LOCUS       NM_001108424            1139 bp    mRNA    linear   ROD 04-DEC-2023
DEFINITION  Rattus norvegicus ring finger protein 125 (Rnf125), mRNA.
ACCESSION   NM_001108424 XM_001054760 XM_341581
VERSION     NM_001108424.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1139)
  AUTHORS   Lv R, Du L and Bai L.
  TITLE     RNF125, transcriptionally regulated by NFATC2, alleviates
            osteoarthritis via inhibiting the Wnt/beta-catenin signaling
            pathway through degrading TRIM14
  JOURNAL   Int Immunopharmacol 125 (Pt B), 111191 (2023)
   PUBMED   37951197
  REMARK    GeneRIF: RNF125, transcriptionally regulated by NFATC2, alleviates
            osteoarthritis via inhibiting the Wnt/beta-catenin signaling
            pathway through degrading TRIM14.
REFERENCE   2  (bases 1 to 1139)
  AUTHORS   Murakawa M, Asahina Y, Kawai-Kitahata F, Nakagawa M, Nitta S, Otani
            S, Nagata H, Kaneko S, Asano Y, Tsunoda T, Miyoshi M, Itsui Y,
            Azuma S, Kakinuma S, Tanaka Y, Iijima S, Tsuchiya K, Izumi N, Tohda
            S and Watanabe M.
  TITLE     Hepatic IFNL4 expression is associated with non-response to
            interferon-based therapy through the regulation of basal
            interferon-stimulated gene expression in chronic hepatitis C
            patients
  JOURNAL   J Med Virol 89 (7), 1241-1247 (2017)
   PUBMED   28036111
REFERENCE   3  (bases 1 to 1139)
  AUTHORS   Bijlmakers MJ, Teixeira JM, Boer R, Mayzel M, Puig-Sarries P,
            Karlsson G, Coll M, Pons M and Crosas B.
  TITLE     A C2HC zinc finger is essential for the RING-E2 interaction of the
            ubiquitin ligase RNF125
  JOURNAL   Sci Rep 6, 29232 (2016)
   PUBMED   27411375
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1139)
  AUTHORS   Hao Q, Jiao S, Shi Z, Li C, Meng X, Zhang Z, Wang Y, Song X, Wang
            W, Zhang R, Zhao Y, Wong CC and Zhou Z.
  TITLE     A non-canonical role of the p97 complex in RIG-I antiviral
            signaling
  JOURNAL   EMBO J 34 (23), 2903-2920 (2015)
   PUBMED   26471729
REFERENCE   5  (bases 1 to 1139)
  AUTHORS   Yang L, Zhou B, Li X, Lu Z, Li W, Huo X and Miao Z.
  TITLE     RNF125 is a ubiquitin-protein ligase that promotes p53 degradation
  JOURNAL   Cell Physiol Biochem 35 (1), 237-245 (2015)
   PUBMED   25591766
REFERENCE   6  (bases 1 to 1139)
  AUTHORS   Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S
            and Russo T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (bases 1 to 1139)
  AUTHORS   Giannini AL, Gao Y and Bijlmakers MJ.
  TITLE     T-cell regulator RNF125/TRAC-1 belongs to a novel family of
            ubiquitin ligases with zinc fingers and a ubiquitin-binding domain
  JOURNAL   Biochem J 410 (1), 101-111 (2008)
   PUBMED   17990982
REFERENCE   8  (bases 1 to 1139)
  AUTHORS   Arimoto K, Takahashi H, Hishiki T, Konishi H, Fujita T and
            Shimotohno K.
  TITLE     Negative regulation of the RIG-I signaling by the ubiquitin ligase
            RNF125
  JOURNAL   Proc Natl Acad Sci U S A 104 (18), 7500-7505 (2007)
   PUBMED   17460044
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473974.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341581.3, XM_001054760.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC162061.1, FQ209520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..1139
                     /gene="Rnf125"
                     /note="ring finger protein 125"
                     /db_xref="GeneID:361296"
                     /db_xref="RGD:1306757"
     exon            1..333
                     /gene="Rnf125"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..871
                     /gene="Rnf125"
                     /EC_number="2.3.2.27"
                     /note="ring finger protein 125, E3 ubiquitin protein
                     ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF125"
                     /protein_id="NP_001101894.1"
                     /db_xref="GeneID:361296"
                     /db_xref="RGD:1306757"
                     /translation="MGSLLSSDSSKSAPTSSARRTLERSGDPELPITSFDCSVCLEVL
                     HQPVRTRCGHVFCRSCIATSIKNNNKWTCPYCRAYLPSEGVPATDIAKRMKSEYQNCT
                     ECGTLVCLSDMRAHIRTCEKYIDKYGPLQELGETTARCVCPFCQRELDEDCLLDHCII
                     HHRSERRPVFCPLCHSQPNESPSTFSGSLIRHLQVSHTLFYDDFIDFDIIEEAIIRRV
                     LDRSLLEYVNQSNTT"
     exon            334..490
                     /gene="Rnf125"
                     /inference="alignment:Splign:2.1.0"
     exon            491..585
                     /gene="Rnf125"
                     /inference="alignment:Splign:2.1.0"
     exon            586..676
                     /gene="Rnf125"
                     /inference="alignment:Splign:2.1.0"
     exon            677..784
                     /gene="Rnf125"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1139
                     /gene="Rnf125"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcgcg ctccgcctgc gctccaccga gaggccccgc gccgcggctg gccgatccag
       61 gaggcggcga tccgggctgg gccgggactt ccttcctccc gggcgggaca acagaaccac
      121 cagcagcccg ctcggagctc ccggcagctt gctgagctac agcgcagcga tgggctccct
      181 gctgagcagc gacagctcca agtccgctcc aacctcctcc gcccggcgga ctctggagcg
      241 tagcggggac ccggagctgc ccatcacctc cttcgactgc tccgtgtgcc tggaggtgct
      301 acaccagccg gtccggaccc gctgtggcca cgtgttctgc cgctcttgca ttgcaaccag
      361 tataaagaac aataataagt ggacatgccc atactgccgc gcgtaccttc cttcagaggg
      421 agtgcccgca actgacatag ccaagaggat gaagtcagaa taccagaact gtactgagtg
      481 tggaactctg gtctgcctca gtgacatgag ggcgcacatt aggacgtgtg agaagtacat
      541 cgataaatat ggcccactgc aagagcttgg agagaccact gcaagatgcg tgtgtccatt
      601 ttgtcagaga gaactggatg aagactgctt gctggatcat tgtattatcc accacagatc
      661 agaaaggagg cctgtgttct gcccactttg ccattcacaa cccaatgaaa gcccaagtac
      721 cttcagtggc agtttaatta gacatttgca agtcagccac actttgtttt acgacgattt
      781 catagatttt gatataattg aggaagccat tattcgcaga gtgttagacc gctcgcttct
      841 tgaatatgtg aatcagtcaa acaccacata attttatgaa taggatgggg accaatcact
      901 cctaccacta aagatgctgc ttgaaggact ggagagaaat tgccaatgct tgatggagaa
      961 gcatgtacta cagtgttatt cgcttgtctc tgttacgttg cattcaaaaa ctgttttcat
     1021 tctggtttgg atctgccttt acgttcttga gtttattaga catttaacca caaggaacgg
     1081 cctccgtcag ccactagcag acggaagaga cacagcacag gctggctatg tgatggagg
//
