LOCUS       NM_001127597            3311 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ring finger protein 168 (Rnf168), mRNA.
ACCESSION   NM_001127597 XM_001065639 XM_001065698 XR_006773
VERSION     NM_001127597.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3311)
  AUTHORS   Panier,S. and Boulton,S.J.
  TITLE     Double-strand break repair: 53BP1 comes into focus
  JOURNAL   Nat Rev Mol Cell Biol 15 (1), 7-18 (2014)
   PUBMED   24326623
  REMARK    Review article
REFERENCE   2  (bases 1 to 3311)
  AUTHORS   Mosammaparast,N., Kim,H., Laurent,B., Zhao,Y., Lim,H.J.,
            Majid,M.C., Dango,S., Luo,Y., Hempel,K., Sowa,M.E., Gygi,S.P.,
            Steen,H., Harper,J.W., Yankner,B. and Shi,Y.
  TITLE     The histone demethylase LSD1/KDM1A promotes the DNA damage response
  JOURNAL   J Cell Biol 203 (3), 457-470 (2013)
   PUBMED   24217620
REFERENCE   3  (bases 1 to 3311)
  AUTHORS   Fradet-Turcotte,A., Canny,M.D., Escribano-Diaz,C., Orthwein,A.,
            Leung,C.C., Huang,H., Landry,M.C., Kitevski-LeBlanc,J.,
            Noordermeer,S.M., Sicheri,F. and Durocher,D.
  TITLE     53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin
            mark
  JOURNAL   Nature 499 (7456), 50-54 (2013)
   PUBMED   23760478
REFERENCE   4  (bases 1 to 3311)
  AUTHORS   Mattiroli,F., Vissers,J.H., van Dijk,W.J., Ikpa,P., Citterio,E.,
            Vermeulen,W., Marteijn,J.A. and Sixma,T.K.
  TITLE     RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage
            signaling
  JOURNAL   Cell 150 (6), 1182-1195 (2012)
   PUBMED   22980979
REFERENCE   5  (bases 1 to 3311)
  AUTHORS   Panier,S., Ichijima,Y., Fradet-Turcotte,A., Leung,C.C., Kaustov,L.,
            Arrowsmith,C.H. and Durocher,D.
  TITLE     Tandem protein interaction modules organize the ubiquitin-dependent
            response to DNA double-strand breaks
  JOURNAL   Mol Cell 47 (3), 383-395 (2012)
   PUBMED   22742833
REFERENCE   6  (bases 1 to 3311)
  AUTHORS   Shanbhag,N.M., Rafalska-Metcalf,I.U., Balane-Bolivar,C.,
            Janicki,S.M. and Greenberg,R.A.
  TITLE     ATM-dependent chromatin changes silence transcription in cis to DNA
            double-strand breaks
  JOURNAL   Cell 141 (6), 970-981 (2010)
   PUBMED   20550933
REFERENCE   7  (bases 1 to 3311)
  AUTHORS   Ramachandran,S., Chahwan,R., Nepal,R.M., Frieder,D., Panier,S.,
            Roa,S., Zaheen,A., Durocher,D., Scharff,M.D. and Martin,A.
  TITLE     The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch
            recombination
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 809-814 (2010)
   PUBMED   20080757
REFERENCE   8  (bases 1 to 3311)
  AUTHORS   Pinato,S., Scandiuzzi,C., Arnaudo,N., Citterio,E., Gaudino,G. and
            Penengo,L.
  TITLE     RNF168, a new RING finger, MIU-containing protein that modifies
            chromatin by ubiquitination of histones H2A and H2AX
  JOURNAL   BMC Mol Biol 10, 55 (2009)
   PUBMED   19500350
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3311)
  AUTHORS   Doil,C., Mailand,N., Bekker-Jensen,S., Menard,P., Larsen,D.H.,
            Pepperkok,R., Ellenberg,J., Panier,S., Durocher,D., Bartek,J.,
            Lukas,J. and Lukas,C.
  TITLE     RNF168 binds and amplifies ubiquitin conjugates on damaged
            chromosomes to allow accumulation of repair proteins
  JOURNAL   Cell 136 (3), 435-446 (2009)
   PUBMED   19203579
REFERENCE   10 (bases 1 to 3311)
  AUTHORS   Stewart,G.S., Panier,S., Townsend,K., Al-Hakim,A.K., Kolas,N.K.,
            Miller,E.S., Nakada,S., Ylanko,J., Olivarius,S., Mendez,M.,
            Oldreive,C., Wildenhain,J., Tagliaferro,A., Pelletier,L.,
            Taubenheim,N., Durandy,A., Byrd,P.J., Stankovic,T., Taylor,A.M. and
            Durocher,D.
