LOCUS       NM_001106836            4829 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus ring finger protein 111 (Rnf111), mRNA.
ACCESSION   NM_001106836 XM_001055544 XM_236380
VERSION     NM_001106836.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4829)
  AUTHORS   Hou,F., Liu,R., Liu,X., Cui,L., Yu,X., Wen,Y., Ding,H. and Yin,C.
  TITLE     Arkadia protein expression is reduced in the liver during the
            progression of hepatic fibrosis
  JOURNAL   Int J Mol Med 41 (3), 1315-1322 (2018)
   PUBMED   29286088
  REMARK    GeneRIF: rkadia may regulate the pathogenesis and progression of
            hepatic fibrosis.
REFERENCE   2  (bases 1 to 4829)
  AUTHORS   Liu,L., Shi,M., Wang,Y., Zhang,C., Su,B., Xiao,Y. and Guo,B.
  TITLE     SnoN upregulation ameliorates renal fibrosis in diabetic
            nephropathy
  JOURNAL   PLoS One 12 (3), e0174471 (2017)
   PUBMED   28350874
  REMARK    GeneRIF: High glucose stress suppresses SnoN while activating
            TGF-beta1 and Rnf111 (Arkadia) in renal tubular epithelial cells
            and diabetic rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4829)
  AUTHORS   Sun,H. and Hunter,T.
  TITLE     Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins
            identified through a string search
  JOURNAL   J Biol Chem 287 (50), 42071-42083 (2012)
   PUBMED   23086935
REFERENCE   4  (bases 1 to 4829)
  AUTHORS   Li,X.Z., Feng,J.T., Hu,C.P., Chen,Z.Q., Gu,Q.H. and Nie,H.P.
  TITLE     Effects of Arkadia on airway remodeling through enhancing TGF-beta
            signaling in allergic rats
  JOURNAL   Lab Invest 90 (7), 997-1003 (2010)
   PUBMED   20386537
  REMARK    GeneRIF: Arkadia may contribute to the pathogenesis of airway
            remodeling through enhancing TGF-beta signaling by inducing the
            reduction of Smad7, SnoN and Ski proteins.
REFERENCE   5  (bases 1 to 4829)
  AUTHORS   Liu,F.Y., Li,X.Z., Peng,Y.M., Liu,H. and Liu,Y.H.
  TITLE     Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in
            a rat model of tubulointerstitial fibrosis
  JOURNAL   Am J Nephrol 27 (2), 176-183 (2007)
   PUBMED   17347560
REFERENCE   6  (bases 1 to 4829)
  AUTHORS   Liu,W., Rui,H., Wang,J., Lin,S., He,Y., Chen,M., Li,Q., Ye,Z.,
            Zhang,S., Chan,S.C., Chen,Y.G., Han,J. and Lin,S.C.
  TITLE     Axin is a scaffold protein in TGF-beta signaling that promotes
            degradation of Smad7 by Arkadia
  JOURNAL   EMBO J 25 (8), 1646-1658 (2006)
   PUBMED   16601693
REFERENCE   7  (bases 1 to 4829)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   8  (bases 1 to 4829)
  AUTHORS   Episkopou,V., Arkell,R., Timmons,P.M., Walsh,J.J., Andrew,R.L. and
            Swan,D.
