LOCUS       NM_001399260            3878 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus ring finger protein 170 (Rnf170), mRNA.
ACCESSION   NM_001399260 XM_344558
VERSION     NM_001399260.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3878)
  AUTHORS   Lu,J.P., Wang,Y., Sliter,D.A., Pearce,M.M. and Wojcikiewicz,R.J.
  TITLE     RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase,
            mediates inositol 1,4,5-trisphosphate receptor ubiquitination and
            degradation
  JOURNAL   J Biol Chem 286 (27), 24426-24433 (2011)
   PUBMED   21610068
  REMARK    GeneRIF: RNF170 plays an essential role in IP(3) receptor
            processing via the ubiquitin-proteasome pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jan 5, 2022 this sequence version replaced XM_344558.9.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1426754.1,
                                           SRR26360172.2830589.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMN06621351 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               JAXUCZ010000016.1  72656661-72656828   c
            169-301             JAXUCZ010000016.1  72655727-72655859   c
            302-442             JAXUCZ010000016.1  72651738-72651878   c
            443-518             JAXUCZ010000016.1  72649619-72649694   c
            519-627             JAXUCZ010000016.1  72646447-72646555   c
            628-701             JAXUCZ010000016.1  72639909-72639982   c
            702-812             JAXUCZ010000016.1  72636398-72636508   c
            813-3878            JAXUCZ010000016.1  72631638-72634703   c
FEATURES             Location/Qualifiers
     source          1..3878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..3878
                     /gene="Rnf170"
                     /note="ring finger protein 170"
                     /db_xref="GeneID:364654"
                     /db_xref="RGD:1590842"
     exon            1..168
                     /gene="Rnf170"
                     /inference="alignment:Splign:2.1.0"
     exon            169..301
                     /gene="Rnf170"
                     /inference="alignment:Splign:2.1.0"
     exon            302..442
                     /gene="Rnf170"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1082
                     /gene="Rnf170"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF170"
                     /protein_id="NP_001386189.1"
                     /db_xref="GeneID:364654"
                     /db_xref="RGD:1590842"
                     /translation="MARYYSEVQSLQQDDSVIEGVSDQVLVAVVVSFALIASLLYALL
                     RNVQQNIHPENQELVRVLREQLQTEQDVPAPARQQFYTEMYCPICLHQASFPVETNCG
                     HLFCGSCIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDDQSQDVVRLRQDVNDYNR
                     RFSGQPRSIMERIMDLPTLLRHAFREVFSVGGLFWMFRIRIMLCVMGAFFYLVSPLDF
                     VPEALFGVLGFLDDFFVIFLLLIYISIMYREVITQRLTR"
     exon            443..518
                     /gene="Rnf170"
                     /inference="alignment:Splign:2.1.0"
     exon            519..627
                     /gene="Rnf170"
                     /inference="alignment:Splign:2.1.0"
     exon            628..701
                     /gene="Rnf170"
                     /inference="alignment:Splign:2.1.0"
     exon            702..812
                     /gene="Rnf170"
                     /inference="alignment:Splign:2.1.0"
     exon            813..3878
                     /gene="Rnf170"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagtcggct cgccctcgct gaggctccgc actgcgcgtg cgccgacgcc ggcgctctcg
       61 ctttagaagc cgcctgtagt tgcaccggga gtagtagcta ggtagtcccc ggaaatgaac
      121 tctattctgt cacacggact ggcacggtag ttcctctgcc gcgacgagtt tagggcgtct
      181 cagaataatg ctataataaa cattcttcta cctggacctt aatgcaaaga tattggcgtt
      241 tccaagacac caagatacaa gatatatgct ttggagccct aggagaattg tggattcaaa
      301 gacctgtaat ggccagatac tacagcgaag ttcaaagttt gcagcaggat gattcagtta
      361 tagaaggagt aagcgaccaa gtacttgtgg cagtggtggt cagcttcgct ttgatcgcct
      421 ctctcctgta tgcactactc agaaatgtac agcagaacat tcatccagaa aaccaagagc
      481 tagtcagggt gcttcgagaa caacttcaaa cagagcagga tgtccctgct cctgctcgac
