LOCUS       NM_001109117            7787 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus ring finger protein 182 (Rnf182), mRNA.
ACCESSION   NM_001109117 XM_001060135 XM_573998
VERSION     NM_001109117.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7787)
  AUTHORS   Liu,Q.Y., Lei,J.X., Sikorska,M. and Liu,R.
  TITLE     A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated
            in the brains of Alzheimer's patients and targets ATP6V0C for
            degradation
  JOURNAL   Mol Neurodegener 3, 4 (2008)
   PUBMED   18298843
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000288.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001109117.3.
            
            On Jul 29, 2021 this sequence version replaced NM_001109117.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760434
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JACYVU010000288.1  6526835-6526924     c
            91-7787             JACYVU010000288.1  6471844-6479540     c
FEATURES             Location/Qualifiers
     source          1..7787
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..7787
                     /gene="Rnf182"
                     /gene_synonym="RGD1560399"
                     /note="ring finger protein 182"
                     /db_xref="GeneID:498726"
                     /db_xref="RGD:1560399"
     exon            1..90
                     /gene="Rnf182"
                     /gene_synonym="RGD1560399"
                     /inference="alignment:Splign:2.1.0"
     exon            91..7787
                     /gene="Rnf182"
                     /gene_synonym="RGD1560399"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..1043
                     /gene="Rnf182"
                     /gene_synonym="RGD1560399"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase RNF182"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF182"
                     /protein_id="NP_001102587.1"
                     /db_xref="GeneID:498726"
                     /db_xref="RGD:1560399"
                     /translation="MASQPPEEPAEFQVSDELECKICYNRYNLKQRKPKVLECCHRVC
                     AKCLYKIIDFGDSPQGVIVCPFCRFETCLPDDEVSSLPDDNNILVNLTCGSKGKKCLP
                     ENPTELLLTPKRLASLVSPSHTSSNCLVITIMEVQRESSPSLSSTPVVEFYRPASFDS
                     VTTVSHNWTVWNCTSLLFQTSIRVLVWLLGLLYFSSLPLGIYLLVSKKVTLGVVFVSL
                     VPSSLVILMVYGFCQCVCHEFLDCMALPS"
ORIGIN      
        1 tcaatcgccg gcgccgccgc cggagtggct ctcggtcctt ccatcgatcc tccggtccgt
       61 cctcccgcgg cccccgccgc cgctggtcag atccttcagc tgccccttta aaatatgtgt
      121 cagagacagc actttgcagg agctgaaaat ggtcaaaaga cttctggatt ttcttcctcc
      181 ctttccagcc cttccagcct ccttgcctga ctcggatgat gtgatattca gagggattcc
      241 ttaatccaag tcaccgctca gccaggcaca tctacagaag attgcatcca taattcaaga
      301 tggccagcca gccgcccgaa gagcctgcag agtttcaggt ctcagatgag ctcgagtgta
      361 agatctgtta caaccggtac aacctgaaac agcggaagcc caaggtcctg gagtgttgtc
      421 acagggtttg cgccaaatgc ctctacaaga tcatagactt tggggactct ccccaaggtg
      481 tcatcgtctg cccgttctgc aggtttgaga cgtgcctgcc ggatgacgaa gttagcagtc
