LOCUS       NM_001191580            4627 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus ring finger protein 123 (Rnf123), mRNA.
ACCESSION   NM_001191580 XM_002729963
VERSION     NM_001191580.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4627)
  AUTHORS   Yuan,Y., Wang,Y.Y., Liu,X., Luo,B., Zhang,L., Zheng,F., Li,X.Y.,
            Guo,L.Y., Wang,L., Jiang,M., Pan,Y.M., Yan,Y.W., Yang,J.Y.,
            Chen,S.Y., Wang,J.N. and Tang,J.M.
  TITLE     KPC1 alleviates hypoxia/reoxygenation-induced apoptosis in rat
            cardiomyocyte cells though BAX degradation
  JOURNAL   J Cell Physiol 234 (12), 22921-22934 (2019)
   PUBMED   31148189
  REMARK    GeneRIF: Bax can be a novel target for the antiapoptotic effects of
            KPC1 on I/R-induced cardiomyocyte apoptosis and render mechanistic
            penetration into at least a subset of the mitochondrial effects of
            KPC1.
REFERENCE   2  (bases 1 to 4627)
  AUTHORS   Zhao,J., Zhang,S., Wu,X., Huan,W., Liu,Z., Wei,H., Shen,A. and
            Teng,H.
  TITLE     KPC1 expression and essential role after acute spinal cord injury
            in adult rat
  JOURNAL   Neurochem Res 36 (3), 549-558 (2011)
   PUBMED   21229311
  REMARK    GeneRIF: results suggest that KPC1 (Kip1 ubiquitylation-promoting
            complex 1) is related to the down-regulation of p27(kip1); this
            event may be involved in the proliferation of astrocytes after
            spinal cord injury
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XM_002729963.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.24068.1,
                                           SRR26643292.35432.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               JAXUCZ010000008.1  117645807-117646274 c
            469-586             JAXUCZ010000008.1  117644707-117644824 c
            587-671             JAXUCZ010000008.1  117644354-117644438 c
            672-745             JAXUCZ010000008.1  117638994-117639067 c
            746-840             JAXUCZ010000008.1  117638788-117638882 c
            841-895             JAXUCZ010000008.1  117638371-117638425 c
            896-981             JAXUCZ010000008.1  117638190-117638275 c
            982-1068            JAXUCZ010000008.1  117637834-117637920 c
            1069-1136           JAXUCZ010000008.1  117637574-117637641 c
            1137-1262           JAXUCZ010000008.1  117637299-117637424 c
            1263-1377           JAXUCZ010000008.1  117636791-117636905 c
            1378-1482           JAXUCZ010000008.1  117636607-117636711 c
            1483-1608           JAXUCZ010000008.1  117636086-117636211 c
            1609-1701           JAXUCZ010000008.1  117635876-117635968 c
            1702-1775           JAXUCZ010000008.1  117635730-117635803 c
            1776-1893           JAXUCZ010000008.1  117634955-117635072 c
            1894-1993           JAXUCZ010000008.1  117634655-117634754 c
            1994-2055           JAXUCZ010000008.1  117634412-117634473 c
            2056-2127           JAXUCZ010000008.1  117634196-117634267 c
            2128-2248           JAXUCZ010000008.1  117633886-117634006 c
            2249-2350           JAXUCZ010000008.1  117633241-117633342 c
            2351-2457           JAXUCZ010000008.1  117631394-117631500 c
            2458-2656           JAXUCZ010000008.1  117630931-117631129 c
            2657-2802           JAXUCZ010000008.1  117630312-117630457 c
            2803-2886           JAXUCZ010000008.1  117630003-117630086 c
            2887-2994           JAXUCZ010000008.1  117629193-117629300 c
            2995-3172           JAXUCZ010000008.1  117626878-117627055 c
            3173-3247           JAXUCZ010000008.1  117625947-117626021 c
            3248-3335           JAXUCZ010000008.1  117625628-117625715 c
            3336-3423           JAXUCZ010000008.1  117625452-117625539 c
