LOCUS       NM_001012010            2276 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ring finger protein 135 (Rnf135), mRNA.
ACCESSION   NM_001012010 XM_220752
VERSION     NM_001012010.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2276)
  AUTHORS   Cadena,C., Ahmad,S., Xavier,A., Willemsen,J., Park,S., Park,J.W.,
            Oh,S.W., Fujita,T., Hou,F., Binder,M. and Hur,S.
  TITLE     Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in
            Innate Immunity
  JOURNAL   Cell 177 (5), 1187-1200 (2019)
   PUBMED   31006531
REFERENCE   2  (bases 1 to 2276)
  AUTHORS   Shi,Y., Yuan,B., Zhu,W., Zhang,R., Li,L., Hao,X., Chen,S. and
            Hou,F.
  TITLE     Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation
            in antiviral innate immunity
  JOURNAL   Nat Commun 8, 15138 (2017)
   PUBMED   28469175
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2276)
  AUTHORS   Oshiumi,H., Miyashita,M., Matsumoto,M. and Seya,T.
  TITLE     A distinct role of Riplet-mediated K63-Linked polyubiquitination of
            the RIG-I repressor domain in human antiviral innate immune
            responses
  JOURNAL   PLoS Pathog 9 (8), e1003533 (2013)
   PUBMED   23950712
REFERENCE   4  (bases 1 to 2276)
  AUTHORS   Oshiumi,H., Miyashita,M., Inoue,N., Okabe,M., Matsumoto,M. and
            Seya,T.
  TITLE     The ubiquitin ligase Riplet is essential for RIG-I-dependent innate
            immune responses to RNA virus infection
  JOURNAL   Cell Host Microbe 8 (6), 496-509 (2010)
   PUBMED   21147464
REFERENCE   5  (bases 1 to 2276)
  AUTHORS   You,F., Sun,H., Zhou,X., Sun,W., Liang,S., Zhai,Z. and Jiang,Z.
  TITLE     PCBP2 mediates degradation of the adaptor MAVS via the HECT
            ubiquitin ligase AIP4
  JOURNAL   Nat Immunol 10 (12), 1300-1308 (2009)
   PUBMED   19881509
REFERENCE   6  (bases 1 to 2276)
  AUTHORS   Gao,D., Yang,Y.K., Wang,R.P., Zhou,X., Diao,F.C., Li,M.D.,
            Zhai,Z.H., Jiang,Z.F. and Chen,D.Y.
  TITLE     REUL is a novel E3 ubiquitin ligase and stimulator of
            retinoic-acid-inducible gene-I
  JOURNAL   PLoS One 4 (6), e5760 (2009)
   PUBMED   19484123
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2276)
  AUTHORS   Oshiumi,H., Matsumoto,M., Hatakeyama,S. and Seya,T.
  TITLE     Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to
            promote interferon-beta induction during the early phase of viral
            infection
  JOURNAL   J Biol Chem 284 (2), 807-817 (2009)
   PUBMED   19017631
REFERENCE   8  (bases 1 to 2276)
  AUTHORS   Gack,M.U., Shin,Y.C., Joo,C.H., Urano,T., Liang,C., Sun,L.,
            Takeuchi,O., Akira,S., Chen,Z., Inoue,S. and Jung,J.U.
  TITLE     TRIM25 RING-finger E3 ubiquitin ligase is essential for
            RIG-I-mediated antiviral activity
  JOURNAL   Nature 446 (7138), 916-920 (2007)
   PUBMED   17392790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 8, 2021 this sequence version replaced NM_001012010.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087718.1, SRR26643291.28675.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               JAXUCZ010000010.1  65668441-65668829
            390-533             JAXUCZ010000010.1  65672741-65672884
            534-696             JAXUCZ010000010.1  65676452-65676614
            697-771             JAXUCZ010000010.1  65683563-65683637
            772-2276            JAXUCZ010000010.1  65685223-65686727
FEATURES             Location/Qualifiers
     source          1..2276
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..2276
                     /gene="Rnf135"
                     /gene_synonym="LRRGT00184"
                     /note="ring finger protein 135"
                     /db_xref="GeneID:303350"
                     /db_xref="RGD:1305252"
     exon            1..389
                     /gene="Rnf135"
                     /gene_synonym="LRRGT00184"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1289
                     /gene="Rnf135"
                     /gene_synonym="LRRGT00184"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase RNF135"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF135"
                     /protein_id="NP_001012010.1"
