LOCUS       NM_182673               2497 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ribonuclease L (Rnasel), mRNA.
ACCESSION   NM_182673
VERSION     NM_182673.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2497)
  AUTHORS   Goldstein,S.A., Thornbrough,J.M., Zhang,R., Jha,B.K., Li,Y.,
            Elliott,R., Quiroz-Figueroa,K., Chen,A.I., Silverman,R.H. and
            Weiss,S.R.
  TITLE     Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus
            Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That
            Antagonize Activation of RNase L
  JOURNAL   J Virol 91 (5), e02201-16 (2017)
   PUBMED   28003490
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2497)
  AUTHORS   Thornbrough,J.M., Jha,B.K., Yount,B., Goldstein,S.A., Li,Y.,
            Elliott,R., Sims,A.C., Baric,R.S., Silverman,R.H. and Weiss,S.R.
  TITLE     Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits
            Host RNase L Activation
  JOURNAL   mBio 7 (2), e00258 (2016)
   PUBMED   27025250
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2497)
  AUTHORS   Han,Y., Donovan,J., Rath,S., Whitney,G., Chitrakar,A. and
            Korennykh,A.
  TITLE     Structure of human RNase L reveals the basis for regulated RNA
            decay in the IFN response
  JOURNAL   Science 343 (6176), 1244-1248 (2014)
   PUBMED   24578532
REFERENCE   4  (bases 1 to 2497)
  AUTHORS   Zhou,Y., Kang,M.J., Jha,B.K., Silverman,R.H., Lee,C.G. and
            Elias,J.A.
  TITLE     Role of ribonuclease L in viral pathogen-associated molecular
            pattern/influenza virus and cigarette smoke-induced inflammation
            and remodeling
  JOURNAL   J Immunol 191 (5), 2637-2646 (2013)
   PUBMED   23913960
REFERENCE   5  (bases 1 to 2497)
  AUTHORS   Li,S.X., Barrett,B.S., Harper,M.S., Heilman,K.J., Halemano,K.,
            Steele,A.K., Guo,K., Silverman,R.H. and Santiago,M.L.
  TITLE     Ribonuclease L is not critical for innate restriction and adaptive
            immunity against Friend retrovirus infection
  JOURNAL   Virology 443 (1), 134-142 (2013)
   PUBMED   23725696
REFERENCE   6  (bases 1 to 2497)
  AUTHORS   Casey,G., Neville,P.J., Plummer,S.J., Xiang,Y., Krumroy,L.M.,
            Klein,E.A., Catalona,W.J., Nupponen,N., Carpten,J.D., Trent,J.M.,
            Silverman,R.H. and Witte,J.S.
  TITLE     RNASEL Arg462Gln variant is implicated in up to 13% of prostate
            cancer cases
  JOURNAL   Nat Genet 32 (4), 581-583 (2002)
   PUBMED   12415269
REFERENCE   7  (bases 1 to 2497)
  AUTHORS   Xiang,Y., Condit,R.C., Vijaysri,S., Jacobs,B., Williams,B.R. and
            Silverman,R.H.
  TITLE     Blockade of interferon induction and action by the E3L
            double-stranded RNA binding proteins of vaccinia virus
  JOURNAL   J Virol 76 (10), 5251-5259 (2002)
   PUBMED   11967338
REFERENCE   8  (bases 1 to 2497)
  AUTHORS   Guidotti,L.G., Morris,A., Mendez,H., Koch,R., Silverman,R.H.,
            Williams,B.R. and Chisari,F.V.
  TITLE     Interferon-regulated pathways that control hepatitis B virus
            replication in transgenic mice
  JOURNAL   J Virol 76 (6), 2617-2621 (2002)
   PUBMED   11861827
REFERENCE   9  (bases 1 to 2497)
  AUTHORS   Dong,B., Xu,L., Zhou,A., Hassel,B.A., Lee,X., Torrence,P.F. and
            Silverman,R.H.
