LOCUS       NM_001415782            3078 bp    mRNA    linear   ROD 10-APR-2024
DEFINITION  Rattus norvegicus ring finger protein 10 (Rnf10), transcript
            variant 2, mRNA.
ACCESSION   NM_001415782 XM_006249434
VERSION     NM_001415782.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3078)
  AUTHORS   Shi,H., Duan,L., Lan,Y., He,Q., Pu,P. and Tang,H.
  TITLE     RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate
            Pirarubicin-Induced Cardiomyocyte Apoptosis
  JOURNAL   Oxid Med Cell Longev 2023, 7872193 (2023)
   PUBMED   36713029
  REMARK    GeneRIF: RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate
            Pirarubicin-Induced Cardiomyocyte Apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3078)
  AUTHORS   Carrano,N., Samaddar,T., Brunialti,E., Franchini,L., Marcello,E.,
            Ciana,P., Mauceri,D., Di Luca,M. and Gardoni,F.
  TITLE     The Synaptonuclear Messenger RNF10 Acts as an Architect of Neuronal
            Morphology
  JOURNAL   Mol Neurobiol 56 (11), 7583-7593 (2019)
   PUBMED   31069631
  REMARK    GeneRIF: protein kinase C [PKC]-dependent phosphorylation of RNF10
            Ser31 was identified as a key step for RNF10 detachment from NMDA
            receptor and its subsequent trafficking to the nucleus.
REFERENCE   3  (bases 1 to 3078)
  AUTHORS   Li,S., Yu,G., Huang,W., Wang,R., Pu,P. and Chen,M.
  TITLE     RING finger protein 10 is a potential drug target for diabetic
            vascular complications
  JOURNAL   Mol Med Rep 20 (2), 931-938 (2019)
   PUBMED   31173254
  REMARK    GeneRIF: The differential expression of RNF10 had a completely
            opposite effect on vascular damage under hyperglycaemia, further
            displaying the core function of RNF10 in regulating vascular
            remodeling induced by diabetes.
REFERENCE   4  (bases 1 to 3078)
  AUTHORS   Yu,G., Chen,J., Li,S., Pu,P., Huang,W., Zhao,Y., Peng,X., Wang,R.
            and Lei,H.
  TITLE     RING finger protein 10 prevents neointimal hyperplasia by promoting
            apoptosis in vitro and in vivo
  JOURNAL   Life Sci 208, 325-332 (2018)
   PUBMED   29723537
  REMARK    GeneRIF: Low RNF10 expression is associated with neointimal
            hyperplasia.
REFERENCE   5  (bases 1 to 3078)
  AUTHORS   Dinamarca,M.C., Guzzetti,F., Karpova,A., Lim,D., Mitro,N.,
            Musardo,S., Mellone,M., Marcello,E., Stanic,J., Samaddar,T.,
            Burguiere,A., Caldarelli,A., Genazzani,A.A., Perroy,J., Fagni,L.,
            Canonico,P.L., Kreutz,M.R., Gardoni,F. and Di Luca,M.
  TITLE     Ring finger protein 10 is a novel synaptonuclear messenger encoding
            activation of NMDA receptors in hippocampus
  JOURNAL   Elife 5, e12430 (2016)
   PUBMED   26977767
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3078)
  AUTHORS   Lee,Y.I., Giovinazzo,D., Kang,H.C., Lee,Y., Jeong,J.S.,
            Doulias,P.T., Xie,Z., Hu,J., Ghasemi,M., Ischiropoulos,H., Qian,J.,
            Zhu,H., Blackshaw,S., Dawson,V.L. and Dawson,T.M.
  TITLE     Protein microarray characterization of the S-nitrosoproteome
  JOURNAL   Mol Cell Proteomics 13 (1), 63-72 (2014)
   PUBMED   24105792
REFERENCE   7  (bases 1 to 3078)
  AUTHORS   Hoshikawa,S., Ogata,T., Fujiwara,S., Nakamura,K. and Tanaka,S.
  TITLE     A novel function of RING finger protein 10 in transcriptional
            regulation of the myelin-associated glycoprotein gene and myelin
            formation in Schwann cells
  JOURNAL   PLoS One 3 (10), e3464 (2008)
   PUBMED   18941509
REFERENCE   8  (bases 1 to 3078)
  AUTHORS   Lin,J., Friesen,M.T., Bocangel,P., Cheung,D., Rawszer,K. and
            Wigle,J.T.
