LOCUS       NP_001402711             803 aa            linear   ROD 10-APR-2024
DEFINITION  E3 ubiquitin-protein ligase RNF10 isoform 2 [Rattus norvegicus].
ACCESSION   NP_001402711 XP_006249496
VERSION     NP_001402711.1
DBSOURCE    REFSEQ: accession NM_001415782.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 803)
  AUTHORS   Shi,H., Duan,L., Lan,Y., He,Q., Pu,P. and Tang,H.
  TITLE     RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate
            Pirarubicin-Induced Cardiomyocyte Apoptosis
  JOURNAL   Oxid Med Cell Longev 2023, 7872193 (2023)
   PUBMED   36713029
  REMARK    GeneRIF: RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate
            Pirarubicin-Induced Cardiomyocyte Apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 803)
  AUTHORS   Carrano,N., Samaddar,T., Brunialti,E., Franchini,L., Marcello,E.,
            Ciana,P., Mauceri,D., Di Luca,M. and Gardoni,F.
  TITLE     The Synaptonuclear Messenger RNF10 Acts as an Architect of Neuronal
            Morphology
  JOURNAL   Mol Neurobiol 56 (11), 7583-7593 (2019)
   PUBMED   31069631
  REMARK    GeneRIF: protein kinase C [PKC]-dependent phosphorylation of RNF10
            Ser31 was identified as a key step for RNF10 detachment from NMDA
            receptor and its subsequent trafficking to the nucleus.
REFERENCE   3  (residues 1 to 803)
  AUTHORS   Li,S., Yu,G., Huang,W., Wang,R., Pu,P. and Chen,M.
  TITLE     RING finger protein 10 is a potential drug target for diabetic
            vascular complications
  JOURNAL   Mol Med Rep 20 (2), 931-938 (2019)
   PUBMED   31173254
  REMARK    GeneRIF: The differential expression of RNF10 had a completely
            opposite effect on vascular damage under hyperglycaemia, further
            displaying the core function of RNF10 in regulating vascular
            remodeling induced by diabetes.
REFERENCE   4  (residues 1 to 803)
  AUTHORS   Yu,G., Chen,J., Li,S., Pu,P., Huang,W., Zhao,Y., Peng,X., Wang,R.
            and Lei,H.
  TITLE     RING finger protein 10 prevents neointimal hyperplasia by promoting
            apoptosis in vitro and in vivo
  JOURNAL   Life Sci 208, 325-332 (2018)
   PUBMED   29723537
  REMARK    GeneRIF: Low RNF10 expression is associated with neointimal
            hyperplasia.
REFERENCE   5  (residues 1 to 803)
  AUTHORS   Dinamarca,M.C., Guzzetti,F., Karpova,A., Lim,D., Mitro,N.,
            Musardo,S., Mellone,M., Marcello,E., Stanic,J., Samaddar,T.,
            Burguiere,A., Caldarelli,A., Genazzani,A.A., Perroy,J., Fagni,L.,
            Canonico,P.L., Kreutz,M.R., Gardoni,F. and Di Luca,M.
  TITLE     Ring finger protein 10 is a novel synaptonuclear messenger encoding
            activation of NMDA receptors in hippocampus
  JOURNAL   Elife 5, e12430 (2016)
   PUBMED   26977767
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 803)
  AUTHORS   Lee,Y.I., Giovinazzo,D., Kang,H.C., Lee,Y., Jeong,J.S.,
            Doulias,P.T., Xie,Z., Hu,J., Ghasemi,M., Ischiropoulos,H., Qian,J.,
            Zhu,H., Blackshaw,S., Dawson,V.L. and Dawson,T.M.
  TITLE     Protein microarray characterization of the S-nitrosoproteome
  JOURNAL   Mol Cell Proteomics 13 (1), 63-72 (2014)
   PUBMED   24105792
REFERENCE   7  (residues 1 to 803)
  AUTHORS   Hoshikawa,S., Ogata,T., Fujiwara,S., Nakamura,K. and Tanaka,S.
  TITLE     A novel function of RING finger protein 10 in transcriptional
            regulation of the myelin-associated glycoprotein gene and myelin
            formation in Schwann cells
  JOURNAL   PLoS One 3 (10), e3464 (2008)
   PUBMED   18941509
REFERENCE   8  (residues 1 to 803)
  AUTHORS   Lin,J., Friesen,M.T., Bocangel,P., Cheung,D., Rawszer,K. and
            Wigle,J.T.
  TITLE     Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription
            factor binding to RING finger protein 10
  JOURNAL   Mol Cell Biochem 275 (1-2), 75-84 (2005)
   PUBMED   16335786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Dec 29, 2022 this sequence version replaced XP_006249496.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.81194.1,
                                           SRR26643297.40378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..803
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     Protein         1..803
                     /product="E3 ubiquitin-protein ligase RNF10 isoform 2"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase RNF10"
                     /calculated_mol_wt=88408
     Region          1..134
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XI59.1)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N5U6; propagated from
                     UniProtKB/Swiss-Prot (Q5XI59.1)"
     Site            110
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N5U6; propagated from
                     UniProtKB/Swiss-Prot (Q5XI59.1)"
     Site            128
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N5U6; propagated from
                     UniProtKB/Swiss-Prot (Q5XI59.1)"
     Region          223..276
                     /region_name="RING-HC_RNF10"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 10 (RNF10) and similar proteins; cd16536"
                     /db_xref="CDD:438198"
     Region          645..664
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XI59.1)"
     Region          716..753
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5XI59.1)"
     CDS             1..803
                     /gene="Rnf10"
                     /coded_by="NM_001415782.1:458..2869"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:288710"
                     /db_xref="RGD:1309282"
ORIGIN      
        1 mpqsspstaa tasdmdknsg snsssassgs skgqqpprsa sagpageskp ksdgknsngs
       61 krynrkreps ypknenfsnq srrsnsqksk tfnktppqrg ggsskpfsss snggrrdeva
      121 eaqraefspa qfsgpkkinl nhllnftfep rgqaghfegs ghgswgkrnk wghkpfnkel
      181 flqancqfvv sedqdytanf adpdtlvnwd fveqvricsh evpscpicly pptaakitrc
      241 ghifcwacil hylslsertw skcpicyssv hkkdlksvva tesrqyvvgd titmqlmkre
      301 kgvlvalpks kwmnvdhpis lgdeqhsqys klllaskeqv lhrvvleekv aleqqlaeek
      361 htpescfiea alqevkiree alsgvaggra evtgvvtale qlvlmaplak esafqprkgv
      421 leylsafdee aaqvcsldpp gplalplvee eeavsepeac edliaddslg egtvcaelsq
      481 eepiakpgft qlssspcyyf yqaedgqhmf lhpvnvrclv reygsleqsp ekisatvvei
      541 agysmsedvr qrhrylshlp ltcefsicel alqppvvske tlemfsddie krkrqrqkka
      601 reerrrerri eleenkrqgr ypevhiplen lqqfpafnsy tcssdsalgp tsteghgals
      661 lsplsrspgs hadflltpls ptasqgspsf cvgsleedsp flsfaqmlrv gkakadgwpk
      721 aapkkddnsl appapvdsdg esdnsdrvpv psfqnsfsqa ieaafmkldt patsdplsed
      781 rggrkrkrqk qkllfstsvv htk
//