  TITLE     Intrinsic molecular activities of the interferon-induced
            2-5A-dependent RNase
  JOURNAL   J Biol Chem 269 (19), 14153-14158 (1994)
   PUBMED   7514601
REFERENCE   10 (bases 1 to 2497)
  AUTHORS   Pfeifer,K., Ushijima,H., Lorenz,B., Muller,W.E. and Schroder,H.C.
  TITLE     Evidence for age-dependent impairment of antiviral
            2',5'-oligoadenylate synthetase/ribonuclease L-system in tissues of
            rat
  JOURNAL   Mech Ageing Dev 67 (1-2), 101-114 (1993)
   PUBMED   8469023
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY262823.1.
            
            On Aug 30, 2012 this sequence version replaced NM_182673.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY262823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2497              AY262823.1         3-2499
FEATURES             Location/Qualifiers
     source          1..2497
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..2497
                     /gene="Rnasel"
                     /note="ribonuclease L"
                     /db_xref="GeneID:359726"
                     /db_xref="RGD:727933"
     exon            1..1519
                     /gene="Rnasel"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2247
                     /gene="Rnasel"
                     /note="ribonuclease L (2, 5-oligoisoadenylate
                     synthetase-dependent); ribonuclease L
                     (2',5'-oligoisoadenylate synthetase-dependent)"
                     /codon_start=1
                     /product="2-5A-dependent ribonuclease"
                     /protein_id="NP_872614.1"
                     /db_xref="GeneID:359726"
                     /db_xref="RGD:727933"
                     /translation="METTDHSTPQCGSASAGGQKTVGKDDYLLIEAVNKGDADRVQQL
                     LEQGADANVCEESGGWTPLHNAVQSGRVDIVNLLLRYGADPHRRKKNGATPFIVAGIC
                     GDVSLLQIFLSRGANINERDMYGFTAFMEAAEYGNVEALKFLFAEGADVNLRRETTED
                     RRRLKQGGATALMSAAENGHPEVVRILLDEMKAEADARDNMGRNALIRSLLNRDCENV
                     EIHVEEITSVLIQYGADINVRGEGEKTPLISAVKRKHTGLVQMLLSQEGIKVNDRDSE
                     GKTALQIAVELKLKEIVRLLLEKGADTKCGDLVWIAKRNYDHGLVKLLLSYEANHDTN
                     PPAKDWLPHSARWGEALERLHSVSRPMTGKLKIFMNDDYKIASTSEGGIYLGIYDNRE
                     VAVKVFCENSSRGRKEVSCLRDCGDHSNLLTFYGSEEHKGSLYVCVSLCESTLEKFLN
                     VPREEPMEKGEDKFALSVLLSIFKGVQKLHMHGYSHQNLQPPNILIDSEKAVRLADFD
                     ESIQWMRESQTVQRDLEDLGRLVLYVVNKGEIPFETLKGQNDEELLTIAPNEETKDLV
                     HCLFSPGENVKNCLMDLLGHPFFWTWENRYRTLRDVGNESDIKVRNNKSKLLKLLQPQ
                     THAPSRSFDRWTSKIDKRVMSDMNGFYKSRKGYRDTVGDLLKFIRNIGEHINEEKNRQ
                     MKEILGDPSRYFQETFPDLVIYIYKKLKETEFRKHFPQPPPSLSVPEAAGPGGVQS"
     exon            1520..1605
                     /gene="Rnasel"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1811
                     /gene="Rnasel"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1944
                     /gene="Rnasel"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2075
                     /gene="Rnasel"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2487