      541 tgcccgatga caataacatc cttgtaaatc tgacttgcgg aagcaaaggg aagaaatgcc
      601 tgcccgagaa ccccaccgag ctgctgctta cccccaagag gctggcttcc cttgtcagcc
      661 cttcccacac atcctccaac tgcttggtga tcaccatcat ggaggtacag agggagagct
      721 ccccgtctct cagctccacc cctgtggtag aattctacag gccagcaagt ttcgactctg
      781 tcaccacagt gtcccacaat tggacagtgt ggaactgcac ctccttgctc tttcagacgt
      841 ccatccgggt actggtgtgg ttgctaggtt tgctgtactt cagctccttg cccttaggga
      901 tctacttact ggtgtctaag aaggtcaccc tgggggtggt ctttgttagc cttgtcccct
      961 ctagccttgt catccttatg gtatatggct tttgccaatg cgtttgtcat gaatttctgg
     1021 actgtatggc acttccttct taatcaatat gcagaatcgg aaactcggca catgtggcta
     1081 cgttcaaccg acgttcgtgt gacctgcttt cctttgtatt ccctacgatt agtgtctgca
     1141 gcctcaatga agcccttggc catgcgtctg cggtccattt tccatccaga gtttggcttg
     1201 atgggttttc ctggattctg aaaaataaaa ataaaaaaaa gttcacttct atataggggc
     1261 gggctggcca agaggcaaag ctgtgtccgc aaacaaaggc ataggcccag ggagtgcttt
     1321 cattcaggta ccaggcaagg tgtgttacaa cgaggcaggt tctttgggcg aaggtgggga
     1381 tgaatggagt cctccttgag gttaggcgcg tcccatgatt gtaggtagat gtcagaggca
     1441 ggctgctcaa aagcacgtgg gagcgcccct cattttcctg gcgctggagc ccctcatcat
     1501 caggtgcttt ctctcctgag gtaatgcttc tctgaagtca gctgcctctt ctcagattcc
     1561 ttttgcgtct gtgcagcccc tctccccctc ccccacactc cagggtcctt caatctcatc
     1621 ttcttgggtg gtttcctgca ggattcctgt tttggctggt ggccgtagaa gacagacatc
     1681 gctgagaggt ttgcacgagg agttagacct catgccaggg catggtcatt tatgttcaac
     1741 acaggccttt tcctccaccc gtgtttttct cccaggctcc tctgggatga tctgaacagt
     1801 ttttgcatgt ggaaatattc accagaatat taaaatgtga aaatgcttcg tttgattttt
     1861 aaccacagtc cccaaccaac ctcatccctt atcctgaaca aagttccatt taaagtagtt
     1921 gcaatcagtt tctggaggct tgttttagaa gtttgcatag ggtgggcttt gctgcccctg
     1981 caatgctctg gagggaacct gtgatcgtga aaacccagca acaggccacc agctgcccta
     2041 gcgcctggca ctaagaacca cgtgttctgc tgagtagtac aagtttatgt cctatgaagt
     2101 ccacacaagg ggagaggtgc agccccgcca agctgatgcc ctgctcgaag tggagtggag
     2161 gtggttaagt gcaggctccc tcgaggctgc ttgctattct gtcagtttgg ggatagattt
     2221 gagactttaa tttattttct gtaaaggcat aagctgcgtg gcttgggtct ggacgccttt
     2281 tcatgaagtg ggggtggggc gggggtgacg ctgaatgtat atatttatgg gagtaagttg
     2341 cccagcaggc tttaggtggg ggaatagaat gttcgcagaa tgttcactag tcagaaagag
     2401 gaaagagtgc ttcttagtct ctgagactta ttactgacaa cttaacaata ttatacccac
     2461 aatgcttagc aaagggcttt accagggttt tgttaacttg tttgtggtga aatatttctt
     2521 gtgtgatata gttgcagggg gccggttctg atctccgcat tgagggaaaa tggatactta
     2581 actagaatag gagttttaat ttcgttgtat aactactgac ttggagaaca tgtatgtcca
     2641 agatacaagt aatgagaaaa tacacgtggg atgtggtcca gtgaaattta aaccccaact
     2701 tagagctaaa tacatttatg attccagaaa ccctagtttt aggtagtgtt gtggatgtgg
     2761 tttccagaat tccgtttgta ctttgactaa atacaatatt taagaggttt tgtggtttgg
     2821 atttatatat ttataaggtt tcctttttaa agatgcacat tttgtctgaa ctgtaacact
     2881 gagtaagctg tcaagtgacc acaggaagag atttccagaa ggcttcggac ccactctgtg
