LOCUS       NM_001033702            1450 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ring finger protein 126 (Rnf126), mRNA.
ACCESSION   NM_001033702
VERSION     NM_001033702.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1450)
  AUTHORS   Huang,C.Y., Lee,F.L., Peng,S.F., Lin,K.H., Chen,R.J., Ho,T.J.,
            Tsai,F.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain
            IGF-IIR expression for hypertension-induced cardiomyocyte
            hypertrophy
  JOURNAL   J Cell Physiol 233 (2), 979-989 (2018)
   PUBMED   28383811
  REMARK    GeneRIF: Angiotensin II activates ERK/GSK3 to phosphorylate HSF1,
            resulting in RNF126 degradation, which stabilizes IGF-IIR protein
            expression and eventually results in cardiac hypertrophy.
REFERENCE   2  (bases 1 to 1450)
  AUTHORS   Rodrigo-Brenni,M.C., Gutierrez,E. and Hegde,R.S.
  TITLE     Cytosolic quality control of mislocalized proteins requires RNF126
            recruitment to Bag6
  JOURNAL   Mol Cell 55 (2), 227-237 (2014)
   PUBMED   24981174
REFERENCE   3  (bases 1 to 1450)
  AUTHORS   Smith,C.J. and McGlade,C.J.
  TITLE     The ubiquitin ligase RNF126 regulates the retrograde sorting of the
            cation-independent mannose 6-phosphate receptor
  JOURNAL   Exp Cell Res 320 (2), 219-232 (2014)
   PUBMED   24275455
REFERENCE   4  (bases 1 to 1450)
  AUTHORS   Smith,C.J., Berry,D.M. and McGlade,C.J.
  TITLE     The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal
            sorting of the epidermal growth factor receptor
  JOURNAL   J Cell Sci 126 (Pt 6), 1366-1380 (2013)
   PUBMED   23418353
REFERENCE   5  (bases 1 to 1450)
  AUTHORS   Delker,R.K., Zhou,Y., Strikoudis,A., Stebbins,C.E. and
            Papavasiliou,F.N.
  TITLE     Solubility-based genetic screen identifies RING finger protein 126
            as an E3 ligase for activation-induced cytidine deaminase
  JOURNAL   Proc Natl Acad Sci U S A 110 (3), 1029-1034 (2013)
   PUBMED   23277564
REFERENCE   6  (bases 1 to 1450)
  AUTHORS   Zhi,X., Zhao,D., Wang,Z., Zhou,Z., Wang,C., Chen,W., Liu,R. and
            Chen,C.
  TITLE     E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by
            targeting the tumor suppressor p21 for ubiquitin-mediated
            degradation
  JOURNAL   Cancer Res 73 (1), 385-394 (2013)
   PUBMED   23026136
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099810.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1450
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1450
                     /gene="Rnf126"
                     /note="ring finger protein 126"
                     /db_xref="GeneID:314613"
                     /db_xref="RGD:1306011"
     exon            1..134
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1046
                     /gene="Rnf126"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF126"
                     /protein_id="NP_001028874.1"
                     /db_xref="GeneID:314613"
                     /db_xref="RGD:1306011"
                     /translation="MAEASPQPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEET
                     RNTENGSAPSTAPTDQNRQPFEVRQGPWAQARPPVLQNVDQHLFTLPQGYSQFAFGIF
                     DDSFEIPAFPPGAQADDGRDPESRREREHQSRHRYGARQPRARLTARRATGRHEGVPT
                     LEGIIQQLVNGIISPAAVPSLGLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTG
                     PPPADKEKIQALPTVPVTEEHVGSGLECPVCKEDYALGERVRQLPCNHLFHDSCIVPW
                     LEQHDSCPVCRKSLTGQNTATNPPGLTGVGFSSSSSSSSSSSPSNENATSNS"
     exon            135..193
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            194..302
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            303..547
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            548..616
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            617..686
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            687..780
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            781..896
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1358
                     /gene="Rnf126"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaaacggcc ggcggcaggc gccgcgcggg gggcgggcgg cgcggaggcg gcggtggcca
       61 tggctgaggc gtcgccgcag cccggacggt acttctgcca ctgctgttcg gtggagatcg
      121 tgccgcgcct gccggattac atctgcccac ggtgcgagtc tggcttcatc gaggagcttc
      181 cagaagagac caggaacaca gaaaacggct cagccccctc cacagcccct actgaccaga
      241 accggcagcc atttgaggtg cgtcagggtc cctgggccca ggcccgccct cctgtcctgc
      301 agaatgtgga ccagcacctg ttcacgctgc cacagggata cagccagttt gcttttggca
      361 tcttcgacga cagctttgag attcctgcgt tccctcctgg ggcccaggcc gatgatggca
      421 gggaccctga gagccgacgg gagagagagc atcagtctcg gcatcggtat ggggcccggc
      481 agccccgtgc ccgcctcact gcccggcggg ccactggccg gcatgaaggc gtccccacgc
      541 tggaagggat catccagcag ctcgtgaatg gcatcatctc tccagctgcc gtacccagcc
      601 tgggccttgg tccctggggc gtcctgcact cgaacccaat ggactacgcc tggggggcca
      661 acggcctgga cgccatcatc acgcagctcc tcaatcagtt tgagaacacc ggccccccac
      721 ctgcagacaa ggagaagatt caggctctcc ccacggtccc agtcacagag gagcacgtgg
      781 gctcagggct ggagtgccca gtgtgcaaag aagactacgc gctgggtgag agagtgcggc
      841 agttaccctg caaccacctg ttccacgaca gctgcatcgt gccctggctg gagcagcatg
      901 acagctgccc ggtctgccgc aagagcctca ctggacagaa cacagccacc aatcctccag
      961 gcctgaccgg tgttggcttc tcctcgtcct cgtcctcatc ctcgtccagc tcacccagca
     1021 acgagaacgc cacaagcaac tcctgagtcc cacctggcca tccccccggg gcttggtcat
     1081 cccacccacc ccaggtgccc cagcaccgcc tgccatggcc gtggactaga ggtgctgccc
     1141 atggcggccg gcagcacctg gcgggcccca ggctgcgggc ggctcggact tggccatggc
     1201 cgctcctgtt tggaggtgtg cacgtgggtc ccatgtcccc agcaggcagg cgccttcagt
     1261 ccgtctttaa cctcaccctc caaatgttca acggcagaag ggtttttatg attttaaatt
     1321 attactgctt tgaaataaat ggacgtttga gccacgtgaa aaaaaaaaaa aaaaaaaaaa
     1381 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaaaaa
//