            3424-3508           JAXUCZ010000008.1  117625282-117625366 c
            3509-3648           JAXUCZ010000008.1  117623960-117624099 c
            3649-3837           JAXUCZ010000008.1  117623675-117623863 c
            3838-3913           JAXUCZ010000008.1  117623510-117623585 c
            3914-3998           JAXUCZ010000008.1  117623200-117623284 c
            3999-4141           JAXUCZ010000008.1  117619563-117619705 c
            4142-4236           JAXUCZ010000008.1  117619338-117619432 c
            4237-4322           JAXUCZ010000008.1  117619160-117619245 c
            4323-4627           JAXUCZ010000008.1  117618776-117619080 c
FEATURES             Location/Qualifiers
     source          1..4627
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4627
                     /gene="Rnf123"
                     /note="ring finger protein 123"
                     /db_xref="GeneID:100190936"
                     /db_xref="RGD:2301394"
     exon            1..468
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            469..586
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..4443
                     /gene="Rnf123"
                     /EC_number="2.3.2.27"
                     /note="kip1 ubiquitination-promoting complex protein 1;
                     RING-type E3 ubiquitin transferase RNF123"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF123"
                     /protein_id="NP_001178509.1"
                     /db_xref="GeneID:100190936"
                     /db_xref="RGD:2301394"
                     /translation="MTSKGAAMSFSRKSYRLTSDAEKSRVTGIVQEKLLSDYLYRIFS
                     SPDHGTPAATSRKPLNFHNLPEHVDQLLQVDDEESQGQVEGRLGPSTVVLDHTGGFEG
                     LLLVDDDLLGVIGHSNFGTIRSSTCVYKGKWVYEVLISSQGLMQIGWCTINCRFNQEE
                     GVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGT
                     AFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGFRPLQDPPFADLVRAQRL
                     LGCFQTVLSVELDPVEGRLVEKESSEWQLHGQPTVLLTLAHIFHHFAPLLRKVYLVEA
                     VLMSFLLGIVEKGTPEQAQSVVHQILDLLWLFMEDYEVQDCLKQLMMSLLRLYRFSPI
                     VPDLGLQIHYLRLTMAVLRHEKSRKFLLSNVLFDMLRSVVFFYIKSPLRVEEAGLKEL
                     IPTTWWPHRSSREGRDGQEAKEETTEERQRRRAYERGCQRLKKRIEVVEELQVQILKL
                     LLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNTPVLCPPEYMVCFLHRLVSALRFY
                     WDEYKASNPRASFSDEAYIPPQIFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKANI
                     VIDPLELQAATMDDLDEDEEPAPTAAQRPVQALAIGGALPLPRPGWLSSPTLGRANRF
                     LSTAAVSLMTPRRLLSTMEKVKVRSLNVEQRTREDIEGSHWNEGLLLGRPPEEPERPL
                     TENSLLEVLDGTVMMYSLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRKDI
                     LAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLQTIEHGDRTGSL
                     FAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADPRIVGT
                     DIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLW
                     RGCGFGYRYTRLPHLLKTKPEDANLPSLQKPCPSTLLQQHMADLLRQGSDVAPSFLNS
                     VLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMTIT
                     LVPEIFLDWSRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPI
                     LVAVTGILVRLLAHGPSSETEQATSVLLADPCFQLRSIRYLLGQPEPLAPGSALPAPD
                     RKRFSLQSYADYISAEELAQVERMLAHLTAASAQAAAASLPTNEEDLCPICYAHPISA
                     VFQPCGHKSCKACINQHLMNNKDCFFCKATIVSVEDWDKAASTSATSSAA"
     exon            587..671
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            672..745
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            746..840
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            841..895
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            896..981
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1068
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1136
