LOCUS       NM_001007641            2002 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus Rho family GTPase 3 (Rnd3), mRNA.
ACCESSION   NM_001007641 XM_215730
VERSION     NM_001007641.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Wu,L., Zhu,X., Luo,C., Zhao,Y., Pan,S., Shi,K., Chen,Y., Qiu,J.,
            Shen,Z., Guo,J. and Jie,W.
  TITLE     Mechanistic role of RND3-regulated IL33/ST2 signaling on
            cardiomyocyte senescence
  JOURNAL   Life Sci 348, 122701 (2024)
   PUBMED   38724005
  REMARK    GeneRIF: Mechanistic role of RND3-regulated IL33/ST2 signaling on
            cardiomyocyte senescence.
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Shao,Z., Wang,K., Zhang,S., Yuan,J., Liao,X., Wu,C., Zou,Y., Ha,Y.,
            Shen,Z., Guo,J. and Jie,W.
  TITLE     Ingenuity pathway analysis of differentially expressed genes
            involved in signaling pathways and molecular networks in RhoE
            gene-edited cardiomyocytes
  JOURNAL   Int J Mol Med 46 (3), 1225-1238 (2020)
   PUBMED   32705255
  REMARK    GeneRIF: Ingenuity pathway analysis of differentially expressed
            genes involved in signaling pathways and molecular networks in RhoE
            geneedited cardiomyocytes.
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Lesiak,A., Pelz,C., Ando,H., Zhu,M., Davare,M., Lambert,T.J.,
            Hansen,K.F., Obrietan,K., Appleyard,S.M., Impey,S. and Wayman,G.A.
  TITLE     A genome-wide screen of CREB occupancy identifies the RhoA
            inhibitors Par6C and Rnd3 as regulators of BDNF-induced
            synaptogenesis
  JOURNAL   PLoS One 8 (6), e64658 (2013)
   PUBMED   23762244
  REMARK    GeneRIF: BDNF can regulate formation of functional synapses by
            increasing the expression of the RhoA inhibitors, Par6C and Rnd3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 2002)
  AUTHORS   Kim,Y.S., Hori,M., Yasuda,K. and Ozaki,H.
  TITLE     Differences in the gestational pattern of mRNA expression of the
            Rnd family in rat and human myometria
  JOURNAL   Comp Biochem Physiol A Mol Integr Physiol 142 (4), 410-415 (2005)
   PUBMED   16311049
  REMARK    GeneRIF: The Rnd3 mRNA levels increased significantly after
            gestation in rat myometria.
REFERENCE   6  (bases 1 to 2002)
  AUTHORS   Villalonga,P., Guasch,R.M., Riento,K. and Ridley,A.J.
  TITLE     RhoE inhibits cell cycle progression and Ras-induced transformation
  JOURNAL   Mol Cell Biol 24 (18), 7829-7840 (2004)
   PUBMED   15340047
REFERENCE   7  (bases 1 to 2002)
  AUTHORS   Riento,K., Guasch,R.M., Garg,R., Jin,B. and Ridley,A.J.
  TITLE     RhoE binds to ROCK I and inhibits downstream signaling
  JOURNAL   Mol Cell Biol 23 (12), 4219-4229 (2003)
   PUBMED   12773565
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001007641.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY461427.1, BC168142.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840108,
                                           SAMN12840110 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               JAXUCZ010000003.1  55998160-55998494   c
            336-423             JAXUCZ010000003.1  55997649-55997736   c
            424-533             JAXUCZ010000003.1  55986706-55986815   c
            534-668             JAXUCZ010000003.1  55984013-55984147   c
            669-2002            JAXUCZ010000003.1  55981142-55982475   c
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..2002
                     /gene="Rnd3"
                     /gene_synonym="Arhe; RHOE"
                     /note="Rho family GTPase 3"
                     /db_xref="GeneID:295588"
                     /db_xref="RGD:1359690"
     exon            1..335
                     /gene="Rnd3"
                     /gene_synonym="Arhe; RHOE"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..920
                     /gene="Rnd3"
