LOCUS       NM_001013222            1639 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus Rho family GTPase 1 (Rnd1), mRNA.
ACCESSION   NM_001013222 XM_343323
VERSION     NM_001013222.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1639)
  AUTHORS   Kluge A, Rangrez AY, Kilian LS, Pott J, Bernt A, Frauen R, Rohrbeck
            A, Frey N and Frank D.
  TITLE     Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive
            activator of cardiomyocyte hypertrophy
  JOURNAL   J Mol Cell Cardiol 129, 130-143 (2019)
   PUBMED   30797814
  REMARK    GeneRIF: Rnd1 as a novel stretch-sensitive gene which influences
            cell proliferation and cellular hypertrophy.
REFERENCE   2  (bases 1 to 1639)
  AUTHORS   de Souza LE, Moura Costa MD, Bilek ES, Lopes MH, Martins VR,
            Puschel AW, Mercadante AF, Nakao LS and Zanata SM.
  TITLE     STI1 antagonizes cytoskeleton collapse mediated by small GTPase
            Rnd1 and regulates neurite growth
  JOURNAL   Exp Cell Res 324 (1), 84-91 (2014)
   PUBMED   24690281
  REMARK    GeneRIF: STI1 participates in Rnd1-induced signal transduction
            pathways that are involved in the dynamics of the actin
            cytoskeleton.
REFERENCE   3  (bases 1 to 1639)
  AUTHORS   Tong Y, Hota PK, Penachioni JY, Hamaneh MB, Kim S, Alviani RS, Shen
            L, He H, Tempel W, Tamagnone L, Park HW and Buck M.
  TITLE     Structure and function of the intracellular region of the plexin-b1
            transmembrane receptor
  JOURNAL   J Biol Chem 284 (51), 35962-35972 (2009)
   PUBMED   19843518
REFERENCE   4  (bases 1 to 1639)
  AUTHORS   Li YH, Ghavampur S, Bondallaz P, Will L, Grenningloh G and Pu Schel
            AW.
  TITLE     Rnd1 regulates axon extension by enhancing the microtubule
            destabilizing activity of SCG10
  JOURNAL   J Biol Chem 284 (1), 363-371 (2009)
   PUBMED   18996843
  REMARK    GeneRIF: SCG10 acts as an effector downstream of Rnd1 to regulate
            axon extensions by modulating microtubule organization.
            Correction to:[J Biol Chem. 284:363.]
REFERENCE   5  (bases 1 to 1639)
  AUTHORS   Ishikawa Y, Katoh H and Negishi M.
  TITLE     Small GTPase Rnd1 is involved in neuronal activity-dependent
            dendritic development in hippocampal neurons
  JOURNAL   Neurosci Lett 400 (3), 218-223 (2006)
   PUBMED   16530331
  REMARK    GeneRIF: Our findings demonstrate that Rnd1 is involved in
            signaling pathways of neuronal activity-dependent dendritic
            development.
REFERENCE   6  (bases 1 to 1639)
  AUTHORS   Kim YS, Hori M, Yasuda K and Ozaki H.
  TITLE     Differences in the gestational pattern of mRNA expression of the
            Rnd family in rat and human myometria
  JOURNAL   Comp Biochem Physiol A Mol Integr Physiol 142 (4), 410-415 (2005)
   PUBMED   16311049
  REMARK    GeneRIF: The RND2 mRNA levels increased significantly was expressed
            in nonpregnant rat myometrium.
            GeneRIF: The RND1 mRNA levels increased significantly was expressed
            in nonpregnant rat myometrium.
REFERENCE   7  (bases 1 to 1639)
  AUTHORS   Harada A, Katoh H and Negishi M.
  TITLE     Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced
            down-regulation of RhoA activity and is involved in fibroblast
            growth factor-induced neurite outgrowth in PC12 cells
  JOURNAL   J Biol Chem 280 (18), 18418-18424 (2005)
   PUBMED   15738000
  REMARK    GeneRIF: The activity of Rnd1, regulated through FRS2beta, plays an
            important role in the fibroblast growth factor signaling during
            neurite outgrowth.
REFERENCE   8  (bases 1 to 1639)
  AUTHORS   Ishikawa Y, Katoh H and Negishi M.
  TITLE     A role of Rnd1 GTPase in dendritic spine formation in hippocampal
            neurons
  JOURNAL   J Neurosci 23 (35), 11065-11072 (2003)
   PUBMED   14657163
  REMARK    GeneRIF: investigated the effect of Rnd1 on neuronal morphology;
            Rnd1 protein was localized in synaptosomal membrane fraction, and
            plays a role in dendritic spine formation in the developmental
            synaptogenic stage.
REFERENCE   9  (bases 1 to 1639)
  AUTHORS   Aoki J, Katoh H, Mori K and Negishi M.
