LOCUS       NM_001007007            1450 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus ribonuclease H2, subunit B (Rnaseh2b), mRNA.
ACCESSION   NM_001007007 XM_341336
VERSION     NM_001007007.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1450)
  AUTHORS   Hiller,B., Achleitner,M., Glage,S., Naumann,R., Behrendt,R. and
            Roers,A.
  TITLE     Mammalian RNase H2 removes ribonucleotides from DNA to maintain
            genome integrity
  JOURNAL   J Exp Med 209 (8), 1419-1426 (2012)
   PUBMED   22802351
REFERENCE   2  (bases 1 to 1450)
  AUTHORS   Figiel,M., Chon,H., Cerritelli,S.M., Cybulska,M., Crouch,R.J. and
            Nowotny,M.
  TITLE     The structural and biochemical characterization of human RNase H2
            complex reveals the molecular basis for substrate recognition and
            Aicardi-Goutieres syndrome defects
  JOURNAL   J Biol Chem 286 (12), 10540-10550 (2011)
   PUBMED   21177858
REFERENCE   3  (bases 1 to 1450)
  AUTHORS   Shaban,N.M., Harvey,S., Perrino,F.W. and Hollis,T.
  TITLE     The structure of the mammalian RNase H2 complex provides insight
            into RNA.NA hybrid processing to prevent immune dysfunction
  JOURNAL   J Biol Chem 285 (6), 3617-3624 (2010)
   PUBMED   19923215
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083791.1.
            
            On Nov 22, 2004 this sequence version replaced XM_341336.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083791.1, FQ220108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1450
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1450
                     /gene="Rnaseh2b"
                     /note="ribonuclease H2, subunit B"
                     /db_xref="GeneID:361056"
                     /db_xref="RGD:1359710"
     exon            1..71
                     /gene="Rnaseh2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..934
                     /gene="Rnaseh2b"
                     /note="RNase H2 subunit B; ribonuclease HI subunit B"
                     /codon_start=1
                     /product="ribonuclease H2 subunit B"
                     /protein_id="NP_001007008.1"
                     /db_xref="GeneID:361056"
                     /db_xref="RGD:1359710"
                     /translation="MAGGRDRGDLAARQLVFLLPEYLKDASRKSKSGLLFVKLVNPHS
                     GEGATYLIDACLQKLFEIKVFKEKHHSWFINQSVQSGGLLHFATPMDPLFLLLHYLIK
                     AGKEGKYQPLDQVVVDDKFPDCTLLLRFPELEKSLRHVTEEKEVNSKKYYKYSTEKTL
                     KWLEKKVNQTVAALKANHVNVGARVQSSAYFSGVQVSRDKEEDYVRYAHGLISDYIPK
                     ELSDDLSKLLKLPEPPASLPNPPAKKLKLADEPVEAKEDYTKFNTKDLKNGKKNSKMT
                     AAQKALAKVDKSGMKSIDAFFGAKNKKTGKI"
     exon            72..143
                     /gene="Rnaseh2b"
                     /inference="alignment:Splign:2.1.0"
     exon            144..251
                     /gene="Rnaseh2b"
                     /inference="alignment:Splign:2.1.0"
     exon            252..328
                     /gene="Rnaseh2b"
                     /inference="alignment:Splign:2.1.0"
     exon            329..443
                     /gene="Rnaseh2b"
                     /inference="alignment:Splign:2.1.0"
     exon            444..508
                     /gene="Rnaseh2b"
                     /inference="alignment:Splign:2.1.0"
     exon            509..614
                     /gene="Rnaseh2b"
                     /inference="alignment:Splign:2.1.0"
     exon            615..696
                     /gene="Rnaseh2b"
                     /inference="alignment:Splign:2.1.0"
     exon            697..739
                     /gene="Rnaseh2b"
                     /inference="alignment:Splign:2.1.0"
     exon            740..820
                     /gene="Rnaseh2b"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1422
                     /gene="Rnaseh2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtgcgac atggccggag gtcgggaccg cggggacttg gctgctaggc agctagtgtt
       61 cctacttcca gaatatttaa aagatgcctc gaggaagtcg aagagcggcc tcctgtttgt
      121 aaagctggtc aacccgcact caggggaagg agccacttac ttaattgatg cgtgtctaca
      181 gaagctgttt gaaataaaag ttttcaagga aaaacaccat tcttggttta taaatcagtc
      241 agttcaatca ggaggccttc tccactttgc cacacccatg gaccctttat ttctgctcct
      301 tcactatctc ataaaggctg gcaaagaggg gaagtatcag cccttggatc aggttgtagt
      361 ggatgacaag tttccagatt gcaccttgct gctgagattt cctgagcttg agaagtcact
      421 tcggcatgtg acagaggaaa aagaagtgaa cagtaagaag tactataagt acagcacgga
      481 gaagacattg aagtggctgg agaagaaggt caaccaaacc gtggcagcac tgaaagccaa
      541 tcatgttaat gttggagccc gggtacagtc ttctgcatat ttctctggtg ttcaggtttc
      601 cagggacaag gaagaagact atgttcgata tgcccatggt ctgatctctg attacatccc
      661 taaagaatta agtgacgatt tatccaagct cttgaagctt ccagaacctc cagcctccct
      721 gccaaaccct ccagcaaaga aactaaagtt agcagatgag cctgtggaag cgaaagaaga
      781 ttacactaag tttaacacta aggacttgaa gaacggcaag aaaaatagca aaatgactgc
      841 agctcagaag gctttggcta aagttgacaa gagcggaatg aaaagtattg atgctttttt
      901 tggcgcaaaa aataaaaaaa ctggaaagat ttgaagcatt gaaaataaaa tccagtggaa
      961 cagaaaaaga agtttgcctc ttgcctattc tgtcttgtct cttcttgccg ctgtccgcga
     1021 ccctaagtca ctccgctgag aaccgagttg ctttcacatc ctgcggacac ttgctgggct
     1081 atgactttgt gtctgactaa cgcaatcatt gtgggaaagt gattgtgcga gcttctgtcc
     1141 agggcctttg gaacgtttgc catgatggaa agtcatcaca gcttccccag ggaggtgtga
     1201 gcggtgccca gctgttccct gctctgtcct gcgtggcctc agctgaaatg agctggacaa
     1261 caaaacagtt cattttggta aattttatga ttagccatat ctttgtgtgg attcttgttc
     1321 tttgtaaaaa gaaaaaaatc aataaaacaa aattgcagtc ttccactatg cgcgcataac
     1381 tagataatct tcttagaata aaaatatttt caagaactct aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaaaaa
//
