LOCUS       NM_001401380            2962 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ring finger protein 2 (Rnf2), mRNA.
ACCESSION   NM_001401380 XM_006249990
VERSION     NM_001401380.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2962)
  AUTHORS   Almeida,M., Pintacuda,G., Masui,O., Koseki,Y., Gdula,M., Cerase,A.,
            Brown,D., Mould,A., Innocent,C., Nakayama,M., Schermelleh,L.,
            Nesterova,T.B., Koseki,H. and Brockdorff,N.
  TITLE     PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome
            inactivation
  JOURNAL   Science 356 (6342), 1081-1084 (2017)
   PUBMED   28596365
REFERENCE   2  (bases 1 to 2962)
  AUTHORS   Gao,Z., Lee,P., Stafford,J.M., von Schimmelmann,M., Schaefer,A. and
            Reinberg,D.
  TITLE     An AUTS2-Polycomb complex activates gene expression in the CNS
  JOURNAL   Nature 516 (7531), 349-354 (2014)
   PUBMED   25519132
REFERENCE   3  (bases 1 to 2962)
  AUTHORS   Gil,J. and O'Loghlen,A.
  TITLE     PRC1 complex diversity: where is it taking us?
  JOURNAL   Trends Cell Biol 24 (11), 632-641 (2014)
   PUBMED   25065329
  REMARK    Review article
REFERENCE   4  (bases 1 to 2962)
  AUTHORS   Frangini,A., Sjoberg,M., Roman-Trufero,M., Dharmalingam,G.,
            Haberle,V., Bartke,T., Lenhard,B., Malumbres,M., Vidal,M. and
            Dillon,N.
  TITLE     The aurora B kinase and the polycomb protein ring1B combine to
            regulate active promoters in quiescent lymphocytes
  JOURNAL   Mol Cell 51 (5), 647-661 (2013)
   PUBMED   24034696
REFERENCE   5  (bases 1 to 2962)
  AUTHORS   Yokobayashi,S., Liang,C.Y., Kohler,H., Nestorov,P., Liu,Z.,
            Vidal,M., van Lohuizen,M., Roloff,T.C. and Peters,A.H.
  TITLE     PRC1 coordinates timing of sexual differentiation of female
            primordial germ cells
  JOURNAL   Nature 495 (7440), 236-240 (2013)
   PUBMED   23486062
REFERENCE   6  (bases 1 to 2962)
  AUTHORS   de Napoles,M., Mermoud,J.E., Wakao,R., Tang,Y.A., Endoh,M.,
            Appanah,R., Nesterova,T.B., Silva,J., Otte,A.P., Vidal,M.,
            Koseki,H. and Brockdorff,N.
  TITLE     Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A
            to heritable gene silencing and X inactivation
  JOURNAL   Dev Cell 7 (5), 663-676 (2004)
   PUBMED   15525528
REFERENCE   7  (bases 1 to 2962)
  AUTHORS   Kaneko,T., Miyagishima,H., Hasegawa,T., Mizutani-Koseki,Y.,
            Isono,K. and Koseki,H.
  TITLE     The mouse YAF2 gene generates two distinct transcripts and is
            expressed in pre-and postimplantation embryos
  JOURNAL   Gene 315, 183-192 (2003)
   PUBMED   14557078
REFERENCE   8  (bases 1 to 2962)
  AUTHORS   Voncken,J.W., Roelen,B.A., Roefs,M., de Vries,S., Verhoeven,E.,
            Marino,S., Deschamps,J. and van Lohuizen,M.
  TITLE     Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle
            inhibition
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2468-2473 (2003)
   PUBMED   12589020
REFERENCE   9  (bases 1 to 2962)
  AUTHORS   Suzuki,M., Mizutani-Koseki,Y., Fujimura,Y., Miyagishima,H.,
            Kaneko,T., Takada,Y., Akasaka,T., Tanzawa,H., Takihara,Y.,
            Nakano,M., Masumoto,H., Vidal,M., Isono,K. and Koseki,H.