  TITLE     Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription
            factor binding to RING finger protein 10
  JOURNAL   Mol Cell Biochem 275 (1-2), 75-84 (2005)
   PUBMED   16335786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Dec 29, 2022 this sequence version replaced XM_006249434.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.81194.1,
                                           SRR26643297.40378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-614               JAXUCZ010000012.1  47002409-47003022
            615-811             JAXUCZ010000012.1  47016458-47016654
            812-1011            JAXUCZ010000012.1  47022823-47023022
            1012-1102           JAXUCZ010000012.1  47024571-47024661
            1103-1287           JAXUCZ010000012.1  47026189-47026373
            1288-1424           JAXUCZ010000012.1  47026455-47026591
            1425-1585           JAXUCZ010000012.1  47027584-47027744
            1586-1711           JAXUCZ010000012.1  47028386-47028511
            1712-1964           JAXUCZ010000012.1  47028874-47029126
            1965-2098           JAXUCZ010000012.1  47029331-47029464
            2099-2216           JAXUCZ010000012.1  47030131-47030248
            2217-2318           JAXUCZ010000012.1  47030434-47030535
            2319-2474           JAXUCZ010000012.1  47031362-47031517
            2475-2575           JAXUCZ010000012.1  47033420-47033520
            2576-2633           JAXUCZ010000012.1  47035208-47035265
            2634-2792           JAXUCZ010000012.1  47035342-47035500
            2793-3078           JAXUCZ010000012.1  47035916-47036201
FEATURES             Location/Qualifiers
     source          1..3078
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3078
                     /gene="Rnf10"
                     /note="ring finger protein 10"
                     /db_xref="GeneID:288710"
                     /db_xref="RGD:1309282"
     exon            1..614
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     CDS             458..2869
                     /gene="Rnf10"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase RNF10"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF10 isoform 2"
                     /protein_id="NP_001402711.1"
                     /db_xref="GeneID:288710"
                     /db_xref="RGD:1309282"
                     /translation="MPQSSPSTAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGP
                     AGESKPKSDGKNSNGSKRYNRKREPSYPKNENFSNQSRRSNSQKSKTFNKTPPQRGGG
                     SSKPFSSSSNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQAGHFEGS
                     GHGSWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYTANFADPDTLVNWDFVEQVRIC
                     SHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSERTWSKCPICYSSVHKKDLK
                     SVVATESRQYVVGDTITMQLMKREKGVLVALPKSKWMNVDHPISLGDEQHSQYSKLLL
                     ASKEQVLHRVVLEEKVALEQQLAEEKHTPESCFIEAALQEVKIREEALSGVAGGRAEV
                     TGVVTALEQLVLMAPLAKESAFQPRKGVLEYLSAFDEEAAQVCSLDPPGPLALPLVEE
                     EEAVSEPEACEDLIADDSLGEGTVCAELSQEEPIAKPGFTQLSSSPCYYFYQAEDGQH
                     MFLHPVNVRCLVREYGSLEQSPEKISATVVEIAGYSMSEDVRQRHRYLSHLPLTCEFS
                     ICELALQPPVVSKETLEMFSDDIEKRKRQRQKKAREERRRERRIELEENKRQGRYPEV
                     HIPLENLQQFPAFNSYTCSSDSALGPTSTEGHGALSLSPLSRSPGSHADFLLTPLSPT
                     ASQGSPSFCVGSLEEDSPFLSFAQMLRVGKAKADGWPKAAPKKDDNSLAPPAPVDSDG
                     ESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPATSDPLSEDRGGRKRKRQKQKLLFSTS
                     VVHTK"
     exon            615..811
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1011
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1102
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1287
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1424
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1585
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1711
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1964
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2098
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2216
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2318
