LOCUS       NM_001010953            1373 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus Rho family GTPase 2 (Rnd2), mRNA.
ACCESSION   NM_001010953 XM_220993
VERSION     NM_001010953.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1373)
  AUTHORS   Furuta,D., Yamane,M., Tsujiuchi,T., Moriyama,R. and Fukushima,N.
  TITLE     Lysophosphatidic acid induces neurite branch formation through LPA3
  JOURNAL   Mol Cell Neurosci 50 (1), 21-34 (2012)
   PUBMED   22465231
REFERENCE   2  (bases 1 to 1373)
  AUTHORS   Tanaka,H., Katoh,H. and Negishi,M.
  TITLE     Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity
  JOURNAL   J Biol Chem 281 (15), 10355-10364 (2006)
   PUBMED   16481321
  REMARK    GeneRIF: Rnd2 regulates neurite outgrowth by functioning as the
            RhoA activator through Pragmin, in contrast to Rnd1 and Rnd3
            inhibiting RhoA signaling
REFERENCE   3  (bases 1 to 1373)
  AUTHORS   Kim,Y.S., Hori,M., Yasuda,K. and Ozaki,H.
  TITLE     Differences in the gestational pattern of mRNA expression of the
            Rnd family in rat and human myometria
  JOURNAL   Comp Biochem Physiol A Mol Integr Physiol 142 (4), 410-415 (2005)
   PUBMED   16311049
  REMARK    GeneRIF: The RND2 mRNA levels increased significantly was expressed
            in nonpregnant rat myometrium.
REFERENCE   4  (bases 1 to 1373)
  AUTHORS   Tanaka,H., Fujita,H., Katoh,H., Mori,K. and Negishi,M.
  TITLE     Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a
            novel Rho family GTPase, Rnd2
  JOURNAL   Biochem J 365 (Pt 2), 349-353 (2002)
   PUBMED   11931639
REFERENCE   5  (bases 1 to 1373)
  AUTHORS   Nishi,M., Takeshima,H., Houtani,T., Nakagawara,K., Noda,T. and
            Sugimoto,T.
  TITLE     RhoN, a novel small GTP-binding protein expressed predominantly in
            neurons and hepatic stellate cells
  JOURNAL   Brain Res Mol Brain Res 67 (1), 74-81 (1999)
   PUBMED   10101234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 8, 2021 this sequence version replaced NM_001010953.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089058.1, D82867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               JAXUCZ010000010.1  86899395-86899669
            276-363             JAXUCZ010000010.1  86900169-86900256
            364-473             JAXUCZ010000010.1  86901044-86901153
            474-608             JAXUCZ010000010.1  86901906-86902040
            609-1373            JAXUCZ010000010.1  86902228-86902992
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1373
                     /gene="Rnd2"
                     /gene_synonym="Arhn; RhoN; Rohn"
                     /note="Rho family GTPase 2"
                     /db_xref="GeneID:303553"
                     /db_xref="RGD:1306172"
     exon            1..275
                     /gene="Rnd2"
                     /gene_synonym="Arhn; RhoN; Rohn"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..860
                     /gene="Rnd2"
                     /gene_synonym="Arhn; RhoN; Rohn"
                     /note="ras homolog gene family, member N; aplysia
                     ras-related homolog N (RhoN)"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoN"
                     /protein_id="NP_001010953.1"
                     /db_xref="GeneID:303553"
                     /db_xref="RGD:1306172"
                     /translation="MEGQSGRCKIVVVGDAECGKTALLQVFAKDAYPGSYVPTVFENY
                     TASFEIDKRRIELNMWDTSGSSYYDNVRPLAYPDSDAVLICFDISRPETLDSVLKKWQ
                     GETQEFCPNAKVVLVGCKLDMRTDLATLRELSKQRLIPVTHEQGTVLAKQVGAVSYVE
                     CSSRSSERSVRDVFHVATVASLGRGGHRQLRRTDSRRGLQRSTQLPGRPDRGNEGEIH
                     KDRAKSCNLM"
     exon            276..363
                     /gene="Rnd2"
                     /gene_synonym="Arhn; RhoN; Rohn"
                     /inference="alignment:Splign:2.1.0"
     exon            364..473
                     /gene="Rnd2"
                     /gene_synonym="Arhn; RhoN; Rohn"
                     /inference="alignment:Splign:2.1.0"
     exon            474..608
                     /gene="Rnd2"
                     /gene_synonym="Arhn; RhoN; Rohn"
                     /inference="alignment:Splign:2.1.0"
     exon            609..1373
                     /gene="Rnd2"
                     /gene_synonym="Arhn; RhoN; Rohn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcggggc ggagggggcc cgcagccccg ggcgggggct cggcgcgggc ccgcgagatg
       61 ccggtgtcgg cggcccgaga ggctgcagct gcagcggcgg gggaggaggc ggcagaggcg
      121 gtggctgtgt ccgggagggg ggctgcgtgg ggggccggcg cgtagccggg actatggagg
      181 ggcagagtgg ccgctgcaag atcgtagtgg tgggggacgc ggagtgcggc aagacagcgc
      241 tgctgcaggt gttcgccaag gacgcctacc ccgggagtta tgtccccaca gtgtttgaga
      301 actacactgc cagcttcgag atcgacaagc gccgcattga gctcaacatg tgggatactt
      361 caggttcctc ttactatgac aatgtccggc ctctggccta cccagattct gatgctgtgc
      421 tcatctgctt tgacattagc cggccagaaa cactggacag tgtcctcaag aagtggcaag
      481 gagagactca ggagttttgc cccaatgcca aggtggtgct ggttggctgt aagctggaca
      541 tgcggactga cctggccacc ctgagggagc tatccaagca gagacttatc cccgtcacac
      601 acgagcaggg tactgtgctg gccaagcagg tgggagctgt gtcctacgtt gaatgctcct
      661 cccggtcttc cgagcgcagt gtcagggacg tcttccatgt ggccacagtg gcttctcttg
      721 gccgtggtgg ccataggcag ctgcgccgta ctgactctcg ccgaggactg cagcgatcca
      781 ctcaactgcc tggacggcca gacagaggaa atgagggcga gatacataaa gatcgagcca
      841 agagctgtaa cctcatgtga ggggttgcag tgtggcagag agggaagagg tctaggtgag
      901 agacaccatt gttcccctgt gcactcctgg actttctgac ctcctgatcc tggccggaag
      961 ggcagggcag gcagaggagc aattctggtt ggaggaagct acttccttat ccctttccct
     1021 gctgctagcc gagagagcta acagggtagg catcggaggc atgaacttgg atagggcagg
     1081 taggtgttcg gaaaaccaga caatgacttt ggttgagtct cctatagaaa gtgtatcttc
     1141 cttgctcacc ctggtcccca tatccccgtc tgccttccct gaggaaagtg tccatcttct
     1201 ctttgtctct cctctcactt ccacatctgt tctcatacac gctaaccttt caggcaacat
     1261 gcactaaatt ttaaagcaag aagttctttc ctcccatcaa ctcaccaacc tgttcgagct
     1321 tcccctcttc cccagcagtc tgcaaataaa agcccatgac catggaaaac ggc
//