                     /db_xref="GeneID:303350"
                     /db_xref="RGD:1305252"
                     /translation="MAAACPGTAVPVWLSEEDLSCIICQGLLDWPTTLPCGHSFCLQC
                     LKDLWVSKRAGVDSCPWACPICRKGPSAKPVLHKNPLLQDLVDKYRQAALELEAGPEP
                     APVPRSLCTPTPPQVTVQKSTTQVVQELTELVGQLVDIVKSLQTQRPSLASGLDNALG
                     ILHMDSSSEEEYPLDSPKLVTFSASQKKIQEILRDLEKIQETLQGSVTGNEAPKKQVE
                     EMASSVGLLPDQRYPVSRKASQFSLWAISPTFDLRSLSCNLEVSNNCRMVTVSRALQP
                     YHWSSERFSISQVLCSQAFSSGQKYWEVDTRNCSHWAVGVASWGMKRDKMLGRTMDSW
                     CIEWRGPSQFSAWAMMKKTDLSSGPPEVVGVWLDLELGKLAFYSVADQERPLYECEVS
                     SSSPLHPAFWLYGLTPGNYLEIL"
     exon            390..533
                     /gene="Rnf135"
                     /gene_synonym="LRRGT00184"
                     /inference="alignment:Splign:2.1.0"
     exon            534..696
                     /gene="Rnf135"
                     /gene_synonym="LRRGT00184"
                     /inference="alignment:Splign:2.1.0"
     exon            697..771
                     /gene="Rnf135"
                     /gene_synonym="LRRGT00184"
                     /inference="alignment:Splign:2.1.0"
     exon            772..2276
                     /gene="Rnf135"
                     /gene_synonym="LRRGT00184"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaggcggga cctaactgtg cttcctggct gtcgcctaac tatggcagcc gcttgtcctg
       61 gcaccgcagt accggtatgg ctgagcgagg aagacctgag ctgcattatc tgccaaggac
      121 tgctggactg gcccaccacc ctgccctgcg gccacagctt ctgtctccag tgcctcaaag
      181 acctgtgggt ctcgaagcgc gcgggcgtgg atagctgccc ttgggcctgc cccatatgcc
      241 ggaagggccc ctcggcgaag cccgtgctgc ataagaaccc gctgctgcaa gacctggtgg
      301 acaagtaccg ccaagcggcg ctggagttgg aggctggtcc cgaacccgcc cctgtgcccc
      361 gttctctgtg tacacctaca ccgccccagg tgacagtaca gaaaagcact acacaagttg
      421 tccaggagct gactgagctg gtgggacagc ttgtagacat tgtcaagagc cttcaaacgc
      481 aaagacctag cttggcatct ggactggaca atgctctagg catcctgcac atggattctt
      541 cctctgagga ggaatatccc ttggattctc caaagctggt gactttcagt gcgtctcaga
      601 agaaaattca ggagattctc cgtgacctag aaaaaattca ggaaaccctg caagggagtg
      661 tcacggggaa cgaagctcct aaaaaacaag ttgaggaaat ggcatcttct gtaggcctgc
      721 tgcctgacca gaggtatcct gtatccagga aagcgtctca gttttcccta tgggccatca
      781 gtccaacctt tgacctgagg agcctctcct gtaacctgga ggtttccaac aattgccgaa
      841 tggtgaccgt gtctcgggct ctacaaccct atcattggag ttccgagaga ttctcaatta
      901 gccaggtctt atgctctcag gccttctctt ctgggcagaa gtactgggaa gtggacactc
      961 ggaactgcag ccactgggct gttggggtgg cttcttgggg catgaagcgg gacaagatgc
     1021 tgggaaggac catggactct tggtgtatag agtggagagg gcccagccag ttctctgctt
     1081 gggccatgat gaagaaaaca gacttgtcct caggccctcc tgaggttgtg ggcgtgtggc
     1141 ttgacctgga gctggggaag cttgccttct actcagtggc tgatcaggag aggcctctgt
     1201 atgagtgtga ggtctccagc tcctctcctc tgcatcctgc cttctggctg tatggcttaa
     1261 ctcctggaaa ctacctggaa atactgtaag taaacacatg aagctccccc tggggctagg
     1321 acagtggctt cttagacttt ctggttaggg gcaactggag aattccactt agggagactg
     1381 gatatggtag cacatgccta taactccagc acttgggaag tggaggcagg aggatcactg
     1441 caagttccag gccagcaatg atgaacaaag agagttcaag gccagcattg actctgccct
     1501 cttttaaagt tagtcttttt tggatggggc aggattaact ttaaacaggt ttgagctctt
     1561 taaacctgag acatttcaga gaaaggactg gtctggagtg tctcctcaca gtgacctctg
     1621 aggcctcaga atagcctact taataagaag gacttcggac cattgaaaga cttcggactg
     1681 ttctctgtgg cctcatctgg gactgaaccg ttcaatcagg ctgtggccaa caagtcacac
     1741 ctacatgact gacacccacc accctcagtt gaaagcctaa cccaacagca tagctgagtg
     1801 aacatctcta gcgtatgcta tgaatgtcct cacttacctc tgttggaagg gtggagcgct
     1861 gtcctatgac tggtaagagg gagtgctcct ggaccctacc tcgtgtgcct ttttctactg
     1921 ttcattttat tctggggact tttgctgtag taaactgcag tcgcgactgt cgtagctgtg
     1981 ctgagttcag tgggtcttag agtgatcttt gaagcatata gtgaccttaa ggacccacaa
     2041 gcagaaggga tatatgttat ttagtcattg tcgtgcaata atagttccac gaggacaggt
     2101 aaagatggac cagcggttaa gagaaccgac tgctcttcca gaggtcctga gttcaattcc
     2161 cagcaaccac atggtggctc acaaccatct gtaatgggat ccgatgccct cttctggtgt
     2221 gtctgaggac agctacagtg tacccatata cattaaataa atatttttta ataagt
//