  TITLE     Involvement of the Polycomb-group gene Ring1B in the specification
            of the anterior-posterior axis in mice
  JOURNAL   Development 129 (18), 4171-4183 (2002)
   PUBMED   12183370
REFERENCE   10 (bases 1 to 2962)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Feb 10, 2022 this sequence version replaced XM_006249990.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1439845.1,
                                           SRR26360172.59193.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000013.1  66132819-66132911   c
            94-182              JAXUCZ010000013.1  66113408-66113496   c
            183-343             JAXUCZ010000013.1  66111086-66111246   c
            344-559             JAXUCZ010000013.1  66110237-66110452   c
            560-832             JAXUCZ010000013.1  66107207-66107479   c
            833-1004            JAXUCZ010000013.1  66106121-66106292   c
            1005-2962           JAXUCZ010000013.1  66103943-66105900   c
FEATURES             Location/Qualifiers
     source          1..2962
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..2962
                     /gene="Rnf2"
                     /note="ring finger protein 2"
                     /db_xref="GeneID:304850"
                     /db_xref="RGD:1305491"
     exon            1..93
                     /gene="Rnf2"
                     /inference="alignment:Splign:2.1.0"
     exon            94..182
                     /gene="Rnf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1106
                     /gene="Rnf2"
                     /EC_number="2.3.2.27"
                     /note="RING1b; RING finger protein 1B; RING-type E3
                     ubiquitin transferase RING2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RING2"
                     /protein_id="NP_001388309.1"
                     /db_xref="GeneID:304850"
                     /db_xref="RGD:1305491"
                     /translation="MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRS
                     LHSELMCPICLDMLKNTMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRP
                     DPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQRGK
                     KQQIENGSGAEDNGDSSHCSNASTHSNQEAGPSNKRTKTSDDSGLELDNNNAAVAIDP
                     VMDGASEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSKG
                     ESNQMNLDTASEKQYTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYAPTKE
                     HK"
     exon            183..343
                     /gene="Rnf2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..559
                     /gene="Rnf2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..832
                     /gene="Rnf2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1004
                     /gene="Rnf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..2962
                     /gene="Rnf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggctcgcc atattgtgcg gcggcaccgg cggttgatcc tcgagtctcg ctccggccgc
       61 ggccagcgca gccccggact ggggcaggag ccgagatgtc tcaggctgtg cagacaaatg
      121 gaactcaacc attaagcaag acatgggagc tcagtttgta cgaattacaa cggacacctc
      181 aggaggcaat aacagatggc ttggaaatcg tggtttcacc tagaagtctt cacagtgagt
      241 tgatgtgccc aatttgtttg gatatgttga agaacaccat gaccacaaag gagtgcttac