     2941 ttttgctagt tcgtgtggtg tctgcagtgc tgaagtcgtt tctgtatgtg ctgtggcaat
     3001 atttttccta acgccagtgt gctgacctgg ttttaaagag ttttgaatgt atgacaacaa
     3061 cacagaacaa cacagctctc catgctgtcg aatgggaggg gcgatcctgt aatgttgtaa
     3121 tctctatgct aatgttctct tgtctattaa attttatgat ttctaagtga gatgtttgct
     3181 ttctctgatt tacggtcgag atgccgttat cactttagat agtcccaagt gcgaactttc
     3241 gttaaaccaa ggcctttatc atccacatgg aaatcttaga agcttcctac aaagctaacc
     3301 acatctatct catctctaca aaggccctca tttttttcca agtggagcag aaggtgaaat
     3361 aagaatatga tctttatcaa tgaaatgttc tatttgattt gatgtgatta attctcccca
     3421 actgcttaac aagatagaat ccagtgtggt gaagacatcc cttacttgta gagtctggcc
     3481 aaactggaaa aaagcacaaa gtttactagt catgatcctc attgagtgat ttaagagtat
     3541 gcagcagctc tgtgttcgta ttagtgaatt agcaccacac gtccatcaag aacaatggtc
     3601 taacgtgctt cagaaatctt tgcacaagtg agcaaagaag caggttgtgg aagatgatcc
     3661 cctggtcccc tgtgattata ctgtgagctc cgccttagct gctgagaaac caggaagcag
     3721 tgcacatttg caggagtgcg agcattgcag aaaccgtgat gaaacttctc agtgcattaa
     3781 cccgacagat gcaaaggcag aggaatcctg acggttgcga gacaagcaga aggagtcaag
     3841 aggggacctt agaggaagga gctgtgaggg actttgagga cctcagaggg aggggcagta
     3901 agggagcttg ggatagtaca atggagatgg ctgtgttctt tattcttttc ttgctgacac
     3961 agtcttaaag gttgccttga cccgttggaa tattttcagt cagactacat aatattctag
     4021 aactttcctc aaaaccaata gcaacagcct cagattcagg taaaatcccc gagtttaacc
     4081 atttgtgttg cagcttgcat tttatatgtt ttccacatct tttccctctt ccgatgtaat
     4141 tatatttctt tatttcagta accatcatgg ggttttacaa atcctgtagg cttagtgctg
     4201 ggtctttcct tgtaagttta cttttgtcta aaatgtttcc ttttaggaaa acgtttcttt
     4261 atgattttat gtgtcgagat gttttgcctg cacatatatc tggaaaccct gtgtatgccc
     4321 ggcgcctgag gtcagaagaa ggtgttgcat tcctctggga ttggagttat tcatggctgt
     4381 tgcaagatca acaagtgttt ttaaccactg aaacatgtct gcagcaccta aaagatggtg
     4441 atttcgattg tggaggatga acgttgaaat atgaataaat tctaaatgag tctcagatac
     4501 attaacgaat aaacccactt tcttatatgg cttaaatccc tggaataatc ccaacctaat
     4561 tgcaatcact gtgtatggtc aggaattaaa ctacagcctc aatactatga tactaagttg
     4621 gggtatacga taacttactt ttcaaagtgg ttgggccttg atttaattca aatatttata
     4681 caagacaatt acctggccaa cattttaatt gatcagatat ttgttgactg tactgtttat
     4741 atgagttcca ggcgaaagtg tcctggatgg gcaggttgcc tgtgaccttg ttgttcctac
     4801 gaagtgtaaa gaaagtcgtt ttgtgtgttt gtgtctatgc ccctcaggga agagcagcct
     4861 gaagtcctgc ctttgcaaag caactgagtc tgtggaagtg gagagatgga tgccgaggca
     4921 gagcaagaaa agcactgacc ctgagcgccc caaacctgga actctgaata cccccccggg
     4981 gggggcgctg gagagaagat tctggaacag ccagatggaa gccagagacc gtatgcttgt
     5041 cagacccaag agggataagg tggaattagc atcatttggt caacacatgt agaaagagat
     5101 ttcagattgg tttataacaa aaaccaaacc aaaccagccc aacaaacaaa acaaagccaa
     5161 cccaacaaca acaacaaaaa gcctagataa gctttccctg tggaaacttg cagaagcatg
     5221 gagcgaagtt gtttgaaaca aagcagttat tgccggttta cttagcatcc agcattggca
     5281 tctaaactaa ccgtgtttgt tttctttgtt gggtaaatgg ggttggggat ttagctcagt
