LOCUS       NM_001106210             963 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus ribonuclease T2 (Rnaset2), mRNA.
ACCESSION   NM_001106210 XM_001070006 XM_214769
VERSION     NM_001106210.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 963)
  AUTHORS   Zeng Z, Zhang X, Li D, Li J, Yuan J, Gu L and Xiong X.
  TITLE     Expression, Location, Clinical Implication, and Bioinformatics
            Analysis of RNASET2 in Gastric Adenocarcinoma
  JOURNAL   Front Oncol 10, 836 (2020)
   PUBMED   32528897
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 963)
  AUTHORS   De Vito A, Orecchia P, Balza E, Reverberi D, Scaldaferri D,
            Taramelli R, Noonan DM, Acquati F and Mortara L.
  TITLE     Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse
            Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage
            Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection
  JOURNAL   Cancers (Basel) 12 (3), 717 (2020)
   PUBMED   32197460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 963)
  AUTHORS   Ou J, Peng Y, Yang W, Zhang Y, Hao J, Li F, Chen Y, Zhao Y, Xie X,
            Wu S, Zha L, Luo X, Xie G, Wang L, Sun W, Zhou Q, Li J and Liang H.
  TITLE     ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil
            via promoting autophagic uracil yield
  JOURNAL   Nat Commun 10 (1), 1078 (2019)
   PUBMED   30842415
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 963)
  AUTHORS   Uccella S, La Rosa S, Scaldaferri D, Monti L, Maragliano R,
            Sorrenti E, Gariboldi M, Taramelli R, Sessa F and Acquati F.
  TITLE     New insights into hypoxia-related mechanisms involved in different
            microvascular patterns of bronchopulmonary carcinoids and poorly
            differentiated neuroendocrine carcinomas. Role of ribonuclease T2
            (RNASET2) and HIF-1alpha
  JOURNAL   Hum Pathol 79, 66-76 (2018)
   PUBMED   29763721
REFERENCE   5  (bases 1 to 963)
  AUTHORS   Sinkevicius KW, Morrison TR, Kulkarni P, Caffrey Cagliostro MK,
            Iriah S, Malmberg S, Sabrick J, Honeycutt JA, Askew KL, Trivedi M
            and Ferris CF.
  TITLE     RNaseT2 knockout rats exhibit hippocampal neuropathology and
            deficits in memory
  JOURNAL   Dis Model Mech 11 (6) (2018)
   PUBMED   29752287
  REMARK    GeneRIF: RNaseT2 knockout rats exhibited memory deficits.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 963)
  AUTHORS   Maletzki C, Huehns M, Bauer I, Ripperger T, Mork MM, Vilar E,
            Klocking S, Zettl H, Prall F and Linnebacher M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   7  (bases 1 to 963)
  AUTHORS   Roiz L, Smirnoff P, Lewin I, Shoseyov O and Schwartz B.
  TITLE     Human recombinant RNASET2: A potential anti-cancer drug
  JOURNAL   Oncoscience 3 (2), 71-84 (2016)
   PUBMED   27014725
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 963)
  AUTHORS   Thorn A, Steinfeld R, Ziegenbein M, Grapp M, Hsiao HH, Urlaub H,
            Sheldrick GM, Gartner J and Kratzner R.
  TITLE     Structure and activity of the only human RNase T2
  JOURNAL   Nucleic Acids Res 40 (17), 8733-8742 (2012)
   PUBMED   22735700
REFERENCE   9  (bases 1 to 963)
  AUTHORS   Campomenosi P, Salis S, Lindqvist C, Mariani D, Nordstrom T,
            Acquati F and Taramelli R.
  TITLE     Characterization of RNASET2, the first human member of the Rh/T2/S
            family of glycoproteins
  JOURNAL   Arch Biochem Biophys 449 (1-2), 17-26 (2006)
   PUBMED   16620762
REFERENCE   10 (bases 1 to 963)
  AUTHORS   Palmer DJ, Kelly VC, Smit AM, Kuy S, Knight CG and Cooper GJ.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474059.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001070006.1, XM_214769.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO554557.1, EV777937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..963
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..963
                     /gene="Rnaset2"
                     /note="ribonuclease T2"
                     /db_xref="GeneID:292306"
                     /db_xref="RGD:1309918"
     exon            1..191
                     /gene="Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..867
                     /gene="Rnaset2"
                     /EC_number="4.6.1.19"
                     /codon_start=1
                     /product="ribonuclease T2 precursor"
                     /protein_id="NP_001099680.1"
                     /db_xref="GeneID:292306"
                     /db_xref="RGD:1309918"
                     /translation="MAEARGALPGWVSVLGWGLALCCLCGAGPLWSGSHEWKKLILTQ
                     HWPPTVCKEVNRCRDSLDYWTIHGLWPDRAEDCNHSWHFNLNEIKDLLRDMKIYWPDV
                     IHPSSNRSQFWKHEWDKHGTCAAQVDALNSERKYFGKSLDLYKQIDLNSVLQKFEIKP
                     SINYYQLADFKDALTRIYGVVPKIQCLMPEQGENVQTIGQIELCFTKEDFHLRNCTEP
                     EEQPSSGQEARLAREASTHGMMVCEDGPIFYPPPKSQH"
     exon            192..252
                     /gene="Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            253..305
                     /gene="Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..363
                     /gene="Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            364..434
                     /gene="Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..548
                     /gene="Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..594
                     /gene="Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            595..669
                     /gene="Rnaset2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..963
                     /gene="Rnaset2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaagcctg aggtgaagag tcgctggcgg tcagtctggt tgccgagcga gcgtgcgcaa
       61 aggccgctgg gaagctgcgg agcccgggac agcgcgatgg cggaggctcg cggcgcgctc
      121 ccgggctggg tctcggtgct gggctggggc ctggcgctgt gctgtctgtg cggggcgggc
      181 ccgctgtgga gtggcagcca tgagtggaaa aaactaattt tgacccagca ctggcccccc
      241 acagtatgca aggaagttaa cagatgtcgg gactctctgg attactggac aatacatgga
      301 ctatggcctg acagagcaga agattgtaac cactcctggc actttaacct aaatgagatt
      361 aaggaccttt tgcgagacat gaagatctac tggcctgatg tgattcaccc gtcttctaat
      421 cgcagccaat tctggaaaca tgaatgggat aaacacggca cctgtgctgc ccaggtggat
      481 gccctcaatt ccgagaggaa gtactttggg aagagcctgg atctatacaa gcagattgac
      541 ctcaacagtg tactacaaaa atttgagatc aagccatcta tcaactacta ccagcttgca
      601 gatttcaaag atgcacttac aagaatctat ggtgtggtgc ctaaaatcca gtgccttatg
      661 ccagaacagg gagagaatgt acagaccatt gggcagatag agctgtgctt caccaaggag
      721 gacttccatt tgcggaactg tactgagcca gaggagcagc catcctccgg gcaggaagcc
      781 cggctggcca gggaggcttc gacgcatggg atgatggtct gcgaagacgg cccgatcttc
      841 tatcctccac ccaagtccca acactgatgt tcacattttg gaaatatttt atgttccaca
      901 aagtaagaga agttcccaaa tcattgcttt ctaaaaattc actaaaaagt ttcttaaaat
      961 gtg
//