  TITLE     The RIDDLE syndrome protein mediates a ubiquitin-dependent
            signaling cascade at sites of DNA damage
  JOURNAL   Cell 136 (3), 420-434 (2009)
   PUBMED   19203578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC166869.1 and JAXUCZ010000011.1.
            
            On Aug 30, 2012 this sequence version replaced NM_001127597.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166869.1, SRR26360172.548336.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2758              BC166869.1         1-2758
            2759-3311           JAXUCZ010000011.1  81991352-81991904   c
FEATURES             Location/Qualifiers
     source          1..3311
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..3311
                     /gene="Rnf168"
                     /note="ring finger protein 168"
                     /db_xref="GeneID:690043"
                     /db_xref="RGD:1585168"
     exon            1..322
                     /gene="Rnf168"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1716
                     /gene="Rnf168"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 168, E3 ubiquitin protein
                     ligase; RING-type E3 ubiquitin transferase RNF168"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF168"
                     /protein_id="NP_001121069.2"
                     /db_xref="GeneID:690043"
                     /db_xref="RGD:1585168"
                     /translation="MKMAAPKNSIPSLAECQCGICMEILVEPVTLPCNHTLCNPCFQS
                     TVEKANLCCPFCRRRVSSWTRYHTRRNSLVNTDLWEIIQKHYAKECKLRISGQESKEI
                     VDEYQPVRLLSKPGELRREYEEEISKVEAERQASKEEENKASEEYIQRLLAEEEEEEK
                     RRTERRRSEMEEQLRGDEELARRLSTSINSNYERNILASPLSSRKSDPVTNKSQKKNT
                     NKQKNFGDIQRYLSPKSKPGTAWACKTEHGEDMCKSKETDSSDTKSPVLQDTDVEESM
                     PTHSPQTCPETQGQGPEPLTEMPVPWLCARNAEQCLEGKAEAVSTNPDDSCIVNDGGP
                     RAIVSNSKEAAVKPPTKIENEEYSVSGVTQLTGGNGVPTESRVYDLLVGKEISERENQ
                     ESVFEEVMDPCFSAKRRKIFITSSLDQEETEVNFTQKLIDLEHMLFERHKQEEQDRLL
                     ALQLQKEADKEKMVPNRQKGSPDQYQLRTSSPPDGLLNGQRKNVKDRNSPKQTADRSK
                     SQRSRKGEYWETFESTWKGSVNGTKMPTPRKDSCNVSKRACPLQHRSAQKSILQMFQR
                     "
     exon            323..399
                     /gene="Rnf168"
                     /inference="alignment:Splign:2.1.0"
     exon            400..579
                     /gene="Rnf168"
                     /inference="alignment:Splign:2.1.0"
     exon            580..701
                     /gene="Rnf168"
                     /inference="alignment:Splign:2.1.0"
     exon            702..780
                     /gene="Rnf168"
                     /inference="alignment:Splign:2.1.0"
     exon            781..3311
                     /gene="Rnf168"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggccacatt agcatatgaa gatggctgca cctaaaaact ccatcccttc cttagcggaa
       61 tgtcagtgcg ggatctgcat ggaaatcctc gtagagcctg ttaccctacc ttgcaaccac
      121 acgctctgta acccatgctt ccaatcgact gttgaaaagg ccaatttatg ctgtcccttc
      181 tgtcgccgcc gggtctcttc gtggactcgg taccataccc gaagaaattc tctggtcaat
      241 acagacctgt gggagattat tcaaaagcac tatgcaaagg aatgcaagct tagaatctct
      301 ggacaagaat caaaggaaat cgttgatgag taccagccag ttcgtctact cagtaaacct
      361 ggggagttga ggcgagaata tgaagaggag ataagcaagg tggaggctga gcgacaagcc
      421 agcaaggaag aggaaaacaa agccagtgag gagtacatac agagactgct ggccgaggag
      481 gaggaggagg agaaaaggcg gacggagaga agacgaagtg agatggagga gcagctgagg