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1262
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1377
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1482
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1608
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1701
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1775
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1893
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1993
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2055
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2127
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2248
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2350
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2457
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2656
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2802
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2886
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2994
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3172
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3247
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3335
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3423
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3508
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            3509..3648
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3837
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            3838..3913
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            3914..3998
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            3999..4141
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            4142..4236
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            4237..4322
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
     exon            4323..4627
                     /gene="Rnf123"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagaggcgg cctggctacg agccgggcgg gtccggtgac tcccttcgag gcccctggcc
       61 gatccagtgc gacagtgccg cggcctgcgg tatagggctc ccagcgggag ctggcctgac
      121 aggtcctatg gagcttgggg ccaagtaggg gcgacctggg ggagcatgcg ctgcccttga
      181 catccttggc cacccagact tagtcggttc ggtttcgagc ctggatctct tagaagggct
      241 gggcagtaat ggcgtggctg ggagccctgg ggcagacgca ggttccgcct ctaaatcctc
      301 tacacttgac acccagagtg tgtgtctgga aggttgactt ccagttctta ctaactgcgt
      361 ccaataagtc cagcaattgt tgcaatataa gagggactgg ttgtggatgt ccatcgaggg
      421 cccccggagg gcggcacagc ggcagaatca ccttcccgag cgagcctgcc tccaggacca
      481 gtgactgccg atgagcggtg aaagatgacg tccaaggggg ctgccatgtc tttctcccga
      541 aagagctata ggttgacctc agatgctgag aagtccaggg tcacaggcat tgtgcaagag
      601 aagctactga gcgactacct gtaccggatc ttttcctctc ctgaccatgg gacccctgca
      661 gccaccagca ggaaaccgct gaacttccat aacctgccag agcatgtgga ccagctgctg
      721 caggtggacg acgaagagag ccagggacaa gttgaaggcc gacttggccc atctactgtg
      781 gtcctagacc acacaggagg ctttgagggg cttctccttg tggacgatga cctcctgggg
      841 gtgattggac acagcaactt tggcactatc cgttcttcca catgtgtgta caaagggaaa
      901 tgggtctacg aggtgctcat ctcctcccag gggctcatgc agatcggctg gtgtaccatc
      961 aactgccgct ttaatcagga ggaaggggtt ggagatacac acaactccta tgcctatgac
     1021 ggcaaccgag tgcgcaagtg gaacgtgacg acgacgaact acggcaaggc atgggcagcg
     1081 ggggacattg tgagctgcct cattgatctg gatgatggta ctctgtcctt ttgcctgaat
     1141 ggtgtgtcac tgggcactgc ctttgagaac ctttccaggg gcctaggaat ggcgtacttc
     1201 ccagccatca gcctgtcgtt caaggagtct gtggcattca actttggcag ccgacctttg
     1261 cgctacccag ttgcgggctt ccggcccctg caggaccctc cctttgctga cctggtccgg
     1321 gcacagaggt tgctgggctg cttccagaca gtgctaagtg tagagctgga ccctgtggaa
     1381 gggcggttgg tggagaagga gagctctgag tggcagctgc acgggcagcc cactgtcctc
     1441 ctcacgctgg cccacatctt ccatcacttt gcaccactgc tgcgcaaggt gtacctagtg
     1501 gaggctgtgc tcatgagctt cctgctgggc attgtggaga agggcacccc tgagcaggcc