                     /gene_synonym="Arhe; RHOE"
                     /note="ras homolog gene family, member E"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoE"
                     /protein_id="NP_001007642.1"
                     /db_xref="GeneID:295588"
                     /db_xref="RGD:1359690"
                     /translation="MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFA
                     KDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICF
                     DISRPETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYD
                     QGANMAKQIGAATYIECSALQSENSVRDIFHVATLACVNKTNKNVKRNKSQRATKRIS
                     HMPSRPELSAVATDLRKDKAKSCTVM"
     exon            336..423
                     /gene="Rnd3"
                     /gene_synonym="Arhe; RHOE"
                     /inference="alignment:Splign:2.1.0"
     exon            424..533
                     /gene="Rnd3"
                     /gene_synonym="Arhe; RHOE"
                     /inference="alignment:Splign:2.1.0"
     exon            534..668
                     /gene="Rnd3"
                     /gene_synonym="Arhe; RHOE"
                     /inference="alignment:Splign:2.1.0"
     exon            669..2002
                     /gene="Rnd3"
                     /gene_synonym="Arhe; RHOE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagaaaac ttgttggaga ggagtaaaga gccgctgcct ctcctcctcc aactccgctg
       61 cgcttaaggg gttccctccg gccttgcgat ttatttttat atccgctttt tatagagaga
      121 agtatatata tttttttctt ctaaagagaa aaattcctgt tccaagagaa aataaggcaa
      181 catcaatgaa ggagagaaga gccagccaga aattatccag taaatctatc atggatccta
      241 atcagaacgt gaaatgcaag atagtagtgg tgggcgacag ccagtgtggg aaaaccgcgc
      301 tgctccacgt cttcgcaaag gactgcttcc ccgaaaatta cgtccctacg gtgtttgaga
      361 attacactgc cagttttgaa atcgacacac aaagaataga gttgagcctg tgggacactt
      421 caggttcccc ttactatgac aacgtccgtc ccctctctta cccagattct gatgctgtgc
      481 tcatttgctt tgacatcagt agaccagaaa ctctggacag tgtcttaaag aagtggaaag
      541 gtgaaatcca ggagttttgt cccaatacca agatgctgtt ggttggttgc aagtctgacc
      601 ttcggacaga tgtcagcaca ctagtggaac tctcaaatca caggcagact cctgtgtcat
      661 atgatcaggg ggcaaacatg gcgaagcaga tcggagcagc cacttacata gaatgctcag
      721 ctttacagtc ggagaacagc gtcagagaca tttttcacgt cgccaccttg gcgtgtgtaa
      781 ataagacaaa taaaaacgtt aagcggaaca aatcacagag ggccacaaag cggatttcac
      841 acatgcctag cagaccagaa ctctcagcag ttgctacgga cttacgaaag gacaaagcca
      901 agagctgcac tgtgatgtga ggcttcaccg tctttaatga ggacacatgg aaatctggtg
      961 taaaaaaaaa attaaaataa aatttgaaac agcaagagca aacggaaaga gggagtcaaa
     1021 tgaagtgcac agccaaagtc acatggacac aaggcgtagg agtcccttga aaaaaaaagt
     1081 ggatacccac ttttcggaat cctgtcctta gtttcggcat gtagaccgag tggtgagaag
     1141 cgaatgcgtt gaagagtttt gtgtaacaag aggtgtgact tgaaaaatac accaaaaaca
     1201 aagggagcta caaacgggcg agcgctagag aagtgggggg ccctggtacc tccaagaaga
     1261 aagtccacgc tttgaatggt gcttgagtat ttttggtttt gtgtttgtgg ttttattaca
     1321 acctattcgt ggatctctac tttgatttag tttttcaatg ttttaatccc tttttccaaa
     1381 aaagtatata ttagtagacc gtcctcgttg ggaactcgca ctgtgacctt agcgtttagt
     1441 tttctagagg atgtgatcta atttcctcct agctcgtcat taaaatggaa attgtactag
     1501 gacccggtgg gattcgagag gaaaaacttg ctgcggcttt gaaatcttga cttcctgaag
     1561 gtcgccgctg agcgagatgg tttgaagcaa ggcttcctgg ccttacaaga tgcgtagacc
     1621 agcactacag agattgcgta gatcaactag aagagagtgt tgctttttct tctgtcttga
     1681 tggttttgtt catcctcgtg attgtcctta aacaagtggt aaatcgttcc gtgtaatatt
     1741 ttttgtgcgc tgtgtagaag agtgtgtgtg tggcttcgtt ttgtttttct tttttctttt
     1801 tgccatcgtt gatgaaaaca agaagtcaaa taaaagatgt cttcgtctga ttgtgatagc
     1861 gtgattaaag aggaggcagg tgggtgccga tttcaccagg agagaccttg aatgaaggag
     1921 tagtgatagc agagagcaca gttggtgaat ggggctgtct ggaaggaagt tatacatcaa
     1981 atacacagag caaaagcact ct
//