      541 ggcgatgagg agctggcgag gaggctgagc accagcatca acagtaacta cgagagaaat
      601 atcttggcat ctcctttgag ttccagaaaa tcagatcccg tcacaaacaa gtcacagaag
      661 aaaaatacga acaaacaaaa aaactttgga gatattcaaa gatacttgtc acctaagtca
      721 aagcctggga cagcatgggc atgtaaaact gagcatggag aagacatgtg caagtctaag
      781 gaaacagaca gtagtgacac gaagagccct gtgttgcaag acacagacgt tgaagaaagc
      841 atgccaacac attctcctca gacctgccca gaaactcaag ggcaaggtcc ggagcctttg
      901 acagagatgc ctgtgccatg gctatgtgca aggaatgctg aacagtgcct tgagggaaaa
      961 gctgaagcag tgtcaaccaa tcctgatgat tcatgtattg taaatgatgg tggacctaga
     1021 gccatagttt ctaactctaa ggaagctgca gttaagcctc ctaccaagat agaaaacgaa
     1081 gagtattctg tgtcaggtgt gacccagtta actgggggca acggagttcc aacagagagc
     1141 agagtgtacg acttactagt cggaaaagag atttccgaaa gagaaaacca ggaatctgtg
     1201 tttgaagaag tcatggatcc atgcttttct gcaaaaagaa ggaaaatatt catcacatcc
     1261 tccttagatc aagaagaaac agaagtgaat tttacacaaa aactgataga tttggaacat
     1321 atgcttttcg agagacataa gcaagaagaa caggacaggt tgttagcatt acaacttcaa
     1381 aaagaggcag ataaagaaaa aatggtgcca aaccggcaga aaggatcccc agatcagtac
     1441 cagctgcgca catcttcacc cccagacggg ttgctgaatg gacagaggaa gaatgtcaaa
     1501 gataggaact ccccaaagca aactgcagat cgttcaaaat ctcagaggag caggaaaggt
     1561 gaatactggg agaccttcga aagcacttgg aagggttcag ttaatggaac gaagatgcca
     1621 actcctagga aagatagttg taatgtatct aaacgtgcct gtcccctaca gcacagaagt
     1681 gcacagaaaa gcattcttca aatgtttcag aggtaaccaa gcaaagcacc gggagagagt
     1741 tctatagtcc agtaaagcta tattatagca aagctagctc ttctccccta aaatcctgag
     1801 atgtgtcatt agtttctgct cagcaaacac acttcttctc tttaagctgt gattacaaag
     1861 gaagaactta cgaatgtgtt tctgcaaaag tcagtgatga ggaaatgtcc ttgagaattg
     1921 tttcccttgt tagcagctgc tgtgttctaa gtgtgacacc tttacaggtg taaaactcct
     1981 cggtcaggac atcttcaggg ccactccctt ttccaaactt ttttttattt ttaatgaatg
     2041 ggtaaggagt ccacacaggg atcttccgta acaccagtaa gtccccatcc cagttttaac
     2101 tctaagcatt ttagcatttc ctttggtgga aagtgggttg gtgtcaacag cagctagtta
     2161 caaagctgct agattgttaa tgcaagggct ttacggtggg ctgggctgag tgctggaatg
     2221 ggagtgaggg gaatccctga actgaatggg tgatcaaaaa ccgggtccag catgggcacc
     2281 agatttcctg tggcagaaca ttctccttag ttcctttgtt aaatgacaga aaatatttgg
     2341 agtttacagc ttttcacgcc atggcatctt ggtgtgaaag ggcaaattgg tatagtttta
     2401 cttatctctt ctagaaaaga aataaattat tgaaggaaaa ttatactgtg ctctgctagc
     2461 attatactga acacccggca ttaccgtctt tattgcgtac tggctcagac tcatgcctgt
     2521 ttgtgcacac agggacgtgg tgtgtgggac ttgtcatgga ttgtcctggg tatgtggggc
     2581 ttgacttgga ttgtcctggg gtccagactg aagtcacctc gtgaagctga gcctctgcta
     2641 ttcaccttct gttaaaacag ctcagcaggc tgtagtctca gtaggatttc tctggtgtct
     2701 tggctccact tatgtcctgc aaacataata aaccgtccta atgcactgtt tgcctttatc
     2761 cacactttgg tcatttgaat ttcttcttac aagttttgag actttttttt tttttatgtt
     2821 tatcttggca gaatttttct ctaaaatcaa tttaacttga tgctttaagg agacagtgtt
     2881 ggaacttcaa attagaaatt atcacattga gtcttcgtgg aatagttcat gaccaaaaag
     2941 ggaataagaa aaacattcta gtatgatata gtgggaattt atatattcac cactagtttg
     3001 tccatgggga gtcatcctga ttgaagttgt tttcaggttt ttcgtttctc tgttagcctt
     3061 tctgttattc ttattgttgg tgcctttgtg ttagaaaaca ttagattttt taaaattggt
     3121 cattagtgaa ctgctttttc ctcatttttg ttggaaaata tttaatatct cagtattaaa
     3181 gctgtgcagc tttgaaaaaa taaaagacgc ctaacatggt ggcacggcct aattaatccc
     3241 agtacttcag agacagggag atctctgtga gttcttttta aaaaaaaaat taaaagaatg
     3301 gttaataaaa a
//