     1561 cagtccgtgg tacaccagat cttggacctc ttgtggctct tcatggagga ctatgaagtt
     1621 caggattgcc tcaagcagtt gatgatgtct ctgctacgtc tctaccgatt ctcgcccatt
     1681 gttccggacc tgggtctaca gatccactac ctgcgcctca ctatggccgt cctgagacat
     1741 gagaagtccc gcaagttcct gcttagcaat gtcctttttg acatgctccg gtccgtggtc
     1801 ttcttttaca ttaagagtcc cctgcgtgtg gaggaagctg gcctgaagga actcatcccc
     1861 accacctggt ggccccatcg ctccagcagg gagggcagag acggtcagga agcaaaggag
     1921 gagaccacgg aagagcggca gcggaggaga gcttacgagc gtggctgcca aagactcaag
     1981 aaacgcattg aagtggtgga agaactgcag gtccagatcc tgaagctgct gttggacaac
     2041 aaagatgaca atgggggtga agcttctcgg tacatctttc tgacaaaatt ccgaaagttc
     2101 ctgcaggaga atgccagtgg ccgggggaac acacccgtgc tctgcccccc tgagtacatg
     2161 gtctgtttcc tacaccggct ggtgtctgcc ttgcgtttct attgggatga atacaaagct
     2221 tccaaccccc gtgcttcctt tagcgatgag gcttatatcc cgcctcagat cttctataat
     2281 ggcaaggtgg actacttcga ccttcagcgc ctcgggggcc tcctctcaca ccttcgaaag
     2341 acccttaaag atgaccttgc ttccaaagcc aatatcgtga ttgatcccct ggagctccag
     2401 gcagccacca tggatgacct ggatgaggat gaagagccgg cccccacagc agcccagcgt
     2461 cccgtgcaag cactggccat aggaggggcc ctgcccctgc cccggcctgg ctggctaagt
     2521 tctccaaccc tgggccgagc caaccgtttc ctcagcacag cagccgtgag cctcatgacc
     2581 ccacggcggc ttctgagcac catggagaaa gtaaaagttc gctccctgaa tgtggaacag
     2641 aggacccgtg aggacattga gggcagccac tggaatgagg gtctgctgtt ggggaggccc
     2701 cctgaagagc ctgagcggcc gcttacggaa aactcgctgt tggaagttct ggatggcaca
     2761 gtcatgatgt acagtctgag cgttcaccag cagctgggca agatggtggg tgtgtctgat
     2821 gatgtcaacg agtatgcaat ggccctgaga gacaccgagg acaagctacg tcggtgccct
     2881 aagaggagga aggatatcct tgcagagttg accaagagcc agaaggtttt ctcagaaaag
     2941 ctggaccacc tgagccgcag gcttgcctgg gtccatgcca ccgtctactc acaggagaaa
     3001 atgctggata tctactggtt actgcgtgtc tgcctacaga ccattgagca tggggatcgc
     3061 acaggatctc tctttgcctt catgcccgag ttttacctaa gtgtggctat caacagctac
     3121 agtgccctta agaattattt tggccctgtg cacagcatgg aggagctccc aggctatgaa
     3181 gagaccctga cccgcttagc tgccatcctc gccaaacact ttgctgaccc tcgaatagta
     3241 ggcactgaca ttcgagactc gctgatgcag gccctggcca gttacgtgtg ttacccacat
     3301 tccctgcggg ccgtggaacg gatccccgag gagcagcgca tcgccatggt gaggaacctt
     3361 ttggccccct atgagcaacg accctgggcc cagaccaact ggatcctggt gcggctttgg
     3421 aggggctgtg gttttgggta ccgctacaca cggctgccac atctgctgaa aaccaagcca
     3481 gaggatgcta atttgccaag cctccaaaag ccctgccctt caaccttgct acagcagcac
     3541 atggcagacc ttctgcgaca aggttctgat gtggcaccaa gcttcctcaa cagcgtcctt
     3601 aaccagctca actgggcctt ctctgagttc atcggcatga tccaggagat tcaacaggct
     3661 gctgaacgcc tagagcgaaa ctttgtggac agccggcagc tcaaggtctg tgccacctgc
     3721 ttcgacctgt cagtcagctt gctgcgcgtc ttggaaatga ccatcacact ggtccctgaa
     3781 atcttccttg actggtcccg ccctacctct gagatgctgc ttcggcgtct tgcacagctg
     3841 ctgaaccagg tgctgaaccg ggtgacagct gagaggaacc tgtttgaccg tgtagtcacg
     3901 ctgcggctac ctgggctgga gagtgtggac cactacccta tcttggtggc agtgaccggc
     3961 atcctggtac gcctcctggc acacggtcca tcctcagaga cagagcaagc cacatctgtg
     4021 ctcctggctg atccctgctt ccagctccgc tctatacgct atctcctggg gcagccagag
     4081 cccctagcac ctggctccgc cttgcctgcc cctgaccgga aacgcttctc tctacagagc
     4141 tatgcagatt acatcagtgc tgaggagctg gcccaggtgg aacggatgct ggctcacctg
     4201 accgcggcat cggcccaggc agcagctgcc tccctgccca ccaatgagga ggacctctgc
     4261 ccaatctgct atgcccaccc catctctgct gtgttccagc cttgtggtca caaatcctgc
     4321 aaagcctgca tcaaccagca tctgatgaac aacaaggact gcttcttctg caaagccacc
     4381 attgtatctg tagaggactg ggacaaggca gccagcacaa gtgccacatc ctcagctgcc
     4441 taggctgtcc tggaaaccca ccatcagacg cagtccgagt cctatttatg agctcccttg
     4501 gccctgtccc catcaccctc gctcttacca ctcccaccca tctgcctgtg tgtgcatagc
     4561 ctcactggtg ggagggagcc tgagtccagt ccaggccaca gtgagcatta aattattatt
     4621 cccttca
//