     5341 ggtagagcgc ttgcctagga agcgcaaggc cctgggttcg gtccccagct ccggaaaaaa
     5401 aaaaaaaaaa atgtatgaca tataattttc agtttaacac tttccctaat tcctcccaac
     5461 acgatctcac tgtagttgag ccgatcaaaa atcatcttct tctgggtcat tagatgtttt
     5521 ttggaccaag ataaggcaat tctgggagct ggcgtcatgt cagttccatc tggagagttt
     5581 ggaatgcatt aaacttttta ttgtcagtct ccagattaaa aggcttgtct tctcacagaa
     5641 ttcttaacaa atcttagtta ttttagcaac acatgtgctt gagacggtgt tttgcatact
     5701 aaggagctcc attaataata aatgaacatc tatttgtgat ctgtgttgaa cccaaacttc
     5761 ccacactctt cccttttagt ccctccccat tctctgatgt ttaaaatgtc atttttagaa
     5821 gaaccccatg caccggttat catcctcctg cgcacacatg cacaagtaca acatgcatgt
     5881 gtatctacat gaatgcacac attcacacgt acatgcttat gcattttagg aaacagctat
     5941 gaaagagaac catgtaagtc taccaacctc ttttaattac ccaggtaagt aatattgaaa
     6001 acatcatcat cgtcgtcgtc gtcgtcgtcg tcgtcgtcat catcatcatc atcattatta
     6061 ttattattat tattattatt attattatta tgaccactaa ctgcctgcct tttcttccct
     6121 gctcatggag tgatgctctc agctgctcgc ctcagagaca attccttcct cttttcccgt
     6181 gttctacatc atcgagcact ggaaatcatc ctagccaagc aatgggcttc ttcgttgaca
     6241 ttgcttctgt ctgatgtgct ttttctcact actccggcta gaactaactg tataggtaat
     6301 gattaaattg gtggtcataa attgtctttg gcttgatctt cagattatac aattatttcc
     6361 agcttcctgt ggtctgagca gctggaaacc accagttaaa acgggacaga tgatgacctg
     6421 attctatggg ccttccttct gccagagtgg agtgtggggt acagagtgat ccctggaggc
     6481 caaggaatgc taaagtctgg ctttggaatg gggagggaag tacactaatc acccctcctg
     6541 ttccccactg cagctccatg tctcaatcga acctcaccag atgttttgac catagcttaa
     6601 agatcattgt tttgacccac attcgagcaa cttacagtgc ataatataaa aaatttcctt
     6661 ggctttttga caggatacct gtgcctttta tgggtcactg ggagaataag aagacaatcc
     6721 tagtttactg ttttgaaaag caggatctta cgatggaaat tactctataa catacgttgt
     6781 ggaatgtgtc agaatggctg atccctgaag ggccactcga gtagaaggag atgaaaggtc
     6841 atggtcttct cagacactca cgagaagtca gtcccttgaa gtctgaggct tagacagacc
     6901 tgcttagtac tgtagtcctt aaacttactt atctcggaag cctttcttac aacacccctt
     6961 agcaataggg ttagttggat gggagacact tggtgaaatc tgcctttgag aatgggaaaa
     7021 aaaaaaaacc aaaccaaaca aaacaaacaa acaaaaaaaa caaacaacaa acaagcaagc
     7081 agccaaatcc tgctatggtg tagaatctga aatcgaatgt aagtcaccga gccagcacat
     7141 gaatttacag gacggccaaa tcaaagcagt ggttcctagg gggtcccaag tagaacggca
     7201 acacgggaaa tgggaaggag agaggagcag gctgccagga gcgcagactg tggcgggcgg
     7261 ttgagattcc cacttgcttc caacttgatt ggcccccttg tccagatttc acagcgtcag
     7321 ccctaacatc tgcatctgca tcagcaccag catctgcatc agcaccagca tcagcatcag
     7381 catcagcatc agcatgagca tgagccttct gagtcactct gcacaaagga agtcctaaat
     7441 atatgcagaa ggaagtctca ggtggagcga ttcctctggt tatttgcttt gcctgtgaaa
     7501 cttccgctgt gaagtcctcg gagtggaacc cggtctccca gcttttggaa aacacgcacc
     7561 agatgcaaaa tcttgatcac agtgttagtg cttgaaatac ttaacggctc agagtgtggc
     7621 tgcctcattt aacaaatgag aaaccaaccc atgggaatga ccaaaggtat cacaggcgcg
     7681 gactagaaac gtgggggact tgacttgatt agggggtgtt ctcagtgtgt cttctttgat
     7741 gtaatggttt gctttctctg taattagatg ccccattcta aaatttc
//
