LOCUS       NM_001127545            2723 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus ring finger protein 139 (Rnf139), mRNA.
ACCESSION   NM_001127545 XM_235338
VERSION     NM_001127545.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2723)
  AUTHORS   Chen CY, Malchus NS, Hehn B, Stelzer W, Avci D, Langosch D and
            Lemberg MK.
  TITLE     Signal peptide peptidase functions in ERAD to cleave the unfolded
            protein response regulator XBP1u
  JOURNAL   EMBO J 33 (21), 2492-2506 (2014)
   PUBMED   25239945
REFERENCE   2  (bases 1 to 2723)
  AUTHORS   Lee JP, Brauweiler A, Rudolph M, Hooper JE, Drabkin HA and Gemmill
            RM.
  TITLE     The TRC8 ubiquitin ligase is sterol regulated and interacts with
            lipid and protein biosynthetic pathways
  JOURNAL   Mol Cancer Res 8 (1), 93-106 (2010)
   PUBMED   20068067
REFERENCE   3  (bases 1 to 2723)
  AUTHORS   Irisawa M, Inoue J, Ozawa N, Mori K and Sato R.
  TITLE     The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8
            hampers ER to Golgi transport of sterol regulatory element-binding
            protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces
            SREBP-2 cleavage
  JOURNAL   J Biol Chem 284 (42), 28995-29004 (2009)
   PUBMED   19706601
REFERENCE   4  (bases 1 to 2723)
  AUTHORS   Stagg HR, Thomas M, van den Boomen D, Wiertz EJ, Drabkin HA,
            Gemmill RM and Lehner PJ.
  TITLE     The TRC8 E3 ligase ubiquitinates MHC class I molecules before
            dislocation from the ER
  JOURNAL   J Cell Biol 186 (5), 685-692 (2009)
   PUBMED   19720873
REFERENCE   5  (bases 1 to 2723)
  AUTHORS   Poland KS, Azim M, Folsom M, Goldfarb R, Naeem R, Korch C, Drabkin
            HA, Gemmill RM and Plon SE.
  TITLE     A constitutional balanced t(3;8)(p14;q24.1) translocation results
            in disruption of the TRC8 gene and predisposition to clear cell
            renal cell carcinoma
  JOURNAL   Genes Chromosomes Cancer 46 (9), 805-812 (2007)
   PUBMED   17539022
REFERENCE   6  (bases 1 to 2723)
  AUTHORS   Brauweiler A, Lorick KL, Lee JP, Tsai YC, Chan D, Weissman AM,
            Drabkin HA and Gemmill RM.
  TITLE     RING-dependent tumor suppression and G2/M arrest induced by the
            TRC8 hereditary kidney cancer gene
  JOURNAL   Oncogene 26 (16), 2263-2271 (2007)
   PUBMED   17016439
REFERENCE   7  (bases 1 to 2723)
  AUTHORS   Gemmill RM, Bemis LT, Lee JP, Sozen MA, Baron A, Zeng C, Erickson
            PF, Hooper JE and Drabkin HA.
  TITLE     The TRC8 hereditary kidney cancer gene suppresses growth and
            functions with VHL in a common pathway
  JOURNAL   Oncogene 21 (22), 3507-3516 (2002)
   PUBMED   12032852
REFERENCE   8  (bases 1 to 2723)
  AUTHORS   Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S and Weissman AM.
  TITLE     RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent
            ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11364-11369 (1999)
   PUBMED   10500182
REFERENCE   9  (bases 1 to 2723)
  AUTHORS   Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li
            F and Drabkin HA.
  TITLE     The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to
            a patched-related gene, TRC8
  JOURNAL   Proc Natl Acad Sci U S A 95 (16), 9572-9577 (1998)
   PUBMED   9689122
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On May 23, 2008 this sequence version replaced XM_235338.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB796312.1, BC161975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2723
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..2723
                     /gene="Rnf139"
                     /gene_synonym="TRC8"
                     /note="ring finger protein 139"
                     /db_xref="GeneID:315000"
                     /db_xref="RGD:1306670"
     exon            1..168
                     /gene="Rnf139"
                     /gene_synonym="TRC8"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1994
                     /gene="Rnf139"
                     /gene_synonym="TRC8"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF139"
                     /protein_id="NP_001121017.1"
                     /db_xref="GeneID:315000"
                     /db_xref="RGD:1306670"
                     /translation="MAQQQVWAALEVALRVPCLYIIDAIFNSYYDSSQSRFCIGLQIF
                     LRLLGIVVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAF
                     GIELLPRKGPSLWMALIVLQLTFGIGYVTLLHIQSIYSQLIILNILVPVIGLITELPL
                     HIRETLVFMSSLILIFNTMLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWK
                     RIRFPDILRVFWLTRITAQATVLMYILRMANETESFLISWDDFWDIICNLIISGCDST
                     LTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPE
                     ERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFHRHFPVLFVSACLFILPV
                     LLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVY
                     FVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQVKNGWKTFM
                     NRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYI
                     QDTCPMCHQKVYIEDDIKDNSNVSNNNGFIAPNENQNPEEALREDAAGSDREMNEDDS
                     TDCDDDIQRERNGGIQHTGAAAAAAEFNDDTD"
     exon            169..2723
                     /gene="Rnf139"
                     /gene_synonym="TRC8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccccgca gcagcaggtg cggatggccc agcagcaggt ctgggcggcg ctcgaagtgg
       61 cgctccgggt gccctgcctc tacatcatcg acgccatctt caactcctac tacgattcca
      121 gccaaagccg gttctgcatc gggcttcaga tctttctccg gctcctcggt atagttgtat
      181 ccagtattgt tctgatcttg tcacagcgat cacttttcaa gttttacatg tacagctcag
      241 cctttctatt agctgcaact tcagtgttgg tgaactacta tgctgctttg cacattgact
      301 tctacggtgc ctacaacacg tcagcatttg gaattgagtt gcttcctcgg aaagggccct
      361 cactgtggat ggcactcatc gttctgcagc taacctttgg aatcggatac gtcactctac
      421 tccacattca gtctatctat tcacagctga ttattctgaa tatcttggtt cctgtaatcg
      481 gcttaatcac agagctacca ttacacatca gagagacgtt agttttcatg tcttccttga
      541 ttctcatatt taacacaatg cttgtcttgg cagtgaaact taagtggttt tattactcta
      601 ctcggtatgt ttacttgtta gtgaggcata tgtaccgaat ttatggatta cagttattga
      661 tggaggacac atggaagcgg attcgtttcc cagacatact tcgggtcttc tggctaacaa
      721 ggattacagc tcaggctaca gtgttgatgt acattttaag gatggcgaat gagactgagt
      781 ccttccttat ttcttgggat gatttctggg acatcatttg caatctaata attagtgggt
      841 gcgattctac actaactgta ctaggcatga gtgctgtaat ttcttcaata gcccattact
      901 tgggccttgg aatattggcc tttattggat caactgaaga agatgacagg cggcttggct
      961 ttgtagcacc tgttttattt ttcattttgg ctcttcagac tggtttaagt gggctgagac
     1021 ctgaagagag acttattcgc ttaagtagaa acatgtgcct tttattaact gcagtcctac
     1081 atttcatcca cggaatgaca gaccccgtgt taatgtctct cagtgcctcc cacgtgtcat
     1141 ctttccacag acattttcct gtgctgtttg tctctgcttg cctgtttatt cttcctgttt
     1201 tactcagtta tgtcctttgg caccactatg cactaaacac gtggctgttt gcagttacag
     1261 ccttctgtgt ggaactctgc ttgaaagtaa ttgtttccct cactgtctac acgctattca
     1321 tgattgatgg ctactataat gtcctctggg aaaagcttga tgattatgtc tactttgttc
     1381 gctcgacagg caatattatc gaatttatat ttggagtagt aatgtttggg aatggggcct
     1441 ataccatgat gtttgagtca ggaagtaaaa tccgggcttg tatgatgtgc ctacatgcat
     1501 attttaacat ctacttacaa gtaaaaaatg gctggaagac attcatgaat cgtagaactg
     1561 ctgttaagaa aattaattca cttcctgaaa taaaagggag ccacttgcaa gaaatagatg
     1621 atgtttgtgc catctgctat catgagttca caacgtctgc tcggattaca ccgtgtaacc
     1681 attatttcca tgcactctgc cttcggaaat ggctgtacat tcaagatact tgtccaatgt
     1741 gtcatcagaa agtgtacatc gaagacgata tcaaggacaa ttcaaatgta tctaacaaca
     1801 acggatttat tgcacccaat gaaaatcaaa acccagagga agctttaaga gaagatgctg
     1861 ctggatctga ccgagaaatg aacgaggatg acagtacaga ctgtgatgat gatattcaaa
     1921 gagaaagaaa cggggggatt cagcacacag gcgcagcagc agcagcagca gaatttaatg
     1981 atgacactga ttaaagtagc atttactaat cattgaggta tttgtttaaa attcagttca
     2041 tccaaaatgg agtaatatgc ttcacgtcag tgtgtaacca agcacaaaaa cagtatcgat
     2101 gttgaaactg tgaatgattt tccgtttact gtgatgtgct actgtaaata tacctcttta
     2161 attacttctg gtctctttgg tgacctattt aaatttgtgt acattattgt acatagaata
     2221 aaatgttttc acgtttttat gacaaaattt gaacaaataa cttcttaata gagataatga
     2281 tcacacggtg cgtcaagtgt gccaaagagc cctcaatgaa atcagaatct gtctaatgct
     2341 gcactctagt ttttctttaa aacgaaggga aaatgaaaat gccgaataaa ggaatgttag
     2401 tataagagac aggagataaa ataatcttga gtagaaaggc tttctaaata aaatgttttc
     2461 taaaactaag gcaagatacc ctgctagaag caactgagaa acttgaaatc tgagtgcagc
     2521 ttagaggcag gttcaaaagt cacacaaatc aaggacagaa ttgagaaata ggcttgttat
     2581 caactaaact ttgacataaa ccaggacatg ctgtctaagt tttaggtaga agcatcactg
     2641 tgtttgcagt gagagtgtaa aactgtcctt tcagacttct gatgagatta cacaataaaa
     2701 aggctgtcac tgttacctaa agc
//