                     /gene="Rnasel"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcattgctca aggaaaaggc attgactatc atggagacca cggatcatag cacacctcag
       61 tgtggatccg catcagcagg tggtcagaag accgttggca aagatgatta tttgttgata
      121 gaagctgtta acaagggaga tgctgacagg gtccagcaat tgttagaaca aggggctgat
      181 gccaatgtct gtgaagaatc tgggggctgg acacctttgc acaacgcggt gcagtctggc
      241 agggtagata ttgtgaatct cctgcttcgt tatggtgctg accctcatcg gaggaagaag
      301 aatggggcca cccccttcat cgttgctggg atctgtggag atgtgagtct gctccagatt
      361 ttcctctctc gaggtgcaaa catcaatgag cgtgacatgt acggattcac ggctttcatg
      421 gaagctgctg agtatggtaa cgttgaagcc ctaaaattcc tttttgctga aggggccgat
      481 gtgaatttga gacgggagac aacggaggac agaaggcgac tgaagcaagg aggggccacg
      541 gctctcatga gcgctgcgga gaatggccac ccggaagtcg tgagaattct cctcgatgaa
      601 atgaaggcag aagccgatgc tcgggacaat atgggcagaa atgccttgat ccgttctctg
      661 ctgaaccgcg attgtgaaaa tgttgaaatt catgtggagg agatcacttc agttctgatt
      721 caatacggcg ctgatattaa tgtgagaggg gaaggtgaga agacacctct gatctcagca
      781 gtgaagagga agcacacagg tttggtgcag atgctcctga gtcaggaggg cataaaggtg
      841 aatgacagag atagcgaggg caagacggcg ctgcaaattg ctgttgaact caaactgaag
      901 gaaatcgtcc ggttgcttct tgaaaaggga gccgatacca agtgtggcga tcttgtttgg
      961 atagccaaga ggaattatga ccatggtcta gtaaaacttc ttctctcgta tgaagctaat
     1021 cacgacacca accctcctgc taaagactgg ttgcctcaca gtgcacgctg gggggaggcc
     1081 ttggaaagac tccacagtgt gtctcgaccc atgactggca aactcaagat cttcatgaat
     1141 gatgactata aaattgccag cacttctgaa gggggcatct acctagggat ctatgacaat
     1201 cgagaggtgg ctgtgaaggt cttctgtgag aatagctcac gtggacgtaa ggaagtctct
     1261 tgtctgcggg actgtggaga ccacagtaac ttactgactt tctatggaag cgaggagcac
     1321 aagggcagtt tatatgtgtg tgtgtccctg tgtgagtcga cattggaaaa gttcctgaat
     1381 gtgcccagag aggaacctat ggagaaaggg gaagacaagt ttgccctcag tgtcctattg
     1441 tctatattta agggtgttca aaaactacac atgcatggat attcccatca gaacctgcaa
     1501 ccgccaaaca tcttaataga ttctgagaaa gctgtccggc tggcagattt tgatgagagc
     1561 atccagtgga tgagagagtc acagacggtc cagagagact tggaggacct tggacgactg
     1621 gttctctatg tggtaaacaa aggtgagatc ccctttgaga cactgaaggg tcagaatgat
     1681 gaagaattgc ttacgatcgc tccaaatgag gagactaagg acctcgttca ttgcctgttt
     1741 tctcctggag aaaatgtaaa gaactgtctg atggacctgc ttggccatcc tttcttttgg
     1801 acttgggaga accgctatag aacgcttcgg gatgtgggaa atgaatctga catcaaagta
     1861 cgaaataata aaagtaaact tctcaagcta ctgcagcctc agacacacgc gccttccaga
     1921 agctttgatc ggtggacgtc taagatcgac aaacgtgtca tgtctgacat gaatggtttc
     1981 tataaatccc gaaagggtta tcgggatact gtaggtgatc tgctgaagtt tattcggaat
     2041 ataggagaac acatcaatga ggaaaaaaac aggcaaatga aggagatact tggagaccct
     2101 tctcgttatt ttcaggagac atttccagat cttgtaatct atatctacaa gaaactaaag
     2161 gaaacggaat tcagaaaaca ctttcctcag cctccaccaa gcctcagcgt gccagaggca
     2221 gcgggaccag ggggtgtaca gagctgagtc ttgaaagttc atgggaccat ttcttccagt
     2281 cagtatagtt cttggcaagt ttcacatttc tggtctctta agcagcctgg ttgctgtgag
     2341 cacttagata gccagtgtgt tggtttctga tgcagtaagt tctacacatt tccatgatca
     2401 caaaagcagt gtactacaaa gctatactgc cccattttag tggatggaat ggggagcgcc
     2461 ttctgttaag attttgttta aaaaaaaaaa aaaaaaa
//
