagaagtcag gttgatggtt ttgacactga
     3661 gaagggaatg tcatagagtg aacatatact attatggagt agtgaacttt tagaaataag
     3721 ctatcgatgg gccccaaatt cttgatttgg taataaacct ttctaaactt aggttgtaaa
     3781 atggtataat tgtgatagtc tctcctggaa ggttcgaagc cttaatgaaa ttatatccag
     3841 gataagtcta tctctcattt ctagtaaact gactttttgg gtcagttgga cttcttgcta
     3901 aagttattta tgttttaagt attcaaatat taataggttt ttttttttaa tttcttaagg
     3961 ccagaatgat ttcaaacatg atagttccta tggttttgct ttttgttttt ttcctcctga
     4021 aatcagactt agtacttaag aagcagcagg aatggattat gaagagatct aggtagtcta
     4081 ggataagatc cagagagggt tggtgaatta tgaattactg tcatcatcct ctcagaggga
     4141 ctctttgatt tctgttttcc agaagattct cagtaatgtt tctgtaggat tttaatattc
     4201 catatacttt caattaaagc aggattcagc tttc
//