  TITLE     Induction of the mammalian node requires Arkadia function in the
            extraembryonic lineages
  JOURNAL   Nature 410 (6830), 825-830 (2001)
   PUBMED   11298452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 23, 2021 this sequence version replaced NM_001106836.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.20509.1,
                                           SRR26643297.28901.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               JAXUCZ010000008.1  80060682-80060984   c
            304-1190            JAXUCZ010000008.1  80024130-80025016   c
            1191-1317           JAXUCZ010000008.1  80017688-80017814   c
            1318-1481           JAXUCZ010000008.1  80012409-80012572   c
            1482-1676           JAXUCZ010000008.1  80011210-80011404   c
            1677-1993           JAXUCZ010000008.1  80006619-80006935   c
            1994-2249           JAXUCZ010000008.1  80002696-80002951   c
            2250-2598           JAXUCZ010000008.1  79997330-79997678   c
            2599-2724           JAXUCZ010000008.1  79996259-79996384   c
            2725-2851           JAXUCZ010000008.1  79994895-79995021   c
            2852-2944           JAXUCZ010000008.1  79990793-79990885   c
            2945-3040           JAXUCZ010000008.1  79989874-79989969   c
            3041-3168           JAXUCZ010000008.1  79988578-79988705   c
            3169-4829           JAXUCZ010000008.1  79984837-79986497   c
FEATURES             Location/Qualifiers
     source          1..4829
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4829
                     /gene="Rnf111"
                     /note="ring finger protein 111"
                     /db_xref="GeneID:300813"
                     /db_xref="RGD:1310097"
     exon            1..303
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     exon            304..1190
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..3286
                     /gene="Rnf111"
                     /note="ring finger 111"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Arkadia"
                     /protein_id="NP_001100306.1"
                     /db_xref="GeneID:300813"
                     /db_xref="RGD:1310097"
                     /translation="MTQWTPEYNELYTLKVAMKSGTPPDAPTTQESLKAVLLHPQPLG
                     ATKSFPAEVEMINSKVGNEFSHLCDDSQKQEKDMNDNQQEQEKSGVVRKKRKSQQAGP
                     SYVQNCVKENQEILGLRQHLATPSDEDDDSSFSECLSSPSSSLHFGDSDTVTSDEDKE
                     VSVRHSQPILSAKSRSHNARSHKWPRTEAEPVPGLLMKRPCFHGSAVRRVPCRKRPVK
                     SSSSQRTQKQKERLLVQRKKLAQRKYALLASSSTSSENDLSSDSSSSSSTDGEEDLCA
                     SASENPSNPAAPSGSIDEDVVVIEASFTPQVTANEEINVTSTDSEVEIVTVGESYRSR
                     STLGHSRSHWSQGSSSHTGRAQEPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVP
                     TTSARMDSQTTSASINNSNPSTSEQGSDTTSTVASSQPSTVSETAATLTSNSATGSSV
                     GDDVRRTASNAVPESGPPAMPRLPSCCPQHSPCGGTSQSHHALAHPHSSCFQQHGHHF
                     QHHHHHHHTPHPAVPVSPSFSDPACPVERPQVQAPCGANSSSGSSYHDQQALPVDLSN
                     SALRTHGSGGFHGASAFDPCCPVSSSRAAVFGHQAAAAPTQPLSIDGYGSSMVAQPQP
                     QPPPQPSLSSCRHYMPPPYASLTRALHHQASACHHSHGSAPPQTQPPPQVDYVIPHPV
                     HAFHSQISTHAASHPVAPPPPTHLGSTAAPIPQHLPPAHQPISHHIPAPAPSAQRLHP
                     HEVMQRMEVQRRRLMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQAPER
                     TAWELGIEAGVTAATYTPGALHPHLAHYHAPPRLHHLQLGALPLMVPDMAGYPHIRYI
                     SSGLDGTSFRGPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKVTTDWFSQ
                     RKLHCKQDGEEGTEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKC
                     PICRVDIEAQLPSES"
     exon            1191..1317
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1481
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1676
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1993
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2249
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2598
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2724
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2851
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2944
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3040
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3168
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..4829
                     /gene="Rnf111"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgcgcagt cggggagggc cggcccaggc tgcggcggcg gcggcgatgg tagcggggcg
       61 ctggggctgc gcggcgtaga gacgccggcc gttcagggtc gcgagcgcgc gtgggccgcg
      121 atcgggtgct ccgagccggg tcgagccgag ccgggcgcag cctcacattc cgcggcggcg
      181 gcgttgtcaa acgccctcct gaggacagcc acccggcccg cctcagcgtc acccggccga
      241 gcgctgttcg ccagcccgcg ccagcgagtc ccggacctgg ccgcacgggg cctgcggact
      301 cgggccttcc ctaaagtttc ccatgactca atggactcct gaatataacg agctctacac
      361 cctgaaagtg gctatgaaga gtgggactcc tcctgatgcg cccactacac aggagagtct
      421 gaaggcggtt cttctgcacc cacagcccct aggggccact aagagcttcc ctgcagaagt
      481 ggagatgatc aatagcaaag tggggaatga attctctcat ctgtgtgatg attcccaaaa
      541 acaagaaaag gatatgaatg acaaccagca agaacaagaa aaaagtggtg ttgtgagaaa
      601 aaagcgcaaa agccagcagg ctggcccctc atatgtgcag aattgtgtca aagaaaatca
      661 ggagatcctc gggttgaggc aacacctagc gacaccaagt gatgaagatg acgactcttc
      721 cttcagcgag tgtctgtctt ctccctcatc tagtctccat tttggggact ctgatactgt
      781 gacttcagat gaggataaag aagtctcagt gagacattcc cagcctattc tgagtgctaa
      841 aagcagaagt cacaatgcaa ggtcccacaa gtggcctcga actgaggcag agcctgtgcc
      901 aggtttgttg atgaaaagac cttgttttca tggcagtgca gtgaggagag tcccatgtag
      961 aaagaggcca gtgaagagca gctcctcaca gaggacacag aagcagaagg agaggctgct
     1021 agtgcagagg aagaagctgg ctcagaggaa gtacgctctt ctcgccagct ccagtacctc
     1081 cagtgagaat gacctcagca gtgattcctc ttccagttcc tccacagatg gagaagagga
     1141 cctgtgtgca tctgccagtg agaaccccag caaccccgct gctccctcag gaagtattga
     1201 tgaagatgtt gtggtgatag aagcttcctt cactccccag gtcactgcca atgaagaaat
     1261 taatgttacc tcaactgaca gtgaagtgga gattgttaca gttggagaaa gctatcggtc
     1321 tcgttcaacc cttgggcact ccagatctca ttggagccaa ggttcaagtt cacacacagg
     1381 ccgggcacag gagcctcgaa accgcagtag gatctctact gtaatacagc ccctgaggca
     1441 gaacgcagca gaagttgtgg accttactgt tgatgaagat gaacctactg tagtaccaac
     1501 cacttctgct agaatggact cacaaactac tagtgcttcc attaacaatt caaatccatc
     1561 tacctctgag caaggctctg atactacttc aactgtggcc agtagccagc cttccacagt
     1621 gtcagagact gcagctactc ttacaagcaa tagtgcaact ggttcttctg tgggcgatga
     1681 cgtgaggaga actgcatcaa atgctgtccc agaaagtggt cctcctgcaa tgccaaggct
     1741 accttcatgc tgcccccagc actcaccatg cggagggaca tcacagagtc accatgcatt
     1801 agcacatcca cactcaagtt gttttcagca gcatggccac cattttcagc atcaccacca
     1861 ccaccaccat actccccacc cagctgtccc agtttctcct tccttcagtg accctgcttg
     1921 tcctgtggaa agacctcaag tacaggcgcc ttgtggagca aatagcagct ctggttccag
     1981 ctaccacgac cagcaggcat tgccagtcga tctgagcaac agtgctctca ggactcatgg
