LOCUS       NM_001012060            1889 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus ring finger protein 146 (Rnf146), mRNA.
ACCESSION   NM_001012060 XM_217722
VERSION     NM_001012060.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1889)
  AUTHORS   Mu,Q., Zhou,H., Xu,Y., He,Q., Luo,X., Zhang,W. and Li,H.
  TITLE     NPD1 inhibits excessive autophagy by targeting RNF146 and
            wnt/beta-catenin pathway in cerebral ischemia-reperfusion injury
  JOURNAL   J Recept Signal Transduct Res 40 (5), 456-463 (2020)
   PUBMED   32326811
  REMARK    GeneRIF: NPD1 inhibits excessive autophagy by targeting RNF146 and
            wnt/beta-catenin pathway in cerebral ischemia-reperfusion injury.
REFERENCE   2  (bases 1 to 1889)
  AUTHORS   Yang,X., Cheng,J., Gao,Y., Ding,J. and Ni,X.
  TITLE     Downregulation of Iduna is associated with AIF nuclear
            translocation in neonatal brain after hypoxia-ischemia
  JOURNAL   Neuroscience 346, 74-80 (2017)
   PUBMED   28108258
  REMARK    GeneRIF: Results suggest that apoptosis-inducing factor nuclear
            translocation and neuronal cell death are associated with Iduna
            loss after severe hypoxic-ischemic in the immature brain.
REFERENCE   3  (bases 1 to 1889)
  AUTHORS   Gero,D. and Szabo,C.
  TITLE     Salvage of nicotinamide adenine dinucleotide plays a critical role
            in the bioenergetic recovery of post-hypoxic cardiomyocytes
  JOURNAL   Br J Pharmacol 172 (20), 4817-4832 (2015)
   PUBMED   26218637
REFERENCE   4  (bases 1 to 1889)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   5  (bases 1 to 1889)
  AUTHORS   Gero,D., Szoleczky,P., Chatzianastasiou,A., Papapetropoulos,A. and
            Szabo,C.
  TITLE     Modulation of poly(ADP-ribose) polymerase-1 (PARP-1)-mediated
            oxidative cell injury by ring finger protein 146 (RNF146) in
            cardiac myocytes
  JOURNAL   Mol Med 20 (1), 313-328 (2014)
   PUBMED   24842055
  REMARK    GeneRIF: Modulation of PARP-1-mediated oxidative cell injury by
            ring finger protein 146 (RNF146) in cardiac myocytes
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1889)
  AUTHORS   Zhang,Y., Liu,S., Mickanin,C., Feng,Y., Charlat,O., Michaud,G.A.,
            Schirle,M., Shi,X., Hild,M., Bauer,A., Myer,V.E., Finan,P.M.,
            Porter,J.A., Huang,S.M. and Cong,F.
  TITLE     RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin
            degradation and Wnt signalling
  JOURNAL   Nat Cell Biol 13 (5), 623-629 (2011)
   PUBMED   21478859
REFERENCE   7  (bases 1 to 1889)
  AUTHORS   von Rotz,R.C., Kins,S., Hipfel,R., von der Kammer,H. and
            Nitsch,R.M.
  TITLE     The novel cytosolic RING finger protein dactylidin is up-regulated
            in brains of patients with Alzheimer's disease
  JOURNAL   Eur J Neurosci 21 (5), 1289-1298 (2005)
   PUBMED   15813938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC083675.1 and CK845087.1.
