LOCUS       NM_053588               2737 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ring finger protein 138 (Rnf138), mRNA.
ACCESSION   NM_053588
VERSION     NM_053588.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2737)
  AUTHORS   Fang,X., Li,Y., Zheng,Y., Wang,Y., Feng,S. and Miao,M.
  TITLE     Ethanol extracts from Ilex pubescens promotes cerebral ischemic
            tolerance via modulation of TLR4-MyD88/TRIF signaling pathway in
            rats
  JOURNAL   J Ethnopharmacol 256, 112680 (2020)
   PUBMED   32084554
  REMARK    GeneRIF: Ethanol extracts from Ilex pubescens promotes cerebral
            ischemic tolerance via modulation of TLR4-MyD88/TRIF signaling
            pathway in rats.
REFERENCE   2  (bases 1 to 2737)
  AUTHORS   Fu,S.J., Jeng,C.J., Ma,C.H., Peng,Y.J., Lee,C.M., Fang,Y.C.,
            Lee,Y.C., Tang,S.C., Hu,M.C. and Tang,C.Y.
  TITLE     Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated
            Aberrant Degradation of Human Cav2.1 (P/Q-Type) Calcium Channels
  JOURNAL   J Neurosci 37 (9), 2485-2503 (2017)
   PUBMED   28167673
REFERENCE   3  (bases 1 to 2737)
  AUTHORS   Schmidt,C.K., Galanty,Y., Sczaniecka-Clift,M., Coates,J., Jhujh,S.,
            Demir,M., Cornwell,M., Beli,P. and Jackson,S.P.
  TITLE     Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting
            DNA repair
  JOURNAL   Nat Cell Biol 17 (11), 1458-1470 (2015)
   PUBMED   26502057
REFERENCE   4  (bases 1 to 2737)
  AUTHORS   Ismail,I.H., Gagne,J.P., Genois,M.M., Strickfaden,H., McDonald,D.,
            Xu,Z., Poirier,G.G., Masson,J.Y. and Hendzel,M.J.
  TITLE     The RNF138 E3 ligase displaces Ku to promote DNA end resection and
            regulate DNA repair pathway choice
  JOURNAL   Nat Cell Biol 17 (11), 1446-1457 (2015)
   PUBMED   26502055
REFERENCE   5  (bases 1 to 2737)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 2737)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (bases 1 to 2737)
  AUTHORS   Yamada,M., Ohnishi,J., Ohkawara,B., Iemura,S., Satoh,K.,
            Hyodo-Miura,J., Kawachi,K., Natsume,T. and Shibuya,H.
  TITLE     NARF, an nemo-like kinase (NLK)-associated ring finger protein
            regulates the ubiquitylation and degradation of T cell
            factor/lymphoid enhancer factor (TCF/LEF)
  JOURNAL   J Biol Chem 281 (30), 20749-20760 (2006)
   PUBMED   16714285
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053588.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061821.1, SRR26643290.50801.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000018.1  12567224-12567383
            161-326             JAXUCZ010000018.1  12574450-12574615
            327-442             JAXUCZ010000018.1  12575343-12575458
            443-499             JAXUCZ010000018.1  12580949-12581005
            500-611             JAXUCZ010000018.1  12584036-12584147
            612-2737            JAXUCZ010000018.1  12588724-12590849
FEATURES             Location/Qualifiers
     source          1..2737
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2737
                     /gene="Rnf138"
                     /gene_synonym="Rsd4; Trif"
                     /note="ring finger protein 138"
                     /db_xref="GeneID:94196"
                     /db_xref="RGD:621485"
     exon            1..160
                     /gene="Rnf138"
                     /gene_synonym="Rsd4; Trif"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..680
                     /gene="Rnf138"
                     /gene_synonym="Rsd4; Trif"
                     /EC_number="2.3.2.27"
                     /note="RSD-4; ring finger protein 138, E3 ubiquitin
                     protein ligase; RING-type E3 ubiquitin transferase RNF138"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF138"
                     /protein_id="NP_446040.1"
                     /db_xref="GeneID:94196"
                     /db_xref="RGD:621485"
                     /translation="MSEELSADTSYTEDDFYCPVCQEVLKTPVRTAACQHVFCRKCFL
                     TAMRESGIHCPLCRGSVTRRERACPERAIDLENIMRRVSGSCRCCSKKIKFYRMRHHY
                     KSCKKYQDEYGVSSVIPNVKISQDSVRSSNRSETSASDNTETYQEDTSSSGHPTFKCP
                     LCQESNFTRQRLLDHCNSNHLFQIVPVNLQLDEETQYQTAVEESFQVNM"
     exon            161..326