  TITLE     Rnd1, a novel rho family GTPase, induces the formation of neuritic
            processes in PC12 cells
  JOURNAL   Biochem Biophys Res Commun 278 (3), 604-608 (2000)
   PUBMED   11095956
REFERENCE   10 (bases 1 to 1639)
  AUTHORS   Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A and Chardin P.
  TITLE     A new member of the Rho family, Rnd1, promotes disassembly of actin
            filament structures and loss of cell adhesion
  JOURNAL   J Cell Biol 141 (1), 187-197 (1998)
   PUBMED   9531558
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089994.1.
            
            On Apr 20, 2005 this sequence version replaced XM_343323.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089994.1, CO397450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840129, SAMN14984033
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1639
                     /gene="Rnd1"
                     /note="Rho family GTPase 1"
                     /db_xref="GeneID:362993"
                     /db_xref="RGD:1306338"
     exon            1..212
                     /gene="Rnd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..791
                     /gene="Rnd1"
                     /codon_start=1
                     /product="rho-related GTP-binding protein Rho6"
                     /protein_id="NP_001013240.1"
                     /db_xref="GeneID:362993"
                     /db_xref="RGD:1306338"
                     /translation="MKERRTPQPVVVRCKLVLVGDVQCGKTAMLQVLAKDCYPETYVP
                     TVFENYTACLETEEQRVELSLWDTSGSPYYDNVRPLCYSDSDAVLLCFDISRPETMDS
                     ALKKWRTEILDYCPSTRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLG
                     AEIYLEGSAFTSETSIHSIFRTASMVCLNKPSPVPPKSPVRSLSKRLLHLPSRSELIT
                     STFKKEKAKSCSIM"
     exon            213..300
                     /gene="Rnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            301..410
                     /gene="Rnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..545
                     /gene="Rnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..1610
                     /gene="Rnd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggaaccg gcaactaggc accagtgtgg acgcttgagg ggcgacctcc tcctcactga
       61 acccgagtcc acgtccctcc taggctgcag ccatgaagga gagacggaca ccgcagccag
      121 tggtggtcag atgtaagctt gtgctggtgg gggacgtgca gtgtgggaag acggcgatgt
      181 tacaggtgct agcgaaagac tgctatcccg agacctatgt gcctaccgtg tttgagaatt
      241 acacagcctg tttggagaca gaggaacaga gagtggagct tagtctctgg gatacctcag
      301 gctctccgta ctatgacaat gtccgtccac tctgctacag cgactcggat gcagtgttgc
      361 tctgcttcga catcagccgt ccagagacga tggacagtgc actcaagaag tggagaacag
      421 aaatcctaga ctattgtccc agcacacgtg ttttgcttat tggctgcaag acagatcttc
      481 gaacagacct gagcactcta atggaactgt cccaccagaa gcaggcaccc atctcctacg
      541 agcagggctg tgcgatagcc aagcagttgg gtgcagagat ctacctggag ggctcagctt
      601 tcacctcgga gacgagcatc cacagcatct tccggacggc atccatggtg tgtctgaaca
      661 agcctagccc agtgcccccg aagagccctg tccgaagcct ctccaagcga ctactccacc
      721 ttcccagtcg ctctgaactc atcacttcta ccttcaagaa ggagaaggcc aaaagctgtt
      781 ctatcatgtg aagttggagc cggaggcggg gaagacagcc ccccacttcc tcccttgggg
      841 tacagaggca tggggagagg gaggatgaga cgttttcaga tggccacgga gagagggctt
      901 tagaaggaga caggaatggt attgaagaag aggccaggcc tggcaggagg gcctgacatt
      961 taagtgaggg ccatcatatc ccaagccagg cgctaggctg gagagggggt cattgcccca
     1021 gtgtcccccc tactccagag gaaggatggg tactggggag atggggacat gatggactca
     1081 tcttcagcat caagcctctt ccgcacatcg ttcccacaca ggctcgggtg ggaggggtcc
     1141 ttggtcccct ctcttcccct ttacgaagtg gcagtggact ggagagtagg aaaacctgga
     1201 ggcagctccc ttgggggctt aacccagatg atgcttcctc actgaaacca ggagggcgag
     1261 ggctgaccag gcctaaaaag gagacctcat ctttgcatag cccatgcatc atggagaggt
     1321 gacatcacac attcacacgc ttctcactga agtcccccgg gcccaaggga gaagccccag
     1381 acccccttct tttgcagaat gtgggggtgg tggtgctgca ggggcaggac tgatgggggg
     1441 ggggtcgtca ccagactttc ctgccctcag ggcagtacag ctgggatttg ttttatagac
     1501 tcttgttttt ggaactgggg gggtggaggg ggagcgcttc gatccgttat atgttctgtg
     1561 tttaaagaag aaaacctatt tattaatgaa atataacata tgaagaggtt aaaaaaaaaa
     1621 aaaaaaaaaa aaaaaaaaa
//