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2474
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2575
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2633
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2792
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..3078
                     /gene="Rnf10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtttggc gactcgtcgc cattcccgga gcagctcggc ctcggcccag aggcgagtgt
       61 cggtcgctgt gtcggagacc ccggtccccg gcaccgagac aaccagccct ctctcctgcc
      121 ccgcggcggg agagcgtgtc cggccggccg gcggggctcg cgaccctccc gcgcctcccc
      181 tttcccctca gcctccgccc cgccaggccc ggcccggacc tccgagcccc ggcctcctcc
      241 tcctcctctt cggtcaccgc cgcctctggg ccccacagcc ccacctgccg cttctccttc
      301 cattttgaga agctgaggaa ggaaacaagg aaaaatgtcg ccatgaaggc cgagaaccgc
      361 tgccgccgcc gacccccgcc ggccctgaac gccatgagcc tgggtccccg ccgcgcccgc
      421 tccgctccga ccgccgtcgc cgccgaggcc ccctttgatg ccgcagagct cccccagcac
      481 cgccgccacc gcctccgaca tggacaagaa cagcggctcc aacagctcct ccgcctcctc
      541 gggcagcagc aaagggcaac agccgccccg ctccgcctcg gcggggccgg ccggcgagtc
      601 taaacccaag agcgatggaa agaactcaaa tggatccaag cgttacaatc gcaagcgtga
      661 accttcctac cccaaaaatg agaattttag caaccagtcc cgtcgctcca attcacagaa
      721 aagcaaaact tttaacaaga cgcctcctca aaggggcggt ggcagcagca aaccctttag
      781 ctcttcttct aatggtggaa gacgggatga ggtagcagag gctcagcggg cagagtttag
      841 ccctgcccag ttctccggcc ctaagaagat caacctgaac cacttgttaa atttcacctt
      901 tgaaccccgt ggccaggcag gtcactttga aggcagtgga catggcagct gggggaaaag
      961 aaacaagtgg ggacacaagc ctttcaacaa ggaactcttt ttacaggcca actgccaatt
     1021 tgtggtgtct gaagaccaag attacacagc taactttgct gaccctgaca ccttagtcaa
     1081 ctgggacttt gtggaacaag tgcgcatctg tagccatgaa gtgccatctt gtccaatatg
     1141 cctctaccca cccactgcag ccaagataac ccgctgtgga cacattttct gctgggcctg
     1201 catcctgcac tatctctcac tcagtgagag aacctggagc aaatgtccca tctgctacag
     1261 ctctgtgcac aagaaggatc tcaagagtgt tgttgccaca gagtctcgac agtatgttgt
     1321 gggtgacacc attacgatgc agctgatgaa gagagagaaa ggagtgttgg tggccctgcc
     1381 caaatccaag tggatgaatg tagaccatcc tattagtcta ggagacgagc agcacagcca
     1441 gtactccaag ctgctgctgg cctctaagga gcaggtgctg caccgggtgg ttctggagga
     1501 gaaagtcgcg ctggagcagc agcttgccga agagaagcac actcctgagt cctgctttat
     1561 tgaggctgct ctccaggagg tcaagattcg ggaagaagct ctgtcaggag tggctggagg
     1621 cagagcggag gtcactggtg ttgtgactgc tctggaacaa ctggtgctga tggctcccct
     1681 ggccaaggag tctgcttttc aacccaggaa gggtgtgcta gagtatctgt ctgcttttga
     1741 tgaagaagct gcacaagttt gttctctgga cccccctggt cctctcgctc tccctttggt
     1801 agaagaagag gaagcagtgt ctgagccaga agcctgtgag gacttaatag ctgatgacag
     1861 tcttggagag gggaccgtct gtgccgagtt gagccaggag gagcccatcg ctaagccagg
     1921 cttcacacag ctgagcagct ctccctgtta ctacttctac caagcggagg atggacagca
     1981 catgttcctg caccctgtca acgtgcgctg ccttgtgcgg gagtatggca gcctggagca
     2041 gagcccggag aagatctcag caaccgtggt agagattgct gggtattcca tgtctgagga
     2101 tgttcgacag cgtcacaggt atctctctca cttgccactc acctgtgagt tcagcatctg
     2161 tgaactggct ctgcagcctc ctgtggtctc taaggaaacc ctagagatgt tctcagatga
     2221 cattgagaaa aggaagcgtc agcgccaaaa gaaggctcgc gaggagcggc gcagagagcg
     2281 cagaattgaa ctggaggaga acaagagaca gggcaggtat cccgaggtcc acattcccct
     2341 cgagaacctt cagcagtttc ctgccttcaa ttcctacacc tgttcctctg attctgcttt
     2401 gggacccacc agcaccgagg gccacggggc cctatccctg tctcctctga gcagaagtcc
     2461 aggttcccat gcagactttc tgctgacccc tctgtcaccc actgccagtc agggcagtcc
     2521 ctccttctgc gttgggagtc tggaagaaga ctctcccttc ctttcctttg cccagatgct
     2581 gagggttggc aaagcaaaag cagacgggtg gcccaaagct gctccaaaga aagacgacaa
     2641 tagcctggct cctcccgccc cggtggacag tgatggggag agtgacaatt ctgaccgtgt
     2701 tcctgtgccc agtttccaaa attccttcag ccaagctatc gaagccgcct tcatgaaatt
     2761 ggacacacca gctacttcag accccctctc tgaagacaga ggagggagga agaggaagag
     2821 gcagaagcag aagctgctgt tcagcacctc ggtcgtccac accaagtgac tactgcccag
     2881 gcgccttctc catcgggttt cttctgtgct ttggtttgct gctgctgtaa tttttaagtg
     2941 tttgagtttg aacagattga ttagcttggg gcggggggag gggctttcca caaagtgagg
     3001 gaaccaagaa aattttaaat acagtgtatt ttccagcttc cctctttaca ccaaaataaa
     3061 gtattgacac tcacatga
//