      541 agcagttcta cactgagatg tactgtccaa tctgcttaca ccaagcctcc tttcctgtcg
      601 aaacaaactg tggacatctc ttttgtggtt cctgcataat tgcatactgg cgatacgggt
      661 cttggcttgg cgcaatcagt tgtcctatct gtagacaaac ggtaactctt ctcctcacag
      721 tgtttggtga agatgatcaa tctcaggatg ttgtaagatt gcgtcaagat gtgaatgatt
      781 ataaccggag attctctggg cagcctagat ctattatgga aaggatcatg gatctcccca
      841 ccttgctgag acatgcattc agggaagtgt tttcagtcgg gggtctcttc tggatgttcc
      901 gaattaggat aatgctttgt gtgatggggg cttttttcta tctagtatcc cctctggact
      961 ttgttcctga agccctgttt ggagttctgg gctttctaga tgacttcttt gttatcttcc
     1021 tgttgcttat ttacatctcc attatgtatc gagaagtgat aacccaaaga ctaaccagat
     1081 gagagaaatg agtttactag agtattggag cttatataaa aatcaaacaa aaggatccat
     1141 ggccgtatcg atcacccaga tattatttta catgcctaaa acacttggct gtcatttgac
     1201 aaatgcctat gaatatacaa ctggaacatt tacatactac agcttctaat gttaacatca
     1261 aatttatagt gagctacagg tttatcttca ttctgtgttg tctgtaaaaa agtatgaaac
     1321 gagctgaaag gggtaatttg ttgttttctt tttctgcaaa ttatttagct tagatacgta
     1381 gttcagtatt gctgaatgta caaatcgtcc tcctcagtgg gtacccatac aataatagag
     1441 aactttgaaa cttacctaaa tacttttgtt aaagtaaaat agtgtatgat acttagggaa
     1501 aggtcagtgt ctcagtgtat gctaagctct gtggacttgg agcagctctg cttttcattt
     1561 ttgtataatt ctttgtgatc aactgaaaat gaaagaaact tgaacttcct gatatgacct
     1621 tattttcagt ctctagaaca ctttaatcaa taggaggatt aacagagtga aaactacgca
     1681 tctcctggag tggcctttgc cactcagtta cgacattaac ccagagtttg gactttttat
     1741 agaaacaagt acaaaagtaa ctgtagccag ctgtggtggc ttctacttgt tatttctgcg
     1801 ttcaggaagc tgaggtatta gattgccaca agttcaaggt cggcctagag ttaaagagtg
     1861 agatcctact caagccaaaa gcagggcagt gagttagggg cttaccacca ggcctgacaa
     1921 cctgggtttg aactctgggc ctcacataag gtaagcacag aacagattcc ccaagttgtc
     1981 ctctgacctt cacatgtgtg ttgtcatgca tgcacagaca cacacacaca cagagtaaat
     2041 aaaataaagt gcaatgaaaa aggaaagaaa gtagcttgta aagggaaatt attttgttct
     2101 aggaacctga gtaacattgc aaactagtag tagttgatag cattttgagg aaacaggctg
     2161 gttatttcta ttggcattcg tcagggcctt taggaaggta caaagaacag tatttagatt
     2221 ttacaaacta tgagttaact cttccggcaa aatgaaggta tttgattagc tgtctgttgc
     2281 cctgaaaatg cagaaatctc atcttctaga tggctcagat tcatcacgtc ttgggcagaa
     2341 tgaggaaatg tgtatgagaa cctcaataat gagggtcaga ctgtttctgc tgttttttat
     2401 ggccctgaca tgggaacgta aggtctgtag ttttgtttgc gtagagtgag tcctgtaact
     2461 gagatgctca ccccagctgt cactgcttcc cagggagcat ctggatggag ggtgtgaggt
     2521 gatgctgaga ccctttgtca tctgatgtca cccttggttt cctagtcagc ctcagtcagt
     2581 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gacataaagc
     2641 taaaatatgt catgttcccc aaaaaatcag attagctgcc aaataatgaa attctgaatg
     2701 aaatgtcagt ttgtctaatg taggcttaac acaaagatgt tgtctgccat ttaaaaaaaa
     2761 aaacataaaa caaaaaccag tccttatata tacatgatca gtgcaatttc tcataatttt
     2821 tattttatcc ttagaagatg ttatgaggac ggtagagtgc catcagcttc ctgtttcaga
     2881 gagaagacct tcatcctgtg ggtgaaagac ttttgttttc ctaacagaat ggaactagtg
     2941 agatttaggt aggcacaaaa gctagtctga ggagaagcag gaggaactgg gattctctgg
     3001 agtcaggttt tcataacaca ttattccttt actggaacag ttttggtgct tctaagctaa
     3061 agctccagga agaagattcc tcagagcctt tacccatctc cagtgaatgc ttccaaatga
     3121 agtacgagtg gcaggcacca cagaaccgtg gccactcgtc accaacccgg aagctgttga
     3181 gtggggagct cgttaccagc ctgggaaaac attttccacc ttttaaaagt gcaatgtgga
     3241 ctatagctct gatttactga aatgatttta ttttctgtgc gtgtgttctg ctccaactgt
     3301 cacacttctg taatatttgg acttactcta atactccgag aagaggtgta ctgtacaaaa
     3361 tctgtaacat acaaaaccac tatgaagtca ctcaagtctt actgaaccaa aaaagggaac
     3421 acagtggtat ctcagaattt gtcatctcct aacccctcat ctttactgat cattaatgat
     3481 aatgcaaaag cagtttgaga aagtattgaa agcgagcaga gtcgatcagt gttgaacatc
     3541 acagcagtac ttcgtattca gaggtcacac aaatcaaagc aacagaacat agtaaccata
     3601 gtgatggcca cagagccatg gtacaggccc aggaacagat gatgattgag cagctctgtg
     3661 gggaacgaga gggaactggt ccattaacaa ctcgctgggg ttgggtttct atagccacca
     3721 ttctcagtgc tgcggaagac agcagagttc ctgagcccca tggtgtacgg tgcctacttc
     3781 acagggtcta tgcagagaag cagaggcttc ttgcaaagct tgtgatttga agagtttgtt
     3841 tggcatttat tctttggaat aaaaatagtt tattttaa
//