      301 atcgcttttg tgcggattgc attatcacgg ccctcagaag tggcaacaaa gaatgcccta
      361 cctgtcggaa aaaactggtt tctaaaagat cactaaggcc agatccaaat tttgatgcac
      421 tcatcagcaa gatttatccg agccgtgatg agtatgaagc tcatcaagag agagtattag
      481 ctaggatcaa caagcacaac aatcagcagg ccctcagcca cagcattgag gaggggctga
      541 agatacaggc catgaacaga ttacagcgag gcaaaaagca gcagattgaa aatggcagcg
      601 gagcagaaga taatggtgac agttcccatt gcagtaatgc gtccacacac agcaatcagg
      661 aagccggccc cagtaacaaa cggaccaaga cctcagatga ctctgggctt gaactcgaca
      721 acaacaatgc agcagtggca atcgatccag tgatggatgg tgccagtgag attgagttgg
      781 tattcaggcc ccacccaact cttatggaga aggacgacag cgcacagacc agatacataa
      841 agacttcagg caatgccact gttgatcact tatccaagta cctggccgtg aggttagctt
      901 tagaagagct tcgaagcaaa ggagagtcaa accagatgaa cctggataca gccagtgaaa
      961 agcagtacac catttacata gctacagcca gtggccagtt cactgtttta aatggctcgt
     1021 tttctttgga gttggtcagt gagaagtact ggaaagtgaa caagcccatg gagctttact
     1081 atgcacccac caaggagcac aagtgagcct taagcaccaa ttccgagact gcacttttta
     1141 tagtctattc ctttaatatt aaagacgtac catcgttact tttatggaca gatctgggat
     1201 atgttcagtt ttctttctga gccagacttg tttacactat tagattaatg tctccttaat
     1261 ttaaagacag tactttttgg aagggactct agttactcag tactccgcac tctcttaacc
     1321 gtgtacctaa gttatatgct tatagaaaat aaacgtggct cctttaggga ggacacctcg
     1381 acctaggagg ttttcacagt tctgtattct ttgctttttc cttccagttt ttgatcttta
     1441 agacagggtc tcattttaaa gccctggcta gcctggacct tactgagcag cacaggctgg
     1501 ccttcactgt gcagtcatac tcctgcccaa gtactgggag tctacgtggc ttacagttca
     1561 gttggccatc agccatcttc cccctttcaa aaggttttag cttaaagaat gttagacaat
     1621 atgtattctg acttttttcc cttggagtct tgtatattta tagttttcta tacaaactgt
     1681 agtatcttca tgaagaccaa ggctcaaatt tactgtgctt aaaacaattc tcataggatt
     1741 attattttca tggtattttc ttacataata tctcatttaa aaggaagttc tttatgaact
     1801 tggtgtccat tgtcatgcaa tgttttgttt ttgtcatgtg ttttcactgt aagtttagaa
     1861 tttctggtca ttggggaaga gttgaacaaa gttctttgag aacatggttc atttacagat
     1921 ttcactgaag aaagaaaagt ttaagttggt gaaaatatat gtattcctct gtacatttga
     1981 gagttctttt tttctgtatt ttactgttcc tttatgtgta tttgatgctt ttctctatta
     2041 aagtaccaga ttatggagca ttttgcacgt tagccttgat gaaaagaagg tctgttcaaa
     2101 gcttccctca cttttcttat taattcaaga ataacatgac acagagttaa aaatggaaaa
     2161 gaaaggcttt gtttgaagag ttctttacat tttgagctgc catgtgttta taaagttagt
     2221 gctctgctga ttacactctg tagaagcagg gtaatggagt gtgaacattg cgttgacata
     2281 taatgagaca attctgtaga agaatgccag ccagttgggt agccattcac gtgtccttag
     2341 ttttgtactg agaaagtgta gatagtctgg gaaccacagt cctgatgcta catatgtctc
     2401 caagtttaca ttctcacagt atttacaacg acacgtttgc attggaaatt taacccaaag
     2461 gggttttgat agaagggaga gacttccaat accattgtaa ctaaggtgtc agtcatttta
     2521 gctatttctc tgtccattta gacagattgg ggccagcttg atgcttttat cttgagccaa
     2581 ctatgaaaac ttaaaggctt actcaatttt ttaccatttt attgaaaatg tttgaaatct
     2641 gtttttacaa ttttttgggt aatctgtgcc ataagatttg aaaaccacca aaaattatac
     2701 aaacttttat atccagttcc ttttctgggg taacgttaag ttgtatagat tactaatgca
     2761 tgtttgctga atataactct ttgttttgtg atgtgattgc ttagatttta ttggtgacat
     2821 tagattagta gttgtattaa ataattaaat tcttgtggtt attgattgaa attttatcaa
     2881 agcagaaagt tatttgtgac tatacatatg tttttatctg tctatgggag tacataaact
     2941 ttgcatcgtt tagttgaagt ta
//