            
            On Oct 30, 2007 this sequence version replaced NM_001012060.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083675.1, CV105582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1874              BC083675.1         1-1874
            1875-1889           CK845087.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..1889
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..1889
                     /gene="Rnf146"
                     /note="ring finger protein 146"
                     /db_xref="GeneID:308051"
                     /db_xref="RGD:1306482"
     exon            1..43
                     /gene="Rnf146"
                     /inference="alignment:Splign:2.1.0"
     exon            44..153
                     /gene="Rnf146"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1213
                     /gene="Rnf146"
                     /EC_number="2.3.2.27"
                     /note="iduna; RING-type E3 ubiquitin transferase RNF146"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF146"
                     /protein_id="NP_001012060.2"
                     /db_xref="GeneID:308051"
                     /db_xref="RGD:1306482"
                     /translation="MEMMAGCGEIDHSLNMLPTNKKASETCSNTAPSLTVPECAICLQ
                     TCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRG
                     NGEYVWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRN
                     EHGRRRKIKRDIIDIPKKGVAGLRLDCDSNTVNLARESSADGADSGSAHTGASVQLPV
                     PSSTRPLTSVDGQLTSPVTPSPDAGASLEDSFAHLQLSGDSIAERSHRGEGEEDHESP
                     SSGRVPDTSTEETESDASSDIEDAPVVVAQHSLTQQRLLVSSANQTVAERSDRPVAGG
                     GTMSVNVRSRRPDGQCTVTEV"
     exon            154..1877
                     /gene="Rnf146"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagatgagg aagtggccag aggtctccat aactaaagaa cagcacagag aatgaaccag
       61 ccttgcagga gaaaacacta caaattagct gacagctggt agagaagatg ctctatttct
      121 gtgctcagtg cctgtgggat ctgtgatgga aatgatggcc ggctgtggtg aaattgatca
      181 ctcactaaat atgcttccta ccaataagaa ggcgagtgag acctgttcta acactgcacc
      241 ttctctaaca gttcccgagt gtgccatttg tctacaaaca tgtgttcatc cagtcagtct
      301 gccctgtaag catgttttct gttatctgtg tgtaaagggc gcttcatggc tcgggaagcg
      361 atgtgctctt tgtcggcaag agattcctga ggattttctt gacaagccaa ccttgttgtc
      421 accagaagaa cttaaggctg caagcagagg aaatggtgaa tatgtgtggt attatgaagg
      481 aagaaatgga tggtggcagt atgatgagcg caccagtcgg gagctagaag atgctttttc
      541 caaaggtaaa aagaacacgg aaatgttaat tgctggattt ctgtacgttg ctgatcttga
      601 aaacatggtt caatatagga gaaatgaaca tggacgtcgc agaaagatta aaagagatat
      661 aatagatata ccaaagaagg gagtggctgg acttcggctg gactgtgaca gcaacactgt
      721 aaatctagcc agagagagtt ctgccgatgg tgcggacagt gggtcagcac acactggagc
      781 ttctgtgcag cttccagtgc catcttctac aaggcctcta acatcagtcg atggtcagtt
      841 aaccagccct gtaacaccgt cccctgatgc aggcgcttct ttggaagact cttttgctca
      901 tttacaactc agtggagaca gcatagctga aaggagtcat agaggtgaag gagaagaaga
      961 tcacgaatca ccatcttctg gtagagtacc agatacgtcc actgaagaaa cagagtcgga
     1021 tgccagtagt gatattgagg atgcccctgt ggtggttgca cagcactcct tgacccaaca
     1081 gagacttttg gtttcaagtg caaatcagac agtagctgaa cggtctgacc gaccagttgc
     1141 agggggtggg accatgagtg tcaatgtcag atccagaagg cctgacggac agtgcacagt
     1201 gacagaggtt taaacagatg tcttcagcac cacactcaag ggtcaaatga atacctgtaa
     1261 atttctgccc acataacatt atactcatcc ttagtagtac attgtgggag ttggggtggg
     1321 aagggatatg ggaaggacag acctgaaatt aaaatgtcta acatgtctct gctgaaattt
     1381 atttaatgtg aggaattggg gtgttgatag ttgagagctg ttcagtataa cacagttttc
     1441 ttggcatctg tttacattag agtgtttgtt ttttaaagtc tttagttctt ttggctagtg
     1501 tgtccccgtg cattaatggc tctcatctga ctcttgcact accttatttt tctgcatgga
     1561 ttggtataaa atcttcacta aaatttggca tctgtgagat acttggtatc atgagcagga
     1621 agcttaatgt ggaaaagaga tgtgaatttg ggagttaaaa atagatgact aacaactact
     1681 ttacagttgg tctcactaag atagaaatgt caagctgtag ctattaagtt tcagactcta
     1741 taacatactt catggtgttc ctttccataa ggtttgctgt cttgtccttg tacttggagg
     1801 tttctcttag tctgcatttt tctttttgat taaaaacact ttataattta ataaatacta
     1861 gaatttatca gaaataaaaa aaaaaaaaa
//