     2041 aagtgggggt ttccatggtg catctgcctt tgacccttgc tgccctgtct cttcttcccg
     2101 ggctgcagtc tttggccatc aggctgctgc agccccaact cagccattat caatagatgg
     2161 ctatggctcc agcatggttg cacagcccca gccccagcca cctccacagc cttctctctc
     2221 atcatgtcgg cactacatgc cacctcctta tgcttccttg acaagagcac tgcaccatca
     2281 agcctcagct tgccatcact ctcatgggag tgctcctcct cagactcagc ctccccctca
     2341 agtggattat gtgattccgc atcctgtcca tgctttccat tctcagattt ctactcacgc
     2401 agcatctcac cctgtggcgc cgccgccccc aacacatcta ggcagtacag cggcacccat
     2461 ccctcagcat cttccacctg ctcaccagcc aatttcacac catattccag ccccagcacc
     2521 ttcagcccag agactgcacc ctcatgaagt gatgcagagg atggaagtgc agaggaggag
     2581 gctgatgcag catcccacgc gggcacatga acggccccca ccccatccac ataggatgca
     2641 cccaaactat ggccatgggc atcatattca tgtgcctcaa accatgtctt cacatcctcg
     2701 ccaggctccg gagagaactg cctgggaact ggggattgaa gctggagtga ctgcagctac
     2761 ctacacacct ggtgcactgc accctcacct ggcccattac cacgccccgc ctcgacttca
     2821 tcacctacag ttaggagcac ttcccttaat ggtccctgac atggcaggct atcctcacat
     2881 ccgttacatt tcttcaggat tggacggaac atcattcaga ggtcctttca ggggcaattt
     2941 tgaggaattg attcatctgg aagaaagatt aggaaatgtc aatcgtggag cctcccaggg
     3001 aacaattgaa agatgcacat acccacataa atacaaaaag gtaacaactg attggttctc
     3061 acagaggaaa ctgcactgca aacaagatgg ggaagaaggg actgaggaag acacagagga
     3121 aaaatgtact atctgtttgt ctattttaga ggaaggtgaa gatgtgagac ggcttccgtg
     3181 tatgcacctt tttcaccaag tgtgtgttga tcagtggctg atcaccaata agaagtgccc
     3241 catatgcaga gtggacatcg aggcccagct gccaagcgaa agttgacatt gtgtttcaga
     3301 actcttgctg tccctctcat tcccatcctt cctggtactg cagtcaacca aagatggcat
     3361 gacttacctg cgcaggtctg gaagccttga tcttgaagtg ctgactctgc tacatggtac
     3421 agctaccgct agacctacaa cttatgtaca cagttgattt cgatgtattt ataaaagctt
     3481 ttgtgttttt ttctagattt gacattactt cctgtatcat tttactgtat ttttgcatga
     3541 ttccttgtat tgcatttctt tgcacatatt atgggcttgt gaccctaaac ttgcaggcaa
     3601 gattagctgc tttagtaagt agtattttgt ggtctttttg gttttgtttt gttttgtttt
     3661 ttgttttttg tttttttttt ttttacatag taccttgaaa attatgaatt tgtttttatc
     3721 cattactaac ctttaattta atcaatcatg tactttagtt taatgtataa agatcctcta
     3781 ggaaatgata atattgtgta ttaagacatt ccttcattaa attaggacaa aatggctgct
     3841 gtatatttac aatatggagt tctgagttaa gtaccaccct taatactggg aacagaatgt
     3901 aacccgtgtc aatcagatgc aggtggtact cacgaccaga gtgatcaata ggaatcttct
     3961 tggtgtatcc tttcttccag cacagtgcaa gatagagttg ctgttgatgc cgtatgttta
     4021 gactgctgtt ctgaccctat ttatctctgc catttggaac tttatcccta acccaggttt
     4081 tgctgctgtg aaacagcgtt gatgaacact aaatattaat ttgagatagc tggattgtat
     4141 atacttgcag atttaaaaaa atagggaaat tgaaaaagac atgtagaatt ttgttaggtc
     4201 ttctgctaag cacgaataag atatctgctt acattaattt tataaagtca ttcagtcaga
     4261 atttaggatt cagtcattgg caggtatcta tgcattcgta gaacttctaa gggtcccagg
     4321 atcactttta agggattttt ttttatagtt taaataaagt cagctgaatc tacatgtctc
     4381 ttgttttatt tctctctaaa cttgaaaaca ataaatctgc agatactgtg aggcacagat
     4441 tatattgtca agctactgtt gctatggtta tagacaccca cttcagacat taccaagagt
     4501 cgatcactga cttaaaaatt ttaatttcta tagttaagat ttacaacata atatagagta
     4561 aaagttaaca tactaacatt tctcctttgg aggaagtttt aatccacttc aggatgcata
     4621 ttatcaagat actttcatat acaggatagt ctaattttat ttgtttaaat atgcttaata
     4681 tgcccaagat tgcaaatgca tccagtcagt aataccactg tctgtatgtg gaagacatgt
     4741 tcccatggat catatgtgaa gatgtcaata agcttgcatt aagccacctg ctttgtaagt
     4801 ggattgatta ataaataact tatatttct
//