                     /gene="Rnf138"
                     /gene_synonym="Rsd4; Trif"
                     /inference="alignment:Splign:2.1.0"
     exon            327..442
                     /gene="Rnf138"
                     /gene_synonym="Rsd4; Trif"
                     /inference="alignment:Splign:2.1.0"
     exon            443..499
                     /gene="Rnf138"
                     /gene_synonym="Rsd4; Trif"
                     /inference="alignment:Splign:2.1.0"
     exon            500..611
                     /gene="Rnf138"
                     /gene_synonym="Rsd4; Trif"
                     /inference="alignment:Splign:2.1.0"
     exon            612..2737
                     /gene="Rnf138"
                     /gene_synonym="Rsd4; Trif"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccacctcgg ctcctgcggg cgctgtcgcc tctcccgccc acccctcgcc atgtccgagg
       61 agctttcggc ggacacgtcc tacacggaag atgatttcta ctgcccagtc tgtcaggagg
      121 tgctcaagac gccggtgcgg accgcggcct gtcagcacgt tttctgtaga aaatgtttcc
      181 tgactgcaat gagagagagt ggaatacatt gtcccctatg tcgcggaagt gtgactagaa
      241 gagaaagagc atgtccggaa cgggccatag atcttgaaaa tatcatgagg agggtttctg
      301 gtagctgcag atgctgttca aaaaagatta aattttatcg catgagacat cattacaaat
      361 cttgtaagaa gtatcaggat gaatatggtg tctcttctgt cattccaaat gttaagattt
      421 ctcaagattc agtaaggagc agtaatagga gtgaaacatc tgcatctgat aacacagaaa
      481 cttatcaaga ggatacaagt tcttctgggc atcccacctt taagtgtccc ttatgtcaag
      541 agtcaaattt caccagacaa cgtttattgg atcactgtaa tagtaaccac ctgtttcaga
      601 tagttcctgt gaatcttcag ctagatgagg aaacccaata tcaaactgct gtggaagagt
      661 ctttccaagt taacatgtga tgtgtgtaga catctctgcc tccttgctac ctacaagtgc
      721 catctttaag gagaagacat gaagtcaccg ttttcagtaa tttgctgtgc atattaataa
      781 aaataataat tcagtctact gtattaggtt tttaattgaa aataaaggtg ggccacccta
      841 attccattct ctagacagtt actttaacag catggaaagg gtcgtatttc acttgtatgg
      901 tgaaaaggga atctgttgtc tttttctttc ttgtattaca tattctgaat gtttaagttg
      961 tttttgataa tttggtacag ttccttctat ttagtacaga gataactgca aattctgaac
     1021 gatgtgattc ctataaaact aataaacctg agccatttgt cagagctgca gagtggaaac
     1081 ttgaagtgca aaggggaggg gggtccaaag gggtttttca aaagaataga tcctagctga
     1141 ggatacaata agaaaattgt atttatataa tgtttagtat ttttgaagac tagtgagatt
     1201 tctttaataa ttttgactct gaaagtgtat tgtacaaatg tttcttcttt tgtggttaga
     1261 agaaacaaga gaaaaagttt tcgttggtgg tgtttgttat ttcaatctag gttgagtaat
     1321 ttgtaagccc aaatatgtta tatgacagtt ctttgtagtc agtgtttctc acttgctgat
     1381 gaaacttttt agtcagtgaa tgatacatta cacttaaatt agttttttaa aaatccaaag
     1441 ttgcagatgt atgtggatat gtacatagac ttttgcatgt atatatacac atatatatcc
     1501 ttgcctagag tttgtcaggt tatgtataga atttctatta aagagtttta ataatggaca
     1561 gcaatatagg attgaagtat ttatctcatt tgtttaaaac tttgtatgtt accacgtttt
     1621 taaaacagta aaccaaatac tacgtggtac agttggctgt tattacacct gaaaaaatgt
     1681 gttaaatggt gctcatttgt tctttttgaa aatgattcat agctgatgtg tggtgagatt
     1741 ttaccagcct ctgtttcact acattttagt caaaaccgag ttcttaatct ttggtataag
     1801 gtaatgtaga gaaggccaag tcacagagtg cagggtgaag agggaattct gacattccac
     1861 gctaacataa cactgttacg ctttctttaa aataactaaa cgcaaaagaa aatctctgaa
     1921 gtagtttgct gctaatatat acatatattg taaaaaaggt atattttgat tttcttaata
     1981 cccttgttga cttttctaca atgaacattt tttttaactt gatttaataa aaatgttaat
     2041 tttggatgtg cagttttgta aaaacctttt tcagttaaac agtaatgact ttatttatgt
     2101 ttagtaatgt agactcacaa caagccatac atcttaatac ctttttattc cctgtcattt
     2161 cttgagcgtg acgtttactg tgttctctag cactttgagt tgacatacaa gagtgtaatc
     2221 ctaggaacat ctatataatg aactctttaa agggagactt ctctccacag aagcaataac
     2281 ctggatgctt ttaaagttaa atttagccag tgcgttgcta aatctccctg ggatgtacaa
     2341 acttaaaggg aaacttgtac tagagatcat tttggaatcc tgtttgaagt cttgtggatg
     2401 agttaaatat taatatattt atagcttttt catgagaatt atctcttttg cattagtaac
     2461 ttattaaaaa tggaaaaaag ttttaaattc ttttttgtca gtagattaag aacaagggtt
     2521 gactttacag tttaattcat ggggaagaag cctcagtggt ggtggttagt agccgccagc
     2581 atgaaggagg aagctgtagc agtgtgctga cgcatcgctt tcacggtacc acttaggaaa
     2641 gccatttctc cttcaactta gtttagtctt tgtccttcaa tacagtgttc attgagatgt
     2701 attgctttat ttttcaatta aaaatggttt tctccta
//
